Research Overview

Dr. Randolph currently leads a 27 center NIH funded study evaluating the immune response to life-threatening and fatal influenza in children. In this study we are investigating the mechanisms underlying disease susceptibility and severity including interferon regulatory pathways, bacterial coinfection with a focus on Staphlococcus aureus, and host genetic susceptibility. The ultimate goal of this research is to identify new therapeutic targets to decrease morbidity and mortality from severe influenza infection. Dr. Randolph also leads studies of influenza vaccine effectiveness in preventing influenza-related critical illness, funded by the CDC Influenza Division and other sources. Dr. Randolph follows a large cohort of children hospitalized for bronchiolitis in infancy caused by respiratory syncytial virus (RSV) with the goal of identifying immunoregulatory genes underlying disease susceptibility.

About Adrienne Randolph

Dr. Randolph is the founder and first Chair of the Pediatric Acute Lung Injury and Sepsis Investigator’s (PALISI) Network, a clinical research consortium of over 80 pediatric ICUs in the U.S. and Canada. Dr. Randolph is a Council member of the International Sepsis Forum and is also active in many other professional societies including the Society for Critical Care Medicine and the American Thoracic Society. She has published numerous multicenter trials, cohort studies and clinical practice guidelines in the area of sepsis and acute lung failure in children. She has received multiple grants to study life-threatening and fatal influenza infection and leads a 40-center Pediatric Critical Care Influenza (PICFlu) Study Group.

Key Publications

Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert K, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children - A randomized controlled trial. Journal of the American Medical Association 2002; 288: 2561-88.

Randolph AG, Gonzales CA, Cortellini L, Yeh TS. Growth of pediatric intensive care units in the United States from 1995 to 2001. Journal of Pediatrics 2004; 144: 792-98

Guidelines for the prevention of intravascular catheter-related infections - art. no. e51. Pediatrics 2002; 110: E51.

Randolph AG, Lange C, Silverman EK, Lazarus R, Silverman ES, Raby B, Brown A, Ozonoff A, Richter B, Weiss ST. IL12B gene is associated with asthma. Am J Hum Genet 2004:75;709-715.

Researcher Services

Researcher Areas

  • Adrienne Randolph

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Randolph AG, Xu R, Novak T, Newhams MM, Bubeck Wardenburg J, Weiss SL, Sanders RC, Thomas NJ, Hall MW, Tarquinio KM, Cvijanovich N, Gedeit RG, Truemper EJ, Markovitz B, Hartman ME, Ackerman KG, Giuliano JS, Shein SL, Moffitt K. Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children with Influenza-Related Critical Illness. Clin Infect Dis. 2018 Jun 09. View abstract
  2. Fiore-Gartland A, Panoskaltsis-Mortari A, Agan AA, Mistry AJ, Thomas PG, Matthay MA, Hertz T, Randolph AG. Cytokine Profiles of Severe Influenza Virus-Related Complications in Children. Front Immunol. 2017; 8:1423. View abstract
  3. Randolph AG. A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? Am J Respir Crit Care Med. 2017 08 15; 196(4):411-413. View abstract
  4. Allen EK, Randolph AG, Bhangale T, Dogra P, Ohlson M, Oshansky CM, Zamora AE, Shannon JP, Finkelstein D, Dressen A, DeVincenzo J, Caniza M, Youngblood B, Rosenberger CM, Thomas PG. SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans. Nat Med. 2017 Aug; 23(8):975-983. View abstract
  5. Geva A, Landrigan CP, van der Velden MG, Randolph AG. Simulation of a Novel Schedule for Intensivist Staffing to Improve Continuity of Patient Care and Reduce Physician Burnout. Crit Care Med. 2017 Jul; 45(7):1138-1144. View abstract
  6. Randolph AG, Yip WK, Allen EK, Rosenberger CM, Agan AA, Ash SA, Zhang Y, Bhangale TR, Finkelstein D, Cvijanovich NZ, Mourani PM, Hall MW, Su HC, Thomas PG. Evaluation of IFITM3 rs12252 Association With Severe Pediatric Influenza Infection. J Infect Dis. 2017 07 01; 216(1):14-21. View abstract
  7. Randolph AG. Why So Few Randomized Trials in Pediatric Critical Care Medicine? Ask the Trialists. Pediatr Crit Care Med. 2017 May; 18(5):486-487. View abstract
  8. Madsen EC, Levy ER, Madden K, Agan AA, Sullivan RM, Graham DA, Randolph AG. Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections. Pediatr Crit Care Med. 2017 Feb; 18(2):103-111. View abstract
  9. Levy E, Zinter M, Madden K, Randolph A. 1444: MANNOSE-BINDING LECTIN AND PEDIATRIC SEPSIS SUSCEPTIBILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS. Crit Care Med. 2016 Dec; 44(12 Suppl 1):436. View abstract
  10. Shein S, Kong M, McKee B, O'Riordan M, Randolph A. 933: ASSOCIATIONS BETWEEN PNEUMONIA AND CLINICAL OUTCOMES IN PICU PATIENTS WITH RSV BRONCHIOLITIS. Crit Care Med. 2016 Dec; 44(12 Suppl 1):309. View abstract
