Research

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Francis Fynn-Thompson, MD

Francis Fynn Thompson MD
Department:
Cardiac Surgery Research
Hospital Title:
Associate in Cardiac Surgery
Academic Title:
Assistant Professor in Surgery, Harvard Medical School

Publications

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  1. Nomoto R, Sleeper LA, Borisuk MJ, Bergerson L, Pigula FA, Emani S, Fynn-Thompson F, Mayer JE, Del Nido PJ, Baird CW. Outcome and performance of bioprosthetic pulmonary valve replacement in patients with congenital heart disease. J Thorac Cardiovasc Surg. 2016 Nov; 152(5):1333-1342.e3.
  2. Matte GS, Connor KR, Toutenel NA, Gottlieb D, Fynn-Thompson F. A Modified EXIT-to-ECMO with Optional Reservoir Circuit for Use during an EXIT Procedure Requiring Thoracic Surgery. J Extra Corpor Technol. 2016 Mar; 48(1):35-8.
  3. Visner GA, Fynn-Thompson F. Paracorporeal lung assist device in infants and toddlers: Coming of age? Pediatr Transplant. 2016 Mar; 20(2):191-3.
  4. Hofferberth SC, Watters K, Rahbar R, Fynn-Thompson F. Evolution of Surgical Approaches in the Management of Congenital Tracheal Stenosis: Single-Center Experience. World J Pediatr Congenit Heart Surg. 2016 Jan; 7(1):16-24.
  5. Hofferberth SC, Watters K, Rahbar R, Fynn-Thompson F. Management of Congenital Tracheal Stenosis. Pediatrics. 2015 Sep; 136(3):e660-9.
  6. Hofferberth SC, Alexander ME, Mah DY, Bautista-Hernandez V, del Nido PJ, Fynn-Thompson F. Impact of pacing on systemic ventricular function in L-transposition of the great arteries. J Thorac Cardiovasc Surg. 2016 Jan; 151(1):131-8.
  7. Quinonez LG, Gauvreau K, Borisuk M, Ireland C, Marshall AM, Mayer JE, Jenkins KJ, Fynn-Thompson FE, Baird CW. Outcomes of surgery for young children with multivessel pulmonary vein stenosis. J Thorac Cardiovasc Surg. 2015 Oct; 150(4):911-7.
  8. Stock C, Nathan M, Murray R, Rahbar R, Fynn-Thompson F. Modified end-to-end anastomosis for the treatment of congenital tracheal stenosis with a bridging bronchus. Ann Thorac Surg. 2015 Jan; 99(1):346-8.
  9. Balkin EM, Wolfe J, Ziniel SI, Lang P, Thiagarajan R, Dillis S, Fynn-Thompson F, Blume ED. Physician and parent perceptions of prognosis and end-of-life experience in children with advanced heart disease. J Palliat Med. 2015 Apr; 18(4):318-23.
  10. Emani S, Trainor B, Zurakowski D, Baird CW, Fynn-Thompson FE, Pigula FA, Emani SM. Aspirin unresponsiveness predicts thrombosis in high-risk pediatric patients after cardiac surgery. J Thorac Cardiovasc Surg. 2014 Sep; 148(3):810-4; discussion 814-6.
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  12. Teele SA, Salvin JW, Barrett CS, Rycus PT, Fynn-Thompson F, Laussen PC, Thiagarajan RR. The association of carotid artery cannulation and neurologic injury in pediatric patients supported with venoarterial extracorporeal membrane oxygenation*. Pediatr Crit Care Med. 2014 May; 15(4):355-61.
  13. Vanderpluym CJ, Fynn-Thompson F, Blume ED. Ventricular assist devices in children: progress with an orphan device application. Circulation. 2014 Apr 8; 129(14):1530-7.
  14. Escobar-Diaz MC, Tworetzky W, Friedman K, Lafranchi T, Fynn-Thompson F, Alexander ME, Mah DY. Perinatal outcome in fetuses with heterotaxy syndrome and atrioventricular block or bradycardia. Pediatr Cardiol. 2014 Aug; 35(6):906-13.
