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Heung Bae Kim, MD

Heung Bae Kim MD
Department:
Surgery Research
Hospital Title:
Director, Pediatric Transplant Center
Academic Title:
Assistant Professor of Surgery, Harvard Medical School
Research Focus Area:
Transplantation tolerance
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Research Overview

Heung Bae Kim's research focuses on developing and testing new alternatives to existing surgical procedures. He originated the serial transverse enteroplasty, or STEP, procedure for short bowel syndrome, in which the bowel is stapled into v-shapes on alternating sides, decreasing its width and increasing its length. The procedure is currently used in instances where standard surgery to correct short-bowel syndrome is not feasible. In addition to the STEP procedure, Dr. Kim has several areas of interest in experimental and clinical transplantation. He has developed both small and large animal models of transplant tolerance induction using In Utero bone marrow transplantation and is currently working on adapting this approach for use in postnatal organ transplantation. As the Surgical Director of the Liver, Intestine, and Kidney transplant programs, he has a keen clinical interest in improving outcomes in pediatric solid organ transplantation through immunosuppression minimization and prevention of infectious complications. Finally, through his work on a national level at the United Network for Organ Sharing (UNOS), he is involved in national clinical policy development to improve organ allocation to pediatric patients.

About Heung Bae Kim

Heung Bae Kim received his MD degree from Albert Einstein College of Medicine. He completed an internship and residency at the Hospital of the University of Pennsylvania and a fellowship at Boston Children's Hospital.

Publications

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  1. Minneman JA, Grijalva JL, LaQuaglia MJ, Kim HB, Rangel SJ, Vakili K. Variation in resource utilization in liver transplantation at freestanding children's hospitals. Pediatr Transplant. 2016 Nov; 20(7):921-925.
  2. Tullius SG, Pomahac B, Kim HB, Carty MJ, Talbot SG, Nelson HM, Delmonico FL. Successful Recovery and Transplantation of 11 Organs Including Face, Bilateral Upper Extremities, and Thoracic and Abdominal Organs From a Single Deceased Organ Donor. Transplantation. 2016 Oct; 100(10):2226-9.
  3. LaQuaglia MJ, Grijalva JL, Mueller KA, Perez-Atayde AR, Kim HB, Sadri-Vakili G, Vakili K. YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma. Sci Rep. 2016; 6:30238.
  4. Fullington NM, Potanos KM, Cauley RP, Purcell P, Zurakowski D, Fishman SJ, Vakili K, Kim HB. Strain induced esophageal growth in a novel rodent model. J Pediatr Surg. 2016 Aug; 51(8):1273-8.
  5. Potanos K, Fullington N, Cauley R, Purcell P, Zurakowski D, Fishman S, Vakili K, Kim HB. Tissue expander stimulated lengthening of arteries (TESLA) induces early endothelial cell proliferation in a novel rodent model. J Pediatr Surg. 2016 Apr; 51(4):617-21.
  6. Cauley RP, Potanos K, Fullington N, Grijalva J, Graham DA, Kim HB, Vakili K. The effect of graft type on mortality in liver transplantation for hepatocellular carcinoma. Ann Transplant. 2015; 20:175-85.
  7. Sheu J, Saavedra AP, Degar BA, Duncan CN, Fawaz R, Tan JK, Schmidt BA, Kim HB, Huang JT. Bone marrow engraftment and associated dermatologic sequelae in a three-yr-old after liver transplantation. Pediatr Transplant. 2015 Mar; 19(2):E41-6.
  8. Schoettler M, Elisofon SA, Kim HB, Blume ED, Rodig N, Boyer D, Neufeld EJ, Grace RF. Treatment and outcomes of immune cytopenias following solid organ transplant in children. Pediatr Blood Cancer. 2015 Feb; 62(2):214-218.
  9. Potanos K, Kim HB. Frostbite of the liver: an unrecognized cause of primary non-function? Pediatr Transplant. 2014 Feb; 18(1):E10-2.
  10. Garnett GM, Kang KH, Jaksic T, Woo RK, Puapong DP, Kim HB, Johnson SM. First STEPs: serial transverse enteroplasty as a primary procedure in neonates with congenital short bowel. J Pediatr Surg. 2014 Jan; 49(1):104-7; discussion 108.
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  12. Sulemanji MN, Azpurua H, Suh M, Potanos K, Cauley R, Kunisaki SM, Modi B, Zurakowski D, Fishman SJ, Kim HB. Ductus venosus closure results in transient portal hypertension--is this the silent trigger for necrotizing enterocolitis? J Pediatr Surg. 2013 Oct; 48(10):2067-74.
  13. Cauley RP, Vakili K, Fullington N, Potanos K, Graham DA, Finkelstein JA, Kim HB. Deceased-donor split-liver transplantation in adult recipients: is the learning curve over? J Am Coll Surg. 2013 Oct; 217(4):672-684.e1.
