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Ellis  Neufeld, MD, PhD

Ellis Neufeld
Research Center:
Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
Medicine Research
Hematology/Oncology Research
Hospital Title:
Associate Chief
Academic Title:
Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Bleeding disorders
Contact Via Email
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Research Overview

Dr. Neufeld’s main research focus is clinical trials in non-malignant blood disorders, including thalassemia and iron overload, Immune Thrombocytopenia (ITP), and hemophilia. He is presently overall principal investigator for two international phase 2 trials of a novel oral iron chelator.

Dr. Neufeld's laboratory studies candidate genes for inherited blood disorders. His group elucidated the thiamine transporter gene, SLC19A2, as the cause of the syndrome of thiamine-responsive megaloblastic anemia (TRMA) with diabetes and deafness, among other disorders.

About Ellis Neufeld

Ellis Neufeld received his MD and PhD degrees from Washington University in St. Louis. He completed training in Pediatrics, Hematology and Medical Genetics at Boston Children's Hospital and Dana Farber Cancer Institute.

He is presently Associate Chief of the Division of Hematology/Oncology at Children's Hospital, Boston, and Professor of Pediatrics at Harvard Medical School, where he holds the Egan Family Foundation Chair in Transitional Medicine. He is co-chief of the Clinical Research Center at Boston Children’s, and he directs the Boston Hemophilia Center, a joint effort of Children’s and Brigham and Women’s Hospital. He also attends on the nonmalignant hematology service and the thrombosis service and anticoagulation program at Children's Hospital. He has published more than 130 papers, related to his research interests including clinical trials in hemophilia, ITP and thalassemia, and laboratory studies of candidate genes for inherited blood disorders. Dr. Neufeld is the Child Health Program Director for the NIH-sponsored Harvard Catalyst Clinical and Translational Sciences Program.


Publications powered by Harvard Catalyst Profiles
  1. Croteau SE, Abajas YL, Wolberg AS, Nielsen BI, Marx GR, Baird CW, Neufeld EJ, Monahan PE. Recombinant porcine factor VIII for high-risk surgery in paediatric congenital haemophilia A with high-titre inhibitor. Haemophilia. 2017 Mar; 23(2):e93-e98.
  2. Nandivada P, Anez-Bustillos L, O'Loughlin AA, Mitchell PD, Baker MA, Dao DT, Fell GL, Potemkin AK, Gura KM, Neufeld EJ, Puder M. Risk of post-procedural bleeding in children on intravenous fish oil. Am J Surg. 2016 Dec 01.
  3. Cattivelli K, Campagna DR, Schmitz-Abe K, Heeney MM, Yaish HM, Caruso Brown AE, Kearney S, Walkovich K, Markianos K, Fleming MD, Neufeld EJ. Ringed sideroblasts in ß-thalassemia. Pediatr Blood Cancer. 2016 Nov 03.
  4. Schoettler ML, Graham D, Tao W, Stack M, Shu E, Kerr L, Neufeld EJ, Grace RF. Increasing observation rates in low-risk pediatric immune thrombocytopenia using a standardized clinical assessment and management plan (SCAMP® ). Pediatr Blood Cancer. 2016 Oct 26.
  5. Recht M, Konkle BA, Jackson S, Neufeld EJ, Rockwood K, Pipe S. Recognizing the need for personalization of haemophilia patient-reported outcomes in the prophylaxis era. Haemophilia. 2016 Nov; 22(6):825-832.
  6. Platt CD, D'Angelo L, Neufeld EJ, Broyles AD. Skin testing, graded challenge, and desensitization to von Willebrand factor (VWF) products in type III von Willebrand disease (VWD). J Allergy Clin Immunol Pract. 2016 Sep-Oct; 4(5):1006-8.
  7. Croteau SE, Nakar C, Neufeld EJ, Shapiro A, Cooper DL. Safety and efficacy of recombinant factor VIIa by pediatric age cohort: reassessment of compassionate use and trial data supporting US label. Pediatr Blood Cancer. 2016 Oct; 63(10):1822-8.
  8. Neunert C, Farah R, Yacobovich J, Neufeld E. Refractory autoimmune disease: an overview of when first-line therapy is not enough. Semin Hematol. 2016 Apr; 53 Suppl 1:S35-8.
  9. Mehta DA, Oladapo AO, Epstein JD, Novack AR, Neufeld EJ, Hay JW. A Budget Impact Model of Hemophilia Bypassing Agent Prophylaxis Relative to Recombinant Factor VIIa On-Demand. J Manag Care Spec Pharm. 2016 Feb; 22(2):149-57.
  10. Croteau SE, Padula M, Quint K, D'Angelo L, Neufeld EJ. Center-Based Quality Initiative Targets Youth Preparedness for Medical Independence: HEMO-Milestones Tool in a Comprehensive Hemophilia Clinic Setting. Pediatr Blood Cancer. 2016 Mar; 63(3):499-503.
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  12. Grace RF, Zanella A, Neufeld EJ, Morton DH, Eber S, Yaish H, Glader B. Erythrocyte pyruvate kinase deficiency: 2015 status report. Am J Hematol. 2015 Sep; 90(9):825-30.
  13. Kumar M, Lambert MP, Breakey V, Buchanan GR, Neier M, Neufeld EJ, Kempert P, Neunert CE, Nottage K, Klaassen RJ. Sports Participation in Children and Adolescents with Immune Thrombocytopenia (ITP). Pediatr Blood Cancer. 2015 Dec; 62(12):2223-5.
  14. Frelinger AL, Grace RF, Gerrits AJ, Berny-Lang MA, Brown T, Carmichael SL, Neufeld EJ, Michelson AD. Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP. Blood. 2015 Aug 13; 126(7):873-9.
  15. Neufeld EJ, Négrier C, Arkhammar P, Benchikh el Fegoun S, Simonsen MD, Rosholm A, Seremetis S. Safety update on the use of recombinant activated factor VII in approved indications. Blood Rev. 2015 Jun; 29 Suppl 1:S34-41.
  16. Torres A, Newton SA, Crompton B, Borzutzky A, Neufeld EJ, Notarangelo L, Berry GT. CSF 5-Methyltetrahydrofolate Serial Monitoring to Guide Treatment of Congenital Folate Malabsorption Due to Proton-Coupled Folate Transporter (PCFT) Deficiency. JIMD Rep. 2015; 24:91-6.
  17. Croteau SE, Neufeld EJ. Author's response: 'Transition considerations for extended half-life factor products'. Haemophilia. 2015 Sep; 21(5):e454-5.
  18. Morris CR, Kim HY, Klings ES, Wood J, Porter JB, Trachtenberg F, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Hassell K, Taher A, Neufeld EJ, Thompson AA, Larkin S, Suh JH, Vichinsky EP, Kuypers FA. Dysregulated arginine metabolism and cardiopulmonary dysfunction in patients with thalassaemia. Br J Haematol. 2015 Jun; 169(6):887-98.
  19. Croteau SE, Neufeld EJ. Transition considerations for extended half-life factor products. Haemophilia. 2015 May; 21(3):285-8.
  20. Tubman VN, Fung EB, Vogiatzi M, Thompson AA, Rogers ZR, Neufeld EJ, Kwiatkowski JL. Guidelines for the Standard Monitoring of Patients With Thalassemia: Report of the Thalassemia Longitudinal Cohort. J Pediatr Hematol Oncol. 2015 Apr; 37(3):e162-9.
  21. Wood JC, Zhang P, Rienhoff H, Abi-Saab W, Neufeld EJ. Liver MRI is more precise than liver biopsy for assessing total body iron balance: a comparison of MRI relaxometry with simulated liver biopsy results. Magn Reson Imaging. 2015 Jul; 33(6):761-7.
