Research Overview

Neuronal plasticity, its mechanistic basis, how it contributes to the normal and abnormal functions of the nervous system, and how it can be a target for therapy comprise the major focus of Dr. Woolf’s investigations. Specifically, he studies neural plasticity in relation to pain, regeneration, neurodegenerative disorders and developmental neurobiology.

Dr. Woolf has spearheaded discoveries on how functional synaptic plasticity, structural reorganization of synaptic architecture, injury-induced transcriptional changes, neuro-immune interactions and activity-dependent loss of interneurons all contribute to the pathogenesis and maintenance of pain. He has linked polymorphisms in human genes with the risk of developing pain and has pioneered new ways of phenotyping pain in patients. His work has led to the identification of novel targets for analgesics, and, with Bruce Bean at HMS, he has discovered a way of producing a long-lasting local analgesia. With Lee Rubin at HU, he has converted human embryonic stem cells into pain neurons for disease modeling and testing analgesics and with Josef Penninger used genome-wide screens in Drosophila to identify novel pain genes.

Additionally, Dr. Woolf has explored how axonal injury activates a survival and regeneration program in sensory and motor neurons, and he has identified the transcription factors that act as master regulators of these. This has led to novel genetic approaches to increase regeneration and ameliorate motor neuron disease.

Currently devoted to investigating how the functional, chemical and structural plasticity of neurons contributes to adaptive and maladaptive functions of the mammalian nervous system, the Woolf lab’s major efforts are dedicated to the study of pain, the formation of neural circuits during development, and the failure of regeneration in the adult CNS. Most of this work is focused on primary sensory and spinal cord neurons, which are studied using a multidisciplinary approach that spans mouse and human genetics, molecular and cell biology, bioinformatics, synaptic electrophysiology, neuroanatomy, integrative systems biology and behavior. The lab represents a complex mixture of basic and translational neuroscience and works closely with a wide number of academic groups and the pharmaceutical and biotechnology industry to identify and validate molecular targets for novel analgesics and axonal growth determinants. 

Some of the Group’s major current interests include: 

  • Neuro-immune interactions
  • Post-translational processing and transcriptional control of membrane receptors and ion channels mediating pain hypersensitivity
  • Intracellular signal transduction cascade in neurons
  • Role of transcription factors as master regulators of neuronal function
  • Exploiting stem cell technology to model human neurological disease
  • Mechanisms responsible for cell survival in injured sensory and motor neurons
  • Contributions of intrinsic growth determinants in establishing regenerative capacity
  • Central sensitization, its mechanism and contribution to pain
  • Bioinformatic analyses of  the transcriptome in neurons
  • Role of tetrahydrobiopterin in pain
  • Genotype – phenotype associations in pain
  • Targeting drugs selectively into neurons via large pore channels

About Clifford Woolf

Clifford Woolf, MB, BCh, PhD was appointed Director of the F.M. Kirby Neurobiology Center and the Neurobiology Program at Boston Children's Hospital in February 2010. After training for his MD and PhD at the University of the Witwatersrand in Johannesburg South Africa, Dr. Woolf moved to England in 1978. He worked at University College London for close on 20 years, towards the latter part as a Professor of Neurobiology. In 1997, Dr. Woolf moved to Boston as the first incumbent of the Richard J Kitz Chair of Anesthesia Research at Harvard Medical School and established the Neural Plasticity Research Group, based in the Department of Anesthesia and Critical Care at the Massachusetts General Hospital. Dr Woolf is a faculty member of the Harvard Stem Cell Institute and the Department of Neurobiology at Harvard Medical School.

Honors: 1973   William Cullen Medal, University of the Witwatersrand, Johannesburg, South Africa, for most distinguished B.Sc. graduate in the Faculty of Science; 1977 South African Medical Association Medal for most distinguished Medical graduate; 1987 Distinguished Young Investigator Award, International Association for the Study of Pain; 1991 Bristol-Myers Squibb Pain Research Award; 2001 Spine Society of Europe Medal; 2002 Bonica Medal; 2004 American Society of Anesthesia Award for Excellence in Research; 2009 Wall Medal, Royal College of Anaesthetists. 2010 Bonica Lecture, International Association for the Study of Pain; 2011 Javits Award NINDS; 2012  American Neurological Association F.E. Bennett Memorial Lectureship Award; 2013 Magnes Medal Israel; 2016 Reeve-Irvine Research Medal; 2017 Gill Distinguished Scientist Award.