  11. Randolph AG. Enterovirus D68 Reemerges Globally as a Severe Pathogen Targeting Children. Pediatr Crit Care Med. 2016 11; 17(11):1088-1089. View abstract
  12. Roumeliotis N, Ducruet T, Bateman ST, Randolph AG, Lacroix J, Emeriaud G. Determinants of red blood cell transfusion in pediatric trauma patients admitted to the intensive care unit. Transfusion. 2017 01; 57(1):187-194. View abstract
  13. Yu KO, Randolph AG, Agan AA, Yip WK, Truemper EJ, Weiss SL, Ackerman KG, Schwarz AJ, Giuliano JS, Hall MW, Bubeck Wardenburg J. Staphylococcus aureus a-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children. J Infect Dis. 2016 Dec 01; 214(11):1638-1646. View abstract
  14. Choong K, Duffett M, Cook DJ, Randolph AG. The Impact of Clinical Trials Conducted by Research Networks in Pediatric Critical Care. Pediatr Crit Care Med. 2016 09; 17(9):837-44. View abstract
  15. Skeens MA, McArthur J, Cheifetz IM, Duncan C, Randolph AG, Stanek J, Lehman L, Bajwa R. High Variability in the Reported Management of Hepatic Veno-Occlusive Disease in Children after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 10; 22(10):1823-1828. View abstract
  16. Tasker RC, Randolph AG. The authors reply. Pediatr Crit Care Med. 2016 06; 17(6):583-4. View abstract
  17. Lee J, Faraoni D, Lee S, Brown M, Odegard K, Randolph A, DiNardo JA, Yuki K. Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children. Paediatr Anaesth. 2016 Jun; 26(6):644-8. View abstract
  18. Randolph AG, Agan AA, Flanagan RF, Meece JK, Fitzgerald JC, Loftis LL, Truemper EJ, Li S, Ferdinands JM. Optimizing Virus Identification in Critically Ill Children Suspected of Having an Acute Severe Viral Infection. Pediatr Crit Care Med. 2016 Apr; 17(4):279-86. View abstract
  19. Randolph AG. Pragmatic trials in critically ill children are CATCHing on. Lancet. 2016 Apr 23; 387(10029):1697-8. View abstract
  20. Zgleszewski SE, Graham DA, Hickey PR, Brustowicz RM, Odegard KC, Koka R, Seefelder C, Navedo AT, Randolph AG. Anesthesiologist- and System-Related Risk Factors for Risk-Adjusted Pediatric Anesthesia-Related Cardiac Arrest. Anesth Analg. 2016 Feb; 122(2):482-9. View abstract
  21. Tasker RC, Randolph AG. Severity-of-Illness Scoring in Pediatric Critical Care: Quo Vadis? Pediatr Crit Care Med. 2016 Jan; 17(1):83-5. View abstract
  22. Torgerson DG, Giri T, Druley TE, Zheng J, Huntsman S, Seibold MA, Young AL, Schweiger T, Yin-Declue H, Sajol GD, Schechtman KB, Hernandez RD, Randolph AG, Bacharier LB, Castro M. Pooled Sequencing of Candidate Genes Implicates Rare Variants in the Development of Asthma Following Severe RSV Bronchiolitis in Infancy. PLoS One. 2015; 10(11):e0142649. View abstract
  23. Madden K, Feldman HA, Chun RF, Smith EM, Sullivan RM, Agan AA, Keisling SM, Panoskaltsis-Mortari A, Randolph AG. Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D. Ann Am Thorac Soc. 2015 Nov; 12(11):1654-61. View abstract
  24. Geva A, Tasker RC, Randolph AG. Therapeutic Hypothermia in Children. N Engl J Med. 2015 09 03; 373(10):979. View abstract
  25. Tasker RC, Randolph AG. Pediatric Pulseless Arrest With "Nonshockable" Rhythm: Does Faster Time to Epinephrine Improve Outcome? JAMA. 2015 Aug 25; 314(8):776-7. View abstract
  26. Yealy DM, Huang DT, Delaney A, Knight M, Randolph AG, Daniels R, Nutbeam T. Recognizing and managing sepsis: what needs to be done? BMC Med. 2015 Apr 27; 13:98. View abstract
  27. Randolph AG. The tremendous burden of sepsis on China's youngest children. Pediatr Crit Care Med. 2014 Nov; 15(9):896-7. View abstract
  28. Higgerson RA, Olsho LE, Christie LM, Rehder K, Doksum T, Gedeit R, Giuliano JS, Brennan B, Wendlandt R, Randolph AG. Variability in IRBs regarding parental acceptance of passive consent. Pediatrics. 2014 Aug; 134(2):e496-503. View abstract
  29. Randolph AG, Kornetsky S. More consistent site institutional review board (IRB) input-more consistent site IRB output. Crit Care Med. 2014 May; 42(5):1292-3. View abstract
  30. Faustino EV, Hanson S, Spinella PC, Tucci M, O'Brien SH, Nunez AR, Yung M, Truemper E, Qin L, Li S, Marohn K, Randolph AG. A multinational study of thromboprophylaxis practice in critically ill children. Crit Care Med. 2014 May; 42(5):1232-40. View abstract
  31. Ferdinands JM, Olsho LE, Agan AA, Bhat N, Sullivan RM, Hall M, Mourani PM, Thompson M, Randolph AG. Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012. J Infect Dis. 2014 Sep 01; 210(5):674-83. View abstract
  32. Randolph AG, Yip WK, Falkenstein-Hagander K, Weiss ST, Janssen R, Keisling S, Bont L. Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis. Clin Exp Allergy. 2014 Feb; 44(2):231-7. View abstract
  33. Goldstein B, Randolph AG. The authors reply. Pediatr Crit Care Med. 2014 Feb; 15(2):183. View abstract
