Research

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Gil Alterovitz, PhD

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Lab:
Program:
Computational Health Informatics Program (CHIP)
Department:
Medicine Research
Hospital Title:
Associate Scientific Researcher
Academic Title:
Assistant Professor, Harvard Medical School
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Publications

Publications powered by Harvard Catalyst Profiles
  1. Kapur A, Marwah K, Alterovitz G. Gene expression prediction using low-rank matrix completion. BMC Bioinformatics. 2016; 17(1):243.
  2. Warner JL, Rioth MJ, Mandl KD, Mandel JC, Kreda DA, Kohane IS, Carbone D, Oreto R, Wang L, Zhu S, Yao H, Alterovitz G. SMART precision cancer medicine: a FHIR-based app to provide genomic information at the point of care. J Am Med Inform Assoc. 2016 Jul; 23(4):701-10.
  3. Warner JL, Zhang P, Liu J, Alterovitz G. Classification of hospital acquired complications using temporal clinical information from a large electronic health record. J Biomed Inform. 2016 Feb; 59:209-17.
  4. Lawler M, Siu LL, Rehm HL, Chanock SJ, Alterovitz G, Burn J, Calvo F, Lacombe D, Teh BT, North KN, Sawyers CL. All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care through the Global Alliance for Genomics and Health. Cancer Discov. 2015 Nov; 5(11):1133-6.
  5. Alterovitz G, Warner J, Zhang P, Chen Y, Ullman-Cullere M, Kreda D, Kohane IS. SMART on FHIR Genomics: facilitating standardized clinico-genomic apps. J Am Med Inform Assoc. 2015 Nov; 22(6):1173-8.
  6. Wang A, An N, Chen G, Li L, Alterovitz G. Improving PLS-RFE based gene selection for microarray data classification. Comput Biol Med. 2015 Jul; 62:14-24.
  7. Maron JL, Hwang JS, Pathak S, Ruthazer R, Russell RL, Alterovitz G. Computational gene expression modeling identifies salivary biomarker analysis that predict oral feeding readiness in the newborn. J Pediatr. 2015 Feb; 166(2):282-8.e5.
  8. Warner JL, Denny JC, Kreda DA, Alterovitz G. Seeing the forest through the trees: uncovering phenomic complexity through interactive network visualization. J Am Med Inform Assoc. 2015 Mar; 22(2):324-9.
  9. Li Y, Wei Y, Li B, Alterovitz G. Modified Anderson-Darling test-based target detector in non-homogenous environments. Sensors (Basel). 2014; 14(9):16046-61.
  10. Gao M, Warner J, Yang P, Alterovitz G. On the Bayesian Derivation of a Treatment-based Cancer Ontology. AMIA Jt Summits Transl Sci Proc. 2014; 2014:209-17.
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  12. Villa A, Zollanvari A, Alterovitz G, Cagetti MG, Strohmenger L, Abati S. Prevalence of halitosis in children considering oral hygiene, gender and age. Int J Dent Hyg. 2014 Aug; 12(3):208-12.
  13. Warner JL, Yang P, Alterovitz G. Reversal of medical practices. Mayo Clin Proc. 2013 Oct; 88(10):1182-3.
  14. Warner JL, Zollanvari A, Ding Q, Zhang P, Snyder GM, Alterovitz G. Temporal phenome analysis of a large electronic health record cohort enables identification of hospital-acquired complications. J Am Med Inform Assoc. 2013 Dec; 20(e2):e281-7.
  15. Sonis S, Antin J, Tedaldi M, Alterovitz G. SNP-based Bayesian networks can predict oral mucositis risk in autologous stem cell transplant recipients. Oral Dis. 2013 Oct; 19(7):721-7.
  16. Warner JL, Alterovitz G, Bodio K, Joyce RM. External phenome analysis enables a rational federated query strategy to detect changing rates of treatment-related complications associated with multiple myeloma. J Am Med Inform Assoc. 2013 Jul-Aug; 20(4):696-9.