  22. Obeng EA, Harney KM, Moniz T, Arnold A, Neufeld EJ, Trenor CC. Pediatric heparin-induced thrombocytopenia: prevalence, thrombotic risk, and application of the 4Ts scoring system. J Pediatr. 2015 Jan; 166(1):144-50.
  23. Croteau SE, Saxena K, Neufeld EJ. Correlation between dispensed and prescribed doses of factor products for bleeding disorders: can a small, centre-based pharmacy hit the mark? Haemophilia. 2015 Mar; 21(2):190-5.
  24. Schoettler M, Elisofon SA, Kim HB, Blume ED, Rodig N, Boyer D, Neufeld EJ, Grace RF. Treatment and outcomes of immune cytopenias following solid organ transplant in children. Pediatr Blood Cancer. 2015 Feb; 62(2):214-218.
  25. Recht M, Neufeld EJ, Sharma VR, Solem CT, Pickard AS, Gut RZ, Cooper DL. Impact of acute bleeding on daily activities of patients with congenital hemophilia with inhibitors and their caregivers and families: observations from the Dosing Observational Study in Hemophilia (DOSE). Value Health. 2014 Sep; 17(6):744-8.
  26. Leissinger C, Josephson CD, Granger S, Konkle BA, Kruse-Jarres R, Ragni MV, Journeycake JM, Valentino L, Key NS, Gill JC, McCrae KR, Neufeld EJ, Manno C, Raffini L, Saxena K, Torres M, Marder V, Bennett CM, Assmann SF. Rituximab for treatment of inhibitors in haemophilia A. A Phase II study. Thromb Haemost. 2014 Sep 02; 112(3):445-58.
  27. Morrison JF, Neufeld EJ, Grace RF. The use of erythropoietin-stimulating agents versus supportive care in newborns with hereditary spherocytosis: a single centre's experience. Eur J Haematol. 2014 Aug; 93(2):161-4.
  28. Nichols-Vinueza DX, White MT, Powell AJ, Banka P, Neufeld EJ. MRI guided iron assessment and oral chelator use improve iron status in thalassemia major patients. Am J Hematol. 2014 Jul; 89(7):684-8.
  29. Trachtenberg FL, Gerstenberger E, Xu Y, Mednick L, Sobota A, Ware H, Thompson AA, Neufeld EJ, Yamashita R. Relationship among chelator adherence, change in chelators, and quality of life in thalassemia. Qual Life Res. 2014 Oct; 23(8):2277-88.
  30. Wood JC, Zhang P, Rienhoff H, Abi-Saab W, Neufeld E. R2 and R2* are equally effective in evaluating chronic response to iron chelation. Am J Hematol. 2014 May; 89(5):505-8.
  31. Shapiro AD, Neufeld EJ, Blanchette V, Salaj P, Gut RZ, Cooper DL. Safety of recombinant activated factor VII (rFVIIa) in patients with congenital haemophilia with inhibitors: overall rFVIIa exposure and intervals following high (&gt240 µg kg?¹) rFVIIa doses across clinical trials and registries. Haemophilia. 2014 Jan; 20(1):e23-31.
  32. Klaassen RJ, Barrowman N, Merelles-Pulcini M, Vichinsky EP, Sweeters N, Kirby-Allen M, Neufeld EJ, Kwiatkowski JL, Wu J, Vickars L, Blanchette VS, Forgie M, Yamashita R, Wong-Rieger D, Young NL. Validation and reliability of a disease-specific quality of life measure (the TranQol) in adults and children with thalassaemia major. Br J Haematol. 2014 Feb; 164(3):431-7.
  33. Vichinsky E, Neumayr L, Trimble S, Giardina PJ, Cohen AR, Coates T, Boudreaux J, Neufeld EJ, Kenney K, Grant A, Thompson AA. Transfusion complications in thalassemia patients: a report from the Centers for Disease Control and Prevention (CME). Transfusion. 2014 Apr; 54(4):972-81; quiz 971.
  34. Thompson AA, Kim HY, Singer ST, Vichinsky E, Eile J, Yamashita R, Giardina PJ, Olivieri N, Parmar N, Trachtenberg F, Neufeld EJ, Kwiatkowski JL. Pregnancy outcomes in women with thalassemia in North America and the United Kingdom. Am J Hematol. 2013 Sep; 88(9):771-3.
  35. Cherry AB, Gagne KE, McLoughlin EM, Baccei A, Gorman B, Hartung O, Miller JD, Zhang J, Zon RL, Ince TA, Neufeld EJ, Lerou PH, Fleming MD, Daley GQ, Agarwal S. Induced pluripotent stem cells with a mitochondrial DNA deletion. Stem Cells. 2013 Jul; 31(7):1287-97.
  36. Croteau SE, Luo HY, Lehmann LE, Chui DH, Neufeld EJ. Novel dominant ß-thalassemia: Hb Boston-Kuwait [codon 139/140(+T)]. Pediatr Blood Cancer. 2013 Oct; 60(10):E131-4.
  37. Porter JB, Wood J, Olivieri N, Vichinsky EP, Taher A, Neufeld E, Giardina P, Thompson A, Moore B, Evans P, Kim HY, Macklin EA, Trachtenberg F. Treatment of heart failure in adults with thalassemia major: response in patients randomised to deferoxamine with or without deferiprone. J Cardiovasc Magn Reson. 2013 May 20; 15:38.
  38. Morris CR, Kim HY, Wood J, Porter JB, Klings ES, Trachtenberg FL, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Singer ST, Taher A, Neufeld EJ, Thompson AA, Sachdev V, Larkin S, Suh JH, Kuypers FA, Vichinsky EP. Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension. Haematologica. 2013 Sep; 98(9):1359-67.
  39. Neunert CE, Buchanan GR, Imbach P, Bolton-Maggs PH, Bennett CM, Neufeld E, Vesely SK, Adix L, Blanchette VS, Kühne T. Bleeding manifestations and management of children with persistent and chronic immune thrombocytopenia: data from the Intercontinental Cooperative ITP Study Group (ICIS). Blood. 2013 May 30; 121(22):4457-62.
  40. Gruppo RA, Kessler CM, Neufeld EJ, Cooper DL. Assessment of individual dose utilization vs. physician prescribing recommendations for recombinant activated factor VII (rFVIIa) in paediatric and adult patients with congenital haemophilia and alloantibody inhibitors (CHwI): the Dosing Observational Study in Hemophilia (DOSE). Haemophilia. 2013 Jul; 19(4):524-32.
  41. Switzer WM, Shankar A, Trimble SR, Thompson AA, Giardina PJ, Cohen AR, Coates TD, Vichinsky E, Neufeld EJ, Boudreaux JM, Heneine W. Human T cell lymphotropic virus type 1 infection among U.S. thalassemia patients. AIDS Res Hum Retroviruses. 2013 Jul; 29(7):1006-9.
  42. Neufeld EJ, Saxena K, Kessler CM, Cooper DL. Dosing, efficacy, and safety of recombinant factor VIIa (rFVIIa) in pediatric versus adult patients: the experience of the Hemostasis and Thrombosis Research Society (HTRS) Registry (2004-2008). Pediatr Blood Cancer. 2013 Jul; 60(7):1178-83.
  43. Matzdorff A, Neufeld EJ, Roganovic J. To treat or not to treat--from guidelines to individualized patient management. Semin Hematol. 2013 Jan; 50 Suppl 1:S12-7.
  44. Trachtenberg FL, Mednick L, Kwiatkowski JL, Neufeld EJ, Haines D, Pakbaz Z, Thompson AA, Quinn CT, Grady R, Sobota A, Olivieri N, Horne R, Yamashita R. Beliefs about chelation among thalassemia patients. Health Qual Life Outcomes. 2012 Dec 07; 10:148.
  45. Walter PB, Porter J, Evans P, Kwiatkowski JL, Neufeld EJ, Coates T, Giardina PJ, Grady RW, Vichinsky E, Olivieri N, Trachtenberg F, Alberti D, Fung E, Ames B, Higa A, Harmatz P. Increased leucocyte apoptosis in transfused ß-thalassaemia patients. Br J Haematol. 2013 Feb; 160(3):399-403.
