Research Overview

Vasilyev Laboratory has been focused on developing image-guided beating-heart cardiovascular interventions and cardiac surgical robotics. This includes clinically driven medical device design, new approaches for device prototyping and manufacturing, development of imaging techniques and image processing, computer modeling and simulation.

About Nikolay V. Vasilyev, MD

Dr. Vasilyev graduated from I.M. Sechenov First Moscow State Medical University. He completed residency in cardiovascular surgery and fellowship in pediatric cardiovascular surgery at A.N. Bakoulev Center for Cardiovascular Surgery in Moscow. Dr. Vasilyev completed his research fellowship at the Cleveland Clinic.

Key Publications

  • Vasilyev NV, Dupont PE, Del Nido PJ. Robotics and imaging in congenital heart surgery. Future Cardiol. 2012 Mar;8(2):285-96.

  • Vasilyev NV, Kawata M, DiBiasio CM, Durand KV, Hopkins J, Traina ZJ, Slocum AH, del Nido PJ. A novel cardioport for beating-heart, image-guided intracardiac surgery. J Thorac Cardiovasc Surg. 2011 Dec;142(6):1545-51.

  • Ren H, Vasilyev NV, Dupont PE. Detection of Curved Robots using 3D Ultrasound. Rep U S. 2011 Sep 25;2011:2083-2089.

  • Perrin DP, Vasilyev NV, Novotny P, Stoll J, Howe RD, Dupont PE, Salgo IS, del Nido PJ. Image Guided Surgical Interventions. Curr Probl Surg. 2009 Sep;46(9):730-66.

  • Vasilyev NV, Novotny PM, Martinez JF, Loyola H, Salgo IS, Howe RD, del Nido PJ. Stereoscopic Vision Display Technology in Real-Time Three-Dimensional Echocardiography-Guided Intracardiac Beating-Heart Surgery. J Thorac Cardiovasc Surg. 2008 Jun;135(6):1334-41.

  • Hoch M, Vasilyev N, Soriano B, Gauvreau K, Marx GR. Variables Influencing the Accuracy of Right Ventricular Volume Assessment by Real-time 3-Dimensional Echocardiography: An In Vitro Validation Study. J Am Soc Echocardiogr. 2007 May;20(5):456-461.

  • Vasilyev NV, Martinez JF, Freudenthal FP, Suematsu Y, Marx GR, del Nido PJ. Three-Dimensional Echo and Videocardioscopy-Guided Atrial Septal Defect Closure. Ann Thorac Surg; 2006 Oct;82(4):1322-6.