Researcher Services

Researcher Areas

  • Pain
  • Formation of Neural Circuits
  • Regeneration

Research Departments

Researcher Programs

Researcher Centers

Researcher Labs

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Sundberg M, Tochitsky I, Buchholz DE, Winden K, Kujala V, Kapur K, Cataltepe D, Turner D, Han MJ, Woolf CJ, Hatten ME, Sahin M. Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin. Mol Psychiatry. 2018 Feb 15. View abstract
  2. Michoud F, Sottas L, Browne LE, Asboth L, Latremoliere A, Sakuma M, Courtine G, Woolf CJ, Lacour SP. Optical cuff for optogenetic control of the peripheral nervous system. J Neural Eng. 2018 Feb; 15(1):015002. View abstract
  3. Cobos EJ, Nickerson CA, Gao F, Chandran V, Bravo-Caparrós I, González-Cano R, Riva P, Andrews NA, Latremoliere A, Seehus CR, Perazzoli G, Nieto FR, Joller N, Painter MW, Ma CHE, Omura T, Chesler EJ, Geschwind DH, Coppola G, Rangachari M, Woolf CJ, Costigan M. Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling. Cell Rep. 2018 Jan 30; 22(5):1301-1312. View abstract
  4. Blake KJ, Baral P, Voisin T, Lubkin A, Pinho-Ribeiro FA, Adams KL, Roberson DP, Ma YC, Otto M, Woolf CJ, Torres VJ, Chiu IM. Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314. Nat Commun. 2018 01 02; 9(1):37. View abstract
  5. Foster SL, Seehus CR, Woolf CJ, Talbot S. Sense and Immunity: Context-Dependent Neuro-Immune Interplay. Front Immunol. 2017; 8:1463. View abstract
  6. Briggs JA, Li VC, Lee S, Woolf CJ, Klein A, Kirschner MW. Mouse embryonic stem cells can differentiate via multiple paths to the same state. Elife. 2017 10 09; 6. View abstract
  7. Yekkirala AS, Roberson DP, Bean BP, Woolf CJ. Breaking barriers to novel analgesic drug development. Nat Rev Drug Discov. 2017 Nov; 16(11):810. View abstract
  8. Chen Y, Zeng X, Huang X, Serag S, Woolf CJ, Spiegelman BM. Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity. Cell. 2017 Nov 02; 171(4):836-848.e13. View abstract
  9. Lisi V, Singh B, Giroux M, Guzman E, Painter MW, Cheng YC, Huebner E, Coppola G, Costigan M, Woolf CJ, Kosik KS. Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury. Cell Rep. 2017 Aug 01; 20(5):1136-1147. View abstract
  10. Browne LE, Latremoliere A, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ. Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses. Cell Rep. 2017 07 05; 20(1):89-98. View abstract
  11. Yekkirala AS, Roberson DP, Bean BP, Woolf CJ. Breaking barriers to novel analgesic drug development. Nat Rev Drug Discov. 2017 Aug; 16(8):545-564. View abstract
  12. Alexandre C, Latremoliere A, Ferreira A, Miracca G, Yamamoto M, Scammell TE, Woolf CJ. Decreased alertness due to sleep loss increases pain sensitivity in mice. Nat Med. 2017 Jun; 23(6):768-774. View abstract
  13. Hohmann SW, Angioni C, Tunaru S, Lee S, Woolf CJ, Offermanns S, Geisslinger G, Scholich K, Sisignano M. The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity. Sci Rep. 2017 03 27; 7(1):446. View abstract
  14. Grosser T, Woolf CJ, FitzGerald GA. Time for nonaddictive relief of pain. Science. 2017 Mar 10; 355(6329):1026-1027. View abstract
  15. Azimi E, Reddy VB, Pereira PJS, Talbot S, Woolf CJ, Lerner EA. Substance P activates Mas-related G protein-coupled receptors to induce itch. J Allergy Clin Immunol. 2017 Aug; 140(2):447-453.e3. View abstract
  16. Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G. Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12544-12549. View abstract
  17. Vardeh D, Mannion RJ, Woolf CJ. Toward a Mechanism-Based Approach to Pain Diagnosis. J Pain. 2016 Sep; 17(9 Suppl):T50-69. View abstract
  18. Perry RB, Rishal I, Doron-Mandel E, Kalinski AL, Medzihradszky KF, Terenzio M, Alber S, Koley S, Lin A, Rozenbaum M, Yudin D, Sahoo PK, Gomes C, Shinder V, Geraisy W, Huebner EA, Woolf CJ, Yaron A, Burlingame AL, Twiss JL, Fainzilber M. Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size. Cell Rep. 2016 08 09; 16(6):1664-1676. View abstract
  19. Chiu IM, Pinho-Ribeiro FA, Woolf CJ. Pain and infection: pathogen detection by nociceptors. Pain. 2016 06; 157(6):1192-3. View abstract
  20. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2016 May 04; 90(3):662. View abstract
  21. Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. Pain. 2016 Apr; 157(4):901-9. View abstract
  22. Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, Ward C, Khanna AR, Mogil JS, Dion PA, Woolf CJ, Inquimbert P, Rouleau GA. Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Sci Signal. 2016 Mar 29; 9(421):ra32. View abstract
  23. Neogi T, Guermazi A, Roemer F, Nevitt MC, Scholz J, Arendt-Nielsen L, Woolf C, Niu J, Bradley LA, Quinn E, Law LF. Association of Joint Inflammation With Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study. Arthritis Rheumatol. 2016 Mar; 68(3):654-61. View abstract
  24. Talbot S, Foster SL, Woolf CJ. Neuroimmunity: Physiology and Pathology. Annu Rev Immunol. 2016 05 20; 34:421-47. View abstract