  46. Neufeld EJ, Recht M, Sabio H, Saxena K, Solem CT, Pickard AS, Gut RZ, Cooper DL. Effect of acute bleeding on daily quality of life assessments in patients with congenital hemophilia with inhibitors and their families: observations from the dosing observational study in hemophilia. Value Health. 2012 Sep-Oct; 15(6):916-25.
  47. Armand P, Sainvil MM, Kim HT, Rhodes J, Cutler C, Ho VT, Koreth J, Alyea EP, Neufeld EJ, Kwong RY, Soiffer RJ, Antin JH. Pre-transplantation iron chelation in patients with MDS or acute leukemia and iron overload undergoing myeloablative allo-SCT. Bone Marrow Transplant. 2013 Jan; 48(1):146-7.
  48. Patel VL, Mahévas M, Lee SY, Stasi R, Cunningham-Rundles S, Godeau B, Kanter J, Neufeld E, Taube T, Ramenghi U, Shenoy S, Ward MJ, Mihatov N, Patel VL, Bierling P, Lesser M, Cooper N, Bussel JB. Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia. Blood. 2012 Jun 21; 119(25):5989-95.
  49. Fung EB, Xu Y, Trachtenberg F, Odame I, Kwiatkowski JL, Neufeld EJ, Thompson AA, Boudreaux J, Quinn CT, Vichinsky EP. Inadequate dietary intake in patients with thalassemia. J Acad Nutr Diet. 2012 Jul; 112(7):980-90.
  50. Josephson CD, Granger S, Assmann SF, Castillejo MI, Strauss RG, Slichter SJ, Steiner ME, Journeycake JM, Thornburg CD, Bussel J, Grabowski EF, Neufeld EJ, Savage W, Sloan SR. Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia. Blood. 2012 Jul 26; 120(4):748-60.
  51. Armand P, Sainvil MM, Kim HT, Rhodes J, Cutler C, Ho VT, Koreth J, Alyea EP, Neufeld EJ, Kwong RY, Soiffer RJ, Antin JH. Does iron overload really matter in stem cell transplantation? Am J Hematol. 2012 Jun; 87(6):569-72.
  52. Kwiatkowski JL, Kim HY, Thompson AA, Quinn CT, Mueller BU, Odame I, Giardina PJ, Vichinsky EP, Boudreaux JM, Cohen AR, Porter JB, Coates T, Olivieri NF, Neufeld EJ. Chelation use and iron burden in North American and British thalassemia patients: a report from the Thalassemia Longitudinal Cohort. Blood. 2012 Mar 22; 119(12):2746-53.
  53. Neufeld EJ, Galanello R, Viprakasit V, Aydinok Y, Piga A, Harmatz P, Forni GL, Shah FT, Grace RF, Porter JB, Wood JC, Peppe J, Jones A, Rienhoff HY. A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload. Blood. 2012 Apr 05; 119(14):3263-8.
  54. Long M, Kalish LA, Neufeld EJ, Grace RF. Trends in anti-D immune globulin for childhood immune thrombocytopenia: usage, response rates, and adverse effects. Am J Hematol. 2012 Mar; 87(3):315-7.
  55. Kurth M, Puetz J, Kouides P, Sanders J, Sexauer C, Bernstein J, Gruppo R, Manco-Johnson M, Neufeld EJ, Rodriguez N, Wicklund B, Quon D, Aledort L. The use of a single von Willebrand factor-containing, plasma-derived FVIII product in hemophilia A immune tolerance induction: the US experience. J Thromb Haemost. 2011 Nov; 9(11):2229-34.
  56. Morris CR, Kim HY, Trachtenberg F, Wood J, Quinn CT, Sweeters N, Kwiatkowski JL, Thompson AA, Giardina PJ, Boudreaux J, Olivieri NF, Porter JB, Neufeld EJ, Vichinsky EP. Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report. Blood. 2011 Oct 06; 118(14):3794-802.
  57. Sobota A, Graham DA, Neufeld EJ, Heeney MM. Thirty-day readmission rates following hospitalization for pediatric sickle cell crisis at freestanding children's hospitals: risk factors and hospital variation. Pediatr Blood Cancer. 2012 Jan; 58(1):61-5.
  58. Grace RF, Long M, Kalish LA, Neufeld EJ. Applicability of 2009 international consensus terminology and criteria for immune thrombocytopenia to a clinical pediatric population. Pediatr Blood Cancer. 2012 Feb; 58(2):216-20.
  59. Grace RF, Bennett CM, Ritchey AK, Jeng M, Thornburg CD, Lambert MP, Neier M, Recht M, Kumar M, Blanchette V, Klaassen RJ, Buchanan GR, Kurth MH, Nugent DJ, Thompson AA, Stine K, Kalish LA, Neufeld EJ. Response to steroids predicts response to rituximab in pediatric chronic immune thrombocytopenia. Pediatr Blood Cancer. 2012 Feb; 58(2):221-5.
  60. Sobota A, Neufeld EJ, Sprinz P, Heeney MM. Transition from pediatric to adult care for sickle cell disease: results of a survey of pediatric providers. Am J Hematol. 2011 Jun; 86(6):512-5.
  61. Trachtenberg F, Vichinsky E, Haines D, Pakbaz Z, Mednick L, Sobota A, Kwiatkowski J, Thompson AA, Porter J, Coates T, Giardina PJ, Olivieri N, Yamashita R, Neufeld EJ. Iron chelation adherence to deferoxamine and deferasirox in thalassemia. Am J Hematol. 2011 May; 86(5):433-6.
  62. Quinn CT, Johnson VL, Kim HY, Trachtenberg F, Vogiatzi MG, Kwiatkowski JL, Neufeld EJ, Fung E, Oliveri N, Kirby M, Giardina PJ. Renal dysfunction in patients with thalassaemia. Br J Haematol. 2011 Apr; 153(1):111-7.
  63. Thompson AA, Cunningham MJ, Singer ST, Neufeld EJ, Vichinsky E, Yamashita R, Giardina P, Kim HY, Trachtenberg F, Kwiatkowski JL. Red cell alloimmunization in a diverse population of transfused patients with thalassaemia. Br J Haematol. 2011 Apr; 153(1):121-8.
  64. Neufeld EJ, Kessler CM, Gill JC, Wilke CT, Cooper DL. Exposure and safety of higher doses of recombinant factor VIIa =250 µg kg(-1) in individuals with congenital haemophilia complicated by alloantibody inhibitors: the Haemophilia and Thrombosis Research Society Registry experience (2004-2008). Haemophilia. 2011 Jul; 17(4):650-6.
  65. Grace RF, Dahlberg SE, Neuberg D, Sallan SE, Connors JM, Neufeld EJ, Deangelo DJ, Silverman LB. The frequency and management of asparaginase-related thrombosis in paediatric and adult patients with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute consortium protocols. Br J Haematol. 2011 Feb; 152(4):452-9.
  66. Trenor CC, Chung RJ, Michelson AD, Neufeld EJ, Gordon CM, Laufer MR, Emans SJ. Hormonal contraception and thrombotic risk: a multidisciplinary approach. Pediatrics. 2011 Feb; 127(2):347-57.
  67. Sobota A, Yamashita R, Xu Y, Trachtenberg F, Kohlbry P, Kleinert DA, Giardina PJ, Kwiatkowski JL, Foote D, Thayalasuthan V, Porter JB, Thompson AA, Schilling L, Quinn CT, Neufeld EJ. Quality of life in thalassemia: a comparison of SF-36 results from the thalassemia longitudinal cohort to reported literature and the US norms. Am J Hematol. 2011 Jan; 86(1):92-5.
