Research

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Ben A. Croker, PhD

Research Center:
Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
Department:
Medicine Research
Division
Hematology/Oncology Research
Hospital Title:
Associate Scientific Researcher
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School
Contact:
617-919-6288
Contact Via Email
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Research Overview

  • Necroptosis in hematopoiesis
  • Pyroptosis and cytopenia
  • Neutrophil death and inflammation

We study non-apoptotic forms of cell death including pyroptosis and necroptosis. The pyroptotic death of hematopoietic stem cells and hematopoietic progenitor cells can induce leukopenia at steady state, and cytopenia and bone marrow failure following infection or chemotherapy.

People

We have a lab with diverse interests and expertise. Our ultimate goal is an understanding of cell death, particularly non-apoptotic cell death, and how this impacts our ability to respond to infection. We study cell death at a genetic, biochemical, cellular, and organismal level in model systems and in the clinic.

Current Lab Members

Stuart Dias
Research Technician
B.Sc. (University of New Hampshire)

Akshay D'Cruz
Post-Doctoral Fellow

Arshed Al-Obeidi
Post-Graduate Fellow

Meghan Bliss-Moreau
Post-Doctoral Fellow

Kathleen Hanlon
Wellesley College

Farida Dhilla
Senior Administrative Associate

Former Lab Members

Joanne O’Donnell
Ph.D. student, The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Australia

Motti Gerlic
Post-Doctoral Fellow, The Walter and Eliza Hall Institute of Medical Research, Australia

Man Lyang Kim
Post-Doctoral Fellow, The Walter and Eliza Hall Institute of Medical Research, Australia

Kate McArthur
B.Sc.(Hons), The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Australia

Maria Sundberg
Ph.D. (University of Tampere/ Institute of Biomedical Technology, Finland)
M.Sc. (University of Helsinki, Finland) 

Publications

BA Croker, E Handman, JD Hayball, TM Baldwin, V Voigt, LA Cluse, FC Yang, DA Williams, AW Roberts. Rac2 deficient mice display perturbed T cell distribution and chemotaxis, but only minor abnormalities in TH1 responses. Immun Cell Biol 2002, 80, 231-40.

BA Croker, DM Tarlinton, LA Cluse, AJ Tuxen, A Light, FC Yang, DA Williams, AW Roberts. The Rac2 GTPase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes. J Immunol 2002, 168, 3376-86.

BA Croker and N Nicola. Cancer Drug Discovery and Development, Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics. The Jak-Stat Pathway of Cytokine Signaling. Humana Press.

BA Croker, DL Krebs, JG Zhang, S Wormald, TA Willson, EG Stanley, L Robb, CJ Greenhalgh, I Förster, BE Clausen, NA Nicola, D Metcalf, DJ Hilton, AW Roberts, WS Alexander . SOCS3 negatively regulates IL-6 signaling in vivo. Nature Immunology 2003, 4, 540-5.

BA Croker, D Metcalf, L Robb, W Wei, S Mifsud, L DiRago, LA Cluse, KD Sutherland, L Hartley, E Williams, JG Zhang, DJ Hilton, NA Nicola, WS Alexander, AW Roberts. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 2004, 20, 153-165.

B Emery, HS Cate, M Marriott, T Merson, MD Binder, C Snell, PY Soo, S Murray, BA Croker, JG Zhang, WS Alexander, H Cooper, H Butzkueven, TJ Kilpatrick. Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination. PNAS 2006, 103:7859-64.

PK Wong, PJ Egan, BA Croker, K O’Donnell, NA Sims, S Drake, H Kiu, EJ McManus, WS Alexander, AW Roberts, IP Wicks. SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest 2006, 116: 1571-81.

WS Alexander, EM Viney, JG Zhang, D Metcalf, M Kauppi, CD Hyland, MR Carpinelli, W Stevenson, BA Croker, AA Hilton, S Ellis, C Selan, HH Nandurkar, CC Goodnow, BT Kile, NA Nicola, AW Roberts, DJ Hilton. Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. PNAS 2006, 103:16442-7.