  15. Restrepo M, Mirabella L, Tang E, Haggerty CM, Khiabani RH, Fynn-Thompson F, Valente AM, McElhinney DB, Fogel MA, Yoganathan AP. Fontan pathway growth: a quantitative evaluation of lateral tunnel and extracardiac cavopulmonary connections using serial cardiac magnetic resonance. Ann Thorac Surg. 2014 Mar; 97(3):916-22.
  16. Weinstein S, Bello R, Pizarro C, Fynn-Thompson F, Kirklin J, Guleserian K, Woods R, Tjossem C, Kroslowitz R, Friedmann P, Jaquiss R. The use of the Berlin Heart EXCOR in patients with functional single ventricle. J Thorac Cardiovasc Surg. 2014 Feb; 147(2):697-704; discussion 704-5.
  17. Hofferberth SC, Cecchin F, Loberman D, Fynn-Thompson F. Left thoracoscopic sympathectomy for cardiac denervation in patients with life-threatening ventricular arrhythmias. J Thorac Cardiovasc Surg. 2014 Jan; 147(1):404-9.
  18. Nathan M, Karamichalis J, Liu H, Gauvreau K, Colan S, Saia M, Pigula F, Fynn-Thompson F, Emani S, Baird C, Mayer JE, del Nido PJ. Technical Performance Scores are strongly associated with early mortality, postoperative adverse events, and intensive care unit length of stay-analysis of consecutive discharges for 2 years. J Thorac Cardiovasc Surg. 2014 Jan; 147(1):389-94, 396.e1-396.e3.
  19. Daly KP, Chandler SF, Almond CS, Singh TP, Mah H, Milford E, Matte GS, Bastardi HJ, Mayer JE, Fynn-Thompson F, Blume ED. Antibody depletion for the treatment of crossmatch-positive pediatric heart transplant recipients. Pediatr Transplant. 2013 Nov; 17(7):661-9.
  20. Allan CK, Pigula F, Bacha EA, Emani S, Fynn-Thompson F, Thiagarajan RR, Imprescia A, Hayes G, Weinstock P. An extracorporeal membrane oxygenation cannulation curriculum featuring a novel integrated skills trainer leads to improved performance among pediatric cardiac surgery trainees. Simul Healthc. 2013 Aug; 8(4):221-8.
  21. Nathan M, Pigula FA, Liu H, Gauvreau K, Colan SD, Fynn-Thompson F, Emani S, Baird CA, Mayer JE, Del Nido PJ. Inadequate technical performance scores are associated with late mortality and late reintervention. Ann Thorac Surg. 2013 Aug; 96(2):664-9.
  22. Karamichalis JM, Colan SD, Nathan M, Pigula FA, Baird C, Marx G, Emani SM, Geva T, Fynn-Thompson FE, Liu H, Mayer JE, del Nido PJ. Technical performance scores in congenital cardiac operations: a quality assessment initiative. Ann Thorac Surg. 2012 Oct; 94(4):1317-23; discussion 1323.
  23. Costello JM, O'Brien M, Wypij D, Shubert J, Salvin JW, Newburger JW, Laussen PC, Arnold JH, Fynn-Thompson F, Thiagarajan RR. Quality of life of pediatric cardiac patients who previously required extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2012 Jul; 13(4):428-34.
  24. Sherwin ED, Gauvreau K, Scheurer MA, Rycus PT, Salvin JW, Almodovar MC, Fynn-Thompson F, Thiagarajan RR. Extracorporeal membrane oxygenation after stage 1 palliation for hypoplastic left heart syndrome. J Thorac Cardiovasc Surg. 2012 Dec; 144(6):1337-43.
  25. Haggerty CM, Fynn-Thompson F, McElhinney DB, Valente AM, Saikrishnan N, Del Nido PJ, Yoganathan AP. Experimental and numeric investigation of Impella pumps as cavopulmonary assistance for a failing Fontan. J Thorac Cardiovasc Surg. 2012 Sep; 144(3):563-9.
