Research Overview

Dr. Rodan’s research interests include MRI pattern recognition and functional MRI studies in the diagnosis and management of neurometabolic disorders. He is currently a sub-investigator for 2 ongoing clinical trials at Boston Children’s Hospital, and has also continued his work as a clinician in the Harvard Undiagnosed Diseases Network (UDN).

About Lance Rodan

Dr. Rodan completed a residency in Pediatric Neurology at the Hospital for Sick Children in Toronto, Canada. He also obtained certification in EEG electrophysiology through the Canadian Society of Clinical Neurophysiologists (CSCN). He then completed fellowships in both Clinical Genetics and Medical Biochemical Genetics at Harvard Medical School. He participated in the Harvard Undiagnosed Diseases Network (UDN) program from July 2015-June 2016. Dr. Rodan’s particular areas of interest are in the fields of Neurometabolism and Neurogenetics. He has a busy clinical practice at Boston Children’s Hospital, where he sees patients in both Genetics/Metabolism and Neurology clinics.

Selected Publications

Rodan LH, Gibson KM, Pearl PL. Clinical Use of CSF Neurotransmitters. Pediatr Neurol 2015.

Rodan LH, Berry GT. N-acetylcysteine therapy in an infant with transaldolase deficiency is well tolerated and associated with normalization of alpha fetoprotein levels. JIMD Reports 2016.

Rodan LH, Cohen J, Fatemi A, Gillis T, Lucente D, Gusella JF, Picker JD. A novel neurodevelopmental disorder associated with compound heterozygous variants in the huntingtin gene accepted for publication in European Journal of Human Genetics 2016.

Rodan LH, Moufawad El Acktar C, Berry GT, Poduri A, Prabhu SP, Yang E, Anselm I. De Novo TUBB2A variant presenting with Anterior Temporal Pachygyria. Journal of Child Neurology 2016.

