Research Overview

Continuous electroencephalography is the gold standard for seizure detection and determination of underlying cerebral function in critically ill neonates and children. Electrographic seizures are noted to affect 10-50% of critically ill children in the intensive care unit. The impact of electrographic seizures on outcome in this patient population remains unclear. Studies suggest that seizure burden may influence neurologic outcome. Other studies have shown an association between electrographic status epilepticus and in-hospital mortality.

Our lab is investigating the impact of electrographic seizures and how they may relate to outcome in critically ill children in both the neonatal and pediatric intensive care unit. We are interested in further defining subpopulations of critically ill children such as children requiring extracorporeal membrane oxygenation, those that are status post congenital heart disease surgery, neonates that are premature, and neonates suspected of having hypoxic ischemic injury to name a few. We are also focusing on seizure prediction in these subpopulations using early clinical and electrographic features.

About Arnold J. Sansevere

Arnold Sansevere received his M.D. from Drexel University College of medicine. He completed a pediatric residency at Schneider’s Children’s Hospital in New Hyde Park, NY. He went on to complete his child neurology residency and epilepsy fellowship at Boston Children’s Hospital. His main interests are in continuous EEG monitoring in the neonatal and pediatric intensive care unit as well as medical education.

Researcher Services

Researcher Areas

  • Continuous EEG monitoring in the pediatric and neonatal ICU

PUBLICATIONS

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  1. Cheng HH, Rajagopal SK, Sansevere AJ, McDavitt E, Wigmore D, Mecklosky J, Andren K, Williams KA, Danehy A, Soul JS. Post-arrest therapeutic hypothermia in pediatric patients with congenital heart disease. Resuscitation. 2018 Feb 21; 126:83-89. View abstract
  2. Sánchez Fernández I, Sansevere AJ, Gaínza-Lein M, Buraniqi E, Tasker RC, Loddenkemper T. Time to continuous electroencephalogram in repeated admissions to the pediatric intensive care unit. Seizure. 2018 Jan; 54:19-26. View abstract
  3. Sansevere AJ, Duncan ED, Libenson MH, Loddenkemper T, Pearl PL, Tasker RC. Continuous EEG in Pediatric Critical Care: Yield and Efficiency of Seizure Detection. J Clin Neurophysiol. 2017 Sep; 34(5):421-426. View abstract
  4. Buraniqi E, Sansevere AJ, Kapur K, Bergin AM, Pearl PL, Loddenkemper T. Electrographic Seizures in Preterm Neonates in the Neonatal Intensive Care Unit. J Child Neurol. 2017 Sep; 32(10):880-885. View abstract
  5. Sansevere AJ, Avalone J, Strauss LD, Patel AA, Pinto A, Ramachandran M, Fernandez IS, Bergin AM, Kimia A, Pearl PL, Loddenkemper T. Diagnostic and Therapeutic Management of a First Unprovoked Seizure in Children and Adolescents With a Focus on the Revised Diagnostic Criteria for Epilepsy. J Child Neurol. 2017 Jul; 32(8):774-788. View abstract
  6. Sánchez Fernández I, Sansevere AJ, Guerriero RM, Buraniqi E, Pearl PL, Tasker RC, Loddenkemper T. Time to electroencephalography is independently associated with outcome in critically ill neonates and children. Epilepsia. 2017 03; 58(3):420-428. View abstract
  7. Kaye HL, Peters JM, Gersner R, Chamberland M, Sansevere A, Rotenberg A. Neurophysiological evidence of preserved connectivity in tuber tissue. Epilepsy Behav Case Rep. 2017; 7:64-68. View abstract
  8. Lee JW, LaRoche S, Choi H, Rodriguez Ruiz AA, Fertig E, Politsky JM, Herman ST, Loddenkemper T, Sansevere AJ, Korb PJ, Abend NS, Goldstein JL, Sinha SR, Dombrowski KE, Ritzl EK, Westover MB, Gavvala JR, Gerard EE, Schmitt SE, Szaflarski JP, Ding K, Haas KF, Buchsbaum R, Hirsch LJ, Wusthoff CJ, Hopp JL, Hahn CD. Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research. J Clin Neurophysiol. 2016 Apr; 33(2):133-40. View abstract