Research

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David B Kantor, MD, PhD

David Kantor MD
Lab:
Hirschhorn Laboratory
Department:
Department of Anesthesiology, Perioperative and Pain Medicine Research
Division
Critical Care Medicine Research
Hospital Title:
Assistant in Critical Care Medicine
Academic Title:
Instructor in Anaesthesia, Harvard Medical School
Research Focus Area:
AsthmaGenetics
Contact:
617-355-7327
Contact Via Email
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Research Summary

My research goal is to understand how host genetic variation and environmental exposures (such as infection) interact to influence the severity of acute disease in children.  We are currently focused on rhinovirus triggered acute asthma exacerbation.  In a separate research track, I am also interested in investigating how point of care ultrasound imaging can be utilized in the intensive care unit to improve patient care.

Key Publications

A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Kantor DB, Lanzrein M, Stary SJ, Sandoval GM, Smith WB, et al. Science (New York, N.Y.). 1996; 274(5293):1744-8. PubMed [journal]PMID: 8939872

Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. Ouyang Y, Kantor D, Harris KM, Schuman EM, Kennedy MB. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1997; 17(14):5416-27. PubMed [journal]PMID: 9204925

Recombinant adenovirus-mediated expression in nervous system of genes coding for ion channels and other molecules involved in synaptic function. Ehrengruber MU, Lanzrein M, Xu Y, Jasek MC, Kantor DB, et al. Methods in enzymology. 1998; 293:483-503. PubMed [journal]PMID: 9711625

Curbing the excesses of youth: molecular insights into axonal pruning. Kantor DB, Kolodkin AL. Neuron. 2003; 38(6):849-52. PubMed [journal]PMID: 12818170

Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, et al. Neuron. 2004; 44(6):961-75. PubMed [journal]PMID: 15603739

The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, et al. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005; 25(4):808-22. PubMed [journal]PMID: 15673660 

Replication and fine mapping of asthma-associated loci in individuals of African ancestry. Kantor DB, Palmer CD, Young TR, Meng Y, Gajdos ZK, et al. Human genetics. 2013; 132(9):1039-47. NIHMSID: NIHMS497079 PubMed [journal]PMID: 23666277 PMCID: PMC3975655

Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Duvall MG, Pikman Y, Kantor DB, Ariagno K, Summers L, et al. Pediatrics. 2013; 132(6):e1699-703. PubMed [journal]PMID: 24190688

Intravenous β agonists and severe pediatric asthma exacerbation: time for a closer look at terbutaline? Kantor DB, Phipatanakul W. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology. 2014; 112(3):187. PubMed [journal]PMID: 24565592

Establishing intensivist-driven ultrasound at the PICU bedside--it's about time*. Su E, Pustavoitau A, Hirshberg EL, Nishisaki A, Conlon T, et al. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2014; 15(7):649-52. PubMed [journal]PMID: 24977438