Researcher Services

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Rodan LH, Qi W, Ducker GS, Demirbas D, Laine R, Yang E, Walker MA, Eichler F, Rabinowitz JD, Anselm I, Berry GT. 5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination. Mol Genet Metab. 2018 Jun 15. View abstract
  2. Rodan LH, Aldubayan SH, Berry GT, Levy HL. Acute Illness Protocol for Urea Cycle Disorders. Pediatr Emerg Care. 2018 Jun; 34(6):e115-e119. View abstract
  3. Almontashiri NAM, Rodan LH, Peake RWA. Serine Deficiency in a Child with Neurological Presentation, Hearing Loss, and Multiple Congenital Anomalies. Clin Chem. 2018 May; 64(5):870-872. View abstract
  4. Rodan LH, Hauptman M, D'Gama AM, Qualls AE, Cao S, Tuschl K, Al-Jasmi F, Hertecant J, Hayflick SJ, Wessling-Resnick M, Yang ET, Berry GT, Gropman A, Woolf AD, Agrawal PB. Novel founder intronic variant in SLC39A14 in two families causing Manganism and potential treatment strategies. Mol Genet Metab. 2018 Jun; 124(2):161-167. View abstract
  5. Gauthier J, Meijer IA, Lessel D, Mencacci NE, Krainc D, Hempel M, Tsiakas K, Prokisch H, Rossignol E, Helm MH, Rodan LH, Karamchandani J, Carecchio M, Lubbe SJ, Telegrafi A, Henderson LB, Lorenzo K, Wallace SE, Glass IA, Hamdan FF, Michaud JL, Rouleau GA, Campeau PM. Recessive mutations in >VPS13D cause childhood onset movement disorders. Ann Neurol. 2018 Mar 08. View abstract
  6. Almuqbil M, Rivkin MJ, Takeoka M, Yang E, Rodan LH. Transient regional cerebral hypoperfusion during a paroxysmal hemiplegic event in GLUT1 deficiency syndrome. Eur J Paediatr Neurol. 2018 May; 22(3):544-547. View abstract
  7. Johannesen KM, Gardella E, Linnankivi T, Courage C, de Saint Martin A, Lehesjoki AE, Mignot C, Afenjar A, Lesca G, Abi-Warde MT, Chelly J, Piton A, Merritt JL, Rodan LH, Tan WH, Bird LM, Nespeca M, Gleeson JG, Yoo Y, Choi M, Chae JH, Czapansky-Beilman D, Reichert SC, Pendziwiat M, Verhoeven JS, Schelhaas HJ, Devinsky O, Christensen J, Specchio N, Trivisano M, Weber YG, Nava C, Keren B, Doummar D, Schaefer E, Hopkins S, Dubbs H, Shaw JE, Pisani L, Myers CT, Tang S, Tang S, Pal DK, Millichap JJ, Carvill GL, Helbig KL, Mecarelli O, Striano P, Helbig I, Rubboli G, Mefford HC, Møller RS. Defining the phenotypic spectrum of SLC6A1 mutations. Epilepsia. 2018 Feb; 59(2):389-402. View abstract
  8. Rodan LH, Aldubayan SH, Berry GT, Levy HL. Acute Illness Protocol for Maple Syrup Urine Disease. Pediatr Emerg Care. 2018 Jan; 34(1):64-67. View abstract
  9. Sacharow SJ, Dudenhausen EE, Lomelino CL, Rodan L, El Achkar CM, Olson HE, Genetti CA, Agrawal PB, McKenna R, Kilberg MS. Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency. Mol Genet Metab. 2018 Mar; 123(3):317-325. View abstract
  10. Ebrahimi-Fakhari D, Hildebrandt C, Davis PE, Rodan LH, Anselm I, Bodamer O. The Spectrum of Movement Disorders in Childhood-Onset Lysosomal Storage Diseases. Mov Disord Clin Pract. 2018 Mar-Apr; 5(2):149-155. View abstract
  11. Peake RWA, Rodan LH. Ethylmalonic Aciduria in an Infant with Neurological and Skin Presentation. Clin Chem. 2017 Nov; 63(11):1771-1773. View abstract
  12. Rajabi F, Rodan LH, Jonas MM, Soul JS, Ullrich NJ, Wessel A, Waisbren SE, Tan WH, Berry GT. Liver Failure as the Presentation of Ornithine Transcarbamylase Deficiency in a 13-Month-Old Female. JIMD Rep. 2018; 40:17-22. View abstract
  13. Wojcik MH, Wierenga KJ, Rodan LH, Sahai I, Ferdinandusse S, Genetti CA, Towne MC, Peake RWA, James PM, Beggs AH, Brownstein CA, Berry GT, Agrawal PB. Beta-Ketothiolase Deficiency Presenting with Metabolic Stroke After a Normal Newborn Screen in Two Individuals. JIMD Rep. 2018; 39:45-54. View abstract
  14. Guerriero RM, Patel AA, Walsh B, Baumer FM, Shah AS, Peters JM, Rodan LH, Agrawal PB, Pearl PL, Takeoka M. Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. Pediatr Neurol. 2017 Nov; 76:47-53. View abstract
  15. Peake RWA, Rodan LH. Raised Anion Gap Metabolic Acidosis in a 4-Day-Old Child. Clin Chem. 2017 Jun; 63(6):1171-1173. View abstract
  16. Aldubayan SH, Rodan LH, Berry GT, Levy HL. Acute Illness Protocol for Fatty Acid Oxidation and Carnitine Disorders. Pediatr Emerg Care. 2017 Apr; 33(4):296-301. View abstract
  17. Aldubayan SH, Rodan LH, Berry GT, Levy HL. Acute Illness Protocol for Organic Acidemias: Methylmalonic Acidemia and Propionic Acidemia. Pediatr Emerg Care. 2017 Feb; 33(2):142-146. View abstract
  18. Rodan LH, Cohen J, Fatemi A, Gillis T, Lucente D, Gusella J, Picker JD. A novel neurodevelopmental disorder associated with compound heterozygous variants in the huntingtin gene. Eur J Hum Genet. 2016 12; 24(12):1833. View abstract
  19. Rodan LH, El Achkar CM, Berry GT, Poduri A, Prabhu SP, Yang E, Anselm I. De Novo TUBB2A Variant Presenting With Anterior Temporal Pachygyria. J Child Neurol. 2017 01; 32(1):127-131. View abstract
