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David Stein, MD

Medicine Research
Developmental Medicine Research
Hospital Title:
Staff Psychologist, Developmental Medicine Center
Academic Title:
Instructor in Psychology, Harvard Medical School
Research Focus Area:
Neurodevelopmental Disorders

Research Overview

Dr. David Stein's principal research interest is in accurate phenotyping and treatment of complex neurodevelopmental disabilities including Down syndrome, intellectual disability, autism spectrum disorder, and ADHD.  He also focuses on quality improvement through research in development of outcome measures and improved clinical efficiency.  Dr. Stein is the Co-Director of Research of the Down Syndrome Program and Director of Quality Improvement for the Pediatric Psychology Program in the Developmental Medicine Center.

Dr. Stein works closely with colleagues in neuroscience, neurodevelopmental disabilities, and developmental-behavioral pediatrics to understand neurodevelopmental disorders broadly, from an interdisciplinary perspective.  The Down Syndrome Program's research team is currently working to assess the impact of Applied Behavior Analysis (ABA) on development and neurological function of preschool children with Down syndrome.  In addition, the team is investigating the phenotype of autism spectrum disorder in Down syndrome.  Dr. Stein is also working to develop a measure to assess the impact of developmental evaluations as part of the larger quality improvement effort in the Developmental Medicine Center.

Dr. Stein completed his BA in clinical psychology at Tufts University, his doctoral degree in clinical psychology at the Massachusetts School of Professional Psychiatry, and his clinical internship and fellowship at Harvard Medical School (The Cambridge Hospital and Boston Children's Hospital, respectively).


Publications powered by Harvard Catalyst Profiles
  1. Stein DS, Munir KM, Karweck AJ, Davidson EJ, Stein MT. Developmental Regression, Depression, and Psychosocial Stress in an Adolescent with Down Syndrome. J Dev Behav Pediatr. 2017 Feb/Mar; 38 Suppl 1:S26-S28.
  2. Stein DS, Welchons LW, Corley KB, Dickinson H, Levin AR, Nelson CA, Stein MT. Autism associated with early institutionalization, high intelligence, and naturalistic behavior therapy in a 7-year-old boy. J Dev Behav Pediatr. 2015 Jan; 36(1):53-5.
  3. Koolwijk I, Stein DS, Chan E, Powell C, Driscoll K, Barbaresi WJ. "Complex" attention-deficit hyperactivity disorder, more norm than exception? Diagnoses and comorbidities in a developmental clinic. J Dev Behav Pediatr. 2014 Nov-Dec; 35(9):591-7.
  4. Stein DS, Munir KM, Karweck AJ, Davidson EJ, Stein MT. Developmental regression, depression, and psychosocial stress in an adolescent with Down syndrome. J Dev Behav Pediatr. 2013 Apr; 34(3):216-8.
  5. Stein DS, Blum NJ, Barbaresi WJ. Developmental and behavioral disorders through the life span. Pediatrics. 2011 Aug; 128(2):364-73.
  6. Rex JH, Pappas PG, Karchmer AW, Sobel J, Edwards JE, Hadley S, Brass C, Vazquez JA, Chapman SW, Horowitz HW, Zervos M, McKinsey D, Lee J, Babinchak T, Bradsher RW, Cleary JD, Cohen DM, Danziger L, Goldman M, Goodman J, Hilton E, Hyslop NE, Kett DH, Lutz J, Rubin RH, Scheld WM, Schuster M, Simmons B, Stein DK, Washburn RG, Mautner L, Chu TC, Panzer H, Rosenstein RB, Booth J. A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects. Clin Infect Dis. 2003 May 15; 36(10):1221-8.
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