  68. Rienhoff HY, Viprakasit V, Tay L, Harmatz P, Vichinsky E, Chirnomas D, Kwiatkowski JL, Tapper A, Kramer W, Porter JB, Neufeld EJ. A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload. Haematologica. 2011 Apr; 96(4):521-5.
  69. Mednick L, Yu S, Trachtenberg F, Xu Y, Kleinert DA, Giardina PJ, Kwiatkowski JL, Foote D, Thayalasuthan V, Porter JB, Thompson AA, Schilling L, Quinn CT, Neufeld EJ, Yamashita R. Symptoms of depression and anxiety in patients with thalassemia: prevalence and correlates in the thalassemia longitudinal cohort. Am J Hematol. 2010 Oct; 85(10):802-5.
  70. Pakbaz Z, Treadwell M, Kim HY, Trachtenberg F, Parmar N, Kwiatkowski JL, Cunningham MJ, Martin M, Sweeters N, Neufeld EJ, Giardina PJ, Olivieri N, Yamashita RC, Vichinsky E. Education and employment status of children and adults with thalassemia in North America. Pediatr Blood Cancer. 2010 Oct; 55(4):678-83.
  71. Mednick LM, Braunstein J, Neufeld E. Oral chelation: should it be used with young children? Pediatr Blood Cancer. 2010 Oct; 55(4):603-5.
  72. Armand P, Kim HT, Rhodes J, Sainvil MM, Cutler C, Ho VT, Koreth J, Alyea EP, Hearsey D, Neufeld EJ, Fleming MD, Steen H, Anderson D, Kwong RY, Soiffer RJ, Antin JH. Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation. Biol Blood Marrow Transplant. 2011 Jun; 17(6):852-60.
  73. Oyeku SO, Feldman HA, Ryan K, Muret-Wagstaff S, Neufeld EJ. Primary care clinicians' knowledge and confidence about newborn screening for sickle cell disease: randomized assessment of educational strategies. J Natl Med Assoc. 2010 Aug; 102(8):676-82.
  74. Vichinsky EP, Neufeld EJ. Preface to Cooley's Anemia: Ninth Symposium. Ann N Y Acad Sci. 2010 Aug; 1202:ix-x.
  75. Harney KM, McCabe M, Branowicki P, Kalish LA, Neufeld EJ. Observational cohort study of pediatric inpatients with central venous catheters at "intermediate risk" of thrombosis and eligible for anticoagulant prophylaxis. J Pediatr Oncol Nurs. 2010 Nov-Dec; 27(6):325-9.
  76. Fung EB, Xu Y, Kwiatkowski JL, Vogiatzi MG, Neufeld E, Olivieri N, Vichinsky EP, Giardina PJ. Relationship between chronic transfusion therapy and body composition in subjects with thalassemia. J Pediatr. 2010 Oct; 157(4):641-7, 647.e1-2.
  77. Trachtenberg F, Foote D, Martin M, Carson S, Coates T, Beams O, Vega O, Merelles-Pulcini M, Giardina PJ, Kleinert DA, Kwiatkowski J, Thompson AA, Neufeld EJ, Schilling L, Thayalasuthan V, Pakbaz Z, Yamashita R. Pain as an emergent issue in thalassemia. Am J Hematol. 2010 May; 85(5):367-70.
  78. Bergmann AK, Grace RF, Neufeld EJ. Genetic studies in pediatric ITP: outlook, feasibility, and requirements. Ann Hematol. 2010 Jul; 89 Suppl 1:S95-103.
  79. Zehnder JL, Semple JW, Imbach P, Neufeld EJ, Buchanan GR, Cines DB. Future research in ITP: an ICIS consensus. Ann Hematol. 2010 Jul; 89 Suppl 1:19-23.
  80. Merrell SC, Rahbar R, Alomari AI, Padua HM, Vargas SO, Neufeld EJ, Dearden JL, Mulliken JB, Greene AK. Infantile myofibroma or lymphatic malformation: differential diagnosis of neonatal cystic cervicofacial lesions. J Craniofac Surg. 2010 Mar; 21(2):422-6.
  81. Bergmann AK, Campagna DR, McLoughlin EM, Agarwal S, Fleming MD, Bottomley SS, Neufeld EJ. Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. Pediatr Blood Cancer. 2010 Feb; 54(2):273-8.
  82. Sobota A, Graham DA, Heeney MM, Neufeld EJ. Corticosteroids for acute chest syndrome in children with sickle cell disease: variation in use and association with length of stay and readmission. Am J Hematol. 2010 Jan; 85(1):24-8.
  83. Neufeld EJ. Update on iron chelators in thalassemia. Hematology Am Soc Hematol Educ Program. 2010; 2010:451-5.
  84. Bergmann AK, Tamary H, Neufeld EJ. Remission from transfusion-dependence in a patient with congenital dyserythropoietic anemia (CDA) and increased intensity of iron chelation. Pediatr Blood Cancer. 2009 Dec; 53(6):1167-8.
  85. Singer ST, Kim HY, Olivieri NF, Kwiatkowski JL, Coates TD, Carson S, Neufeld E, Cunningham MJ, Giardina PJ, Mueller BU, Quinn CT, Fung E, Vichinsky E. Hemoglobin H-constant spring in North America: an alpha thalassemia with frequent complications. Am J Hematol. 2009 Nov; 84(11):759-61.
  86. Borzutzky A, Crompton B, Bergmann AK, Giliani S, Baxi S, Martin M, Neufeld EJ, Notarangelo LD. Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter. Clin Immunol. 2009 Dec; 133(3):287-94.
  87. Chirnomas D, Smith AL, Braunstein J, Finkelstein Y, Pereira L, Bergmann AK, Grant FD, Paley C, Shannon M, Neufeld EJ. Deferasirox pharmacokinetics in patients with adequate versus inadequate response. Blood. 2009 Nov 05; 114(19):4009-13.
  88. Bergmann AK, Sahai I, Falcone JF, Fleming J, Bagg A, Borgna-Pignati C, Casey R, Fabris L, Hexner E, Mathews L, Ribeiro ML, Wierenga KJ, Neufeld EJ. Thiamine-responsive megaloblastic anemia: identification of novel compound heterozygotes and mutation update. J Pediatr. 2009 Dec; 155(6):888-892.e1.
  89. Grace RF, Mednick RE, Neufeld EJ. Compliance with immunizations in splenectomized individuals with hereditary spherocytosis. Pediatr Blood Cancer. 2009 Jul; 52(7):865-7.
  90. Kentsis A, Anewalt R, Ganguly A, Allen JB, Neufeld EJ. Discordant haemophilia A in male siblings due to a de novo mutation on a familial missense mutant allele. Haemophilia. 2009 Jul; 15(4):971-2.
  91. Odegard KC, Zurakowski D, DiNardo JA, Castro RA, McGowan FX, Neufeld EJ, Laussen PC. Prospective longitudinal study of coagulation profiles in children with hypoplastic left heart syndrome from stage I through Fontan completion. J Thorac Cardiovasc Surg. 2009 Apr; 137(4):934-41.
  92. Mueller BU, Bennett CM, Feldman HA, Bussel JB, Abshire TC, Moore TB, Sawaf H, Loh ML, Rogers ZR, Glader BE, McCarthy MC, Mahoney DH, Olson TA, Feig SA, Lorenzana AN, Mentzer WC, Buchanan GR, Neufeld EJ. One year follow-up of children and adolescents with chronic immune thrombocytopenic purpura (ITP) treated with rituximab. Pediatr Blood Cancer. 2009 Feb; 52(2):259-62.
  93. Sobota A, Neufeld EJ, Lapsia S, Bennett CM. Response to mercaptopurine for refractory autoimmune cytopenias in children. Pediatr Blood Cancer. 2009 Jan; 52(1):80-4.