  34. Valentine SL, Lightdale JR, Tran CM, Jiang H, Sloan SR, Kleinman ME, Randolph AG. Assessment of hemoglobin threshold for packed RBC transfusion in a medical-surgical PICU. Pediatr Crit Care Med. 2014 Feb; 15(2):e89-94. View abstract
  35. Randolph AG. Rigorous scoping review of randomized trials in pediatric critical care highlights need for a rigorous rethink. Crit Care. 2013 Dec 20; 17(6):1024. View abstract
  36. Randolph AG, McCulloh RJ. Pediatric sepsis: important considerations for diagnosing and managing severe infections in infants, children, and adolescents. Virulence. 2014 Jan 01; 5(1):179-89. View abstract
  37. Carcillo JA, Randolph AG, Hazelzet JA, Dellinger RP. The authors reply. Crit Care Med. 2013 Oct; 41(10):e295. View abstract
  38. Santschi M, Randolph AG, Rimensberger PC, Jouvet P. Mechanical ventilation strategies in children with acute lung injury: a survey on stated practice pattern*. Pediatr Crit Care Med. 2013 Sep; 14(7):e332-7. View abstract
  39. Valentine S, Sapru A, Randolph A. The authors reply. Crit Care Med. 2013 May; 41(5):e49. View abstract
  40. Hall MW, Geyer SM, Guo CY, Panoskaltsis-Mortari A, Jouvet P, Ferdinands J, Shay DK, Nateri J, Greathouse K, Sullivan R, Tran T, Keisling S, Randolph AG. Innate immune function and mortality in critically ill children with influenza: a multicenter study. Crit Care Med. 2013 Jan; 41(1):224-36. View abstract
  41. Eriksson CO, Graham DA, Uyeki TM, Randolph AG. Risk factors for mechanical ventilation in U.S. children hospitalized with seasonal influenza and 2009 pandemic influenza A*. Pediatr Crit Care Med. 2012 Nov; 13(6):625-31. View abstract
  42. Thomas NJ, Guardia CG, Moya FR, Cheifetz IM, Markovitz B, Cruces P, Barton P, Segal R, Simmons P, Randolph AG. A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure. Pediatr Crit Care Med. 2012 Nov; 13(6):646-53. View abstract
  43. Valentine SL, Sapru A, Higgerson RA, Spinella PC, Flori HR, Graham DA, Brett M, Convery M, Christie LM, Karamessinis L, Randolph AG. Fluid balance in critically ill children with acute lung injury. Crit Care Med. 2012 Oct; 40(10):2883-9. View abstract
  44. Madden K, Feldman HA, Smith EM, Gordon CM, Keisling SM, Sullivan RM, Hollis BW, Agan AA, Randolph AG. Vitamin D deficiency in critically ill children. Pediatrics. 2012 Sep; 130(3):421-8. View abstract
  45. Rice TW, Rubinson L, Uyeki TM, Vaughn FL, John BB, Miller RR, Higgs E, Randolph AG, Smoot BE, Thompson BT. Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States. Crit Care Med. 2012 May; 40(5):1487-98. View abstract
  46. Lightdale JR, Randolph AG, Tran CM, Jiang H, Colon A, Houlahan K, Billet A, Sloan S, Lehmann LE. Impact of a conservative red blood cell transfusion strategy in children undergoing hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2012 May; 18(5):813-7. View abstract
  47. Randolph AG, Vaughn F, Sullivan R, Rubinson L, Thompson BT, Yoon G, Smoot E, Rice TW, Loftis LL, Helfaer M, Doctor A, Paden M, Flori H, Babbitt C, Graciano AL, Gedeit R, Sanders RC, Giuliano JS, Zimmerman J, Uyeki TM. Critically ill children during the 2009-2010 influenza pandemic in the United States. Pediatrics. 2011 Dec; 128(6):e1450-8. View abstract
  48. Faustino EV, Patel S, Thiagarajan RR, Cook DJ, Northrup V, Randolph AG. Survey of pharmacologic thromboprophylaxis in critically ill children. Crit Care Med. 2011 Jul; 39(7):1773-8. View abstract
  49. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph AG, Rupp ME, Saint S. Guidelines for the prevention of intravascular catheter-related infections. Am J Infect Control. 2011 May; 39(4 Suppl 1):S1-34. View abstract
  50. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph AG, Rupp ME, Saint S. Summary of recommendations: Guidelines for the Prevention of Intravascular Catheter-related Infections. Clin Infect Dis. 2011 May; 52(9):1087-99. View abstract
  51. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph AG, Rupp ME, Saint S. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 2011 May; 52(9):e162-93. View abstract
  52. Massicotte MP, Randolph A, Bauman M. Central venous line thromboprophylaxis: transforming "experience-based care" into "evidence-based care". J Intensive Care Med. 2011 Sep-Oct; 26(5):341-2. View abstract
  53. Santschi M, Jouvet P, Leclerc F, Gauvin F, Newth CJ, Carroll CL, Flori H, Tasker RC, Rimensberger PC, Randolph AG. Acute lung injury in children: therapeutic practice and feasibility of international clinical trials. Pediatr Crit Care Med. 2010 Nov; 11(6):681-9. View abstract
  54. Wylie MC, Graham DA, Potter-Bynoe G, Kleinman ME, Randolph AG, Costello JM, Sandora TJ. Risk factors for central line-associated bloodstream infection in pediatric intensive care units. Infect Control Hosp Epidemiol. 2010 Oct; 31(10):1049-56. View abstract
  55. Ventre K, Randolph A. WITHDRAWN: Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children. Cochrane Database Syst Rev. 2010 May 12; (5):CD000181. View abstract
