Research

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Anne  Hansen, MD, MPH

Anne Hansen
Department:
Medicine Research
Division
Newborn Medicine Research
Hospital Title:
Associate in Medicine; Medical Director, Neonatal Intensive Care Unit
Academic Title:
Associate Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Neurologic and pulmonary newborn conditionsglobal health
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Research Overview

My research focuses on improving the care of newborns seriously ill with medical and surgical conditions as well as those in resource limited settings. For medical patients, in collaboration with the Wyss Institute, I am developing a Central Venous Catheter with decreased propensity for infection or clot formation. I have examined innovative approaches to the treatment of neonatal conditions including intraventricular urokinase for the prevention of posthemorrhagic hydrocephalus, once daily gentamicin dosing for infants, substitution of cord for infant blood in peri-natal sepsis evaluations, and inhaled racemic epinephrine for the treatments of TTN. I developed and implemented the first therapeutic hypothermia program in New England. I am a co-editor of the Manual of Neonatal Care, due out in its 8th edition in 2016. For surgical patients, I am again collaborating with the Wyss Institute to develop a novel, minimally invasive approach to esophageal growth induction for patients with long gap esophageal atresia. I was lead investigator in a study of Donation after Cardiac Death (DCD) in the NICU. I am co-editor of the Manual of Neonatal Surgical Intensive care, about to come out in its 3rd edition.

Using my experiences from the CHB NICU, I am working on several neonatology projects for the resource limited setting. In collaboration with the Wyss Institute, I am developing a simple and inexpensive Point of Care test based on a bio-engineered Mannose Binding Lectin technology to diagnose bacteremia in settings in which a blood culture is not feasible. In collaboration with the Lawrence Berkeley National Laboratory Institute for Globally Transformative Technologies, I am developing an inexpensive nonelectric infant warmer. In partnership with the Rwandan Ministry of Health (MOH), I helped to develop and implement a package of newborn medicine materials for Rwanda that was accepted as the national standard for neonatal care. We have written the 2nd edition and conducted national trainings with nurses and doctors from all Rwandan provincial hospitals.

About Anne Hansen

Anne Hansen received her MD from Harvard Medical School and her MPH from Harvard School of Public Health with a concentration in Clinical Effectiveness. She completed pediatric residency at Children’s Hospital Boston and fellowship in Newborn Medicine at Children’s Hospital Boston, Beth Israel Hospital and Brigham and Women’s Hospital. Dr. Hansen joined the Harvard Medical School faculty in 1996 and is currently an Associate Professor of Pediatrics. Dr. Hansen has acted as Chair of the Harvard-wide Neonatal Research Review Committee since 2004, and as Neonatology Consultant for the Rwinkwavu, Kirehe and Butaro Hospitals in Rwanda since 2010. She is a member of multiple committees, including the Children’s Hospital Boston Steering Committee (Medical chair), the Harvard neonatal-Perinatal Medicine Training Program Fellowship Committee, the NICU Nutrition Committee, and the Neonatology Representative for the Advanced Fetal Care Center at Children’s Hospital Boston. She is also a Fellow in the American Academy of Pediatrics. Dr. Hansen has been nominated for the Harvard Medical School Prize for Excellence in Teaching twice, the Harvard Medical School Humanism in Medicine Award, and was awarded the Best Tutor of the Year Harvard Medical School Teaching Award in 2004.