  17. Kallenbach J, Hsu WL, Dunker AK, Alterovitz G. Order-disorder interface characterization reveals critical factors for disease and drug targets. AMIA Jt Summits Transl Sci Proc. 2013; 2013:101.
  18. K Koppula S, Zollanvari A, An N, Alterovitz G. Robust prediction-based analysis for genome-wide association and expression studies. AMIA Jt Summits Transl Sci Proc. 2013; 2013:104.
  19. Warner J, Denny J, Kreda D, Alterovitz G. Analytic approaches to phenotypic complexity. Stud Health Technol Inform. 2013; 192:1267.
  20. Warner J, Yang P, Alterovitz G. Automated synthesis and visualization of a chemotherapy treatment regimen network. Stud Health Technol Inform. 2013; 192:62-6.
  21. Warner JL, Alterovitz G. Phenome based analysis as a means for discovering context dependent clinical reference ranges. AMIA Annu Symp Proc. 2012; 2012:1441-9.
  22. Yu YH, Chiou GY, Huang PI, Lo WL, Wang CY, Lu KH, Yu CC, Alterovitz G, Huang WC, Lo JF, Hsu HS, Chiou SH. Network biology of tumor stem-like cells identified a regulatory role of CBX5 in lung cancer. Sci Rep. 2012; 2:584.
  23. Quo CF, Kaddi C, Phan JH, Zollanvari A, Xu M, Wang MD, Alterovitz G. Reverse engineering biomolecular systems using -omic data: challenges, progress and opportunities. Brief Bioinform. 2012 Jul; 13(4):430-45.
  24. Parikh N, Zollanvari A, Alterovitz G. An automated bayesian framework for integrative gene expression analysis and predictive medicine. AMIA Jt Summits Transl Sci Proc. 2012; 2012:95-104.
  25. Deng M, Zollanvari A, Alterovitz G. A bayesian translational framework for knowledge propagation, discovery, and integration under specific contexts. AMIA Jt Summits Transl Sci Proc. 2012; 2012:25-34.
  26. Ting C, Alterovitz G, Merlob A, Abdi R. Genomic studies of GVHD-lessons learned thus far. Bone Marrow Transplant. 2013 Jan; 48(1):4-9.
  27. Alterovitz G, Tuthill C, Rios I, Modelska K, Sonis S. Personalized medicine for mucositis: Bayesian networks identify unique gene clusters which predict the response to gamma-D-glutamyl-L-tryptophan (SCV-07) for the attenuation of chemoradiation-induced oral mucositis. Oral Oncol. 2011 Oct; 47(10):951-5.
  28. Alterovitz G, Cavalcanti S, Muso TM, Ramoni MF, Wang M. REVERSE ENGINEERING AND SYNTHESIS OF BIOMOLECULAR SYSTEMS - Session Introduction. Pac Symp Biocomput. 2011; 300-1.
  29. Zollanvari A, Saccone NL, Bierut LJ, Ramoni MF, Alterovitz G. Is the reduction of dimensionality to a small number of features always necessary in constructing predictive models for analysis of complex diseases or behaviours? Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:3573-6.
  30. Alterovitz G, Xiang M, Hill DP, Lomax J, Liu J, Cherkassky M, Dreyfuss J, Mungall C, Harris MA, Dolan ME, Blake JA, Ramoni MF. Ontology engineering. Nat Biotechnol. 2010 Feb; 28(2):128-30.
  31. Alterovitz G, Cavalcanti S, Muso TM, Ramoni MF, Wang M. REVERSE ENGINEERING AND SYNTHESIS OF BIOMOLECULAR SYSTEMS - Session Introduction. Pac Symp Biocomput. 2010; 383-4.
  32. Alterovitz G, Jiwaji A, Ramoni MF. Automated programming for bioinformatics algorithm deployment. Bioinformatics. 2008 Feb 1; 24(3):450-1.
  33. Alterovitz G, Xiang M, Liu J, Chang A, Ramoni MF. System-wide peripheral biomarker discovery using information theory. Pac Symp Biocomput. 2008; 231-42.