GCT Yeoh, M Ernst, S Rose-John, B Akhurst, C Payne, S Long, W Alexander, BA Croker, D Grail, VB Matthews. Opposing roles of gp130 mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation. Hepatology 2007; 45:486-94.

BA Croker, K Crozat, M Berger, Y Xia, S Sovath, I Eleftherianos, JL Imler, B Beutler. ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nature Genetics 2007, Dec 39: 1453-60. Citations:26

JL Eyles, MJ Hickey, MU Norman, BA Croker, AW Roberts, SF Drake, WG James, D Metcalf, IK Campbell, IP Wicks. A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis. Blood 2008, 112: 5193-5201.

BA Croker, L Mielke, S Wormald, D Metcalf, H Kiu, WS Alexander, DJ Hilton, AW Roberts. Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation. Experimental Hematology 2008, 36, 786-798.

BA Croker, BR Lawson, M Berger, C Eidenschenk, AL Blasius, EY Moresco, S Sovath, L Cengia, LD Shultz, AN Theofilopoulos, S Pettersson, BA Beutler. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, Myd88, and a microbial trigger. PNAS 2008, 105:15028.

BA Croker, H Kiu, SE Nicholson. SOCS regulation of the JAK/STAT signaling pathway. Semin Cell Dev Biol 2008, 19:414-422.

M Berger, P Krebs, K Crozat, X Li, BA Croker, OM Siggs, D Popkin, X Du, BR Lawson, AN Theofilopoulos, Y Xia, K Khovananth, EMY Moresco, T Satoh, O Takeuchi, S Akira, Bruce Beutler. A Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nature Immunology 2010, 11:335-43.

Y Zhan, Y Xu, S Seah, JL Brady, EM Carrington, C Cheers, BA Croker, L Wu, JA Villadangos, AM Lew. Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways. J Immunology 2010,185:2125-33.

SL Masters, LA Mielke, AL Cornish, CE Sutton, J O’Donnell, LH Cengia, AW Roberts, IP Wicks, KHG Mills, BA Croker. Regulation of IL-1b by IFNg is species-specific, limited by SOCS1 and influences IL-17 production. EMBO reports 2010, 11:640-6.

BA Croker, RS Lewis, JJ Babon, JD Mintern, DE Jenne, D Metcalf, JG Zhang, LH Cengia, JA O’Donnell, AW Roberts. Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease. J Immunology 2011 186:1131-9.

MD Tate, LJ Ioannidis, BA Croker, LE Brown, AG Brooks, PC Reading. The role of neutrophils during mild and severe influenza virus infections of mice. PLOS One 2011, 6:e17618. PMID:21423798.

BA Croker, JA O’Donnell, CJ Nowell, D Metcalf, G Dewson, KJ Campbell, KL Rogers, Y Hu, GK Smyth, JG Zhang, M White, K Lackovic, LH Cengia, LA O’Reilly, P Bouillet, S Cory, A Strasser, AW Roberts. Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak and Bax and inhibited by Bcl-2 and Mcl-1. PNAS 2011, 108:13135-40.

BA Croker, AW Roberts, NA Nicola. Towards a four-dimensional view of neutrophils. Leucocytes: Methods and Protocols. Humana Press 2012, 844: 87-99.

23. BA Croker, H Kiu, M Pellegrini, J Toe, S Preston, D Metcalf, JA O’Donnell, LH Cengia, K McArthur, NA Nicola, WS Alexander, AW Roberts. IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3. Immunology and Cell Biology 2012, 90:124-9.