All publications in PubMed

Researcher Services

Researcher Areas

  • Cardiac Surgery

Research Departments

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. McAlvin JB, Wylie RG, Ramchander K, Nguyen MT, Lok CK, Moroi M, Shomorony A, Vasilyev NV, Armstrong P, Yang J, Lieber AM, Okonkwo OS, Karnik R, Kohane DS. Antibody-modified conduits for highly selective cytokine elimination from blood. JCI Insight. 2018 Jul 12; 3(13). View abstract
  2. Horvath MA, Varela CE, Dolan EB, Whyte W, Monahan DS, Payne CJ, Wamala IA, Vasilyev NV, Pigula FA, Mooney DJ, Walsh CJ, Duffy GP, Roche ET. Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart. Ann Biomed Eng. 2018 Oct; 46(10):1534-1547. View abstract
  3. Wamala I, Saeed M, Ghelani SJ, Gauvreau K, Hammer PE, Vasilyev NV, Del Nido PJ. A leaflet plication clip is an effective surgical template for mitral valve foldoplasty. Eur J Cardiothorac Surg. 2018 May 01; 53(5):939-944. View abstract
  4. Danilov VV, Skirnevskiy IP, Gerget OM, Shelomentcev EE, Kolpashchikov DY, Vasilyev NV. Efficient workflow for automatic segmentation of the right heart based on 2D echocardiography. Int J Cardiovasc Imaging. 2018 Jul; 34(7):1041-1055. View abstract
  5. Payne CJ, Wamala I, Bautista-Salinas D, Saeed M, Thalhofer T, Horvath MA, Abah C, Van Story D, del Nido PJ, Walsh CJ, Vasilyev NV. Soft robotic ventricular assist device with septal bracing for therapy of heart failure. Science Robotics. 2017; 12(2):eaan6736. View abstract
  6. Feins EN, Lee Y, O'Cearbhaill ED, Vasilyev NV, Shimada S, Friehs I, Perrin D, Hammer PE, Yamauchi H, Marx G, Gosline A, Arabagi V, Karp JM, Del Nido PJ. A Growth-Accommodating Implant for Paediatric Applications. Nat Biomed Eng. 2017; 1:818-825. View abstract
  7. Li J, Celiz AD, Yang J, Yang Q, Wamala I, Whyte W, Seo BR, Vasilyev NV, Vlassak JJ, Suo Z, Mooney DJ. Tough adhesives for diverse wet surfaces. Science. 2017 07 28; 357(6349):378-381. View abstract
  8. Payne CJ, Wamala I, Abah C, Thalhofer T, Saeed M, Bautista-Salinas D, Horvath MA, Vasilyev NV, Roche ET, Pigula FA, Walsh CJ. An Implantable Extracardiac Soft Robotic Device for the Failing Heart: Mechanical Coupling and Synchronization. Soft Robot. 2017 Sep; 4(3):241-250. View abstract
  9. Horvath MA, Wamala I, Rytkin E, Doyle E, Payne CJ, Thalhofer T, Berra I, Solovyeva A, Saeed M, Hendren S, Roche ET, Del Nido PJ, Walsh CJ, Vasilyev NV. An Intracardiac Soft Robotic Device for Augmentation of Blood Ejection from the Failing Right Ventricle. Ann Biomed Eng. 2017 Sep; 45(9):2222-2233. View abstract
  10. Roche ET, Horvath MA, Wamala I, Alazmani A, Song SE, Whyte W, Machaidze Z, Payne CJ, Weaver JC, Fishbein G, Kuebler J, Vasilyev NV, Mooney DJ, Pigula FA, Walsh CJ. Soft robotic sleeve supports heart function. Sci Transl Med. 2017 01 18; 9(373). View abstract
  11. Filippov AA, Del Nido PJ, Vasilyev NV. Management of Systemic Right Ventricular Failure in Patients With Congenitally Corrected Transposition of the Great Arteries. Circulation. 2016 Oct 25; 134(17):1293-1302. View abstract
  12. Ataollahi A, Berra I, Vasilyev NV, Machaidze Z, Dupont PE. Cardioscopic Tool-delivery Instrument for Beating-heart Surgery. IEEE ASME Trans Mechatron. 2016 Feb; 21(1):584-590. View abstract
  13. Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Whyte W, Casar Berazaluce AM, Bueno A, Lang N, Pereira MJ, Feins E, Wasserman S, O'Cearbhaill ED, Vasilyev NV, Mooney DJ, Karp JM, Del Nido PJ, Walsh CJ. A light-reflecting balloon catheter for atraumatic tissue defect repair. Sci Transl Med. 2015 Sep 23; 7(306):306ra149. View abstract
  14. Villert A, Kolomiets L, Vasilyev N, Perelmuter V, Savenkova O. Extraskeletal myxoid chondrosarcoma of the vulva: A case report. Oncol Lett. 2015 Oct; 10(4):2095-2099. View abstract