  20. Rodan LH, Cohen J, Fatemi A, Gillis T, Lucente D, Gusella J, Picker JD. A novel neurodevelopmental disorder associated with compound heterozygous variants in the huntingtin gene. Eur J Hum Genet. 2016 12; 24(12):1826-1827. View abstract
  21. Beinvogl BC, Rosman NP, Baumer FM, Rodan LH, Forster CS, Kwon AH, Berry GT. A 10-Month-Old With Intermittent Hypotonia and Paralysis. Pediatrics. 2016 07; 138(1). View abstract
  22. Prabhakara J, Rodan L, Peake RW. Now You See It, Now You Don't: Unidentified Plasma Amino Acid Peak. Clin Chem. 2016 05; 62(5):781-2. View abstract
  23. Rodan LH, Berry GT. N-Acetylcysteine Therapy in an Infant with Transaldolase Deficiency Is Well Tolerated and Associated with Normalization of Alpha Fetoprotein Levels. JIMD Rep. 2017; 31:73-77. View abstract
  24. Dy ME, Chang FC, Jesus SD, Anselm I, Mahant N, Zeilman P, Rodan LH, Foote KD, Tan WH, Eskandar E, Sharma N, Okun MS, Fung VS, Waugh JL. Treatment of ADCY5-Associated Dystonia, Chorea, and Hyperkinetic Disorders With Deep Brain Stimulation: A Multicenter Case Series. J Child Neurol. 2016 07; 31(8):1027-35. View abstract
  25. Lamont RE, Tan WH, Innes AM, Parboosingh JS, Schneidman-Duhovny D, Rajkovic A, Pappas J, Altschwager P, DeWard S, Fulton A, Gray KJ, Krall M, Mehta L, Rodan LH, Saller DN, Steele D, Stein D, Yatsenko SA, Bernier FP, Slavotinek AM. Expansion of phenotype and genotypic data in CRB2-related syndrome. Eur J Hum Genet. 2016 10; 24(10):1436-44. View abstract
  26. Rodan LH, Zak M, Stavropoulos J, Joseph-George AM, Minassian BA. Co-occurrence of 16p13.11 microdeletion and ring chromosome 20 syndrome. Neurol Genet. 2016 Feb; 2(1):e43. View abstract
  27. Yang H, Douglas G, Monaghan KG, Retterer K, Cho MT, Escobar LF, Tucker ME, Stoler J, Rodan LH, Stein D, Marks W, Enns GM, Platt J, Cox R, Wheeler PG, Crain C, Calhoun A, Tryon R, Richard G, Vitazka P, Chung WK. De novo truncating variants in the AHDC1 gene encoding the AT-hook DNA-binding motif-containing protein 1 are associated with intellectual disability and developmental delay. Cold Spring Harb Mol Case Stud. 2015 Oct; 1(1):a000562. View abstract
  28. Brownstein CA, Beggs AH, Rodan L, Shi J, Towne MC, Pelletier R, Cao S, Rosenberg PA, Urion DK, Picker J, Tan WH, Agrawal PB. Clinical heterogeneity associated with KCNA1 mutations include cataplexy and nonataxic presentations. Neurogenetics. 2016 Jan; 17(1):11-6. View abstract
  29. Rodan LH, Gibson KM, Pearl PL. Clinical Use of CSF Neurotransmitters. Pediatr Neurol. 2015 Oct; 53(4):277-86. View abstract
  30. Rodan LH, Wells GD, Banks L, Thompson S, Schneiderman JE, Tein I. L-Arginine Affects Aerobic Capacity and Muscle Metabolism in MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes) Syndrome. PLoS One. 2015; 10(5):e0127066. View abstract
  31. Rodan LH, Poublanc J, Fisher JA, Sobczyk O, Wong T, Hlasny E, Mikulis D, Tein I. Cerebral hyperperfusion and decreased cerebrovascular reactivity correlate with neurologic disease severity in MELAS. Mitochondrion. 2015 May; 22:66-74. View abstract
  32. Rodan LH, Tein I, Buncic R. Clinical reasoning: a case of abnormal eye movements in an infant: more than meets the eye. Neurology. 2013 Oct 08; 81(15):e112-5. View abstract
  33. Mishra N, Rodan LH, Nita DA, Gresa-Arribas N, Kobayashi J, Benseler SM. Anti-glutamic Acid decarboxylase antibody associated limbic encephalitis in a child: expanding the spectrum of pediatric inflammatory brain diseases. J Child Neurol. 2014 May; 29(5):677-83. View abstract
  34. Rodan LH, Mishra N, Tein I. MR spectroscopy in pediatric Wernicke encephalopathy. Neurology. 2013 Mar 05; 80(10):969. View abstract
  35. Rodan LH, Mishra N, Yau I, Andrade A, Siriwardena K, Tein I. Expanding the Spectrum of Methylmalonic Acid-Induced Pallidal Stroke: First Reported Case of Metabolic Globus Pallidus Stroke in Transcobalamin II Deficiency. JIMD Rep. 2013; 11:7-11. View abstract
  36. Soon GS, Rodan LH, Laughlin S, Laxer RM, Benseler S, Silverman ED. Reversible splenial lesion syndrome in pediatric systemic lupus erythematosus. J Rheumatol. 2012 Aug; 39(8):1698-9. View abstract
  37. Rodan L, Tein I. Clinical reasoning: encephalopathy in a 10-year-old boy. Neurology. 2012 Jul 17; 79(3):e12-8. View abstract
  38. Rodan L, McCrindle BW, Manlhiot C, MacGregor DL, Askalan R, Moharir M, deVeber G. Stroke recurrence in children with congenital heart disease. Ann Neurol. 2012 Jul; 72(1):103-11. View abstract
  39. Gladstone DJ, Rodan LH, Sahlas DJ, Lee L, Murray BJ, Ween JE, Perry JR, Chenkin J, Morrison LJ, Beck S, Black SE. A citywide prehospital protocol increases access to stroke thrombolysis in Toronto. Stroke. 2009 Dec; 40(12):3841-4. View abstract
  40. Rodan LH, Aviv RI, Sahlas DJ, Murray BJ, Gladstone JP, Gladstone DJ. Seizures during stroke thrombolysis heralding dramatic neurologic recovery. Neurology. 2006 Dec 12; 67(11):2048-9. View abstract