LM Lindqvist, I Vikström, JM Chambers, K McArthur, MA Anderson, KJ Henley, L Happo, L Cluse, RW Johnstone, AW Roberts, BT Kile, BA Croker, CJ Burns, MA Rizzacasa, A Strasser, DCS Huang. Multiple mechanisms drive the induction of hematopoietic cell death by translation inhibitors: minor contribution of Mcl-1 reduction. Cell Death Diff 2012, 3:e409.

SL Masters, M Gerlic, D Metcalf, S Preston, M Pellegrini, JA O’Donnell, K McArthur, TM Baldwin, S Chevrier, CJ Nowell, LH Cengia, KJ Henley, JE Collinge, DL Kastner, L Feigenbaum, DJ Hilton, WS Alexander, BT Kile, BA Croker. NLRP1 activation induces pyroptosis of hematopoietic progenitor cells. Immunity 2012, 37: 1009.

BA Croker, JA O’Donnell, Motti Gerlic. Pyroptotic death storms and cytopenia. Current Opinion in Immunology. 2013, 26: 128-137.

BA Croker. Neutrophil life in the death zone. Blood (Inside Blood) 2014 Jan 16;123(3):307-8.

Gerlic M, Croker BA, Cengia LH, Moayeri M, Kile BT, Masters SL. NLRP1a Expression in Srebp-1a-Deficient Mice. Cell Metab. 2014, 19(3):345-6.

JA Rickard, JA O'Donnell, JM Evans, N Lalaoui, AR Poh, T Rogers, JE Vince, KE Lawlor, RL Ninnis, H Anderton, C Hall, SK Spall, TJ Phesse, HE Abud, LH Cengia, J Corbin, S Mifsud, L Di Rago, D Metcalf, AW Roberts, WS Alexander, JM Murphy, PG Ekert, SL Masters, *BA Croker, *M Gerlic, *J Silke. RIPK1 regulates RIPK3-MLKL driven systemic inflammation and emergency hematopoiesis. Cell (in press) *contributed equally

Necroptosis in hematopoiesis

Transplantation of bone marrow or peripheral blood stem cells are major treatment modalities for patients who have undergone hemoablative chemotherapy to eliminate leukemia. However, engraftment of autologous or allogeneic hematopoietic stem cells (HSCs) in patients takes several weeks, while a return to full immunocompetence takes up to 2 years, leaving patients vulnerable to life-threatening infection. We are investigating how the RIPK3/MLKL-dependent necroptotic cell death pathway limits the self-renewal capacity of HSCs.

References

JA Rickard, JA O'Donnell, JM Evans, N Lalaoui, AR Poh, T Rogers, JE Vince, KE Lawlor, RL Ninnis, H Anderton, C Hall, SK Spall, TJ Phesse, HE Abud, LH Cengia, J Corbin, S Mifsud, L Di Rago, D Metcalf, AW Roberts, WS Alexander, JM Murphy, PG Ekert, SL Masters, *BA Croker, *M Gerlic, *J Silke. RIPK1 regulates RIPK3-MLKL driven systemic inflammation and emergency hematopoiesis. Cell (in press) *contributed equally

Pyroptosis and cytopenia

Pyroptosis is a non-apoptotic form of cell death that aids in the clearance of intracellular bacteria and viral infection. In hematopoietic cells, the systemic induction of pyroptosis can induce cytopenia and immunosuppression. This research investigates the molecular regulators of pyroptosis in mature and immature hematopoietic cells and the role of this pathway in controlling viral infection.

References

SL Masters, LA Mielke, AL Cornish, CE Sutton, J O’Donnell, LH Cengia, AW Roberts, IP Wicks, KHG Mills, BA Croker. Regulation of IL-1b by IFNg is species-specific, limited by SOCS1 and influences IL-17 production. EMBO reports 2010, 11:640-6. PMID: 20596075.

