Research Overview

The main focus of our research is to delineate the underlying molecular mechanisms by which type 2 diabetes and insulin resistance develop in obesity and also understand the cause of obesity. We are dedicated to understanding the insulin signaling pathways and identifying key metabolic molecules that determines the cell's fate and leads to pathophysiology in obesity. Our current work is mainly focused on understanding the role of BRD7 in glucose metabolism and ER homeostasis. The ultimate goal of our research is to identify a therapeutic target for the treatment of type 2 diabetes and obesity.

Please visit the Park Laboratory for for information.

Researcher Services

Researcher Areas

  • Glucose metabolism and insulin signaling pathway

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Golick L, Han Y, Kim Y, Park SW. BRD7 regulates the insulin-signaling pathway by increasing phosphorylation of GSK3ß. Cell Mol Life Sci. 2018 May; 75(10):1857-1869. View abstract
  2. Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. Inflammation Improves Glucose Homeostasis through IKKß-XBP1s Interaction. Cell. 2016 11 03; 167(4):1052-1066.e18. View abstract
  3. Kim Y, Andrés Salazar Hernández M, Herrema H, Delibasi T, Park SW. The role of BRD7 in embryo development and glucose metabolism. J Cell Mol Med. 2016 08; 20(8):1561-70. View abstract
  4. Park SW, Pyo CW, Choi SY. High-efficiency lentiviral transduction of primary human CD34? hematopoietic cells with low-dose viral inocula. Biotechnol Lett. 2015 Feb; 37(2):281-8. View abstract
  5. Park SW, Herrema H, Salazar M, Cakir I, Cabi S, Basibuyuk Sahin F, Chiu YH, Cantley LC, Ozcan U. BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. Cell Metab. 2014 Jul 01; 20(1):73-84. View abstract
  6. Park SW, Ozcan U. Potential for therapeutic manipulation of the UPR in disease. Semin Immunopathol. 2013 May; 35(3):351-73. View abstract
  7. Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med. 2011 Sep 04; 17(10):1251-60. View abstract
  8. Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 2011 Mar; 17(3):356-65. View abstract
  9. Park SW, Zhou Y, Lee J, Lee J, Ozcan U. Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19320-5. View abstract
  10. Park SW, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med. 2010 Apr; 16(4):429-37. View abstract
  11. Lee SH, Park SW, Pyo CW, Yoo NK, Kim J, Choi SY. Requirement of the JNK-associated Bcl-2 pathway for human lactoferrin-induced apoptosis in the Jurkat leukemia T cell line. Biochimie. 2009 Jan; 91(1):102-8. View abstract
  12. Park SW, Choi SY. Long-term expression of von Willebrand Factor by a VSV-G pseudotyped lentivirus enhances the functional activity of secreted B-Domain-deleted Coagulation Factor VIII. Mol Cells. 2007 Aug 31; 24(1):125-31. View abstract
  13. Park SW, Choi SY. A stable gene transfer system for hematopoietic progenitor cells from human bone marrow using pseudotyped retroviral vectors. Mol Cells. 2004 Apr 30; 17(2):297-303. View abstract