  25. Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016 Mar 02; 89(5):956-70. View abstract
  26. Ghasemlou N, Chiu IM, Julien JP, Woolf CJ. CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6808-17. View abstract
  27. Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18; 88(4):704-19. View abstract
  28. Sakuma M, Gorski G, Sheu SH, Lee S, Barrett LB, Singh B, Omura T, Latremoliere A, Woolf CJ. Lack of motor recovery after prolonged denervation of the neuromuscular junction is not due to regenerative failure. Eur J Neurosci. 2016 Feb; 43(3):451-62. View abstract
  29. Nie D, Chen Z, Ebrahimi-Fakhari D, Di Nardo A, Julich K, Robson VK, Cheng YC, Woolf CJ, Heiman M, Sahin M. The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex. J Neurosci. 2015 Jul 29; 35(30):10762-72. View abstract
  30. McNeish J, Gardner JP, Wainger BJ, Woolf CJ, Eggan K. From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. Cell Stem Cell. 2015 Jul 02; 17(1):8-10. View abstract
  31. Gewandter JS, Dworkin RH, Turk DC, Farrar JT, Fillingim RB, Gilron I, Markman JD, Oaklander AL, Polydefkis MJ, Raja SN, Robinson JP, Woolf CJ, Ziegler D, Ashburn MA, Burke LB, Cowan P, George SZ, Goli V, Graff OX, Iyengar S, Jay GW, Katz J, Kehlet H, Kitt RA, Kopecky EA, Malamut R, McDermott MP, Palmer P, Rappaport BA, Rauschkolb C, Steigerwald I, Tobias J, Walco GA. Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations. Pain. 2015 Jul; 156(7):1184-97. View abstract
  32. Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15; 87(2):341-54. View abstract
  33. Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. 2015 Jun 17; 86(6):1393-406. View abstract
  34. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2015 Jun 03; 86(5):1215-27. View abstract
  35. Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA. Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron. 2015 May 20; 86(4):1000-1014. View abstract
  36. Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med. 2015 May; 21(5):518-23. View abstract
  37. Foster SL, Talbot S, Woolf CJ. CNS injury: IL-33 sounds the alarm. Immunity. 2015 Mar 17; 42(3):403-5. View abstract
  38. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C. Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2015 Feb 06; 4:e06720. View abstract
  39. Muscara F, McCarthy MC, Woolf C, Hearps SJ, Burke K, Anderson VA. Early psychological reactions in parents of children with a life threatening illness within a pediatric hospital setting. Eur Psychiatry. 2015 Jul; 30(5):555-61. View abstract
  40. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2014 Dec 19; 3. View abstract
  41. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24. View abstract
  42. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. View abstract
  43. Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery. 2014 Aug; 61 Suppl 1:214. View abstract
  44. Woolf CJ. What to call the amplification of nociceptive signals in the central nervous system that contribute to widespread pain? Pain. 2014 Oct; 155(10):1911-2. View abstract
  45. Painter MW, Brosius Lutz A, Cheng YC, Latremoliere A, Duong K, Miller CM, Posada S, Cobos EJ, Zhang AX, Wagers AJ, Havton LA, Barres B, Omura T, Woolf CJ. Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration. Neuron. 2014 Jul 16; 83(2):331-343. View abstract
  46. Fell GL, Robinson KC, Mao J, Woolf CJ, Fisher DE. Skin ß-endorphin mediates addiction to UV light. Cell. 2014 Jun 19; 157(7):1527-34. View abstract
  47. Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. JAMA Neurol. 2014 May; 71(5):640-5. View abstract
  48. Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014 Apr 10; 7(1):1-11. View abstract
  49. Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014 Jun 05; 14(6):781-95. View abstract
  50. Browne LE, Woolf CJ. Casting light on pain. Nat Biotechnol. 2014 Mar; 32(3):240-1. View abstract
  51. Seijffers R, Zhang J, Matthews JC, Chen A, Tamrazian E, Babaniyi O, Selig M, Hynynen M, Woolf CJ, Brown RH. ATF3 expression improves motor function in the ALS mouse model by promoting motor neuron survival and retaining muscle innervation. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1622-7. View abstract
  52. Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. Br J Pharmacol. 2014 Jan; 171(2):438-51. View abstract
  53. Neogi T, Frey-Law L, Scholz J, Niu J, Arendt-Nielsen L, Woolf C, Nevitt M, Bradley L, Felson DT. Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state? Ann Rheum Dis. 2015 Apr; 74(4):682-8. View abstract
  54. Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013 Sep 05; 501(7465):52-7. View abstract
  55. Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, Duan B, Oh SB, Bean BP, Ma Q, Binshtok AM, Woolf CJ. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci. 2013 Jul; 16(7):910-8. View abstract