  34. Maron JL, Johnson KL, Slonim D, Lai CQ, Ramoni M, Alterovitz G, Jarrah Z, Yang Z, Bianchi DW. Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood. J Clin Invest. 2007 Oct; 117(10):3007-19.
  35. Alterovitz G, Liu J, Afkhami E, Ramoni MF. Bayesian methods for proteomics. Proteomics. 2007 Aug; 7(16):2843-55.
  36. Aivado M, Spentzos D, Germing U, Alterovitz G, Meng XY, Grall F, Giagounidis AA, Klement G, Steidl U, Otu HH, Czibere A, Prall WC, Iking-Konert C, Shayne M, Ramoni MF, Gattermann N, Haas R, Mitsiades CS, Fung ET, Libermann TA. Serum proteome profiling detects myelodysplastic syndromes and identifies CXC chemokine ligands 4 and 7 as markers for advanced disease. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1307-12.
  37. Alterovitz G, Xiang M, Mohan M, Ramoni MF. GO PaD: the Gene Ontology Partition Database. Nucleic Acids Res. 2007 Jan; 35(Database issue):D322-7.
  38. Alterovitz G, Liu J, Chow J, Ramoni MF. Automation, parallelism, and robotics for proteomics. Proteomics. 2006 Jul; 6(14):4016-22.
  39. Alterovitz G, Ramoni MF. Discovering biological guilds through topological abstraction. AMIA Annu Symp Proc. 2006; 1-5.
  40. Aivado M, Spentzos D, Alterovitz G, Otu HH, Grall F, Giagounidis AA, Wells M, Cho JY, Germing U, Czibere A, Prall WC, Porter C, Ramoni MF, Libermann TA. Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling. Clin Chem Lab Med. 2005; 43(2):133-40.
  41. Alterovitz G, Aivado M, Spentzos D, Libermann TA, Ramoni M, Kohane IS. Analysis and robot pipelined automation for SELDI-TOF mass spectrometry. Conf Proc IEEE Eng Med Biol Soc. 2004; 4:3068-71.
  42. Alterovitz G. Electrical engineering and nontechnical design variables of multiple inductive loop systems for auditoriums. J Deaf Stud Deaf Educ. 2004; 9(2):202-9.
  43. Alterovitz G, Staelin DH, Philip JH. Temporal patient state characterization using Iterative Order and Noise (ION) estimation: applications to anesthesia patient monitoring. J Clin Monit Comput. 2002 Aug; 17(6):351-9.
  44. Alterovitz G, Muso T, Ramoni MF. The challenges of informatics in synthetic biology: from biomolecular networks to artificial organisms. Brief Bioinform. 2010 Jan; 11(1):80-95.
  45. Hartwig S, Ho J, Pandey P, Macisaac K, Taglienti M, Xiang M, Alterovitz G, Ramoni M, Fraenkel E, Kreidberg JA. Genomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development. Development. 2010 Apr; 137(7):1189-203.
  46. Chang HH, McGeachie M, Alterovitz G, Ramoni MF. Mapping transcription mechanisms from multimodal genomic data. BMC Bioinformatics. 2010 Oct 28; 11 Suppl 9:S2.
  47. Maron JL, Alterovitz G, Ramoni M, Johnson KL, Bianchi DW. High-throughput discovery and characterization of fetal protein trafficking in the blood of pregnant women. Proteomics Clin Appl. 2009 Dec; 3(12):1389-96.
  48. Marwah K, Katzin D, Zollanvari A, Noy NF, Ramoni M, Alterovitz G. Context-specific ontology integration: a bayesian approach. AMIA Jt Summits Transl Sci Proc. 2012; 2012:79-86.
  49. Celi LA, Hinske LC, Alterovitz G, Szolovits P. An artificial intelligence tool to predict fluid requirement in the intensive care unit: a proof-of-concept study. Crit Care. 2008; 12(6):R151.
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