BA Croker, RS Lewis, JJ Babon, JD Mintern, DE Jenne, D Metcalf, JG Zhang, LH Cengia, JA O’Donnell, AW Roberts. Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease. J Immunology 2011, 186:1131-9. PMID: 21160041

BA Croker, BR Lawson, M Berger, C Eidenschenk, AL Blasius, EY Moresco, S Sovath, L Cengia, LD Shultz, AN Theofilopoulos, S Pettersson, BA Beutler. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, Myd88, and a microbial trigger. PNAS 2008, 105:15028. PMID: 18806225

SL Masters, M Gerlic, D Metcalf, S Preston, M Pellegrini, JA O’Donnell, K McArthur, TM Baldwin, S Chevrier, CJ Nowell, LH Cengia, KJ Henley, JE Collinge, DL Kastner, L Feigenbaum, DJ Hilton, WS Alexander, BT Kile, BA Croker. NLRP1 activation induces pyroptosis of hematopoietic progenitor cells. Immunity 2012, 37: 1009.

BA Croker, JA O’Donnell, Motti Gerlic. Pyroptotic death storms and cytopenia. Current Opinion in Immunology. 2013, 26: 128-137.

Neutrophil death and inflammation

A circumscribed neutrophilic inflammatory response requires regulation of neutrophil lifespan. The variation of neutrophil lifespan is likely to reflect a balancing act by the host, allowing neutrophils time to eliminate pathogens before a cell death pathway is triggered. A deviation in the programmed neutrophil lifespan during infection is likely to be detrimental, affecting the efficiency of pathogen clearance, the number of apoptotic neutrophils in an inflamed tissue, the ability of phagocytic cells to clear apoptotic bodies, and the potential for a chronic inflammatory response to be initiated. Altered lifespan of neutrophils has been associated with many diseases including acute lung injury, systemic inflammatory response syndrome (SIRS), bronchiolitis obliterans organizing pneumonia (BOOP), acute respiratory distress syndrome (ARDS) and pathogenic infections, including influenza, Streptococcus pneumoniae, RSV, Herpes Simplex Virus and human cytomegalovirus. However the relevance of these changes is unclear. During homeostatic conditions, approximately 100 billion neutrophils are produced daily in humans, and they display a remarkably constant, and short, lifespan following exit from the bone marrow into the peripheral circulation. Without activation, neutrophils exit the circulation and are removed by macrophages in the spleen, liver, lung and bone marrow. Following infection or tissue damage, the lifespan of a neutrophil will change as it enters damaged or inflamed tissues, and is exposed to inflammatory mediators. Our research seeks to identify the key regulators of neutrophil lifespan during inflammatory responses.

References

BA Croker, D Metcalf, L Robb, W Wei, S Mifsud, L DiRago, LA Cluse, KD Sutherland, L Hartley, E Williams, JG Zhang, DJ Hilton, NA Nicola, WS Alexander, AW Roberts. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 2004, 20, 153-165. PMID: 14975238

BA Croker, JA O’Donnell, CJ Nowell, D Metcalf, G Dewson, KJ Campbell, KL Rogers, Y Hu, GK Smyth, JG Zhang, M White, K Lackovic, LH Cengia, LA O’Reilly, P Bouillet, S Cory, A Strasser, AW Roberts. Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak and Bax and inhibited by Bcl-2 and Mcl-1. PNAS 2011, 108:13135-40.

BA Croker, RS Lewis, JJ Babon, JD Mintern, DE Jenne, D Metcalf, JG Zhang, LH Cengia, JA O’Donnell, AW Roberts. Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease. J Immunology 2011 186:1131-9.

BA Croker, AW Roberts, NA Nicola. Towards a four-dimensional view of neutrophils. Leucocytes: Methods and Protocols. Humana Press 2012, 844: 87-99.

BA Croker. Neutrophil life in the death zone. Blood (Inside Blood) 2014 Jan 16;123(3):307-8.