  56. Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LL. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell. 2013 Jun 06; 12(6):713-26. View abstract
  57. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28; 495(7442):474-80. View abstract
  58. Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr; 9(4):257-63. View abstract
  59. Bruehl S, Apkarian AV, Ballantyne JC, Berger A, Borsook D, Chen WG, Farrar JT, Haythornthwaite JA, Horn SD, Iadarola MJ, Inturrisi CE, Lao L, Mackey S, Mao J, Sawczuk A, Uhl GR, Witter J, Woolf CJ, Zubieta JK, Lin Y. Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain. 2013 Feb; 14(2):103-13. View abstract
  60. Puopolo M, Binshtok AM, Yao GL, Oh SB, Woolf CJ, Bean BP. Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol. 2013 Apr; 109(7):1704-12. View abstract
  61. Brenneis C, Kistner K, Puopolo M, Segal D, Roberson D, Sisignano M, Labocha S, Ferreirós N, Strominger A, Cobos EJ, Ghasemlou N, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing. J Neurosci. 2013 Jan 02; 33(1):315-26. View abstract
  62. Woolf CJ. Pain: morphine, metabolites, mambas, and mutations. Lancet Neurol. 2013 Jan; 12(1):18-20. View abstract
  63. Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet. 2012; 8(12):e1003071. View abstract
  64. Chiu IM, von Hehn CA, Woolf CJ. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci. 2012 Jul 26; 15(8):1063-7. View abstract
  65. Korngut L, Ma CH, Martinez JA, Toth CC, Guo GF, Singh V, Woolf CJ, Zochodne DW. Overexpression of human HSP27 protects sensory neurons from diabetes. Neurobiol Dis. 2012 Sep; 47(3):436-43. View abstract
  66. Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C. 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. J Neurosci. 2012 May 02; 32(18):6364-72. View abstract
  67. Hughes JP, Chessell I, Malamut R, Perkins M, Backonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I, McMahon SB, Porreca F, Rappaport BA, Rice F, Richman LK, Segerdahl M, Seminowicz DA, Watkins LR, Waxman SG, Wiech K, Woolf C. Understanding chronic inflammatory and neuropathic pain. Ann N Y Acad Sci. 2012 May; 1255:30-44. View abstract
  68. Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, John SL, Slade GD, Jordan J, Woolf CJ, Peltz G, Maixner W, Diatchenko L, Seltzer Z, Salter MW, Mogil JS. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med. 2012 Mar 25; 18(4):595-9. View abstract
  69. von Hehn CA, Baron R, Woolf CJ. Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron. 2012 Feb 23; 73(4):638-52. View abstract
  70. Cobos EJ, Ghasemlou N, Araldi D, Segal D, Duong K, Woolf CJ. Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia. Pain. 2012 Apr; 153(4):876-84. View abstract
  71. Costigan M, Latremoliere A, Woolf CJ. Analgesia by inhibiting tetrahydrobiopterin synthesis. Curr Opin Pharmacol. 2012 Feb; 12(1):92-9. View abstract
  72. Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA. The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. J Neurosci. 2011 Dec 14; 31(50):18391-400. View abstract
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  186. Benn SC, Costigan M, Tate S, Fitzgerald M, Woolf CJ. Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons. J Neurosci. 2001 Aug 15; 21(16):6077-85. View abstract
  187. Chen ZF, Rebelo S, White F, Malmberg AB, Baba H, Lima D, Woolf CJ, Basbaum AI, Anderson DJ. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001 Jul 19; 31(1):59-73. View abstract
  188. Coggeshall RE, Lekan HA, White FA, Woolf CJ. A-fiber sensory input induces neuronal cell death in the dorsal horn of the adult rat spinal cord. J Comp Neurol. 2001 Jul 02; 435(3):276-82. View abstract
  189. Woolf CJ, Max MB. Mechanism-based pain diagnosis: issues for analgesic drug development. Anesthesiology. 2001 Jul; 95(1):241-9. View abstract
  190. García-Añoveros J, Samad TA, Zuvela-Jelaska L, Woolf CJ, Corey DP. Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons. J Neurosci. 2001 Apr 15; 21(8):2678-86. View abstract
  191. Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, Bonventre JV, Woolf CJ. Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature. 2001 Mar 22; 410(6827):471-5. View abstract
  192. Baba H, Kohno T, Moore KA, Woolf CJ. Direct activation of rat spinal dorsal horn neurons by prostaglandin E2. J Neurosci. 2001 Mar 01; 21(5):1750-6. View abstract
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  194. Ji RR, Woolf CJ. Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiol Dis. 2001 Feb; 8(1):1-10. View abstract
  195. Delany NS, Hurle M, Facer P, Alnadaf T, Plumpton C, Kinghorn I, See CG, Costigan M, Anand P, Woolf CJ, Crowther D, Sanseau P, Tate SN. Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol Genomics. 2001 Jan 19; 4(3):165-74. View abstract
  196. Woolf CJ. Turbocharging neurons for growth: accelerating regeneration in the adult CNS. Nat Neurosci. 2001 Jan; 4(1):7-9. View abstract