  14. Cauley RP, Vakili K, Potanos K, Fullington N, Graham DA, Finkelstein JA, Kim HB. Deceased donor liver transplantation in infants and small children: are partial grafts riskier than whole organs? Liver Transpl. 2013 Jul; 19(7):721-9.
  15. Porras D, Stein DR, Ferguson MA, Chaudry G, Alomari A, Vakili K, Fishman SJ, Lock JE, Kim HB. Midaortic syndrome: 30 years of experience with medical, endovascular and surgical management. Pediatr Nephrol. 2013 Oct; 28(10):2023-33.
  16. Cauley RP, Stoffan A, Potanos K, Fullington N, Graham DA, Finkelstein JA, Kim HB, Wilson JM. Pulmonary support on day 30 as a predictor of morbidity and mortality in congenital diaphragmatic hernia. J Pediatr Surg. 2013 Jun; 48(6):1183-9.
  17. Kim HB, Lillehei CW. Organ donation for children: the road ahead. Pediatrics. 2013 Jun; 131(6):e1946-7.
  18. Kim HB, Vakili K, Modi BP, Ferguson MA, Guillot AP, Potanos KM, Prabhu SP, Fishman SJ. A novel treatment for the midaortic syndrome. N Engl J Med. 2012 Dec 13; 367(24):2361-2.
  19. Kang KH, Gutierrez IM, Zurakowski D, Diperna S, Buonomo C, Kim HB, Jaksic T. Bowel re-dilation following serial transverse enteroplasty (STEP). Pediatr Surg Int. 2012 Dec; 28(12):1189-93.
  20. Misra MV, Mullen MP, Vargas SO, Kim HB, Boyer D. Bilateral lung transplant for hereditary hemorrhagic telangiectasia in a pediatric patient. Pediatr Transplant. 2012 Dec; 16(8):E364-7.
  21. Ho DT, Rodig NM, Kim HB, Lidov HG, Shapiro FD, Raju GP, Kang PB. Rapid reversal of uremic neuropathy following renal transplantation in an adolescent. Pediatr Transplant. 2012 Nov; 16(7):E296-300.
  22. McGuire MM, Demehri S, Kim HB, Kamin D. Hypertrophic osteoarthropathy in intestinal transplant recipients. J Pediatr Surg. 2010 Nov; 45(11):e19-22.
  23. Kim HB. Urgent revascularization for hepatic artery thrombosis: maybe good for the few, definitely good for the many. Liver Transpl. 2010 Jul; 16(7):812-4.
  24. Jones BA, Hull MA, Kim HB. Autologous intestinal reconstruction surgery for intestinal failure management. Curr Opin Organ Transplant. 2010 Jun; 15(3):341-5.
  25. McGuire MM, Jones BA, Hull MA, Misra MV, Smithers CJ, Feins NR, Jenkins RL, Lillehei CW, Harmon WE, Jonas MM, Kim HB. Combined en bloc liver-double kidney transplantation in an infant with IVC thrombosis. Pediatr Transplant. 2011 Nov; 15(7):E142-4.
  26. Jones BA, Hull MA, McGuire MM, Kim HB. Autologous intestinal reconstruction surgery. Semin Pediatr Surg. 2010 Feb; 19(1):59-67.
  27. Page MP, Kim HB, Fishman SJ. Small intestinal volvulus caused by loose surgical staples. J Pediatr Surg. 2009 Sep; 44(9):1824-6.
  28. Zenzen W, Perez-Atayde AR, Elisofon SA, Kim HB, Alomari AI. Hepatic failure in a rapidly involuting congenital hemangioma of the liver: failure of embolotherapy. Pediatr Radiol. 2009 Oct; 39(10):1118-23.
  29. Misra MV, Gutweiler JR, Suh MY, Twark CM, Valim C, Perez-Atayde A, Kim HB. A murine model of graft-vs-host disease after in utero hematopoietic cell transplantation. J Pediatr Surg. 2009 Jun; 44(6):1102-7; discussion 1107.
  30. Ching YA, Fitzgibbons S, Valim C, Zhou J, Duggan C, Jaksic T, Kim HB. Long-term nutritional and clinical outcomes after serial transverse enteroplasty at a single institution. J Pediatr Surg. 2009 May; 44(5):939-43.
  31. Perger L, Kim HB, Jaksic T, Jennings RW, Linden BC. Thoracoscopic aortopexy for treatment of tracheomalacia in infants and children. J Laparoendosc Adv Surg Tech A. 2009 Apr; 19 Suppl 1:S249-54.
  32. Modi BP, Ching YA, Langer M, Donovan K, Fauza DO, Kim HB, Jaksic T, Nurko S. Preservation of intestinal motility after the serial transverse enteroplasty procedure in a large animal model of short bowel syndrome. J Pediatr Surg. 2009 Jan; 44(1):229-35; discussion 235.