  15. Bergeles C, Gosline AH, Vasilyev NV, Codd PJ, Del Nido PJ, Dupont PE. Concentric Tube Robot Design and Optimization Based on Task and Anatomical Constraints. IEEE Trans Robot. 2015 Feb 03; 31(1):67-84. View abstract
  16. Roche ET, Hastings CL, Lewin SA, Shvartsman D, Brudno Y, Vasilyev NV, O'Brien FJ, Walsh CJ, Duffy GP, Mooney DJ. Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart. Biomaterials. 2014 Aug; 35(25):6850-6858. View abstract
  17. Lang N, Pereira MJ, Lee Y, Friehs I, Vasilyev NV, Feins EN, Ablasser K, O'Cearbhaill ED, Xu C, Fabozzo A, Padera R, Wasserman S, Freudenthal F, Ferreira LS, Langer R, Karp JM, del Nido PJ. A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects. Sci Transl Med. 2014 Jan 08; 6(218):218ra6. View abstract
  18. Feins EN, Yamauchi H, Marx GR, Freudenthal FP, Liu H, Del Nido PJ, Vasilyev NV. Repair of posterior mitral valve prolapse with a novel leaflet plication clip in an animal model. J Thorac Cardiovasc Surg. 2014 Feb; 147(2):783-90; discussion 790-1. View abstract
  19. Roche ET, Wohlfarth R, Overvelde JT, Vasilyev NV, Pigula FA, Mooney DJ, Bertoldi K, Walsh CJ. A bioinspired soft actuated material. Adv Mater. 2014 Feb 26; 26(8):1200-6. View abstract
  20. Yamauchi H, Feins EN, Vasilyev NV, Shimada S, Zurakowski D, Del Nido PJ. Creation of nonischemic functional mitral regurgitation by annular dilatation and nonplanar modification in a chronic in vivo swine model. Circulation. 2013 Sep 10; 128(11 Suppl 1):S263-70. View abstract
  21. Vasilyev NV, Gosline AH, Butler E, Lang N, Codd PJ, Yamauchi H, Feins EN, Folk CR, Cohen AL, Chen R, Zurakowski D, del Nido PJ, Dupont PE. Percutaneous steerable robotic tool delivery platform and metal microelectromechanical systems device for tissue manipulation and approximation: closure of patent foramen ovale in an animal model. Circ Cardiovasc Interv. 2013 Aug; 6(4):468-75. View abstract
  22. Gosline AH, Vasilyev NV, Butler EJ, Folk C, Cohen A, Chen R, Lang N, Del Nido PJ, Dupont PE. Percutaneous intracardiac beating-heart surgery using metal MEMS tissue approximation tools. Int J Rob Res. 2012 Aug 01; 31(9):1081-1093. View abstract
  23. Yap CH, Saikrishnan N, Tamilselvan G, Vasilyev N, Yoganathan AP. The congenital bicuspid aortic valve can experience high-frequency unsteady shear stresses on its leaflet surface. Am J Physiol Heart Circ Physiol. 2012 Sep 15; 303(6):H721-31. View abstract
  24. Brattain LJ, Vasilyev NV, Howe RD. Enabling 3D Ultrasound Procedure Guidance through Enhanced Visualization. Inf Process Comput Assist Interv (2012). 2012 Jun; 7330:115-124. View abstract
  25. Vasilyev NV, Dupont PE, del Nido PJ. Robotics and imaging in congenital heart surgery. Future Cardiol. 2012 Mar; 8(2):285-96. View abstract
  26. Perrin DP, Vasilyev NV, Marx GR, del Nido PJ. Temporal enhancement of 3D echocardiography by frame reordering. JACC Cardiovasc Imaging. 2012 Mar; 5(3):300-4. View abstract
  27. Yamauchi H, Vasilyev NV, Marx GR, Loyola H, Padala M, Yoganathan AP, del Nido PJ. Right ventricular papillary muscle approximation as a novel technique of valve repair for functional tricuspid regurgitation in an ex vivo porcine model. J Thorac Cardiovasc Surg. 2012 Jul; 144(1):235-42. View abstract
  28. Saikrishnan N, Yap CH, Milligan NC, Vasilyev NV, Yoganathan AP. In vitro characterization of bicuspid aortic valve hemodynamics using particle image velocimetry. Ann Biomed Eng. 2012 Aug; 40(8):1760-75. View abstract
  29. Gosline AH, Vasilyev NV, Veeramani A, Wu M, Schmitz G, Chen R, Arabagi V, Del Nido PJ, Dupont PE. Metal MEMS Tools for Beating-heart Tissue Removal. IEEE Int Conf Robot Autom. 2012. View abstract
  30. Tenenholtz NA, Hammer PE, Schneider RJ, Vasilyev NV, Howe RD. On the Design of an Interactive, Patient-Specific Surgical Simulator for Mitral Valve Repair. Rep U S. 2011 Dec 31; 2011:1327-1332. View abstract