  56. Karam O, Tucci M, Bateman ST, Ducruet T, Spinella PC, Randolph AG, Lacroix J. Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study. Crit Care. 2010; 14(2):R57. View abstract
  57. Fowler RA, Webb SA, Rowan KM, Sprung CL, Thompson BT, Randolph AG, Jouvet P, Lapinsky S, Rubinson L, Rello J, Cobb JP, Rice TW, Uyeki T, Marshall JC. Early observational research and registries during the 2009-2010 influenza A pandemic. Crit Care Med. 2010 Apr; 38(4 Suppl):e120-32. View abstract
  58. Khemani RG, Randolph A, Markovitz B. Steroids for post extubation stridor: pediatric evidence is still inconclusive. Intensive Care Med. 2010 Jul; 36(7):1276-7. View abstract
  59. Spragg RG, Bernard GR, Checkley W, Curtis JR, Gajic O, Guyatt G, Hall J, Israel E, Jain M, Needham DM, Randolph AG, Rubenfeld GD, Schoenfeld D, Thompson BT, Ware LB, Young D, Harabin AL. Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med. 2010 May 15; 181(10):1121-7. View abstract
  60. Herscu P, Hoover TA, Randolph AG. Clinical prediction rules: new opportunities for pharma. Drug Discov Today. 2009 Dec; 14(23-24):1143-9. View abstract
  61. Halpern SD, Randolph AG, Angus DC. No child left behind: Enrolling children and adults simultaneously in critical care randomized trials. Crit Care Med. 2009 Sep; 37(9):2638-41. View abstract
  62. Randolph AG. Management of acute lung injury and acute respiratory distress syndrome in children. Crit Care Med. 2009 Aug; 37(8):2448-54. View abstract
  63. Khemani RG, Randolph A, Markovitz B. Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev. 2009 Jul 08; (3):CD001000. View abstract
  64. Randolph AG. The unique challenges of enrolling patients into multiple clinical trials. Crit Care Med. 2009 Jan; 37(1 Suppl):S107-11. View abstract
  65. Calhoun AW, Guyatt GH, Cabana MD, Lu D, Turner DA, Valentine S, Randolph AG. Addressing the unit of analysis in medical care studies: a systematic review. Med Care. 2008 Jun; 46(6):635-43. View abstract
  66. Bateman ST, Lacroix J, Boven K, Forbes P, Barton R, Thomas NJ, Jacobs B, Markovitz B, Goldstein B, Hanson JH, Li HA, Randolph AG. Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. Am J Respir Crit Care Med. 2008 Jul 01; 178(1):26-33. View abstract
  67. Markovitz BP, Randolph AG, Khemani RG. Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev. 2008 Apr 16; (2):CD001000. View abstract
  68. Waisbren SE, Bowles H, Hasan T, Zou KH, Emans SJ, Goldberg C, Gould S, Levine D, Lieberman E, Loeken M, Longtine J, Nadelson C, Patenaude AF, Quinn D, Randolph AG, Solet JM, Ullrich N, Walensky R, Weitzman P, Christou H. Gender differences in research grant applications and funding outcomes for medical school faculty. J Womens Health (Larchmt). 2008 Mar; 17(2):207-14. View abstract
  69. Randolph AG, Ogawa S. The financial impact of underestimating personnel needs associated with implementing a computerized patient record in the intensive care unit. J Crit Care. 2007 Mar; 22(1):34-9. View abstract
  70. Ventre K, Randolph AG. Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children. Cochrane Database Syst Rev. 2007 Jan 24; (1):CD000181. View abstract
  71. Durall AL, Laussen PC, Randolph AG. Potential for donation after cardiac death in a children's hospital. Pediatrics. 2007 Jan; 119(1):e219-24. View abstract
  72. Duffett M, Choong K, Ng V, Randolph A, Cook DJ. Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis. Crit Care. 2007; 11(3):R66. View abstract
  73. Zhang Y, Silvers CT, Randolph AG. Real-time evaluation of patient monitoring algorithms for critical care at the bedside. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:2783-6. View abstract
  74. Randolph AG, Forbes PW, Gedeit RG, Arnold JH, Wetzel RC, Luckett PM, O'Neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH. Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. Pediatr Crit Care Med. 2005 Nov; 6(6):642-7. View abstract
  75. Randolph AG, Lange C, Silverman EK, Lazarus R, Weiss ST. Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes. Am J Respir Crit Care Med. 2005 Sep 15; 172(6):687-92. View abstract
  76. Randolph AG, Brun-Buisson C, Goldmann D. Identification of central venous catheter-related infections in infants and children. Pediatr Crit Care Med. 2005 May; 6(3 Suppl):S19-24. View abstract
  77. Vitali SH, Randolph AG. Assessing the quality of case-control association studies on the genetic basis of sepsis. Pediatr Crit Care Med. 2005 May; 6(3 Suppl):S74-7. View abstract
  78. Dahmer MK, Randolph A, Vitali S, Quasney MW. Genetic polymorphisms in sepsis. Pediatr Crit Care Med. 2005 May; 6(3 Suppl):S61-73. View abstract
  79. Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005 Jan; 6(1):2-8. View abstract
  80. Randolph AG, Reder L, Englund JA. Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit. Pediatr Infect Dis J. 2004 Nov; 23(11):990-4. View abstract