  26. Kovach JR, Naftel DC, Pearce FB, Tresler MA, Edens RE, Shuhaiber JH, Blume ED, Fynn-Thompson F, Kirklin JK, Zangwill SD. Comparison of risk factors and outcomes for pediatric patients listed for heart transplantation after bidirectional Glenn and after Fontan: an analysis from the Pediatric Heart Transplant Study. J Heart Lung Transplant. 2012 Feb; 31(2):133-9.
  27. Betit P, Matte GS, Howe R, Iudiciani P, Barrett C, Thiagarajan R, Fynn-Thompson F. The addition of a membrane oxygenator to a ventricular assist device in a patient with acute respiratory distress syndrome. J Extra Corpor Technol. 2011 Dec; 43(4):264-6.
  28. Bautista-Hernandez V, Sanchez-Andres A, Portela F, Fynn-Thompson F. Current pharmacologic management of pediatric heart failure in congenital heart disease. Curr Vasc Pharmacol. 2011 Sep; 9(5):619-28.
  29. Karamanlidis G, Bautista-Hernandez V, Fynn-Thompson F, Del Nido P, Tian R. Impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease. Circ Heart Fail. 2011 Nov; 4(6):707-13.
  30. Karamichalis JM, del Nido PJ, Thiagarajan RR, Jenkins KJ, Liu H, Gauvreau K, Pigula FA, Fynn-Thompson FE, Emani SM, Mayer JE, Bacha EA. Early postoperative severity of illness predicts outcomes after the stage I Norwood procedure. Ann Thorac Surg. 2011 Aug; 92(2):660-5.
  31. Ford MA, Almond CS, Gauvreau K, Piercey G, Blume ED, Smoot LB, Fynn-Thompson F, Singh TP. Association of graft ischemic time with survival after heart transplant among children in the United States. J Heart Lung Transplant. 2011 Nov; 30(11):1244-9.
  32. Almond CS, Singh TP, Gauvreau K, Piercey GE, Fynn-Thompson F, Rycus PT, Bartlett RH, Thiagarajan RR. Extracorporeal membrane oxygenation for bridge to heart transplantation among children in the United States: analysis of data from the Organ Procurement and Transplant Network and Extracorporeal Life Support Organization Registry. Circulation. 2011 Jun 28; 123(25):2975-84.
  33. Shuhaiber J, Thiagarajan RR, Laussen PC, Fynn-Thompson F, del Nido P, Pigula F. Survival of children requiring repeat extracorporeal membrane oxygenation after congenital heart surgery. Ann Thorac Surg. 2011 Jun; 91(6):1949-55.
  34. Shuhaiber J, Rehman M, Jenkins K, Fynn-Thompson F, Bacha E. The role of surgical therapy for pulmonary vein atresia in childhood. Pediatr Cardiol. 2011 Jun; 32(5):639-45.
  35. Rood KL, Teele SA, Barrett CS, Salvin JW, Rycus PT, Fynn-Thompson F, Laussen PC, Thiagarajan RR. Extracorporeal membrane oxygenation support after the Fontan operation. J Thorac Cardiovasc Surg. 2011 Sep; 142(3):504-10.
  36. Morales DL, Almond CS, Jaquiss RD, Rosenthal DN, Naftel DC, Massicotte MP, Humpl T, Turrentine MW, Tweddell JS, Cohen GA, Kroslowitz R, Devaney EJ, Canter CE, Fynn-Thompson F, Reinhartz O, Imamura M, Ghanayem NS, Buchholz H, Furness S, Mazor R, Gandhi SK, Fraser CD. Bridging children of all sizes to cardiac transplantation: the initial multicenter North American experience with the Berlin Heart EXCOR ventricular assist device. J Heart Lung Transplant. 2011 Jan; 30(1):1-8.