  197. Bester H, Beggs S, Woolf CJ. Changes in tactile stimuli-induced behavior and c-Fos expression in the superficial dorsal horn and in parabrachial nuclei after sciatic nerve crush. J Comp Neurol. 2000 Dec 04; 428(1):45-61. View abstract
  198. Woolf CJ. Pain. Neurobiol Dis. 2000 Oct; 7(5):504-10. View abstract
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  204. Tandrup T, Woolf CJ, Coggeshall RE. Delayed loss of small dorsal root ganglion cells after transection of the rat sciatic nerve. J Comp Neurol. 2000 Jun 26; 422(2):172-80. View abstract
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  207. Amaya F, Decosterd I, Samad TA, Plumpton C, Tate S, Mannion RJ, Costigan M, Woolf CJ. Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2. Mol Cell Neurosci. 2000 Apr; 15(4):331-42. View abstract
  208. Kitt CA, Gruber K, Davis M, Woolf CJ, Levine JD. Trigeminal neuralgia: opportunities for research and treatment. Pain. 2000 Mar; 85(1-2):3-7. View abstract
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  213. Behar O, Mizuno K, Badminton M, Woolf CJ. Semaphorin 3A growth cone collapse requires a sequence homologous to tarantula hanatoxin. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13501-5. View abstract
  214. Lewis SE, Mannion RJ, White FA, Coggeshall RE, Beggs S, Costigan M, Martin JL, Dillmann WH, Woolf CJ. A role for HSP27 in sensory neuron survival. J Neurosci. 1999 Oct 15; 19(20):8945-53. View abstract
  215. Mannion RJ, Costigan M, Decosterd I, Amaya F, Ma QP, Holstege JC, Ji RR, Acheson A, Lindsay RM, Wilkinson GA, Woolf CJ. Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. Proc Natl Acad Sci U S A. 1999 Aug 03; 96(16):9385-90. View abstract
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  217. Chong MS, Woolf CJ, Haque NS, Anderson PN. Axonal regeneration from injured dorsal roots into the spinal cord of adult rats. J Comp Neurol. 1999 Jul 19; 410(1):42-54. View abstract
  218. Woolf CJ, Costigan M. Transcriptional and posttranslational plasticity and the generation of inflammatory pain. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7723-30. View abstract
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  224. Bester H, Allchorne AJ, Woolf CJ. Recovery of C-fiber-induced extravasation following peripheral nerve injury in the rat. Exp Neurol. 1998 Dec; 154(2):628-36. View abstract
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  228. Howard MK, Kershaw T, Gibb B, Storey N, MacLean AR, Zeng BY, Tel BC, Jenner P, Brown SM, Woolf CJ, Anderson PN, Coffin RS, Latchman DS. High efficiency gene transfer to the central nervous system of rodents and primates using herpes virus vectors lacking functional ICP27 and ICP34.5. Gene Ther. 1998 Aug; 5(8):1137-47. View abstract
  229. Banner LR, Patterson PH, Allchorne A, Poole S, Woolf CJ. Leukemia inhibitory factor is an anti-inflammatory and analgesic cytokine. J Neurosci. 1998 Jul 15; 18(14):5456-62. View abstract
  230. Schindler M, Holloway S, Hathway G, Woolf CJ, Humphrey PP, Emson PC. Identification of somatostatin sst2(a) receptor expressing neurones in central regions involved in nociception. Brain Res. 1998 Jul 06; 798(1-2):25-35. View abstract
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  234. Doubell TP, Woolf CJ. Growth-associated protein 43 immunoreactivity in the superficial dorsal horn of the rat spinal cord is localized in atrophic C-fiber, and not in sprouted A-fiber, central terminals after peripheral nerve injury. J Comp Neurol. 1997 Sep 15; 386(1):111-8. View abstract
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  237. Doubell TP, Mannion RJ, Woolf CJ. Intact sciatic myelinated primary afferent terminals collaterally sprout in the adult rat dorsal horn following section of a neighbouring peripheral nerve. J Comp Neurol. 1997 Mar 31; 380(1):95-104. View abstract
  238. Ma QP, Woolf CJ. Tachykinin NK1 receptor antagonist RP67580 attenuates progressive hypersensitivity of flexor reflex during experimental inflammation in rats. Eur J Pharmacol. 1997 Mar 19; 322(2-3):165-71. View abstract
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  245. Woolf CJ. Windup and central sensitization are not equivalent. Pain. 1996 Aug; 66(2-3):105-8. View abstract
  246. Bush MS, Tonge DA, Woolf C, Gordon-Weeks PR. Expression of a developmentally regulated, phosphorylated isoform of microtubule-associated protein 1B in regenerating axons of the sciatic nerve. Neuroscience. 1996 Jul; 73(2):553-63. View abstract
  247. Chong MS, Woolf CJ, Turmaine M, Emson PC, Anderson PN. Intrinsic versus extrinsic factors in determining the regeneration of the central processes of rat dorsal root ganglion neurons: the influence of a peripheral nerve graft. J Comp Neurol. 1996 Jun 17; 370(1):97-104. View abstract