  81. Ventre K, Randolph A. Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children. Cochrane Database Syst Rev. 2004 Oct 18; (4):CD000181. View abstract
  82. Al-Majed SI, Thompson JE, Watson KF, Randolph AG. Effect of lung compliance and endotracheal tube leakage on measurement of tidal volume. Crit Care. 2004 Dec; 8(6):R398-402. View abstract
  83. Davison C, Ventre KM, Luchetti M, Randolph AG. Efficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta-analysis. Pediatr Crit Care Med. 2004 Sep; 5(5):482-9. View abstract
  84. Randolph AG, Lange C, Silverman EK, Lazarus R, Silverman ES, Raby B, Brown A, Ozonoff A, Richter B, Weiss ST. The IL12B gene is associated with asthma. Am J Hum Genet. 2004 Oct; 75(4):709-15. View abstract
  85. Randolph AG, Gonzales CA, Cortellini L, Yeh TS. Growth of pediatric intensive care units in the United States from 1995 to 2001. J Pediatr. 2004 Jun; 144(6):792-8. View abstract
  86. Venkataraman S, Randolph A, Hanson J, Forbes P, Cheifetz I, Gedeit R, Luckett P. All roses are flowers, but not all flowers are roses. Am J Respir Crit Care Med. 2004 Apr 15; 169(8):969. View abstract
  87. Randolph AG. How are children mechanically ventilated in pediatric intensive care units? Intensive Care Med. 2004 May; 30(5):746-7. View abstract
  88. Lyon H, Lange C, Lake S, Silverman EK, Randolph AG, Kwiatkowski D, Raby BA, Lazarus R, Weiland KM, Laird N, Weiss ST. IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol. 2004 Feb; 26(2):155-65. View abstract
  89. Lyon H, Lange C, Lake S, Silverman EK, Randolph AG, Kwiatkowski D, Raby BA, Lazarus R, Weiland KM, Laird N, Weiss ST. IL-10 gene polymorphisms are associated with asthma phenotypes in children. Genetic Edidemiol. 2004; 26:155-65. View abstract
  90. Al-Majed SI, Thompson JE, Watson KF, Randolph AG. Effect of endotracheal tube leak and lung compliance on measurement of tidal volume in children. Citical Care. 2004; 8:398-402. View abstract
  91. Goldstein B, Giroir B, Randolph A. . International Pediatric Sepsis Consensus Conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med, in press. 2004. View abstract
  92. Randolph AG. How are children mechanically ventilated in PICUs?. Intensive Care Med. 2004; 30:746. View abstract
  93. Randolph AG. A practical approach to evidence-based medicine: lessons learned from developing ventilator management protocols. Crit Care Clin. 2003 Jul; 19(3):515-27. View abstract
  94. Randolph AG. Central line complications in an infant. AHRQ Web M&M Spotlight Commentary. 2003; (http://webmm.ahrq.gov). View abstract
  95. Nicholson CE, Gans BM, Chang AC, Pollack MM, Blackman J, Giroir BP, Wilson D, Zimmerman JJ, Whyte J, Dalton HJ, Carcillo JA, Randolph AG, Kochanek PM. Pediatric critical care medicine: planning for our research future. Pediatr Crit Care Med. 2003 Apr; 4(2):196-202. View abstract
  96. Randolph AG, Meert KL, O'Neil ME, Hanson JH, Luckett PM, Arnold JH, Gedeit RG, Cox PN, Roberts JS, Venkataraman ST, Forbes PW, Cheifetz IM. The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Respir Crit Care Med. 2003 May 15; 167(10):1334-40. View abstract
  97. Randolph AG, Meert KL, O’Neil ME, Hanson JH, Luckett PM, Arnold JH, Gedeit RG, Cox PN, Roberts JS, Venkataraman ST, Forbes PW, Cheifetz IM. for the Pediatric Acute Lung Injury and Sepsis Investigator’s Network. The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Resp Crit Care Med. 2003; 167:1334-40. View abstract
  98. Cooper M, Randolph AG. Preventing central venous catheter-related complications. In Evidence-Based Resource in Anaesthesia and Analgesia, Editor: Martin R. Tramer. BMJ Books, London UK. 2003; 126-139. View abstract
  99. Randolph AG, Lange C, Silverman EK, Weiss ST. Association between IL12B polymorphisms in the CAMP study. Amer J Resp Crit Care Med. 2003; 167:A750. View abstract
  100. O'grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, Masur H, McCormick RD, Mermel LA, Pearson ML, Raad II, Randolph A, Weinstein RA. Guidelines for the prevention of intravascular catheter-related infections. Am J Infect Control. 2002 Dec; 30(8):476-89. View abstract
  101. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, Masur H, McCormick RD, Mermel LA, Pearson ML, Raad II, Randolph A, Weinstein RA. Guidelines for the prevention of intravascular catheter-related infections. Infect Control Hosp Epidemiol. 2002 Dec; 23(12):759-69. View abstract
  102. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, Masur H, McCormick RD, Mermel LA, Pearson ML, Raad II, Randolph A, Weinstein RA. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 2002 Dec 1; 35(11):1281-307. View abstract
  103. Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA. 2002 Nov 27; 288(20):2561-8. View abstract
