The Stamoulis laboratory at Boston Children's Hospital/Harvard Medical School is a computational Neuroscience laboratory that focuses on the development of novel computational approaches and mathematical models for the investigation of multi-scale brain dynamics. Our ultimate goals are to improve our fundamental understanding of the neural underpinnings of complex behaviors in the human brain and to identify robust neural signatures of neurological/neurodevelopmental disorders.

Our research activities lie at the intersection of neuroscience, electrical engineering, applied mathematics and statistics. Our current projects focus on two broad topics:

  1. Improving our fundamental understanding of the emergence and organization of functional networks in the typically developing infant brain during the first few years of life;
  2. Estimating multi-scale brain networks from very high-dimensional multi-modal data, collected over long periods of time and/or in naturalistic settings.

Our research is supported by the National Science Foundation (BRAIN Initiative) and the National Institutes of Health.


Dr Stamoulis is currently Assistant Professor of Pediatrics at Harvard Medical School

She completed both undergraduate and graduate studies at MIT and received a PhD in the field of Underwater Acoustics. For several years she conducted research in this field, first studying the acoustic environment under the ice cap in the Arctic ocean and later acoustic wave propagation in shallow water. She switched fields and transitioned into Neuroscience in 2004. Following post-doctoral training in Neuroscience (MIT) and Biostatistics (Harvard School of Public Health), she joined the faculty at Harvard Medical School in 2009. Her broad research interests are in computational Neuroscience, signal processing, neurostatistics and bioinformatics.