For more information, please visit www.crokerlab.com

Publications

Publications powered by Harvard Catalyst Profiles
  1. O'Donnell JA, Kennedy CL, Pellegrini M, Nowell CJ, Zhang JG, O'Reilly LA, Cengia L, Dias S, Masters SL, Hartland EL, Roberts AW, Gerlic M, Croker BA. Fas regulates neutrophil lifespan during viral and bacterial infection. J Leukoc Biol. 2015 Feb; 97(2):321-6.
  2. Gerlic M, Croker BA, Cengia LH, Moayeri M, Kile BT, Masters SL. NLRP1a expression in Srebp-1a-deficient mice. Cell Metab. 2014 Mar 4; 19(3):345-6.
  3. Croker BA. Neutrophil survival in the death zone. Blood. 2014 Jan 16; 123(3):307-8.
  4. Croker BA, O'Donnell JA, Gerlic M. Pyroptotic death storms and cytopenia. Curr Opin Immunol. 2014 Feb; 26:128-37.
  5. Masters SL, Gerlic M, Metcalf D, Preston S, Pellegrini M, O'Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT, Croker BA. NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity. 2012 Dec 14; 37(6):1009-23.
  6. Lindqvist LM, Vikström I, Chambers JM, McArthur K, Ann Anderson M, Henley KJ, Happo L, Cluse L, Johnstone RW, Roberts AW, Kile BT, Croker BA, Burns CJ, Rizzacasa MA, Strasser A, Huang DC. Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor. Cell Death Dis. 2012 Oct 11; 3:e409.
  7. Croker BA, Roberts AW, Nicola NA. Towards a four-dimensional view of neutrophils. Methods Mol Biol. 2012; 844:87-99.
  8. Croker BA, O'Donnell JA, Nowell CJ, Metcalf D, Dewson G, Campbell KJ, Rogers KL, Hu Y, Smyth GK, Zhang JG, White M, Lackovic K, Cengia LH, O'Reilly LA, Bouillet P, Cory S, Strasser A, Roberts AW. Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1. Proc Natl Acad Sci U S A. 2011 Aug 9; 108(32):13135-40.
  9. Croker BA, Lewis RS, Babon JJ, Mintern JD, Jenne DE, Metcalf D, Zhang JG, Cengia LH, O'Donnell JA, Roberts AW. Neutrophils require SHP1 to regulate IL-1ß production and prevent inflammatory skin disease. J Immunol. 2011 Jan 15; 186(2):1131-9.
  10. Zhan Y, Xu Y, Seah S, Brady JL, Carrington EM, Cheers C, Croker BA, Wu L, Villadangos JA, Lew AM. Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways. J Immunol. 2010 Aug 15; 185(4):2125-33.
  11. Show all
  12. Eyles JL, Hickey MJ, Norman MU, Croker BA, Roberts AW, Drake SF, James WG, Metcalf D, Campbell IK, Wicks IP. A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis. Blood. 2008 Dec 15; 112(13):5193-201.
  13. Alexander WS, Viney EM, Zhang JG, Metcalf D, Kauppi M, Hyland CD, Carpinelli MR, Stevenson W, Croker BA, Hilton AA, Ellis S, Selan C, Nandurkar HH, Goodnow CC, Kile BT, Nicola NA, Roberts AW, Hilton DJ. Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16442-7.
  14. Croker BA, Handman E, Hayball JD, Baldwin TM, Voigt V, Cluse LA, Yang FC, Williams DA, Roberts AW. Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses. Immunol Cell Biol. 2002 Jun; 80(3):231-40.
  15. Croker BA, Tarlinton DM, Cluse LA, Tuxen AJ, Light A, Yang FC, Williams DA, Roberts AW. The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes. J Immunol. 2002 Apr 1; 168(7):3376-86.
  16. Kile BT, Viney EM, Willson TA, Brodnicki TC, Cancilla MR, Herlihy AS, Croker BA, Baca M, Nicola NA, Hilton DJ, Alexander WS. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. Gene. 2000 Nov 27; 258(1-2):31-41.