  104. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, Masur H, McCormick RD, Mermel LA, Pearson ML, Raad II, Randolph A, Weinstein RA. Guidelines for the prevention of intravascular catheter-related infections. The Hospital Infection Control Practices Advisory Committee, Center for Disease Control and Prevention, U.S. Pediatrics. 2002 Nov; 110(5):e51. View abstract
  105. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, Masur H, McCormick RD, Mermel LA, Pearson ML, Raad II, Randolph A, Weinstein RA. Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention. MMWR Recomm Rep. 2002 Aug 09; 51(RR-10):1-29. View abstract
  106. Randolph AG. What underlies race and sex differences in acute respiratory distress syndrome-associated mortality? Crit Care Med. 2002 Aug; 30(8):1907-9. View abstract
  107. Markovitz BP, Randolph AG. Corticosteroids for the prevention of reintubation and postextubation stridor in pediatric patients: A meta-analysis. Pediatr Crit Care Med. 2002 Jul; 3(3):223-226. View abstract
  108. Randolph AG. Mining for the genetic determinants of septic shock: when is it really gold? Crit Care Med. 2002 May; 30(5):1161-3. View abstract
  109. Randolph AG, Lacroix J. Randomized clinical trials in pediatric critical care: Rarely done but desperately needed. Pediatr Crit Care Med. 2002 Apr; 3(2):102-106. View abstract
  110. Randolph AG, Pronovost P. Reorganizing the delivery of intensive care could improve efficiency and save lives. J Eval Clin Pract. 2002 Feb; 8(1):1-8. View abstract
  111. Al-Majed S, Thompson JE, Watson KF, Palmer L, Randolph AG. Measured tidal volume is influenced by lung compliance. Amer J Resp Crit Care Med. 2002; 165:A376. View abstract
  112. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, Masur H, McCormick RD, Mermel LA, Pearson ML, Raad II, Randolph A, Weinstein RA. . Guidelines for the prevention of intravascular catheter-related infections. Pediatrics. 2002; 110:e51. View abstract
  113. Randolph AG. What underlies racial and gender differences in ARDS-associated mortality?. Crit Care Med. 2002; 3:1907-1909. View abstract
  114. Randolph AG, Pronovost P. Reorganising the delivery of intensive care could improve efficiency and save lives. J Eval Clin Practice. 2002; 8:1-8. View abstract
  115. Markovitz B, Randolph AG. Corticosteroids for the prevention of reintubation and post-extubation stridor in pediatric patients: a meta-analysis. Pediatr Crit Care Med. 2002; 3:223-226. View abstract
  116. Randolph AG, Graham R. Measuring the health status of pediatric intensive care unit survivors. 2002 Yearbook of Intensive Care and Emergency Medicine, Ed. J.L. Vincent, in press. 2002. View abstract
  117. Randolph AG, Venkataraman ST, Gedeit R, Hanson JH, Meert K, Luckett PM, Arnold J, Lilley M, Thompson J, Cheifetz IM, Wetzel R, Cox P, Roberts J. for the Pediatric Acute Lung Injury and Sepsis Investigator’s Network. Weaning critically ill children from ventilator support: a randomized trial comparing two protocols to standard care. Amer J Resp Crit Care Med. 2002; 165:A156. View abstract
  118. Randolph AG. Upper gastrointestinal bleeding in the pediatric intensive care unit: clinically important but questionably preventable. Pediatr Crit Care Med. 2001 Oct; 2(4):349-50. View abstract
  119. Randolph A, Haynes B, Wyatt J, Cook D, Guyatt G. Therapy and validity: Computer Decision Support Systems. In: Guyatt G, Rennie D, editors. Users’ guides to the medical literature. Chicago: AMA Press. 2001; 291-308. View abstract
  120. Al-Majed SI, Thompson JE, Watson KF, Palmer L, Randolph AG. Tidal volume (VT) is most accurately measured at the endotracheal tube when lung compliance is poor. Crit Care Med. 2001; 29:A69. View abstract
  121. Davison C, Luchetti M, Randolph AG. Systematic review of treatments for critically ill infants with bronchiolitis. Crit Care Med. 2001; 29:A144. View abstract
  122. Randolph AG, Venkataraman S, Hanson J, Luckett P, Gedeit R, Meert K, Wetzel R, Cheifetz I, Cox P, Roberts J, Lilley M, Thompson J, Arnold J. Evaluation of a pediatric extubation readiness test. Crit Care Med. 2001; 29:A142. View abstract
  123. Randolph AG. Randomized clinical trials in pediatric critical care. 2001 Yearbook of Intensive Care and Emergency Medicine, Ed. J.-L. Vincent. 2001; 676-684. View abstract
  124. Randolph A, Bucher H, Richardson WS, Wells G, Tugwell P, Guyatt G. Prognosis. In: Guyatt G, Rennie D, editors. Users’ guides to the medical literature. Chicago: AMA Press. 2001; 141-54. View abstract
  125. Randolph AG, Wang EE. Ribavirin for respiratory syncytial virus infection of the lower respiratory tract. Cochrane Database Syst Rev. 2000; (2):CD000181. View abstract
  126. Markovitz BP, Randolph AG. Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev. 2000; (2):CD001000. View abstract