  31. Schneider RJ, Perrin DP, Vasilyev NV, Marx GR, del Nido PJ, Howe RD. Mitral annulus segmentation from four-dimensional ultrasound using a valve state predictor and constrained optical flow. Med Image Anal. 2012 Feb; 16(2):497-504. View abstract
  32. Schneider RJ, Perrin DP, Vasilyev NV, Marx GR, Del Nido PJ, Howe RD. Real-time image-based rigid registration of three-dimensional ultrasound. Med Image Anal. 2012 Feb; 16(2):402-14. View abstract
  33. Ren H, Vasilyev NV, Dupont PE. Detection of Curved Robots using 3D Ultrasound. Rep U S. 2011 Sep 25; 2011:2083-2089. View abstract
  34. Vasilyev NV, Kawata M, DiBiasio CM, Durand KV, Hopkins J, Traina ZJ, Slocum AH, del Nido PJ. A novel cardioport for beating-heart, image-guided intracardiac surgery. J Thorac Cardiovasc Surg. 2011 Dec; 142(6):1545-51. View abstract
  35. Butler EJ, Folk C, Cohen A, Vasilyev NV, Chen R, Del Nido PJ, Dupont PE. Metal MEMS Tools for Beating-heart Tissue Approximation. IEEE Int Conf Robot Autom. 2011 May 09; 2011:411-416. View abstract
  36. Walter EM, Delmo Walter EM, Vasilyev NV, Sill B, Padala M, Jimenez J, Yoganathan AP, Hetzer R, del Nido PJ. Creation of a tricuspid valve regurgitation model from tricuspid annular dilatation using the cardioport video-assisted imaging system. J Heart Valve Dis. 2011 Mar; 20(2):184-8. View abstract
  37. Lang N, Kozlik-Feldmann R, Meyer-Gold A, Fuchs F, Lehner A, Abicht J, Sodian R, Vasilyev N, del Nido P, Netz H, Reichart B, Schmitz C. Modification of a hybrid technique for closure of muscular ventricular septal defects in a pig model. Heart Surg Forum. 2010 Oct; 13(5):E299-304. View abstract
  38. Yuen SG, Perrin DP, Vasilyev NV, Del Nido PJ, Howe RD. Force Tracking with Feed-Forward Motion Estimation for Beating Heart Surgery. IEEE Trans Robot. 2010 Aug 16; 26(5):888-896. View abstract
  39. Yuen SG, Vasilyev NV, del Nido PJ, Howe RD. Robotic tissue tracking for beating heart mitral valve surgery. Med Image Anal. 2013 Dec; 17(8):1236-42. View abstract
  40. Schneider RJ, Perrin DP, Vasilyev NV, Marx GR, del Nido PJ, Howe RD. Mitral annulus segmentation from 3D ultrasound using graph cuts. IEEE Trans Med Imaging. 2010 Sep; 29(9):1676-87. View abstract
  41. Kawata M, Vasilyev NV, Perrin DP, del Nido PJ. Beating-heart mitral valve suture annuloplasty under real-time three-dimensional echocardiography guidance: an ex vivo study. Interact Cardiovasc Thorac Surg. 2010 Jul; 11(1):6-9. View abstract
  42. Yuen SG, Yip MC, Vasilyev NV, Perrin DP, Del Nido PJ, Howe RD. Robotic Force Stabilization for Beating Heart Intracardiac Surgery. Med Image Comput Comput Assist Interv. 2009 Oct 01; 5761(2009):26-33. View abstract
  43. Perrin DP, Vasilyev NV, Novotny P, Stoll J, Howe RD, Dupont PE, Salgo IS, del Nido PJ. Image guided surgical interventions. Curr Probl Surg. 2009 Sep; 46(9):730-66. View abstract
  44. Perrin DP, Vasilyev NV, Novotny P, Stoll J, Howe RD, Dupont PE, Salgo IS, Del Nido PJ. In brief. Curr Probl Surg. 2009 Sep; 46(9):723-7. View abstract
  45. Kozlik-Feldmann R, Lang N, Lehner A, Sigler M, Schmitz C, Sodian R, Freudenthal F, Dalla-Pozza R, Vasilyev NV, del Nido PJ, Netz H. Evaluation of a new hybrid technique for closure of muscular ventricular septal defects in a long-term setting. J Thorac Cardiovasc Surg. 2009 Aug; 138(2):365-73. View abstract
  46. Yuen SG, Yip MC, Vasilyev NV, Perrin DP, del Nido PJ, Howe RD. Robotic force stabilization for beating heart intracardiac surgery. Med Image Comput Comput Assist Interv. 2009; 12(Pt 1):26-33. View abstract
  47. Schneider RJ, Perrin DP, Vasilyev NV, Marx GR, Del Nido PJ, Howe RD. Mitral Annulus Segmentation from Three-Dimensional Ultrasound. Proc IEEE Int Symp Biomed Imaging. 2009; 779-782. View abstract
  48. Padala M, Vasilyev NV, Owen JW, Jimenez JH, Dasi LP, del Nido PJ, Yoganathan AP. Cleft closure and undersizing annuloplasty improve mitral repair in atrioventricular canal defects. J Thorac Cardiovasc Surg. 2008 Nov; 136(5):1243-9. View abstract