  94. Deborah Chirnomas S, Geukes-Foppen M, Barry K, Braunstein J, Kalish LA, Neufeld EJ, Powell AJ. Practical implications of liver and heart iron load assessment by T2*-MRI in children and adults with transfusion-dependent anemias. Am J Hematol. 2008 Oct; 83(10):781-3.
  95. Bennett CM, Boye E, Neufeld EJ. Female monozygotic twins discordant for hemophilia A due to nonrandom X-chromosome inactivation. Am J Hematol. 2008 Oct; 83(10):778-80.
  96. Neunert CE, Buchanan GR, Imbach P, Bolton-Maggs PH, Bennett CM, Neufeld EJ, Vesely SK, Adix L, Blanchette VS, Kühne T. Severe hemorrhage in children with newly diagnosed immune thrombocytopenic purpura. Blood. 2008 Nov 15; 112(10):4003-8.
  97. Mullen MP, Wessel DL, Thomas KC, Gauvreau K, Neufeld EJ, McGowan FX, Dinardo JA. The incidence and implications of anti-heparin-platelet factor 4 antibody formation in a pediatric cardiac surgical population. Anesth Analg. 2008 Aug; 107(2):371-8.
  98. Abel GA, Neufeld EJ, Sorel M, Weeks JC. Direct-to-consumer advertising for bleeding disorders: a content analysis and expert evaluation of advertising claims. J Thromb Haemost. 2008 Oct; 6(10):1680-4.
  99. Harmatz P, Jonas MM, Kwiatkowski JL, Wright EC, Fischer R, Vichinsky E, Giardina PJ, Neufeld EJ, Porter J, Olivieri N. Safety and efficacy of pegylated interferon alpha-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia. Haematologica. 2008 Aug; 93(8):1247-51.
  100. Walter PB, Macklin EA, Porter J, Evans P, Kwiatkowski JL, Neufeld EJ, Coates T, Giardina PJ, Vichinsky E, Olivieri N, Alberti D, Holland J, Harmatz P. Inflammation and oxidant-stress in beta-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial. Haematologica. 2008 Jun; 93(6):817-25.
  101. Porter J, Galanello R, Saglio G, Neufeld EJ, Vichinsky E, Cappellini MD, Olivieri N, Piga A, Cunningham MJ, Soulières D, Gattermann N, Tchernia G, Maertens J, Giardina P, Kwiatkowski J, Quarta G, Jeng M, Forni GL, Stadler M, Cario H, Debusscher L, Della Porta M, Cazzola M, Greenberg P, Alimena G, Rabault B, Gathmann I, Ford JM, Alberti D, Rose C. Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study. Eur J Haematol. 2008 Feb; 80(2):168-76.
  102. de Ferranti S, Shapiro D, Markowitz R, Neufeld E, Rifai N, Bernstein H. Nonfasting low-density lipoprotein testing: utility for cholesterol screening in pediatric primary care. Clin Pediatr (Phila). 2007 Jun; 46(5):441-5.
  103. Klaassen RJ, Blanchette VS, Barnard D, Wakefield CD, Curtis C, Bradley CS, Neufeld EJ, Buchanan GR, Silva MP, Chan AK, Young NL. Validity, reliability, and responsiveness of a new measure of health-related quality of life in children with immune thrombocytopenic purpura: the Kids' ITP Tools. J Pediatr. 2007 May; 150(5):510-5, 515.e1.
  104. Odegard KC, Zurakowski D, Hornykewycz S, DiNardo JA, Castro RA, Neufeld EJ, Laussen PC. Evaluation of the coagulation system in children with two-ventricle congenital heart disease. Ann Thorac Surg. 2007 May; 83(5):1797-803.
  105. Giulino LB, Bussel JB, Neufeld EJ. Treatment with rituximab in benign and malignant hematologic disorders in children. J Pediatr. 2007 Apr; 150(4):338-44, 344.e1.
  106. El-Hallak M, Binstadt BA, Leichtner AM, Bennett CM, Neufeld EJ, Fuhlbrigge RC, Zurakowski D, Sundel RP. Clinical effects and safety of rituximab for treatment of refractory pediatric autoimmune diseases. J Pediatr. 2007 Apr; 150(4):376-82.
  107. Tubman VN, Levine JE, Campagna DR, Monahan-Earley R, Dvorak AM, Neufeld EJ, Fleming MD. X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation. Blood. 2007 Apr 15; 109(8):3297-9.
  108. Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA, Cunningham MJ. Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer. 2007 Jan; 48(1):57-63.
  109. Bennett CM, de Jong JL, Neufeld EJ. Targeted ITP strategies: do they elucidate the biology of ITP and related disorders? Pediatr Blood Cancer. 2006 Oct 15; 47(5 Suppl):706-9.
  110. Almond CS, Harrington J, Thiagarajan R, Duncan CN, LaPierre R, Halwick D, Blume ED, Del Nido PJ, Neufeld EJ, McGowan FX. Successful use of bivalirudin for cardiac transplantation in a child with heparin-induced thrombocytopenia. J Heart Lung Transplant. 2006 Nov; 25(11):1376-9.
  111. Cunningham M, Weiss M, Neufeld EJ. Thalassemia. Clinical Hematology, Eds. Young NL, Gerson SL, High KA. 2006; 281-291.
  112. Neufeld EJ. Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions. Blood. 2006 May 01; 107(9):3436-41.
  113. Fox RA, Neufeld EJ, Bennett CM. Rituximab for adolescents with haemophilia and high titre inhibitors. Haemophilia. 2006 May; 12(3):218-22.
  114. Liberman MC, Tartaglini E, Fleming JC, Neufeld EJ. Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype. J Assoc Res Otolaryngol. 2006 Sep; 7(3):211-7.
  115. Chui DH, Cunningham MJ, Luo HY, Wolfe LC, Neufeld EJ, Steinberg MH. Screening and counseling for thalassemia. Blood. 2006 Feb 15; 107(4):1735-7.
  116. Bennett CM, Rogers ZR, Kinnamon DD, Bussel JB, Mahoney DH, Abshire TC, Sawaf H, Moore TB, Loh ML, Glader BE, McCarthy MC, Mueller BU, Olson TA, Lorenzana AN, Mentzer WC, Buchanan GR, Feldman HA, Neufeld EJ. Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura. Blood. 2006 Apr 01; 107(7):2639-42.
  117. Vogiatzi MG, Macklin EA, Fung EB, Vichinsky E, Olivieri N, Kwiatkowski J, Cohen A, Neufeld E, Giardina PJ. Prevalence of fractures among the Thalassemia syndromes in North America. Bone. 2006 Apr; 38(4):571-5.
  118. Sahai I, Montefusco MC, Fleming JC, Boros L, Tartaglini E, Chick G, Neufeld EJ. Role of defective high-affinity thiamine transporter slc19a2 in marrow from a mouse model of thiamine-responsive anemia syndrome: Evidence for defective deoxyribose and heme synthesis. Blood. 2005; 106(11):154A.
  119. Bennett CM, Bussel JB, Mueller BU, Abshire TC, Sawaf H, Moore TB, Loh ML, Rogers ZR, Feldman HA, Neufeld EJ. Phamacokinetics (PK) substudy of rituximab in a prospective clinical trial for pediatric chronic immune thrombocytopenic purpura (cITP). Blood. 2005; 106(11):362A.
  120. Walter P, Macklin E, Porter J, Evans P, Coates T, Olivieri NF, Giardina P, Kwiatkowski J, Neufeld E, Ames B, Holland J, Marks P, Vichinsky E, Harmatz P. Control of oxidant-stress and inflammation by iron chelators deferasirox (ICL670) or deferoxamine in beta-thalassemia: An ancillary study of the novartis CICL670A0107 trial. Blood. 2005; 106(11):1003A.
  121. Montefusco MC, Fleming JC, Chick G, Neufeld EJ. Thiamine deprivation induces reticulocytopenic anemia in Slc19A2 knockout marrow: Evidence for cell-intrinsic defect. Blood. 2005; 106(11):1004A-5A.