  127. Randolph AG, Haynes RB, Wyatt JC, Cook DJ, Guyatt GH. Users' Guides to the Medical Literature: XVIII. How to use an article evaluating the clinical impact of a computer-based clinical decision support system. JAMA. 1999 Jul 07; 282(1):67-74. View abstract
  128. Randolph AG. Reorganizing the delivery of intensive care may improve patient outcomes. JAMA. 1999 Apr 14; 281(14):1330-1. View abstract
  129. Randolph AG, Zollo MB, Egger MJ, Guyatt GH, Nelson RM, Stidham GL. Variability in physician opinion on limiting pediatric life support. Pediatrics. 1999 Apr; 103(4):e46. View abstract
  130. Truog RD, Robinson W, Randolph A, Morris A. Is informed consent always necessary for randomized, controlled trials? . N Engl J Med. 1999 Mar 11; 340(10):804-7. View abstract
  131. Markovitz B, Randolph AG. The Pediatric Critical Care Evidence-Based Internet Journal Club: interim evaluation. Crit Care Med. 1999; 27:A99. View abstract
  132. Ackerman KG, Creery D, Randolph AG. Outcome of out-of-hospital pediatric pulseless arrest. Crit Care Med. 1999; 27:A65. View abstract
  133. Randolph AG. Weaning from mechanical ventilation. New Horiz. 1999; 7:374-385. View abstract
  134. Randolph AG, Cook DJ. Antiseptic hub connectors reduce central venous catheter-related sepsis. Crit Care Med. 1999; 27:A141. View abstract
  135. Randolph AG, DeJonghe B, Merrer J, Cook DJ. Single versus multilumen central venous catheters: a critical appraisal of the infection risk. Crit Care Med. 1999; 27:A141. View abstract
  136. Bateman S, Randolph AG. Efficacy of continuous vs. intermittent furosemide. Crit Care Med. 1999; 27:A59. View abstract
  137. Randolph AG, Clemmer TP, East TD, Kinder AT, Orme JF, Wallace CJ, Morris AH. Evaluation of compliance with a computerized protocol: weaning from mechanical ventilator support using pressure support. Comput Methods Programs Biomed. 1998 Nov; 57(3):201-15. View abstract
  138. Randolph AG, Guyatt GH, Calvin JE, Doig G, Richardson WS. Understanding articles describing clinical prediction tools. Evidence Based Medicine in Critical Care Group. Crit Care Med. 1998 Sep; 26(9):1603-12. View abstract
  139. Randolph AG, Cook DJ, Gonzales CA, Brun-Buisson C. Tunneling short-term central venous catheters to prevent catheter-related infection: a meta-analysis of randomized, controlled trials. Crit Care Med. 1998 Aug; 26(8):1452-7. View abstract
  140. Randolph AG. An evidence-based approach to central venous catheter management to prevent catheter-related infection in critically ill patients. Crit Care Clin. 1998 Jul; 14(3):411-21. View abstract
  141. Randolph AG, Guyatt GH, Richardson WS. Prognosis in the intensive care unit: finding accurate and useful estimates for counseling patients. Crit Care Med. 1998 Apr; 26(4):767-72. View abstract
  142. Randolph AG, Guyatt GH, Carlet J. Understanding articles comparing outcomes among intensive care units to rate quality of care. Evidence Based Medicine in Critical Care Group. Crit Care Med. 1998 Apr; 26(4):773-81. View abstract
  143. Randolph AG, Cook DJ, Gonzales CA, Andrew M. Benefit of heparin in peripheral venous and arterial catheters: systematic review and meta-analysis of randomised controlled trials. BMJ. 1998 Mar 28; 316(7136):969-75. View abstract
  144. McGinn T, Randolph A, Richardson S, Sackett D. Clinical prediction guides. ACP J Club. 1998 Jan-Feb; 128(1):A14-5. View abstract
  145. Randolph AG, Kane J. Potential for meeting clinician information requirements in an intensive care unit (ICU) via the web. Proc AMIA Symp. 1998; 96-100. View abstract
  146. Randolph AG, Cook DJ, Gonzales CA, Andrew M. Benefit of heparin in central venous and pulmonary artery catheters: a meta-analysis of randomized controlled trials. Chest. 1998 Jan; 113(1):165-71. View abstract
  147. Randolph AG. An evidence based approach to central venous catheter management. Crit Care Clinics. 1998; 14:411-21. View abstract
  148. Randolph AG, Cook DJ, Gonzales CA, Brun-Buisson C. Tunneling of central venous catheters: a meta-analysis of randomized controlled trials. Crit Care Med. 1998; 26:1452-7. View abstract
  149. McGinn T, Randolph A, Richardson S, Sackett D. Clinical Prediction Guidelines. Evidence Based Medicine. 1998; 3:5-6. View abstract
  150. Randolph AG, Zollo MB, Egger JM, Guyatt GH, Nelson RM, Stidham GL. Variability in physician opinion on limiting pediatric life support. URL http://www.pediatrics.org/cgi/content/full/103/4/e46. Pediatrics. 1998; 103:807. View abstract
  151. Randolph AG, Guyatt GH, Calvin JE, Doig G. Understanding articles describing clinical prediction tools. Crit Care Med. 1998; 26:1603-12. View abstract
  152. Azzam MA, Randolph AG, Butt W. Positive predictive value of bilateral absence of somatosensory evoked potentials in severe traumatic brain injury. Pediatr Res. 1998; 43:33A. View abstract
  153. Randolph AG, Goldmann DA. Cost-effectiveness of 10 strategies for managing suspected central venous catheter-related infections. Pediatr Res. 1998; 43:155A. View abstract