  49. Vasilyev NV, Novotny PM, Martinez JF, Loyola H, Salgo IS, Howe RD, del Nido PJ. Stereoscopic vision display technology in real-time three-dimensional echocardiography-guided intracardiac beating-heart surgery. J Thorac Cardiovasc Surg. 2008 Jun; 135(6):1334-41. View abstract
  50. Kozlik-Feldmann R, Lang N, Aumann R, Lehner A, Rassoulian D, Sodian R, Schmitz C, Hinterseer M, Hinkel R, Thein E, Freudenthal F, Vasilyev NV, Vasylev NV, del Nido PJ, Netz H. Patch closure of muscular ventricular septal defects with a new hybrid therapy in a pig model. J Am Coll Cardiol. 2008 Apr 22; 51(16):1597-603. View abstract
  51. Vasilyev NV, Melnychenko I, Kitahori K, Freudenthal FP, Phillips A, Kozlik-Feldmann R, Salgo IS, del Nido PJ, Bacha EA. Beating-heart patch closure of muscular ventricular septal defects under real-time three-dimensional echocardiographic guidance: a preclinical study. J Thorac Cardiovasc Surg. 2008 Mar; 135(3):603-9. View abstract
  52. Linguraru MG, Vasilyev NV, Marx GR, Tworetzky W, Del Nido PJ, Howe RD. Fast block flow tracking of atrial septal defects in 4D echocardiography. Med Image Anal. 2008 Aug; 12(4):397-412. View abstract
  53. Yuen SG, Kesner SB, Vasilyev NV, Del Nido PJ, Howe RD. 3D ultrasound-guided motion compensation system for beating heart mitral valve repair. Med Image Comput Comput Assist Interv. 2008; 11(Pt 1):711-9. View abstract
  54. Huang J, Triedman JK, Vasilyev NV, Suematsu Y, Cleveland RO, Dupont PE. Imaging artifacts of medical instruments in ultrasound-guided interventions. J Ultrasound Med. 2007 Oct; 26(10):1303-22. View abstract
  55. Novotny PM, Stoll JA, Vasilyev NV, del Nido PJ, Dupont PE, Zickler TE, Howe RD. GPU based real-time instrument tracking with three-dimensional ultrasound. Med Image Anal. 2007 Oct; 11(5):458-64. View abstract
  56. Linguraru MG, Vasilyev NV, Del Nido PJ, Howe RD. Statistical segmentation of surgical instruments in 3-D ultrasound images. Ultrasound Med Biol. 2007 Sep; 33(9):1428-37. View abstract
  57. Hoch M, Vasilyev NV, Soriano B, Gauvreau K, Marx GR. Variables influencing the accuracy of right ventricular volume assessment by real-time 3-dimensional echocardiography: an in vitro validation study. J Am Soc Echocardiogr. 2007 May; 20(5):456-61. View abstract
  58. Vasilyev NV, Martinez JF, Freudenthal FP, Suematsu Y, Marx GR, del Nido PJ. Three-dimensional echo and videocardioscopy-guided atrial septal defect closure. Ann Thorac Surg. 2006 Oct; 82(4):1322-6; discussion 1326. View abstract
  59. Novotny PM, Jacobsen SK, Vasilyev NV, Kettler DT, Salgo IS, Dupont PE, Del Nido PJ, Howe RD. 3D ultrasound in robotic surgery: performance evaluation with stereo displays. Int J Med Robot. 2006 Sep; 2(3):279-85. View abstract
  60. Friehs I, Barillas R, Vasilyev NV, Roy N, McGowan FX, del Nido PJ. Vascular endothelial growth factor prevents apoptosis and preserves contractile function in hypertrophied infant heart. Circulation. 2006 Jul 04; 114(1 Suppl):I290-5. View abstract
  61. Novotny PM, Stoll JA, Vasilyev NV, del Nido PJ, Dupont PE, Howe RD. GPU based real-time instrument tracking with three dimensional ultrasound. Med Image Comput Comput Assist Interv. 2006; 9(Pt 1):58-65. View abstract
  62. Linguraru MG, Vasilyev NV, del Nido PJ, Howe RD. Atrial septal defect tracking in 3D cardiac ultrasound. Med Image Comput Comput Assist Interv. 2006; 9(Pt 1):596-603. View abstract
  63. Vasilyev N, Williams T, Brennan ML, Unzek S, Zhou X, Heinecke JW, Spitz DR, Topol EJ, Hazen SL, Penn MS. Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation. 2005 Nov 01; 112(18):2812-20. View abstract
  64. Mumtaz MA, Fraga CH, Nicholls CM, Desai S, Vasilyev N, Joshi R, Mee RB, Duncan BW. Increased expression of vascular endothelial growth factor messenger RNA in lungs of rats after cavopulmonary anastomosis. J Thorac Cardiovasc Surg. 2005 Jan; 129(1):209-10. View abstract