  17. Croker BA, Kiu H, Nicholson SE. SOCS regulation of the JAK/STAT signalling pathway. Semin Cell Dev Biol. 2008 Aug; 19(4):414-22.
  18. Berger M, Krebs P, Crozat K, Li X, Croker BA, Siggs OM, Popkin D, Du X, Lawson BR, Theofilopoulos AN, Xia Y, Khovananth K, Moresco EM, Satoh T, Takeuchi O, Akira S, Beutler B. An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol. 2010 Apr; 11(4):335-43.
  19. Croker BA, Krebs DL, Zhang JG, Wormald S, Willson TA, Stanley EG, Robb L, Greenhalgh CJ, Förster I, Clausen BE, Nicola NA, Metcalf D, Hilton DJ, Roberts AW, Alexander WS. SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol. 2003 Jun; 4(6):540-5.
  20. Croker BA, Kiu H, Pellegrini M, Toe J, Preston S, Metcalf D, O'Donnell JA, Cengia LH, McArthur K, Nicola NA, Alexander WS, Roberts AW. IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3. Immunol Cell Biol. 2012 Jan; 90(1):124-9.
  21. Wong PK, Egan PJ, Croker BA, O'Donnell K, Sims NA, Drake S, Kiu H, McManus EJ, Alexander WS, Roberts AW, Wicks IP. SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest. 2006 Jun; 116(6):1571-81.
  22. Croker BA, Mielke LA, Wormald S, Metcalf D, Kiu H, Alexander WS, Hilton DJ, Roberts AW. Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation. Exp Hematol. 2008 Jul; 36(7):786-98.
  23. Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15028-33.
  24. Masters SL, Mielke LA, Cornish AL, Sutton CE, O'Donnell J, Cengia LH, Roberts AW, Wicks IP, Mills KH, Croker BA. Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production. EMBO Rep. 2010 Aug; 11(8):640-6.
  25. Croker BA, Metcalf D, Robb L, Wei W, Mifsud S, DiRago L, Cluse LA, Sutherland KD, Hartley L, Williams E, Zhang JG, Hilton DJ, Nicola NA, Alexander WS, Roberts AW. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity. 2004 Feb; 20(2):153-65.
  26. Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J. RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell. 2014 May 22; 157(5):1175-88.
  27. Liu X, Croker BA, Campbell IK, Gauci SJ, Alexander WS, Tonkin BA, Walsh NC, Linossi EM, Nicholson SE, Lawlor KE, Wicks IP. Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis. Arthritis Rheumatol. 2014 Sep; 66(9):2391-402.
  28. Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nat Commun. 2015 Feb 18; 6:6282.
  29. Kim ML, Chae JJ, Park YH, De Nardo D, Stirzaker RA, Ko HJ, Tye H, Cengia L, DiRago L, Metcalf D, Roberts AW, Kastner DL, Lew AM, Lyras D, Kile BT, Croker BA, Masters SL. Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1ß. J Exp Med. 2015 Jun 1; 212(6):927-38.
  30. Croker BA, Silke J, Gerlic M. Fight or flight: regulation of emergency hematopoiesis by pyroptosis and necroptosis. Curr Opin Hematol. 2015 Jul; 22(4):293-301.
  31. Liu X, Liu R, Croker BA, Lawlor KE, Smyth GK, Wicks IP. Distinctive pro-inflammatory gene signatures induced in articular chondrocytes by oncostatin M and IL-6 are regulated by Suppressor of Cytokine Signaling-3. Osteoarthritis Cartilage. 2015 Oct; 23(10):1743-54.
  32. Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL. IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome. Cell Metab. 2016 Jan 12; 23(1):155-64.
  33. Bliss-Moreau M, Chen AA, D'Cruz A, Croker BA. A motive for killing: Effector functions of regulated lytic cell death. Immunol Cell Biol. 2016 Nov 09.
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