  154. Cook D, Randolph A, Kernerman P, Cupido C, King D, Soukup C, Brun-Buisson C. Central venous catheter replacement strategies: a systematic review of the literature. Crit Care Med. 1997 Aug; 25(8):1417-24. View abstract
  155. Randolph AG, Zollo MB, Wigton RS, Yeh TS. Factors explaining variability among caregivers in the intent to restrict life-support interventions in a pediatric intensive care unit. Crit Care Med. 1997 Mar; 25(3):435-9. View abstract
  156. Randolph AG. Paediatric index of mortality (PIM): do we need another paediatric mortality prediction score? Intensive Care Med. 1997 Feb; 23(2):141-2. View abstract
  157. Gonzalez CA, Randolph AG, Perloff WH, Yeh TS. Pediatric intensive care units in 1995;numbers, characteristics, and distribution. Pediatrics. 1997; 100(3):449. View abstract
  158. Randolph AG. Critical appraisal of “Dexamethasone in the prevention of postextubation stridor in children” by DW Tellez et al. PedsCCM Evidence-Based Journal Club. 1997; http://PedsCCM.wustl.edu/EBJ/T. View abstract
  159. Randolph AG. Critical appraisal of “Dexamethasone for the prevention of postextubation airway obstruction: a prospective, randomized, double-blind, placebo-controlled trial” by O. Anene et al. PedsCCM Evidence-Based Journal Club. 1997; http://PedsCCM.wustl.edu/EBJ/T. View abstract
  160. Randolph AG. Critical appraisal of “Diagnosis and treatment of ventilator-associated pneumonia—impact on survival” by TR Sterling et al. PedsCCM Evidence-Based Journal Club. 1997; http://PedsCCM.wustl.edu/EBJ/D. View abstract
  161. Randolph AG. Critical appraisal of “UK collaborative randomized trial of neonatal extracorporeal membrane oxygenation” by the UK Collaborative ECMO Trial Group. PedsCCM Evidence-Based Journal Club. 1997; http://PedsCCM.wustl.edu/EBJ/T. View abstract
  162. Randolph AG. Critical appraisal of “Outcome of out-of-hospital cardiac or respiratory arrest in children” by MB Schindler et al. PedsCCM Evidence-Based Journal Club. 1997; http://PedsCCM.wustl.edu/EBJ/P. View abstract
  163. Cook DJ, Randolph AG, Kernerman P, Cupido C, Soukup M, King D, Brun-Buisson C. Central venous catheter exchange strategies: a meta-analysis of randomized controlled trials. Crit Care Med. 1997; 25:1417-24. View abstract
  164. Randolph AG, Markovitz B. Resources for applying evidence based medicine in the Pediatric Intensive Care Unit (PICU). J Int Care Med. 1997; 12:316-320. View abstract
  165. Randolph AG. The critical care database of randomized controlled trials: A resource to facilitate evidence-based practice in the intensive care unit. Critical Care. 1997; 0:25-8. View abstract
  166. Randolph AG, Cook DJ, Gonzales CA, Pribble CG. Ultrasound guidance for placement of central venous catheters: a meta-analysis of the literature. Crit Care Med. 1996 Dec; 24(12):2053-8. View abstract
  167. Randolph AG, Hartshorn RM, Washington AE. Acyclovir prophylaxis in late pregnancy to prevent neonatal herpes: a cost-effectiveness analysis. Obstet Gynecol. 1996 Oct; 88(4 Pt 1):603-10. View abstract
  168. Randolph AG, Wang EE. Ribavirin for respiratory syncytial virus lower respiratory tract infection. A systematic overview. Arch Pediatr Adolesc Med. 1996 Sep; 150(9):942-7. View abstract
  169. Sailors RM, East TD, Wallace CJ, Carlson DA, Franklin MA, Heermann LK, Kinder AT, Bradshaw RL, Randolph AG, Morris AH. Testing and validation of computerized decision support systems. Proc AMIA Annu Fall Symp. 1996; 234-8. View abstract
  170. Randolph AG, Wang EEL. Ribavirin for respiratory syncytial virus lower respiratory tract infection: a systematic overview. Arch Pediatr Adol Med. 1996; 150:942-7. View abstract
  171. Randolph AG. A computerized protocol for weaning patients from mechanical ventilation using the pressure support mode. 1996. View abstract
  172. Randolph AG. Learning airway management skills: guidelines for pediatrics. Arch Pediatr Adolesc Med. 1994 Feb; 148(2):227-8. View abstract
  173. Randolph AG. Learning airway management skills: guidelines for pediatrics. Arch Pediatr Adoles Med. 1994; 148:227-8. View abstract
  174. Randolph AG, Washington AE, Prober CG. Cesarean delivery for women presenting with genital herpes lesions. Efficacy, risks, and costs. JAMA. 1993 Jul 07; 270(1):77-82. View abstract
  175. Randolph AG, Washington AE. Screening for Chlamydia trachomatis in adolescent males: a cost-based decision analysis. Am J Public Health. 1990 May; 80(5):545-50. View abstract
  176. Randolph AG, Washington AE. Screening for Chlamydia trachomatis in adolescent males: cost and benefits of the leukocyte esterase urine dipstick test. Am J Pub Health. 1990; 80:545-50. View abstract
  177. Randolph AG. Cerebral hemisphere involvement in recognizing nonsense words, and in matching picture patterns and facial emotions. 1985. View abstract