  33. Suh MY, Wang K, Gutweiler JR, Misra MV, Krawczuk LE, Jenkins RL, Lillehei CW, Jonas MM, Kim HB. Safety of minimal immunosuppression in liver transplantation for hepatoblastoma. J Pediatr Surg. 2008 Jun; 43(6):1148-52.
  34. Modi BP, Suh MY, Jonas MM, Lillehei C, Kim HB. Ileal exclusion for refractory symptomatic cholestasis in Alagille syndrome. J Pediatr Surg. 2007 May; 42(5):800-5.
  35. Piper H, Modi BP, Kim HB, Fauza D, Glickman J, Jaksic T. The second STEP: the feasibility of repeat serial transverse enteroplasty. J Pediatr Surg. 2006 Dec; 41(12):1951-6.
  36. Chang RW, Javid PJ, Oh JT, Andreoli S, Kim HB, Fauza D, Jaksic T. Serial transverse enteroplasty enhances intestinal function in a model of short bowel syndrome. Ann Surg. 2006 Feb; 243(2):223-8.
  37. Javid PJ, Kim HB, Duggan CP, Jaksic T. Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndrome. J Pediatr Surg. 2005 Jun; 40(6):1019-23; discussion 1023-4.
  38. Javid PJ, Collier S, Richardson D, Iglesias J, Gura K, Lo C, Kim HB, Duggan CP, Jaksic T. The role of enteral nutrition in the reversal of parenteral nutrition-associated liver dysfunction in infants. J Pediatr Surg. 2005 Jun; 40(6):1015-8.
  39. Lee PW, Cina RA, Randolph MA, Arellano R, Goodrich J, Rowland H, Huang CA, Sachs DH, Kim HB. In utero bone marrow transplantation induces kidney allograft tolerance across a full major histocompatibility complex barrier in Swine. Transplantation. 2005 May 15; 79(9):1084-90.
  40. Lee PW, Cina RA, Randolph MA, Goodrich J, Rowland H, Arellano R, Kim HB, Sachs DH, Huang CA. Stable multilineage chimerism across full MHC barriers without graft-versus-host disease following in utero bone marrow transplantation in pigs. Exp Hematol. 2005 Mar; 33(3):371-9.
  41. Jonas MM, Krawczuk LE, Kim HB, Lillehei C, Perez-Atayde A. Rapid recurrence of nonalcoholic fatty liver disease after transplantation in a child with hypopituitarism and hepatopulmonary syndrome. Liver Transpl. 2005 Jan; 11(1):108-10.
  42. Di Luozzo G, Kim HB, Boiselle PM, Colin AA, Fishman SJ. Congenital absence of the right upper lobe bronchus with double segmental tracheal bronchi. Ann Thorac Surg. 2005 Jan; 79(1):331-4.
  43. Downard CD, Kim HB, Laningham F, Fishman SJ. Esophageal atresia, duodenal atresia, and unilateral lung agenesis: a case report. J Pediatr Surg. 2004 Aug; 39(8):1283-5.
  44. Fishman SJ, Jennings RW, Johnson SM, Kim HB. Contouring buttock reconstruction after sacrococcygeal teratoma resection. J Pediatr Surg. 2004 Mar; 39(3):439-41; discussion 439-41.
  45. Peranteau WH, Hayashi S, Kim HB, Shaaban AF, Flake AW. In utero hematopoietic cell transplantation: what are the important questions? Fetal Diagn Ther. 2004 Jan-Feb; 19(1):9-12.
  46. Kim HB, Lee PW, Garza J, Duggan C, Fauza D, Jaksic T. Serial transverse enteroplasty for short bowel syndrome: a case report. J Pediatr Surg. 2003 Jun; 38(6):881-5.
  47. Kim HB, Fauza D, Garza J, Oh JT, Nurko S, Jaksic T. Serial transverse enteroplasty (STEP): a novel bowel lengthening procedure. J Pediatr Surg. 2003 Mar; 38(3):425-9.
  48. Ng E, Kim HB, Lillehei CW, Seefelder C. Life threatening tension pneumoperitoneum from intestinal perforation during air reduction of intussusception. Paediatr Anaesth. 2002 Nov; 12(9):798-800.
  49. Liechty KW, Kim HB, Adzick NS, Crombleholme TM. Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair. J Pediatr Surg. 2000 Jun; 35(6):866-72; discussion 872-3.
  50. Shaaban AF, Kim HB, Milner R, Flake AW. A kinetic model for the homing and migration of prenatally transplanted marrow. Blood. 1999 Nov 1; 94(9):3251-7.
