Research

LIke ThisLIke ThisLIke This

Guzman Sanchez-Schmitz, MSc, PhD

Man no face
Lab:
Levy Lab
Division
Infectious Diseases Research
Hospital Title:
Co-Principal Investigator & Staff Scientist
Academic Title:
Research Associate in Pediatrics, Harvard Medical School
Research Focus Area:
Tissue EngineeringVaccinologyMicrophysiologyImmunology
Contact:
508-404-8618
Contact Via Email
Send an email to SendYour Name*Your Email Address*Subject*Comments*

Research Overview

Design and development of three-dimensional bioactive tissue constructs reproducing in vivo immune-physiology to provide fundamental insights into how vaccines, adjuvants, chemicals and biologicals, work in humans.

About the Researcher

Dr. Sanchez-Schmitz has a dual-major in Chemistry and Biology, with a Masters Degree in Molecular Biology focused on Genetics and a Ph.D. in Immunology focused on Human Bioengineering. During his Ph.D. research work at Mount Sinai School of Medicine in New York City, he tested the effect of microphysiologic hypoxia on the autonomous development of dendritic cells from a human Tissue Construct. Thanks to his experience, he was invited to participate in a small biotech company funded by DARPA to develop a human model for Rapid Vaccine Assessment program. His successful work there produced many patents. After 5 years in industry, Dr. Sanchez-Schmitz was invited to join Dr. Levy at Boston Children’s Hospital and Harvard School of Medicine in 2010 where he was able to focus on his scientific passion: the design and development of human three-dimensional bioactive tissue constructs reproducing in vivo physiology. His new microphysiologic age-specific human Tissue Construct reproduces in vivo primary responses of neonates after in vitro immunization with licensed pediatric vaccines such as HBV, BCG, DTaP, PCV-13, and PCP. His work had helped to secure millions of dollars in grant money from sources such as DARPA, the NIH and Bill & Melinda Gates Foundation. Dr. Sanchez-Schmitz is convinced that better, safer and more efficacious therapeutics for humans can be achieved by focusing pre-clinical selection of candidates on human cells under microphysiological conditions. His breakthrough work could provide fundamental insights into how vaccines, adjuvants, chemicals and biologicals, work in humans. His more than 15 years of relevant experience in cutting-edge scientific research developing predictable in vitro human models that fatefully and reproducibly recapitulate the in vivo physiology of targeted organs, have lead to several peer-review publications, patents, Standard Operating Procedures, grants and sponsored research agreements. “I am extremely honored with the opportunity of been part of Dr. Levy’s Precision Vaccines Program here at Boston Children’s Hospital and Harvard School of Medicine ---Dr. Sanchez-Schmitz”.

Publications

Publications powered by Harvard Catalyst Profiles
  1. Dowling DJ, Scott EA, Scheid A, Bergelson I, Joshi S, Pietrasanta C, Brightman S, Sanchez-Schmitz G, Van Haren SD, Ninkovic J, Kats D, Guiducci C, de Titta A, Bonner DK, Hirosue S, Swartz MA, Hubbell JA, Levy O. Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses. J Allergy Clin Immunol. 2017 Nov; 140(5):1339-1350.
  2. Aguilar-Medina M, Escamilla-Tilch M, Frías-Castro LO, Romero-Quintana G, Estrada-García I, Estrada-Parra S, Granados J, Arambula Meraz E, Sánchez-Schmitz G, Khader SA, Rangel-Moreno J, Ramos-Payán R. HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population. Ann Hum Genet. 2017 Jan; 81(1):35-40.
  3. Cervin Serrano S, González Villareal D, Aguilar-Medina M, Romero-Navarro JG, Romero Quintana JG, Arámbula Meraz E, Osuna Ramírez I, Picos-Cárdenas V, Granados J, Estrada-García I, Sánchez-Schmitz G, Ramos-Payán R. Genetic polymorphisms of interleukin-1 alpha and the vitamin d receptor in mexican mestizo patients with intervertebral disc degeneration. Int J Genomics. 2014; 2014:302568.
  4. Sanchez-Schmitz G, Levy O. Development of newborn and infant vaccines. Sci Transl Med. 2011 Jul 06; 3(90):90ps27.
  5. Ma Y, Poisson L, Sanchez-Schmitz G, Pawar S, Qu C, Randolph GJ, Warren WL, Mishkin EM, Higbee RG. Assessing the immunopotency of Toll-like receptor agonists in an in vitro tissue-engineered immunological model. Immunology. 2010 Jul; 130(3):374-87.
  6. Higbee RG, Byers AM, Dhir V, Drake D, Fahlenkamp HG, Gangur J, Kachurin A, Kachurina O, Leistritz D, Ma Y, Mehta R, Mishkin E, Moser J, Mosquera L, Nguyen M, Parkhill R, Pawar S, Poisson L, Sanchez-Schmitz G, Schanen B, Singh I, Song H, Tapia T, Warren W, Wittman V. An immunologic model for rapid vaccine assessment -- a clinical trial in a test tube. Altern Lab Anim. 2009 Sep; 37 Suppl 1:19-27.
  7. Randolph GJ, Sanchez-Schmitz G, Angeli V. Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances. Springer Semin Immunopathol. 2005 Jan; 26(3):273-87.
  8. Qu C, Edwards EW, Tacke F, Angeli V, Llodrá J, Sanchez-Schmitz G, Garin A, Haque NS, Peters W, van Rooijen N, Sanchez-Torres C, Bromberg J, Charo IF, Jung S, Lira SA, Randolph GJ. Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med. 2004 Nov 15; 200(10):1231-41.
  9. Randolph GJ, Sanchez-Schmitz G, Liebman RM, Schäkel K. The CD16(+) (FcgammaRIII(+)) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting. J Exp Med. 2002 Aug 19; 196(4):517-27.
  10. Sánchez-Torres C, García-Romo GS, Cornejo-Cortés MA, Rivas-Carvalho A, Sánchez-Schmitz G. CD16+ and CD16- human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4+ T cells. Int Immunol. 2001 Dec; 13(12):1571-81.
  11. Show all
  12. Gómez C, Pérez DG, Sánchez G, Marchat L, Paz F, Orozco E. Cis-elements upregulate the activity of the Entamoeba histolytica EhPgp1 gene promoter. Arch Med Res. 2000 Jul-Aug; 31(4 Suppl):S275-6.
LIke ThisLIke ThisLIke This

Featured Lab

Levy Lab

Learn more
Close