  122. Renfroe JL, Forbes P, Braunstein J, Neufeld EJ. Relationship of transfusion and iron-related complications to cost of care in thalassemia. Blood. 2005; 106(11):631A.
  123. Neufeld, EJ Ed. Improving Transfusion Outcomes. (a CME course on CD-ROM, on diagnosis and treatment of iron overload in sickle cell disease, thalassemia and MDS.). 2005.
  124. de Ferranti SD, Gauvreau K, Ludwig DS, Neufeld EJ, Newburger JW, Rifai N. Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation. 2004 Oct 19; 110(16):2494-7.
  125. Geva A, Clark JJ, Zhang Y, Popowicz A, Manning JM, Neufeld EJ. Hemoglobin Jamaica plain--a sickling hemoglobin with reduced oxygen affinity. N Engl J Med. 2004 Oct 07; 351(15):1532-8.
  126. Ellis JM, Gura KM, Patterson A, Neufeld EJ. Development and validation of guidelines for Enoxaparin use in high risk pediatric patients. Pediatr Res. 2004; 44(4 Suppl. S):286A.
  127. Cunningham MJ, Macklin EA, Muraca G, Neufeld EJ. Successful pregnancy in thalassemia major women in the thalassemia clinical research network. Pediatr Res. 2004; 55(4 suppl. S):294A.
  128. Cunningham MJ, Macklin EA, Neufeld EJ, Cohen AR. Complications of beta-thalassemia major in North America. Blood. 2004 Jul 01; 104(1):34-9.
  129. Ryan K, Heeney, MA, Neufeld EJ. Curriculum on newborn screening for hemoglobinopathies. 2004.
  130. Yao DC, Tolan DR, Murray MF, Harris DJ, Darras BT, Geva A, Neufeld EJ. Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr). Blood. 2004 Mar 15; 103(6):2401-3.
  131. Fleming JC, Tartaglini E, Kawatsuji R, Yao D, Fujiwara Y, Bednarski JJ, Fleming MD, Neufeld EJ. Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2. Mol Genet Metab. 2003 Sep-Oct; 80(1-2):234-41.
  132. Boros LG, Steinkamp MP, Fleming JC, Lee WN, Cascante M, Neufeld EJ. Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA). Blood. 2003 Nov 15; 102(10):3556-61.
  133. Nisbet-Brown E, Olivieri NF, Giardina PJ, Grady RW, Neufeld EJ, Séchaud R, Krebs-Brown AJ, Anderson JR, Alberti D, Sizer KC, Nathan DG. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet. 2003 May 10; 361(9369):1597-602.
  134. Thiagarajan RR, Roth SJ, Margossian S, Mackie AS, Neufeld EJ, Laussen PC, Forbess JM, Blume ED. Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A. Intensive Care Med. 2003 Jun; 29(6):985-8.
  135. Bennett CM, Boye E, Neufeld EJ. Monozygotic female twins discordant for factor VIII deficiency due to non-random X-chromosome inactivation in one twin. Pediatr Res. 2003; 53(4 Suppl. S):285A.
  136. Tabbutt S, Newburger JW, Hickey PR, Mayer JE, Neufeld EJ. Time course of early induction of intracellular adhesion molecule-1 messenger RNA during reperfusion, following cardiopulmonary bypass with hypothermic circulatory arrest in lambs. Pediatr Crit Care Med. 2003 Jan; 4(1):83-8.
  137. deFerranti S, Neufeld EJ. Hyperlipidemia, Cardiovascular Disease and Nutrition in Childhood. Nutrition in Pediatrics. Eds: Walker WA, Watkins JB, Duggan C. 2003; 799-810.
  138. Steinkamp M, Geva A, Joffe S, Lapp CN, Neufeld EJ. Chronic disseminated intravascular coagulation and childhood-onset skin necrosis resulting from homozygosity for a protein C Gla domain mutation, Arg15Trp. J Pediatr Hematol Oncol. 2002 Nov; 24(8):685-8.
  139. Hresko MT, McDougall PA, Gorlin JB, Vamvakas EC, Kasser JR, Neufeld EJ. Prospective reevaluation of the association between thrombotic diathesis and legg-perthes disease. J Bone Joint Surg Am. 2002 Sep; 84-A(9):1613-8.
  140. Sass AE, Neufeld EJ. Risk factors for thromboembolism in teens: when should I test? Curr Opin Pediatr. 2002 Aug; 14(4):370-8.
  141. Luong MX, van der Meijden CM, Xing D, Hesselton R, Monuki ES, Jones SN, Lian JB, Stein JL, Stein GS, Neufeld EJ, van Wijnen AJ. Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol Cell Biol. 2002 Mar; 22(5):1424-37.
  142. Odegard KC, McGowan FX, DiNardo JA, Castro RA, Zurakowski D, Connor CM, Hansen DD, Neufeld EJ, del Nido PJ, Laussen PC. Coagulation abnormalities in patients with single-ventricle physiology precede the Fontan procedure. J Thorac Cardiovasc Surg. 2002 Mar; 123(3):459-65.
  143. Nelson DP, Wechsler SB, Miura T, Stagg A, Newburger JW, Mayer JE, Neufeld EJ. Myocardial immediate early gene activation after cardiopulmonary bypass with cardiac ischemia-reperfusion. Ann Thorac Surg. 2002 Jan; 73(1):156-62.
  144. Neufeld EJ. Megaloblastic Anemias. Current Pediatric Therapy. Eds: Burg FD, Ingelfinger JR, Polin RA, Gershon AA. 2002; 637-638.
  145. Neufeld EJ. Disorders of Platelet Number and Function. Current Pediatric Therapy. Eds: Burg FD, Ingelfinger JR, Polin RA, Gershon AA. 2002; 664-670.
  146. Sinclair AM, Lee JA, Goldstein A, Xing D, Liu S, Ju R, Tucker PW, Neufeld EJ, Scheuermann RH. Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice. Blood. 2001 Dec 15; 98(13):3658-67.
  147. Mason KP, Neufeld EJ, Karian VE, Zurakowski D, Koka BV, Burrows PE. Coagulation abnormalities in pediatric and adult patients after sclerotherapy or embolization of vascular anomalies. AJR Am J Roentgenol. 2001 Dec; 177(6):1359-63.
  148. Higuchi LM, Joffe S, Neufeld EJ, Weisdorf S, Rosh J, Murch S, Devenyi A, Thompson JF, Lewis JD, Bousvaros A. Inflammatory bowel disease associated with immune thrombocytopenic purpura in children. J Pediatr Gastroenterol Nutr. 2001 Nov; 33(5):582-7.
  149. Fleming JC, Steinkamp MP, Kawatsuji R, Tartaglini E, Pinkus JL, Pinkus GS, Fleming MD, Neufeld EJ. Characterization of a murine high-affinity thiamine transporter, Slc19a2. Mol Genet Metab. 2001 Sep-Oct; 74(1-2):273-80.
  150. Said HM, Ortiz A, Subramanian VS, Neufeld EJ, Moyer MP, Dudeja PK. Mechanism of thiamine uptake by human colonocytes: studies with cultured colonic epithelial cell line NCM460. Am J Physiol Gastrointest Liver Physiol. 2001 Jul; 281(1):G144-50.
  151. Gritli S, Omar S, Tartaglini E, Guannouni S, Fleming JC, Steinkamp MP, Berul CI, Hafsia R, Jilani SB, Belhani A, Hamdi M, Neufeld EJ. A novel mutation in the SLC19A2 gene in a Tunisian family with thiamine-responsive megaloblastic anaemia, diabetes and deafness syndrome. Br J Haematol. 2001 May; 113(2):508-13.