  51. Kim HB, Shaaban AF, Milner R, Fichter C, Flake AW. In utero bone marrow transplantation induces donor-specific tolerance by a combination of clonal deletion and clonal anergy. J Pediatr Surg. 1999 May; 34(5):726-9; discussion 729-30.
  52. Milner R, Shaaban A, Kim HB, Fichter C, Flake AW. Postnatal booster injections increase engraftment after in utero stem cell transplantation. J Surg Res. 1999 May 1; 83(1):44-7.
  53. Yang EY, Kim HB, Shaaban AF, Milner R, Adzick NS, Flake AW. Persistent postnatal transgene expression in both muscle and liver after fetal injection of recombinant adenovirus. J Pediatr Surg. 1999 May; 34(5):766-72; discussion 772-3.
  54. Kim HB, Shaaban AF, Yang EY, Liechty KW, Flake AW. Microchimerism and tolerance after in utero bone marrow transplantation in mice. J Surg Res. 1998 Jun; 77(1):1-5.
  55. Kim HB, Maller E, Redd D, Hebra A, Davidoff A, Buzby M, Hoffman MA. Orthotopic liver transplantation for inflammatory myofibroblastic tumor of the liver hilum. J Pediatr Surg. 1996 Jun; 31(6):840-2.
  56. Kim HB, Raghavendran K, Kleinhaus S. Management of an abdominal cerebrospinal fluid pseudocyst using laparoscopic techniques. Surg Laparosc Endosc. 1995 Apr; 5(2):151-4.
  57. Kim HB, Gregor MB, Boley SJ, Kleinhaus S. Digitally assisted laparoscopic drainage of multiple intraabdominal abscesses. J Laparoendosc Surg. 1993 Oct; 3(5):477-9.
  58. Modi BP, Langer M, Duggan C, Kim HB, Jaksic T. Serial transverse enteroplasty for management of refractory D-lactic acidosis in short-bowel syndrome. J Pediatr Gastroenterol Nutr. 2006 Sep; 43(3):395-7.
  59. Kim HB, Pomposelli JJ, Lillehei CW, Jenkins RL, Jonas MM, Krawczuk LE, Fishman SJ. Mesogonadal shunts for extrahepatic portal vein thrombosis and variceal hemorrhage. Liver Transpl. 2005 Nov; 11(11):1389-94.
  60. Duggan C, Piper H, Javid PJ, Valim C, Collier S, Kim HB, Jaksic T. Growth and nutritional status in infants with short-bowel syndrome after the serial transverse enteroplasty procedure. Clin Gastroenterol Hepatol. 2006 Oct; 4(10):1237-41.
  61. Modi BP, Javid PJ, Jaksic T, Piper H, Langer M, Duggan C, Kamin D, Kim HB. First report of the international serial transverse enteroplasty data registry: indications, efficacy, and complications. J Am Coll Surg. 2007 Mar; 204(3):365-71.
  62. Tsai A, Paltiel HJ, Sena LM, Kim HB, Fishman SJ, Alomari AI. Neonatal hemochromatosis and patent ductus venosus: clinical course and diagnostic pitfalls. Pediatr Radiol. 2009 Aug; 39(8):823-7.
  63. Shaaban AF, Kim HB, Milner R, Crombleholme T. The role of ultrasonography in fetal surgery and invasive fetal procedures. Semin Roentgenol. 1999 Jan; 34(1):62-77.
  64. Gutweiler JR, Yu DC, Kim HB, Kozakewich HP, Marcus KJ, Shamberger RC, Weldon CB. Hepatoblastoma presenting with focal nodular hyperplasia after treatment of neuroblastoma. J Pediatr Surg. 2008 Dec; 43(12):2297-300.
  65. Myers LB, Bulich LA, Mizrahi A, Barnewolt C, Estroff J, Benson C, Kim HB, Jennings R. Ultrasonographic guidance for location of the trachea during the EXIT procedure for cervical teratoma. J Pediatr Surg. 2003 Apr; 38(4):E12.
  66. Bairdain S, Modi BP, Kim HB, Mooney DP, Durkin E, Vakili K. Pediatric blunt abdominal aortic injury and the use of intra-operative aortic ultrasound for surgical decision making. J Pediatr Surg. 2013 Jul; 48(7):1584-7.
  67. Al Masalmeh O, Shaikh R, Chaudry G, Kim HB, Fishman SJ, Alomari AI. Transjugular retrograde cannulation of the portal vein via patent ductus venosus: alternative access for endovascular hepatic interventions. J Vasc Interv Radiol. 2013 Jan; 24(1):81-4.
  68. Valentino PL, Jonas MM, Lee CK, Kim HB, Vakili K, Elisofon SA. Outcomes after discontinuation of routine use of transanastomotic biliary stents in pediatric liver transplantation at a single site. Pediatr Transplant. 2016 Aug; 20(5):647-51.
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