  248. Safieh-Garabedian B, Poole S, Allchorne A, Kanaan S, Saade N, Woolf CJ. Zinc reduces the hyperalgesia and upregulation of NGF and IL-1 beta produced by peripheral inflammation in the rat. Neuropharmacology. 1996 May; 35(5):599-603. View abstract
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  250. Woolf CJ. Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain. Philos Trans R Soc Lond B Biol Sci. 1996 Mar 29; 351(1338):441-8. View abstract
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  253. Nagy I, Woolf CJ. Lignocaine selectively reduces C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing N-methyl-D-aspartate and neurokinin receptor-mediated post-synaptic depolarizations; implications for the development of novel centrally acting analgesics. Pain. 1996 Jan; 64(1):59-70. View abstract
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  266. Constantinou J, Reynolds ML, Woolf CJ, Safieh-Garabedian B, Fitzgerald M. Nerve growth factor levels in developing rat skin: upregulation following skin wounding. Neuroreport. 1994 Nov 21; 5(17):2281-4. View abstract
  267. Nagy I, Miller BA, Woolf CJ. NK1 and NK2 receptors contribute to C-fibre evoked slow potentials in the spinal cord. Neuroreport. 1994 Oct 27; 5(16):2105-8. View abstract
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  279. Woolf CJ, Chong MS. Preemptive analgesia--treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg. 1993 Aug; 77(2):362-79. View abstract
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  283. Nagy I, Urban L, Woolf CJ. Morphological and membrane properties of young rat lumbar and thoracic dorsal root ganglion cells with unmyelinated axons. Brain Res. 1993 Apr 23; 609(1-2):193-200. View abstract
  284. Shortland P, Woolf CJ. Chronic peripheral nerve section results in a rearrangement of the central axonal arborizations of axotomized A beta primary afferent neurons in the rat spinal cord. J Comp Neurol. 1993 Apr 01; 330(1):65-82. View abstract
  285. Shortland P, Woolf CJ. Morphology and somatotopy of the central arborizations of rapidly adapting glabrous skin afferents in the rat lumbar spinal cord. J Comp Neurol. 1993 Mar 22; 329(4):491-511. View abstract
  286. Nagy I, Maggi CA, Dray A, Woolf CJ, Urban L. The role of neurokinin and N-methyl-D-aspartate receptors in synaptic transmission from capsaicin-sensitive primary afferents in the rat spinal cord in vitro. Neuroscience. 1993 Feb; 52(4):1029-37. View abstract
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  308. Woolf CJ, King AE. Subthreshold components of the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat lumbar spinal cord. J Neurophysiol. 1989 Oct; 62(4):907-16. View abstract
  309. Woolf CJ. Recent advances in the pathophysiology of acute pain. Br J Anaesth. 1989 Aug; 63(2):139-46. View abstract
  310. O'Brien C, Woolf CJ, Fitzgerald M, Lindsay RM, Molander C. Differences in the chemical expression of rat primary afferent neurons which innervate skin, muscle or joint. Neuroscience. 1989; 32(2):493-502. View abstract
  311. Millard CL, Woolf CJ. Sensory innervation of the hairs of the rat hindlimb: a light microscopic analysis. J Comp Neurol. 1988 Nov 08; 277(2):183-94. View abstract
  312. King AE, Thompson SW, Urban L, Woolf CJ. The responses recorded in vitro of deep dorsal horn neurons to direct and orthodromic stimulation in the young rat spinal cord. Neuroscience. 1988 Oct; 27(1):231-42. View abstract
  313. King AE, Thompson SW, Urban L, Woolf CJ. An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice. Neurosci Lett. 1988 Jul 08; 89(3):286-92. View abstract
  314. Woolf CJ, Thompson SW, King AE. Prolonged primary afferent induced alterations in dorsal horn neurones, an intracellular analysis in vivo and in vitro. J Physiol (Paris). 1988-1989; 83(3):255-66. View abstract
  315. Woolf CJ, King AE. Physiology and morphology of multireceptive neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cord. J Neurophysiol. 1987 Sep; 58(3):460-79. View abstract
  316. Fitzgerald M, King AE, Thompson SW, Woolf CJ. The postnatal development of the ventral root reflex in the rat; a comparative in vivo and in vitro study. Neurosci Lett. 1987 Jul 09; 78(1):41-5. View abstract
  317. Woolf CJ. Central terminations of cutaneous mechanoreceptive afferents in the rat lumbar spinal cord. J Comp Neurol. 1987 Jul 01; 261(1):105-19. View abstract
  318. Woolf CJ. Excitatory amino acids increase glycogen phosphorylase activity in the rat spinal cord. Neurosci Lett. 1987 Jan 27; 73(3):209-14. View abstract
  319. Cook AJ, Woolf CJ, Wall PD, McMahon SB. Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input. Nature. 1987 Jan 8-14; 325(7000):151-3. View abstract
  320. Woolf CJ. Physiological, inflammatory and neuropathic pain. Adv Tech Stand Neurosurg. 1987; 15:39-62. View abstract
  321. Cook AJ, Woolf CJ, Wall PD. Prolonged C-fibre mediated facilitation of the flexion reflex in the rat is not due to changes in afferent terminal or motoneurone excitability. Neurosci Lett. 1986 Sep 25; 70(1):91-6. View abstract