  152. Neufeld EJ, Fleming JC, Tartaglini E, Steinkamp MP. Thiamine-responsive megaloblastic anemia syndrome: a disorder of high-affinity thiamine transport. Blood Cells Mol Dis. 2001 Jan-Feb; 27(1):135-8.
  153. Neufeld EJ, Fleming JC, Tartaglini E, Steinkamp M . Thiamine-responsive megaloblastic anemia (TRMA) syndrome: a disorder of high affinity transport. Blood Cells Mol Dis. 2001; 27(1):135-138.
  154. Mullen MP, Thomas KC, McGowan FX, Neufeld EJ, Wessel DL. Heparin-induced thrombocytopenia in pediatric patients undergoing cardiopulmonary bypass surgery. Circulation. 2000; 102(18):468.
  155. O'Brien M, Parness IA, Neufeld EJ, Baker AL, Sundel RP, Newburger JW. Ticlopidine plus aspirin for coronary thrombosis in Kawasaki disease. Pediatrics. 2000 May; 105(5):E64.
  156. Fox VL, Nurko S, Jones MM, Rufo PA, Neufeld EJ, Antonioli DA. Solitary colonic ulcer associated with coagulation factor deficiency. Gastro Endoscopy. 2000; 51(4 Pt. 2):Ab134.
  157. Yu HH, Markowitz R, De Ferranti SD, Neufeld EJ, Farrow G, Bernstein HH, Rifai N. Direct measurement of LDL-C in children: performance of two surfactant-based methods in a general pediatric population. Clin Biochem. 2000 Mar; 33(2):89-95.
  158. van Gurp MF, Pratap J, Luong M, Javed A, Hoffmann H, Giordano A, Stein JL, Neufeld EJ, Lian JB, Stein GS, van Wijnen AJ. The CCAAT displacement protein/cut homeodomain protein represses osteocalcin gene transcription and forms complexes with the retinoblastoma protein-related protein p107 and cyclin A. Cancer Res. 1999 Dec 01; 59(23):5980-8.
  159. Liu J, Barnett A, Neufeld EJ, Dudley JP. Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation. Mol Cell Biol. 1999 Jul; 19(7):4918-26.
  160. Fleming JC, Tartaglini E, Steinkamp MP, Schorderet DF, Cohen N, Neufeld EJ. The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Nat Genet. 1999 Jul; 22(3):305-8.
  161. Neufeld EJ. The future of heart disease markers in pediatrics. Clin Chem. 1999; 45(6 Pt. 2):S33.
  162. Li S, Moy L, Pittman N, Shue G, Aufiero B, Neufeld EJ, LeLeiko NS, Walsh MJ. Transcriptional repression of the cystic fibrosis transmembrane conductance regulator gene, mediated by CCAAT displacement protein/cut homolog, is associated with histone deacetylation. J Biol Chem. 1999 Mar 19; 274(12):7803-15.
  163. Stagg AR, Fleming JC, Baker MA, Sakamoto M, Cohen N, Neufeld EJ. Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts. J Clin Invest. 1999 Mar; 103(5):723-9.
  164. Wang Z, Goldstein A, Zong RT, Lin D, Neufeld EJ, Scheuermann RH, Tucker PW. Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator. Mol Cell Biol. 1999 Jan; 19(1):284-95.
  165. Ong BC, Zimmerman AA, Zappulla DC, Neufeld EJ, Burrows FA. Prevalence of factor V Leiden in a population of patients with congenital heart disease. Can J Anaesth. 1998 Dec; 45(12):1176-80.
  166. DiMichele D, Neufeld EJ. Hemophilia. A new approach to an old disease. Hematol Oncol Clin North Am. 1998 Dec; 12(6):1315-44.
  167. Neufeld EJ. Update on genetic risk factors for thrombosis and atherosclerotic vascular disease. Hematol Oncol Clin North Am. 1998 Dec; 12(6):1193-209, vi.
  168. Neufeld, EJ, Ed. Coagulation Disorders. Hematology/Oncology Clinics of North America. 1998.
  169. Raz T, Barrett T, Szargel R, Mandel H, Neufeld EJ, Nosaka K, Viana MB, Cohen N. Refined mapping of the gene for thiamine-responsive megaloblastic anemia syndrome and evidence for genetic homogeneity. Hum Genet. 1998 Oct; 103(4):455-61.
  170. Ticho BS, Neufeld EJ, Newburger JW, Harris N, Baker A, Rifai N. Utility of direct measurement of low-density lipoprotein cholesterol in dyslipidemic pediatric patients. Arch Pediatr Adolesc Med. 1998 Aug; 152(8):787-91.
  171. Tufarelli C, Fujiwara Y, Zappulla DC, Neufeld EJ. Hair defects and pup loss in mice with targeted deletion of the first cut repeat domain of the Cux/CDP homeoprotein gene. Dev Biol. 1998 Aug 01; 200(1):69-81.
  172. Vernacchio L, Neufeld EJ, MacDonald K, Kurth S, Murakami S, Hohne C, King M, Molrine D. Combined schedule of 7-valent pneumococcal conjugate vaccine followed by 23-valent pneumococcal vaccine in children and young adults with sickle cell disease. J Pediatr. 1998 Aug; 133(2):275-8.
  173. Neufeld EJ, Mandel H, Raz T, Szargel R, Yandava CN, Stagg A, Fauré S, Barrett T, Buist N, Cohen N. Localization of the gene for thiamine-responsive megaloblastic anemia syndrome, on the long arm of chromosome 1, by homozygosity mapping. Am J Hum Genet. 1997 Dec; 61(6):1335-41.
  174. Blume ED, Nelson DP, Gauvreau K, Walsh AZ, Plumb C, Neufeld EJ, Hickey PR, Mayer JE, Newburger JW. Soluble adhesion molecules in infants and children undergoing cardiopulmonary bypass. Circulation. 1997 Nov 04; 96(9 Suppl):II-352-7.
  175. Jenkins KJ, du Plessis AJ, Gauvreau KG, Burnett JT, Woolsey LR, Neufeld EJ . Hereditary resistance to activated protein C is not responsible for increased strokes in patients with cogenital heart disease. Circulation. 1997; 96(8 Suppl. S):727.
  176. Khanna-Gupta A, Zibello T, Kolla S, Neufeld EJ, Berliner N. CCAAT displacement protein (CDP/cut) recognizes a silencer element within the lactoferrin gene promoter. Blood. 1997 Oct 01; 90(7):2784-95.
  177. Lievens PM, Tufarelli C, Donady JJ, Stagg A, Neufeld EJ. CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro. Gene. 1997 Sep 15; 197(1-2):73-81.
  178. Neufeld EJ, Mietus-Snyder M, Beiser AS, Baker AL, Newburger JW. Passive cigarette smoking and reduced HDL cholesterol levels in children with high-risk lipid profiles. Circulation. 1997 Sep 02; 96(5):1403-7.
  179. Tabbutt S, Nelson DP, Tsai N, Miura T, Hickey PR, Mayer JE, Neufeld EJ. Induction of aquaporin-1 mRNA following cardiopulmonary bypass and reperfusion. Mol Med. 1997 Sep; 3(9):600-9.
  180. Parsons SK, Skapek SX, Neufeld EJ, Kuhlman C, Young ML, Donnelly M, Brunzell JD, Otvos JD, Sallan SE, Rifai N. Asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia. Blood. 1997 Mar 15; 89(6):1886-95.
  181. Miura T, Nelson DP, Schermerhorn ML, Shin'oka T, Zund G, Hickey PR, Neufeld EJ, Mayer JE. Blockade of selectin-mediated leukocyte adhesion improves postischemic function in lamb hearts. Ann Thorac Surg. 1996 Nov; 62(5):1295-300.
  182. van Wijnen AJ, van Gurp MF, de Ridder MC, Tufarelli C, Last TJ, Birnbaum M, Vaughan PS, Giordano A, Krek W, Neufeld EJ, Stein JL, Stein GS. CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11516-21.