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  1. Golub SA, Maza Reyes JC, Stamoulis C, Leal Pensabene A, Tijerino Cordón PA, Calgua E, Hassan A. Guatemala City youth: an analysis of health indicators through the lens of a clinical registry. Int Health. 2019 07 01; 11(4):265-271. View abstract
  2. Stamoulis C, Connoly J, Duffy FH. Data-driven separation and estimation of atrial dynamics in very high-dimensional electrocardiograms from epilepsy patients. Conf Proc IEEE Eng Med Biol Soc. 2019 07; 2019:91-94. View abstract
  3. Gooding HC, Brown CA, Liu J, Revette AC, Stamoulis C, de Ferranti SD. Will Teens Go Red? Low Cardiovascular Disease Awareness Among Young Women. J Am Heart Assoc. 2019 03 19; 8(6):e011195. View abstract
  4. Bartenstein DW, Fisher JM, Stamoulis C, Weldon C, Huang JT, Gellis SE, Liang MG, Schmidt B, Hawryluk EB. Clinical features and outcomes of spitzoid proliferations in children and adolescents. Br J Dermatol. 2019 Aug; 181(2):366-372. View abstract
  5. Kwatra NS, Nurko S, Stamoulis C, Falone AE, Grant FD, Treves ST. Chronic Acalculous Cholecystitis in Children With Biliary Symptoms: Usefulness of Hepatocholescintigraphy. J Pediatr Gastroenterol Nutr. 2019 01; 68(1):68-73. View abstract
  6. Stamoulis C, Connolly J, Axeen E, Kaulas H, Bolton J, Dorfman K, Halford JJ, Duffy FH, Treves ST, Pearl PL. Non-invasive Seizure Localization with Ictal Single-Photon Emission Computed Tomography is Impacted by Preictal/Early Ictal Network Dynamics. IEEE Trans Biomed Eng. 2018 Nov 09. View abstract
  7. Wang LT, Cleveland RH, Binder W, Zwerdling RG, Stamoulis C, Ptak T, Sherman M, Haver K, Sagar P, Hibberd P. Similarity of chest X-ray and thermal imaging of focal pneumonia: a randomised proof of concept study at a large urban teaching hospital. BMJ Open. 2018 01 05; 8(1):e017964. View abstract
  8. Karwowski MP, Stamoulis C, Wenren LM, Faboyede GM, Quinn N, Gura KM, Bellinger DC, Woolf AD. Blood and Hair Aluminum Levels, Vaccine History, and Early Infant Development: A Cross-Sectional Study. Acad Pediatr. 2018 03; 18(2):161-165. View abstract
  9. Stamoulis C, Vanderwert RE, Zeanah CH, Fox NA, Nelson CA. Neuronal networks in the developing brain are adversely modulated by early psychosocial neglect. J Neurophysiol. 2017 10 01; 118(4):2275-2288. View abstract
  10. Stamoulis C, Verma N, Kaulas H, Halford JJ, Duffy FH, Pearl PL, Treves ST. The promise of subtraction ictal SPECT co-registered to MRI for improved seizure localization in pediatric epilepsies: Affecting factors and relationship to the surgical outcome. Epilepsy Res. 2017 01; 129:59-66. View abstract
  11. Monuteaux MC, Stamoulis C. Machine Learning: A Primer for Child Psychiatrists. J Am Acad Child Adolesc Psychiatry. 2016 10; 55(10):835-6. View abstract
  12. Vajapeyam S, Stamoulis C, Ricci K, Kieran M, Poussaint TY. Automated Processing of Dynamic Contrast-Enhanced MRI: Correlation of Advanced Pharmacokinetic Metrics with Tumor Grade in Pediatric Brain Tumors. AJNR Am J Neuroradiol. 2017 Jan; 38(1):170-175. View abstract
  13. Tsai A, Stamoulis C, Barber I, Kleinman PK. Infant lower extremity long bone growth rates: comparison of contemporary with early 20th century data using mixed effect models. Am J Hum Biol. 2017 Jan; 29(1). View abstract
  14. Stamoulis C, Betensky RA. Optimization of Signal Decomposition Matched Filtering (SDMF) for Improved Detection of Copy-Number Variations. IEEE/ACM Trans Comput Biol Bioinform. 2016 May-Jun; 13(3):584-91. View abstract
  15. Swenson DW, Schooler GR, Stamoulis C, Lee EY. MRI of the normal appendix in children: data toward a new reference standard. Pediatr Radiol. 2016 Jun; 46(7):1003-10. View abstract
  16. Tsai A, Stamoulis C, Bixby SD, Breen MA, Connolly SA, Kleinman PK. Infant bone age estimation based on fibular shaft length: model development and clinical validation. Pediatr Radiol. 2016 Mar; 46(3):342-56. View abstract
  17. Drubach LA, Jenkins KJ, Stamoulis C, Palmer EL, Lee EY. Evaluation of Primary Pulmonary Vein Stenosis in Children: Comparison of Radionuclide Perfusion Lung Scan and Angiography. AJR Am J Roentgenol. 2015 Oct; 205(4):873-7. View abstract
  18. Stamoulis C, Vanderwert RE, Zeanah CH, Fox NA, Nelson CA. Early Psychosocial Neglect Adversely Impacts Developmental Trajectories of Brain Oscillations and Their Interactions. J Cogn Neurosci. 2015 Dec; 27(12):2512-28. View abstract
  19. Cleveland RH, Sawicki GS, Stamoulis C. Similar performance of Brasfield and Wisconsin scoring systems in young children with cystic fibrosis. Pediatr Radiol. 2015 Oct; 45(11):1624-8. View abstract
  20. Bick J, Zhu T, Stamoulis C, Fox NA, Zeanah C, Nelson CA. Effect of early institutionalization and foster care on long-term white matter development: a randomized clinical trial. JAMA Pediatr. 2015 Mar; 169(3):211-9. View abstract
  21. Callahan MJ, Anandalwar SP, MacDougall RD, Stamoulis C, Kleinman PL, Rangel SJ, Bachur RG, Taylor GA. Pediatric CT dose reduction for suspected appendicitis: a practice quality improvement project using artificial gaussian noise--part 2, clinical outcomes. AJR Am J Roentgenol. 2015 Mar; 204(3):636-44. View abstract
  22. Stamoulis C, Vogel-Farley V, Degregorio G, Jeste SS, Nelson CA. Resting and task-modulated high-frequency brain rhythms measured by scalp encephalography in infants with tuberous sclerosis complex. J Autism Dev Disord. 2015 Feb; 45(2):336-53. View abstract