  322. Woolf CJ, Fitzgerald M. Somatotopic organization of cutaneous afferent terminals and dorsal horn neuronal receptive fields in the superficial and deep laminae of the rat lumbar spinal cord. J Comp Neurol. 1986 Sep 22; 251(4):517-31. View abstract
  323. Woolf C, Wiesenfeld-Hallin Z. Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptive flexor withdrawal reflex in the rat. Neurosci Lett. 1986 May 15; 66(2):226-30. View abstract
  324. Woolf CJ, Wall PD. Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat. J Neurosci. 1986 May; 6(5):1433-42. View abstract
  325. Wall PD, Woolf CJ. The brief and the prolonged facilitatory effects of unmyelinated afferent input on the rat spinal cord are independently influenced by peripheral nerve section. Neuroscience. 1986 Apr; 17(4):1199-205. View abstract
  326. Woolf CJ, Wall PD. Morphine-sensitive and morphine-insensitive actions of C-fibre input on the rat spinal cord. Neurosci Lett. 1986 Feb 28; 64(2):221-5. View abstract
  327. Woolf CJ, Wiesenfeld-Hallin Z. The systemic administration of local anaesthetics produces a selective depression of C-afferent fibre evoked activity in the spinal cord. Pain. 1985 Dec; 23(4):361-74. View abstract
  328. Woolf CJ, McMahon SB. Injury-induced plasticity of the flexor reflex in chronic decerebrate rats. Neuroscience. 1985 Oct; 16(2):395-404. View abstract
  329. Cook AJ, Woolf CJ. Cutaneous receptive field and morphological properties of hamstring flexor alpha-motoneurones in the rat. J Physiol. 1985 Jul; 364:249-63. View abstract
  330. Woolf CJ, Chong MS, Rashdi TA. Mapping increased glycogen phosphorylase activity in dorsal root ganglia and in the spinal cord following peripheral stimuli. J Comp Neurol. 1985 Apr 01; 234(1):60-76. View abstract
  331. Swett JE, Woolf CJ. The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord. J Comp Neurol. 1985 Jan 01; 231(1):66-77. View abstract
  332. McMahon SB, Sykova E, Wall PD, Woolf CJ, Gibson SJ. Neurogenic extravasation and substance P levels are low in muscle as compared to skin the rat hindlimb. Neurosci Lett. 1984 Dec 21; 52(3):235-40. View abstract
  333. Wall PD, Woolf CJ. Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat. J Physiol. 1984 Nov; 356:443-58. View abstract
  334. Woolf CJ, Chong MS, Ainsworth A. Axotomy increases glycogen phosphorylase activity in motoneurones. Neuroscience. 1984 Aug; 12(4):1261-9. View abstract
  335. Woolf CJ, Swett JE. The cutaneous contribution to the hamstring flexor reflex in the rat: an electrophysiological and anatomical study. Brain Res. 1984 Jun 15; 303(2):299-312. View abstract
  336. Woolf CJ. Long term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat. Pain. 1984 Apr; 18(4):325-43. View abstract
  337. Woolf CJ. A selective effect of naloxone on heterosynaptic C-fibre-mediated inhibitions in the rat dorsal horn. Neurosci Lett. 1984 Mar 23; 45(2):169-74. View abstract
  338. Fitzgerald M, Woolf CJ, Gibson SJ, Mallaburn PS. Alterations in the structure, function, and chemistry of C fibers following local application of vinblastine to the sciatic nerve of the rat. J Neurosci. 1984 Feb; 4(2):430-41. View abstract
  339. Woolf CJ, Fitzgerald M. The properties of neurones recorded in the superficial dorsal horn of the rat spinal cord. J Comp Neurol. 1983 Dec 10; 221(3):313-28. View abstract
  340. Woolf CJ. Evidence for a central component of post-injury pain hypersensitivity. Nature. 1983 Dec 15-21; 306(5944):686-8. View abstract
  341. Woolf CJ, Wall PD. Endogenous opioid peptides and pain mechanisms: a complex relationship. Nature. 1983 Dec 22-1984 Jan 4; 306(5945):739-40. View abstract
  342. Woolf CJ. C-primary afferent fibre mediated inhibitions in the dorsal horn of the decerebrate-spinal rat. Exp Brain Res. 1983; 51(2):283-90. View abstract
  343. Wall PD, Fitzgerald M, Woolf CJ. Effects of capsaicin on receptive fields and on inhibitions in rat spinal cord. Exp Neurol. 1982 Nov; 78(2):425-36. View abstract
  344. Woolf CJ, Wall PD. Chronic peripheral nerve section diminishes the primary afferent A-fibre mediated inhibition of rat dorsal horn neurones. Brain Res. 1982 Jun 17; 242(1):77-85. View abstract
  345. Woolf CJ, Fitzgerald M. Do opioid peptides mediate a presynaptic control of C-fibre transmission in the rat spinal cord? Neurosci Lett. 1982 Mar 17; 29(1):67-72. View abstract
  346. Fitzgerald M, Woolf CJ. The time course and specificity of the changes in the behavioural and dorsal horn cell responses to noxious stimuli following peripheral nerve capsaicin treatment in the rat. Neuroscience. 1982; 7(9):2051-6. View abstract
  347. Fitzgerald M, Woolf CJ. Effects of cutaneous nerve and intraspinal conditioning of C-fibre afferent terminal excitability in decerebrate spinal rats. J Physiol. 1981 Sep; 318:25-39. View abstract