  37. Bautista-Hernandez V, Scheurer M, Thiagarajan R, Salvin J, Pigula FA, Emani S, Fynn-Thompson F, Loyola H, Schiff J, del Nido PJ, Bacha EA. Right ventricle and tricuspid valve function at midterm after the Fontan operation for hypoplastic left heart syndrome: impact of shunt type. Pediatr Cardiol. 2011 Feb; 32(2):160-6.
  38. Goldfarb SB, Gaynor JW, Fuller S, Kreindler J, Montenegro LM, Fynn-Thompson F, Visner G. Induction therapy with antithymocyte globulin before reperfusion. Ann Thorac Surg. 2010 Oct; 90(4):1110-4; discussion 1114-5.
  39. Kane DA, Thiagarajan RR, Wypij D, Scheurer MA, Fynn-Thompson F, Emani S, del Nido PJ, Betit P, Laussen PC. Rapid-response extracorporeal membrane oxygenation to support cardiopulmonary resuscitation in children with cardiac disease. Circulation. 2010 Sep 14; 122(11 Suppl):S241-8.
  40. Silva JN, Canter CE, Singh TP, Gauvreau K, Piercey GE, Berul CI, Smoot LB, Blume ED, Fynn-Thompson F, Almond CS. Outcomes of heart transplantation using donor hearts from infants with sudden infant death syndrome. J Heart Lung Transplant. 2010 Nov; 29(11):1226-30.
  41. Almond CS, Gauvreau K, Thiagarajan RR, Piercey GE, Blume ED, Smoot LB, Fynn-Thompson F, Singh TP. Impact of ABO-incompatible listing on wait-list outcomes among infants listed for heart transplantation in the United States: a propensity analysis. Circulation. 2010 May 4; 121(17):1926-33.
  42. Bautista-Hernandez V, Thiagarajan RR, Fynn-Thompson F, Rajagopal SK, Nento DE, Yarlagadda V, Teele SA, Allan CK, Emani SM, Laussen PC, Pigula FA, Bacha EA. Preoperative extracorporeal membrane oxygenation as a bridge to cardiac surgery in children with congenital heart disease. Ann Thorac Surg. 2009 Oct; 88(4):1306-11.
  43. Mah D, Singh TP, Thiagarajan RR, Gauvreau K, Piercey GE, Blume ED, Fynn-Thompson F, Almond CS. Incidence and risk factors for mortality in infants awaiting heart transplantation in the USA. J Heart Lung Transplant. 2009 Dec; 28(12):1292-8.
  44. Kaza AK, Lim HG, Dibardino DJ, Bautista-Hernandez V, Robinson J, Allan C, Laussen P, Fynn-Thompson F, Bacha E, del Nido PJ, Mayer JE, Pigula FA. Long-term results of right ventricular outflow tract reconstruction in neonatal cardiac surgery: options and outcomes. J Thorac Cardiovasc Surg. 2009 Oct; 138(4):911-6.
  45. Takahashi K, Cecchin F, Fortescue E, Berul CI, Alexander ME, Walsh EP, Fynn-Thompson F, Triedman JK. Permanent atrial pacing lead implant route after Fontan operation. Pacing Clin Electrophysiol. 2009 Jun; 32(6):779-85.
  46. Lim HG, Bacha EA, Marx GR, Marshall A, Fynn-Thompson F, Mayer JE, Del Nido P, Pigula FA. Biventricular repair in patients with heterotaxy syndrome. J Thorac Cardiovasc Surg. 2009 Feb; 137(2):371-379.e3.
  47. Almond CS, Thiagarajan RR, Piercey GE, Gauvreau K, Blume ED, Bastardi HJ, Fynn-Thompson F, Singh TP. Waiting list mortality among children listed for heart transplantation in the United States. Circulation. 2009 Feb 10; 119(5):717-27.