  23. Silvera VM, Danehy AR, Newton AW, Stamoulis C, Carducci C, Grant PE, Wilson CR, Kleinman PK. Retroclival collections associated with abusive head trauma in children. Pediatr Radiol. 2014 Dec; 44 Suppl 4:S621-31. View abstract
  24. Novais EN, Heyworth BE, Stamoulis C, Sullivan K, Millis MB, Kim YJ. Open surgical treatment of femoroacetabular impingement in adolescent athletes: preliminary report on improvement of physical activity level. J Pediatr Orthop. 2014 Apr-May; 34(3):287-94. View abstract
  25. Cleveland RH, Stamoulis C, Sawicki G, Kelliher E, Zucker EJ, Wood C, Zurakowski D, Lee E. Brasfield and Wisconsin scoring systems have equal value as outcome assessment tools of cystic fibrosis lung disease. Pediatr Radiol. 2014 May; 44(5):529-34. View abstract
  26. Paltiel HJ, Estrada CR, Alomari AI, Stamoulis C, Passerotti CC, Meral FC, Lee RS, Clement GT. Multi-planar dynamic contrast-enhanced ultrasound assessment of blood flow in a rabbit model of testicular torsion. Ultrasound Med Biol. 2014 Feb; 40(2):361-70. View abstract
  27. Orbach DB, Stamoulis C, Strauss KJ, Manchester J, Smith ER, Scott RM, Lin N. Neurointerventions in children: radiation exposure and its import. AJNR Am J Neuroradiol. 2014 Apr; 35(4):650-6. View abstract
  28. Tsai A, McDonald AG, Rosenberg AE, Stamoulis C, Kleinman PK. Discordant radiologic and histological dimensions of the zone of provisional calcification in fetal piglets. Pediatr Radiol. 2013 Dec; 43(12):1606-14. View abstract
  29. Stamoulis C, Schomer DL, Chang BS. Information theoretic measures of network coordination in high-frequency scalp EEG reveal dynamic patterns associated with seizure termination. Epilepsy Res. 2013 Aug; 105(3):299-315. View abstract
  30. Heyworth BE, Hedequist DJ, Nasreddine AY, Stamoulis C, Hresko MT, Yen YM. Distal femoral valgus deformity following plate fixation of pediatric femoral shaft fractures. J Bone Joint Surg Am. 2013 Mar 20; 95(6):526-33. View abstract
  31. Stamoulis C, Chang BS. Estimation of temporal scales of variation in long-term scalp electroencephalograms from epilepsy patients. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:2894-7. View abstract
  32. Stamoulis C, Chang BS. Modeling noninvasive neurostimulation in epilepsy as stochastic interference in brain networks. IEEE Trans Neural Syst Rehabil Eng. 2013 May; 21(3):354-63. View abstract
  33. Stamoulis C, Gruber LJ, Schomer DL, Chang BS. High-frequency neuronal network modulations encoded in scalp EEG precede the onset of focal seizures. Epilepsy Behav. 2012 Apr; 23(4):471-80. View abstract
  34. Stamoulis C, Fernández IS, Chang BS, Loddenkemper T. Signal subspace integration for improved seizure localization. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:1016-9. View abstract
  35. Stamoulis C, Chang BS. Space-time adaptive processing for improved estimation of preictal seizure activity. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:6157-60. View abstract
  36. Stamoulis C, Betensky RA. A novel signal processing approach for the detection of copy number variations in the human genome. Bioinformatics. 2011 Sep 01; 27(17):2338-45. View abstract
  38. Barnes TD, Mao JB, Hu D, Kubota Y, Dreyer AA, Stamoulis C, Brown EN, Graybiel AM. Advance cueing produces enhanced action-boundary patterns of spike activity in the sensorimotor striatum. J Neurophysiol. 2011 Apr; 105(4):1861-78. View abstract
  39. Stamoulis C, Oberman LM, Praeg E, Bashir S, Pascual-Leone A. Single pulse TMS-induced modulations of resting brain neurodynamics encoded in EEG phase. Brain Topogr. 2011 Jun; 24(2):105-13. View abstract
  40. Stamoulis C, Chang BS. Multiscale information for network characterization in epilepsy. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:5908-11. View abstract
  41. Stamoulis C. Estimation of correlations between copy-number variants in non-coding DNA. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:5563-6. View abstract
  42. Stamoulis C, Richardson AG. Encoding of brain state changes in local field potentials modulated by motor behaviors. J Comput Neurosci. 2010 Dec; 29(3):475-83. View abstract
  43. Stamoulis C, Gruber LJ, Chang BS. Network dynamics of the epileptic brain at rest. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:150-3. View abstract
  44. Stamoulis C, Chang BS, Madsen JR. Estimation of Eeg Signal Dispersion During Seizure Propagation. Int Conf Digit Signal Process Proc. 2009 Sep 18; 2009:1-5. View abstract
  45. Stamoulis C, Chang BS. Application of Matched-Filtering to Extract EEG Features and Decouple Signal Contributions from Multiple Seizure Foci in Brain Malformations. Int IEEE EMBS Conf Neural Eng. 2009 Jun 23; 2009:514-517. View abstract
  46. Stamoulis C, Richardson AG. Application of matched filtering to identify behavioral modulation of brain oscillations. J Comput Neurosci. 2010 Aug; 29(1-2):63-72. View abstract
  47. Stamoulis C, Praeg E, Chang BS, Bashir S, Pascual-Leone A. Estimation of brain state changes associated with behavior, stimulation and epilepsy. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:4719-22. View abstract
  48. Stamoulis C, Betensky RA, Mohapatra G, Louis DN. Application of signal processing techniques for estimating regions of copy number variations in human meningioma DNA. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:6973-6. View abstract
  49. Stamoulis C, Dyer I. Acoustically derived ice-fracture velocity in central Arctic pack ice. J Acoust Soc Am. 2000 Jul; 108(1):96-104. View abstract