  183. Rifai N, Neufeld E, Ahlstrom P, Rimm E, D'Angelo L, Hicks JM. Failure of current guidelines for cholesterol screening in urban African-American adolescents. Pediatrics. 1996 Sep; 98(3 Pt 1):383-8.
  184. Harris N, Neufeld EJ, Newburger JW, Ticho B, Baker A, Ginsburg GS, Rimm E, Rifai N. Analytical performance and clinical utility of a direct LDL-cholesterol assay in a hyperlipidemic pediatric population. Clin Chem. 1996 Aug; 42(8 Pt 1):1182-8.
  185. Zünd G, Nelson DP, Neufeld EJ, Dzus AL, Bischoff J, Mayer JE, Colgan SP. Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells. Proc Natl Acad Sci U S A. 1996 Jul 09; 93(14):7075-80.
  186. Yandava CN, Zappulla DC, Korf BR, Neufeld EJ. ARMS test for diagnosis of factor VLeiden mutation, a common cause of inherited thrombotic tendency. J Clin Lab Anal. 1996; 10(6):414-7.
  187. Burns SA, Newburger JW, Xiao M, Mayer JE, Walsh AZ, Neufeld EJ. Induction of interleukin-8 messenger RNA in heart and skeletal muscle during pediatric cardiopulmonary bypass. Circulation. 1995 Nov 01; 92(9 Suppl):II315-21.
  188. Burns SA, DeGuzman BJ, Newburger JW, Mayer JE, Neufeld EJ, Briscoe DM. P-selectin expression in myocardium of children undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1995 Oct; 110(4 Pt 1):924-33.
  189. Windsor S, Lyng A, Taylor SA, Ewenstein BM, Neufeld EJ, Lillicrap D. Severe haemophilia A in a female resulting from two de novo factor VIII mutations. Br J Haematol. 1995 Aug; 90(4):906-9.
  190. Lievens PM, Donady JJ, Tufarelli C, Neufeld EJ. Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells. J Biol Chem. 1995 May 26; 270(21):12745-50.
  191. Suss., et al. Guidlines for medical evaluation of patients with Fanconi Anemia. Fanconi Anemia Handbook, 2nd Ed. 1995.
  192. Aufiero B, Neufeld EJ, Orkin SH. Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7757-61.
  193. Kilbridge PM, Mayer JE, Newburger JW, Hickey PR, Walsh AZ, Neufeld EJ. Induction of intercellular adhesion molecule-1 and E-selectin mRNA in heart and skeletal muscle of pediatric patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1994 May; 107(5):1183-92.
  194. Neufeld EJ. Inherited dyslipidemias in childhood. Curr Opin Pediatr. 1993 Dec; 5(6):707-11.
  195. Ritte U, Neufeld E, Broit M, Shavit D, Motro U. The differences among Jewish communities--maternal and paternal contributions. J Mol Evol. 1993 Oct; 37(4):435-40.
  196. Colletti RB, Neufeld EJ, Roff NK, McAuliffe TL, Baker AL, Newburger JW. Niacin treatment of hypercholesterolemia in children. Pediatrics. 1993 Jul; 92(1):78-82.
  197. Mietus-Snyder M, Baker AL, Neufeld EJ, Roberts C, Dermarkarian S, Beiser AS, Newburger JW. Effects of nutritional counseling on lipoprotein levels in a pediatric lipid clinic. Am J Dis Child. 1993 Apr; 147(4):378-81.
  198. Scherer SW, Neufeld EJ, Lievens PM, Orkin SH, Kim J, Tsui LC. Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids. Genomics. 1993 Mar; 15(3):695-6.
  199. Skalnik DG, Neufeld EJ. Sequence-specific binding of HMG-I (Y) to the proximal promoter of the gp91-phox gene. Biochem Biophys Res Commun. 1993 Jan 15; 190(1):308-9.
  200. Neufeld EJ, Newburger JW . How should children with hypercholesterolemia be managed?. Choices in Cardiology. 1993; 7:233-236.
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  202. Neufeld EJ, Skalnik DG, Lievens PM, Orkin SH. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Nat Genet. 1992 Apr; 1(1):50-5.
  203. Krueger CM, Neufeld EJ, Saffitz JE. Preservation of arachidonoyl phospholipids during tissue processing for electron microscopic autoradiography. J Histochem Cytochem. 1985 Aug; 33(8):799-802.
  204. Neufeld EJ, Majerus PW, Krueger CM, Saffitz JE. Uptake and subcellular distribution of [3H]arachidonic acid in murine fibrosarcoma cells measured by electron microscope autoradiography. J Cell Biol. 1985 Aug; 101(2):573-81.
  205. Neufeld, EJ. Arachadonate metabolism in platelets and cultured cells. 1985.
  206. Wilson DB, Neufeld EJ, Majerus PW. Phosphoinositide interconversion in thrombin-stimulated human platelets. J Biol Chem. 1985 Jan 25; 260(2):1046-51.
  207. Majerus PW, Wilson DB, Connolly TM, Bross TE, Neufeld EJ. Pathways of phosphoinositide metabolism in human platelets. Adv Prostaglandin Thromboxane Leukot Res. 1985; 15:109-12.
  208. Majerus PW, Neufeld EJ, Laposata M . Mechanisms for eicosanoid precursor uptake and release by a tissue culture cell line. Inositol and Phosphoinositide Metabolism and Regulation. 1985.
  209. Majerus PW, Wilson DB, Connolly TM, Bross TE, Neufeld EJ. Phosphoinositide turnover provides a link in stimulus-response coupling. Tr Biochem Sci. 1985; 10:168-171.
  210. Majerus PW, Neufeld EJ, Wilson DB. Production of phosphoinositide-derived messengers. Cell. 1984 Jul; 37(3):701-3.
  211. Neufeld EJ, Majerus PW, Sprecher H. Role of arachidonoyl-CoA synthetase in eicosanoid precursor uptake and release. J Am Oil Chem Soc. 1984; 61(4):673-674.
  212. Neufeld EJ, Sprecher H, Evans RW, Majerus PW. Fatty acid structural requirements for activity of arachidonoyl-CoA synthetase. J Lipid Res. 1984 Mar; 25(3):288-93.
  213. Neufeld EJ, Bross TE, Majerus PW. A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase. J Biol Chem. 1984 Feb 10; 259(3):1986-92.
  214. Neufeld EJ, Wilson DB, Sprecher H, Majerus PW. High affinity esterification of eicosanoid precursor fatty acids by platelets. J Clin Invest. 1983 Jul; 72(1):214-20.
  215. Neufeld EJ, Majerus PW. Arachidonate release and phosphatidic acid turnover in stimulated human platelets. J Biol Chem. 1983 Feb 25; 258(4):2461-7.
  216. Majerus PW, Prescott SM, Hofmann SL, Neufeld EJ, Wilson DB. Uptake and release of arachidonate by platelets. Adv Prostaglandin Thromboxane Leukot Res. 1983; 11:45-52.
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  218. Levi A, Shechter Y, Neufeld EJ, Schlessinger J. Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell line. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3469-73.
  219. Neufeld EJ, Pastan I. A mutant fibroblast cell line defective in glycoprotein synthesis due to a deficiency of glucosamine phosphate acetyltransferase. Arch Biochem Biophys. 1978 Jun; 188(2):323-7.
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Dana-Farber/Boston Children’s Cancer and Blood Disorders Center

Dana-Farber/Boston Children's Cancer and Blood Disorders Center is one of the top research centers in the world for pediatric cancers and blood diseases. It brings together laboratory scientists and clinical researchers from Dana-Farber Cancer Institute and Boston Children’s Hospital in a single program. We investigate pediatric cancers and non-malignant blood disorders from every angle—from examining cells under the microscope to tracking the effectiveness of current drug regimens using the most advanced molecular methods—so that we can create better treatments for children seen here and around the world.

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