Publications

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  1. ) Hansen A, Magge H, Labrecque M, Munyanez R, Nahimana E, Nyishime M, Mwali A. The Development and Implementation of a Newborn Medicine Program in a Resource Limited Setting . Public Health Action. 2015.
  2. Leslie DC, Waterhouse A, Berthet JB, Valentin TM, Watters AL, Jain A, Kim P, Hatton BD, Nedder A, Donovan K, Super EH, Howell C, Johnson CP, Vu TL, Bolgen DE, Rifai S, Hansen AR, Aizenberg M, Super M, Aizenberg J, Ingber DE. A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling. Nat Biotechnol. 2014 Nov; 32(11):1134-40.
  3. Gupta M, Ringer S, Tess A, Hansen A, Zupancic J. Developing a quality and safety curriculum for fellows: lessons learned from a neonatology fellowship program. Acad Pediatr. 2014 Jan-Feb; 14(1):47-53.
  4. Touma M, Joshi M, Connolly MC, Grant PE, Hansen AR, Khwaja O, Berry GT, Kinney HC, Poduri A, Agrawal PB. Whole genome sequencing identifies SCN2A mutation in monozygotic twins with Ohtahara syndrome and unique neuropathologic findings. Epilepsia. 2013 May; 54(5):e81-5.
  5. Wintermark P, Boyd T, Gregas MC, Labrecque M, Hansen A. Placental pathology in asphyxiated newborns meeting the criteria for therapeutic hypothermia. Am J Obstet Gynecol. 2010 Dec; 203(6):579.e1-9.
  6. Wintermark P, Labrecque M, Warfield SK, DeHart S, Hansen A. Can induced hypothermia be assured during brain MRI in neonates with hypoxic-ischemic encephalopathy? Pediatr Radiol. 2010 Dec; 40(12):1950-4.
  7. Labrecque M, Parad R, Gupta M, Hansen A. Donation after cardiac death: the potential contribution of an infant organ donor population. J Pediatr. 2011 Jan; 158(1):31-6.
  8. Meyer EC, Brodsky D, Hansen AR, Lamiani G, Sellers DE, Browning DM. An interdisciplinary, family-focused approach to relational learning in neonatal intensive care. J Perinatol. 2011 Mar; 31(3):212-9.
  9. Wintermark P, Hansen A, Soul J, Labrecque M, Robertson RL, Warfield SK. Early versus late MRI in asphyxiated newborns treated with hypothermia. Arch Dis Child Fetal Neonatal Ed. 2011 Jan; 96(1):F36-44.
  10. Barnes CM, McElrath TF, Folkman J, Hansen AR. Correlation of 2-methoxyestradiol levels in cord blood and complications of prematurity. Pediatr Res. 2010 May; 67(5):545-50.
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  12. Hansen AR, Barnés CM, Folkman J, McElrath TF. Maternal preeclampsia predicts the development of bronchopulmonary dysplasia. J Pediatr. 2010 Apr; 156(4):532-6.
  13. Degn SE, Hansen AG, Steffensen R, Jacobsen C, Jensenius JC, Thiel S. MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. J Immunol. 2009 Dec 1; 183(11):7371-8.
  14. Kao B, Stewart de Ramirez SA, Belfort MB, Hansen A. Inhaled epinephrine for the treatment of transient tachypnea of the newborn. J Perinatol. 2008 Mar; 28(3):205-10.
  15. Nybo M, Brusgaard K, Hansen AB. No certain predictors for mutation status in a Danish cohort with familial hypercholesterolemia: a descriptive study. Clin Biochem. 2007 Dec; 40(18):1347-52.
  16. Hansen A, Forbes P, Buck R. Potential substitution of cord blood for infant blood in the neonatal sepsis evaluation. Biol Neonate. 2005; 88(1):12-8.
  17. Hansen AR, Madsen JR. Antenatal neurosurgical counseling: approach to the unborn patient. Pediatr Clin North Am. 2004 Apr; 51(2):491-505.
  18. Hansen A, Forbes P, Arnold A, O'Rourke E. Once-daily gentamicin dosing for the preterm and term newborn: proposal for a simple regimen that achieves target levels. J Perinatol. 2003 Dec; 23(8):635-9.
  19. Hansen AR, Collins MH, Genest D, Heller D, Schwarz S, Banagon P, Allred EN, Leviton A. Very low birthweight Infant's placenta and its relation to pregnancy and fetal characteristics. Pediatr Dev Pathol. 2000 Sep-Oct; 3(5):419-30.
  20. Hansen AR, Collins MH, Genest D, Heller D, Shen-Schwarz S, Banagon P, Allred EN, Leviton A. Very low birthweight placenta: clustering of morphologic characteristics. Pediatr Dev Pathol. 2000 Sep-Oct; 3(5):431-8.
  21. Hansen AR, Lapp C, Brugnara C. Plasminogen activator inhibitor-1: defining characteristics in the cerebrospinal fluid of newborns. J Pediatr. 2000 Jul; 137(1):132-4.
  22. Haller GW, Esnaola N, Yamada K, Wu A, Shimizu A, Hansen A, Ferrara VR, Allison KS, Colvin RB, Sykes M, Sachs DH. Thymic transplantation across an MHC class I barrier in swine. J Immunol. 1999 Oct 1; 163(7):3785-92.
  23. Hansen AR, Snyder EY. Medical management of neonatal posthemorrhagic hydrocephalus. Neurosurg Clin N Am. 1998 Jan; 9(1):95-104.
  24. Hansen AR. CNS fibrinolysis: a review of the literature with a pediatric emphasis. Pediatr Neurol. 1998 Jan; 18(1):15-21.
  25. Hansen AR, Volpe JJ, Goumnerova LC, Madsen JR. Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus. Pediatr Neurol. 1997 Oct; 17(3):213-7.
  26. Hansen A, Whitelaw A, Lapp C, Brugnara C. Cerebrospinal fluid plasminogen activator inhibitor-1: a prognostic factor in posthaemorrhagic hydrocephalus. Acta Paediatr. 1997 Sep; 86(9):995-8.
  27. Hansen AR, Allred EN, Leviton A. Predictors of ventriculoperitoneal shunt among babies with intraventricular hemorrhage. J Child Neurol. 1997 Sep; 12(6):381-6.
  28. Hansen A, Guerina N, Lerman-Sagie T, Korson M. Central apnea in a child with congenital autonomic dysfunction and universal pain loss. J Child Neurol. 1996 Mar; 11(2):162-4.
  29. Goldfield EC, Buonomo C, Fletcher K, Perez J, Margetts S, Hansen A, Smith V, Ringer S, Richardson MJ, Wolff PH. Premature infant swallowing: patterns of tongue-soft palate coordination based upon videofluoroscopy. Infant Behav Dev. 2010 Apr; 33(2):209-18.
  30. Hansen A, Leviton A. Labor and delivery characteristics and risks of cranial ultrasonographic abnormalities among very-low-birth-weight infants. The Developmental Epidemiology Network Investigators. Am J Obstet Gynecol. 1999 Oct; 181(4):997-1006.
  31. Thiel S, Kolev M, Degn S, Steffensen R, Hansen AG, Ruseva M, Jensenius JC. Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. J Immunol. 2009 Mar 1; 182(5):2939-47.
  32. Aslam M, Guglietti D, Hansen AR. Neonatal arterial thrombosis at birth: case report and literature review. Am J Perinatol. 2008 Jun; 25(6):347-52.
  33. Hansen AR, DiSalvo D, Kazam E, Allred EN, Leviton A. Sonographically detected subarachnoid hemorrhage: an independent predictor of neonatal posthemorrhagic hydrocephalus? Clin Imaging. 2000 May-Jun; 24(3):121-9.
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