  48. Atallah J, Fynn-Thompson F, Cecchin F, DiBardino DJ, Walsh EP, Berul CI. Video-assisted thoracoscopic cardiac denervation: a potential novel therapeutic option for children with intractable ventricular arrhythmias. Ann Thorac Surg. 2008 Nov; 86(5):1620-5.
  49. Cecchin F, Frangini PA, Brown DW, Fynn-Thompson F, Alexander ME, Triedman JK, Gauvreau K, Walsh EP, Berul CI. Cardiac resynchronization therapy (and multisite pacing) in pediatrics and congenital heart disease: five years experience in a single institution. J Cardiovasc Electrophysiol. 2009 Jan; 20(1):58-65.
  50. Bacha EA, Larrazabal LA, Pigula FA, Gauvreau K, Jenkins KJ, Colan SD, Fynn-Thompson F, Mayer JE, del Nido PJ. Measurement of technical performance in surgery for congenital heart disease: the stage I Norwood procedure. J Thorac Cardiovasc Surg. 2008 Oct; 136(4):993-7, 997.e1-2.
  51. Takahashi K, Fynn-Thompson F, Cecchin F, Khairy P, del Nido P, Triedman JK. Clinical outcomes of Fontan conversion surgery with and without associated arrhythmia intervention. Int J Cardiol. 2009 Nov 12; 137(3):260-6.
  52. Scheurer MA, Salvin JW, Vida VL, Fynn-Thompson F, Bacha EA, Pigula FA, Mayer JE, del Nido PJ, Wessel DL, Laussen PC, Thiagarajan RR. Survival and clinical course at Fontan after stage one palliation with either a modified Blalock-Taussig shunt or a right ventricle to pulmonary artery conduit. J Am Coll Cardiol. 2008 Jul 1; 52(1):52-9.
  53. Vida VL, Bacha EA, Larrazabal A, Gauvreau K, Dorfman AL, Marx G, Geva T, Marshall AC, Pigula FA, Mayer JE, del Nido PJ, Fynn-Thompson F. Surgical outcome for patients with the mitral stenosis-aortic atresia variant of hypoplastic left heart syndrome. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):339-46.
  54. Vida VL, Bacha EA, Larrazabal A, Gauvreau K, Thiagaragan R, Fynn-Thompson F, Pigula FA, Mayer JE, del Nido PJ, Tworetzky W, Lock JE, Marshall AC. Hypoplastic left heart syndrome with intact or highly restrictive atrial septum: surgical experience from a single center. Ann Thorac Surg. 2007 Aug; 84(2):581-5; discussion 586.
  55. Fynn-Thompson F, Almond C. Pediatric ventricular assist devices. Pediatr Cardiol. 2007 Mar-Apr; 28(2):149-55.
  56. Larrazabal LA, del Nido PJ, Jenkins KJ, Gauvreau K, Lacro R, Colan SD, Pigula F, Benavidez OJ, Fynn-Thompson F, Mayer JE, Bacha EA. Measurement of technical performance in congenital heart surgery: a pilot study. Ann Thorac Surg. 2007 Jan; 83(1):179-84.
  57. P. Frangini, F. Cecchin, F. Fynn-Thompson, D. Brown, M. Alexander, J. Triedman, E. Walsh, C. Berul. Cardiac resynchronization therapy is associated with improved systolic ventricular function in pediatrics and congenital heart disease. Heart Rhythm. 2006; 3(5):S172.
  58. Nathan M, Baird C, Fynn-Thompson F, Almond C, Thiagarajan R, Laussen P, Blume E, Pigula F. Successful implantation of a Berlin heart biventricular assist device in a failing single ventricle. J Thorac Cardiovasc Surg. 2006 Jun; 131(6):1407-8.
  59. Christopher Baird, Francis Fynn-Thompson, Meena Nathan, Frank Pigula. Berlin Heart: Biventricular Assist Device. 2005.
  60. Fynn-Thompson F, Vander Salm TJ. Methods for reduction of sternal wound infection. Semin Thorac Cardiovasc Surg. 2004; 16(1):77-80.