  348. Woolf CJ, Fitzgerald M. Lamina-specific alteration of C-fibre evoked activity by morphine in the dorsal horn of the rat spinal cord. Neurosci Lett. 1981 Aug 07; 25(1):37-41. View abstract
  349. Dickenson AH, Hellon RF, Woolf CJ. Tooth pulp input to the spinal trigeminal nucleus: a comparison of inhibitions following segmental and raphe magnus stimulation. Brain Res. 1981 Jun 09; 214(1):73-87. View abstract
  350. Dawson NJ, Dickenson AH, Hellon RF, Woolf CJ. Inhibitory controls on thermal neurones in the spinal trigeminal nucleus of cats and rats. Brain Res. 1981 Mar 30; 209(2):440-5. View abstract
  351. Woolf CJ. Intrathecal high dose morphine produces hyperalgesia in the rat. Brain Res. 1981 Mar 30; 209(2):491-5. View abstract
  352. Aziz LA, Forsling ML, Woolf CJ. The effect of intracerebroventricular injections of morphine on vasopressin release in the rat. J Physiol. 1981 Feb; 311:401-9. View abstract
  353. Fitzgerald M, Woolf CJ. The stereospecific effect of naloxone on rat dorsal horn neurones; inhibition in superficial laminae and excitation in deeper laminae. Pain. 1980 Dec; 9(3):293-306. View abstract
  354. Wall PD, Woolf CJ. What we don't know about pain. Nature. 1980 Sep 18; 287(5779):185-6. View abstract
  355. Woolf CJ. Intracerebral naloxone and the reaction to thermal noxious stimulation in the rat. Brain Res. 1980 May 26; 190(2):578-83. View abstract
  356. Woolf CJ. Analgesia and hyperalgesia produced in the rat by intrathecal naloxone. Brain Res. 1980 May 12; 189(2):593-7. View abstract
  357. Woolf CJ, Mitchell D, Barrett GD. Antinociceptive effect of peripheral segmental electrical stimulation in the rat. Pain. 1980 Apr; 8(2):237-52. View abstract
  358. Willies GH, Woolf CJ. The site of action of corticosteroid antipyresis in the rabbit. J Physiol. 1980 Mar; 300:1-6. View abstract
  359. Woolf CJ. Transcutaneous electrical nerve stimulation and the reaction to experimental pain in human subjects. Pain. 1979 Oct; 7(2):115-27. View abstract
  360. Mitchell D, Woolf CJ. Descending tryptaminergic pathways and the antinociceptive effect produced by peripheral electrical stimulation in the rat [proceedings]. J Physiol. 1979 Aug; 293:59P-60P. View abstract
  361. Chandler HD, Woolf CJ, Hepburn HR. Gliding edge dislocations in proteins as a mechanism for active ion transport. Biochem J. 1978 Mar 01; 169(3):559-65. View abstract
  362. Woolf CJ, Mitchell D, Myers RA, Barrett GD. Failure of naloxone to reverse peripheral transcutaneous electro-analgesia in patients suffering from acute trauma. S Afr Med J. 1978 Feb 04; 53(5):179-80. View abstract
  363. Woolf CJ, Barrett GD, Mitchell D, Myers RA. Naloxone-reversible peripheral electroanalgesia in intact and spinal rats. Eur J Pharmacol. 1977 Oct 01; 45(3):311-4. View abstract
  364. Myers RA, Woolf CJ, Mitchell D. Management of acute traumatic pain by peripheral transcutaneous electrical stimulation. S Afr Med J. 1977 Aug 13; 52(8):309-12. View abstract
  365. Borsook D, Laburn HP, Rosendorff C, Willies GH, Woolf CJ. A dissociation between temperature regulation and fever in the rabbit. J Physiol. 1977 Apr; 266(2):423-33. View abstract
  366. Willies GH, Woolf CJ, Rosendorff C. The effect of an inhibitor of adenylate cyclase on the development of pyrogen, prostaglandin and cyclic AMP fevers in the rabbit. Pflugers Arch. 1976 Dec 28; 367(2):177-81. View abstract
  367. Woolf CJ, Willies GH, Rosendorff C. Does cyclic AMP have a role in the pathogenesis of fever in the rabbit? Naturwissenschaften. 1976 Feb; 63(2):94-5. View abstract
  368. Willies GH, Woolf CJ, Rosendorff C. The effect of sodium salicylate on dibutyryl cyclic AMP fever in the conscious rabbit. Neuropharmacology. 1976 Jan; 15(1):9-10. View abstract
  369. Laburn H, Woolf CJ, Willies GH, Rosendorff C. Pyrogen and prostaglandin fever in the rabbit-II: Effects of noradrenaline depletion and adrenergic receptor blockade. Neuropharmacology. 1975 May-Jun; 14(5-6):405-11. View abstract
  370. Woolf CJ, Willies GH, Laburn H, Rosendorff C. Pyrogen and prostaglandin fever in the rabbit-I: Effects of salicylate and the role of cyclic AMP. Neuropharmacology. 1975 May-Jun; 14(5-6):397-403. View abstract
  371. Woolf CJ, Laburn HP, Willies GH, Rosendorff C. Hypothalamic heating and cooling in monoamine-depleted rabbits. Am J Physiol. 1975 Feb; 228(2):569-74. View abstract
  372. Woolf CJ, Willies GH, Hepburn HR, Rosendorff C. Time dependence of a neurochemical correlate of a learning task: a non-disruptive approach to memory consolidation. Experientia. 1974 Jul 15; 30(7):760-2. View abstract
  373. Laburn HP, Rosendorff C, Willies G, Woolf C. Proceedings: A role for noradrenaline and cyclic AMP in prostaglandin E1 Fever. J Physiol. 1974 Jul; 240(2):49P-50P. View abstract
  374. Suero JT, Woolf CR. Alterations in the mechanical properties of the lung during dyspnea in chronic obstructive pulmonary disease. J Clin Invest. 1970 Apr; 49(4):747-51. View abstract