Publications

Publications powered by Harvard Catalyst Profiles
  1. Bairdain S, Zurakowski D, Vargas SO, Stenquist N, McDonald M, Towne MC, Miller DT, Jennings RW, Kantor DB, Agrawal PB. Long-Gap Esophageal Atresia Is a Unique Entity within the Esophageal Atresia Defect Spectrum. Neonatology. 2016 Oct 19; 111(2):140-144.
  2. Su E, Pustavoitau A, Hirshberg EL, Nishisaki A, Conlon T, Kantor DB, Weber MD, Godshall AJ, Burzynski JH, Thompson AE. Establishing intensivist-driven ultrasound at the PICU bedside--it's about time*. Pediatr Crit Care Med. 2014 Sep; 15(7):649-52.
  3. Kantor DB, Phipatanakul W. Intravenous ß agonists and severe pediatric asthma exacerbation: time for a closer look at terbutaline? Ann Allergy Asthma Immunol. 2014 Mar; 112(3):187.
  4. Duvall MG, Pikman Y, Kantor DB, Ariagno K, Summers L, Sectish TC, Mullen MP. Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Pediatrics. 2013 Dec; 132(6):e1699-703.
  5. David B. Kantor. Functional Regulation of the Axon Guidance Cue Semaphorin 5A by Sulfated Proteoglycans. 2005.
  6. Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ, Flanagan JG, Yamaguchi Y, Sretavan DW, Giger RJ, Kolodkin AL. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Neuron. 2004 Dec 16; 44(6):961-75.
  7. Kantor DB, Kolodkin AL. Curbing the excesses of youth: molecular insights into axonal pruning. Neuron. 2003 Jun 19; 38(6):849-52.
  8. Kantor, D.B., Giger, R.J., and Kolodkin, A.L. Sema5A affects axon outgrowth from the habenular nucleus. Keystone symposia, Axonal connections: molecular cues for development and regeneration. 2003.
  9. Ehrengruber MU, Lanzrein M, Xu Y, Jasek MC, Kantor DB, Schuman EM, Lester HA, Davidson N. Recombinant adenovirus-mediated expression in nervous system of genes coding for ion channels and other molecules involved in synaptic function. Methods Enzymol. 1998; 293:483-503.
  10. Ouyang Y, Kantor D, Harris KM, Schuman EM, Kennedy MB. Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. J Neurosci. 1997 Jul 15; 17(14):5416-27.
  11. Show all
  12. Kantor, D.B., Zirlinger, M., Smith, W.B., Lanzrein, M., Sullivan, B.M., Davidson, N., and Schuman, E.M. The effect of endothelial nitric oxide synthase subcellular localization on nitric oxide release and long-term potentiation. Society for Neuroscience abstracts. 1997; 23:47.18.
  13. Potter, S., Kantor, D.B., Mamelak, A.N., Fraser, S.E., and Schuman, E.M. 3D time-lapse imaging of hippocampal dendritic spine plasticity using 2-photon microscopy. Society for Neuroscience abstracts. 1997; 23:136.5.
  14. Kantor DB, Lanzrein M, Stary SJ, Sandoval GM, Smith WB, Sullivan BM, Davidson N, Schuman EM. A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Science. 1996 Dec 6; 274(5293):1744-8.
  15. Kantor, D.B., Stary, S.J., Smith, W.B., Sullivan, B.M., Davidson, N., and Schuman, E.M. Expression of a mutant endothelial nitric oxide synthase (eNOS) blocks long-term potentiation (LTP). Society for Neuroscience abstracts. 1996; 22:598.16.
  16. Kantor, D.B., Sandoval, G.M.R., and Schuman, E.M. . A potential role for protein myristoylation and an endothelial nitric oxide synthase (eNOS) in long-term potentiation (LTP). Society for Neuroscience abstracts 21, 711.14. 1995; 21:711.14.
  17. Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, Newman BA, Mage R, Rader C, Giger RJ. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. J Neurosci. 2005 Jan 26; 25(4):808-22.
  18. Kantor DB, Palmer CD, Young TR, Meng Y, Gajdos ZK, Lyon H, Price AL, Pollack S, London SJ, Loehr LR, Smith LJ, Kumar R, Jacobs DR, Petrini MF, O'Connor GT, White WB, Papanicolaou G, Burkart KM, Heckbert SR, Barr RG, Hirschhorn JN. Replication and fine mapping of asthma-associated loci in individuals of African ancestry. Hum Genet. 2013 Sep; 132(9):1039-47.
  19. Su E, Kantor DB, Conlon T. Looking for Tips on Central Venous Catheter Insertion? Try Ultrasound. Pediatr Crit Care Med. 2015 Nov; 16(9):891-3.
  20. Conlon T, Su E, Hirshberg E, Burzynski J, Godshall A, Kantor D, Sanchez-de-Toledo J, Nishisaki A. 395: BENEFITS AND BARRIERS TO BEDSIDE ULTRASOUND: A SURVEY OF THE SCCM PEDIATRIC ULTRASOUND COURSE. Crit Care Med. 2016 Dec; 44(12 Suppl 1):175.
  21. Kantor DB, Stenquist N, McDonald MC, Schultz BJ, Hauptman M, Smallwood CD, Nelson KA, Perzanowski MS, Matsui EC, Phipatanakul W, Hirschhorn JN. Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children. J Allergy Clin Immunol. 2016 Nov; 138(5):1467-1471.e9.
  22. Firtha F, Fekete A, Kaszab T, Gillay B, Nogula-Nagy M, Kovács Z, Kantor DB. Methods for Improving Image Quality and Reducing Data Load of NIR Hyperspectral Images. Sensors (Basel). 2008 May 19; 8(5):3287-3298.
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