  61. Fynn-Thompson, F., Allan, J.,. Management of tracheobronchial and esophageal trauma. The Trauma Handbook of the Massachusetts General Hospital. 2004; 314-327 .
  62. Horiuchi K, Fynn-Thompson F, Ohene-Frempong K. Quantitative analysis of the degree of irreversible deformation of F cells and non-F cells and its relationship to cell density in sickle cell disease. Exp Hematol. 1994 Oct; 22(11):1058-63.
  63. Fynn-Thompson, F.,. Dynamics of Health Care in Ghana: A model for Africa. 1993.
  64. Radbill AE, Triedman JK, Berul CI, Fynn-Thompson F, Atallah J, Alexander ME, Walsh EP, Cecchin F. System survival of nontransvenous implantable cardioverter-defibrillators compared to transvenous implantable cardioverter-defibrillators in pediatric and congenital heart disease patients. Heart Rhythm. 2010; 7(2):193-8.
  65. Shuhaiber JH, Bergersen L, Pigula F, Emani S, McElhinney D, Marshall A, Fynn-Thompson F, Bacha EA. Intraoperative assessment after pediatric cardiac surgical repair: initial experience with C-arm angiography. J Thorac Cardiovasc Surg. 2010 Jul; 140(1):e1-3.
  66. Nathan M, Liu H, Pigula FA, Fynn-Thompson F, Emani S, Baird CA, Marx G, Mayer JE, Del Nido PJ. Biventricular conversion after single-ventricle palliation in unbalanced atrioventricular canal defects. Ann Thorac Surg. 2013 Jun; 95(6):2086-95; discussion 2095-6.
  67. Mah DY, Alexander ME, Banka P, Abrams DJ, Triedman JK, Walsh EP, Fynn-Thompson F, Mayer JE, Cecchin F. The role of cardiac resynchronization therapy for arterial switch operations complicated by complete heart block. Ann Thorac Surg. 2013 Sep; 96(3):904-9.
  68. Yankah C, Fynn-Thompson F, Antunes M, Edwin F, Yuko-Jowi C, Mendis S, Thameur H, Urban A, Bolman R. Cardiac surgery capacity in sub-saharan Africa: quo vadis? Thorac Cardiovasc Surg. 2014 Aug; 62(5):393-401.
  69. Nathan M, Marshall AC, Kerstein J, Liu H, Fynn-Thompson F, Baird CW, Mayer JE, Pigula FA, del Nido PJ, Emani S. Technical performance score as predictor for post-discharge reintervention in valve-sparing tetralogy of Fallot repair. Semin Thorac Cardiovasc Surg. 2014; 26(4):297-303.
  70. Faella KH, Whiting D, Fynn-Thompson F, Matte GS. Bivalirudin Anticoagulation for a Pediatric Patient with Heparin-Induced Thrombocytopenia and Thrombosis Requiring Cardiopulmonary Bypass for Ventricular Assist Device Placement. J Extra Corpor Technol. 2016 Mar; 48(1):39-42.
  71. Toprak D, Midyat L, Freiberger D, Boyer D, Fynn-Thompson F, Visner G. Outcomes of mechanical support in a pediatric lung transplant center. Pediatr Pulmonol. 2016 Oct 27.
  72. Alexander P, Fynn-Thompson F, Buchmiller T, Porras D, Marshall A, Thiagarajan R, Arnold J. 1629: LIQUID FLUOROCARBON LAVAGE FOR AIRWAY THROMBUS AFTER SEVERE HEMOPTYSIS REQUIRING ECMO. Crit Care Med. 2016 Dec; 44(12 Suppl 1):482.
  73. Alexander P, Nair A, Smoot L, Wigmore D, McDavitt E, Bastardi H, Fynn-Thompson F, Thiagarajan R. 143: OUTCOMES OF EARLY GRAFT FAILURE IN PEDIATRIC HEART TRANSPLANTATION MANAGED WITH ECMO. Crit Care Med. 2016 Dec; 44(12 Suppl 1):113.
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