Research Overview

Web Site:  Fetal-Neonatal Neuroimaging and Developmental Science Center

Christos Papadelis is an Assistant Professor of Pediatrics at Harvard Medical School and Head of the Children’s Brain Dynamics laboratory in the Division of Newborn Medicine at Boston Children’s Hospital. Dr. Papadelis has more than ten years of experience in magnetoencephalography (MEG) and electroencephalography (EEG) technology with both adults and children. He received the Diploma in Electrical Engineering from the Aristotle University of Thessaloniki, Greece, in 1998, and his MSc and PhD in Medical Informatics, in 2001 and 2005 respectively, from the same institute. After his PhD graduation, he worked as Post-Doc Researcher in the Brain Science Institute (BSI) of RIKEN, Japan, from 2005 to 2008, and in the Center for Mind/Brain Sciences (CIMeC) of University of Trento, Italy, from 2008 to 2011. Back in 2011, he moved to Boston to join the Fetal-Neonatal Neuroimaging and Developmental Science Center (FNNDSC) as Instructor in Neurology and Manager of the BabyMEG facility, one of the very few MEG laboratories in the world fully dedicated to pediatric research.

His research covers a broad range of studies on neuroscience, clinical neurophysiology, and biomedical engineering. Dr. Papadelis has a record of productive research projects leading to more than 40 peer-reviewed research investigation articles and numerous articles in conference proceedings. He has funded projects from the National Institute of Child Health and Human Development, the American Epilepsy Society, the Faculty Development Office at Harvard Medical School, and the Boston Children's Hospital. He is Academic Editor in PLOS ONE, ad-hoc reviewer in more than 40 journals, as well as guest editor in special issues of his field. Figures of his work have been selected as covers in scientific journals.

His main research activities include:

Presurgical Mapping in Childhood Epilepsy: A large proportion of pediatric epileptic patients become medically intractable and require resective surgery. To be successful, epilepsy surgery requires a comprehensive preoperative evaluation for defining the epileptogenic zone. A battery of presurgical diagnostic tests is used to assess the epileptogenic zone. However, the results of these tests are often insufficiently concordant or inconclusive. Dr. Papadelis works on the development of a non-invasively acquired robust biomarker that identifies the epileptogenic zone and eventually improves the outcome of surgical treatment in pediatric patients with epilepsy.

Anatomical and Functional Deficits in the Brain of Children with Cerebral Palsy: Although cerebral palsy is among the most common causes of physical disability in early childhood, we know little about the functional and structural changes of this disorder in the developing brain. Dr. Papadelis investigates with different neuroimaging modalities whether spastic cerebral palsy is associated with functional and anatomical abnormalities in the sensorimotor network. This research has important implications for the diagnosis and the rehabilitation of patients with spastic cerebral palsy. Such interventions should be applied early in life when the brain demonstrates the ability to plasticity, allowing it to readily reorganize in the face of injury. 

Involvement of Cerebellum in the Processing of Emotions: Despite findings that a wide variety of psychiatric disorders have been associated with abnormalities in the cerebellum, this brain structure is often overlooked as a contributor to the neural basis of emotion. Dr. Papadelis’ goal is to examine the functional role of cerebellum in the processing of emotional stimuli. This kind of knowledge could aid in the development of novel therapies to detect and treat early manifestations of psychiatric disorders, such as those affecting mood and anxiety. 

Dr. Papadelis is Guest Associate Editor in the Frontiers in Human Neuroscience, Associate Editor in the Journal of Information Technology Research (JITR), Guest Editor in Biomedical Signal Processing and Control, and ad-hoc reviewer in more than twenty peer-reviewed journals such as Neuroimage, Brain Research, Journal of Sleep Research, and others. He has published more than 30 papers in peer-reviewed journals, while figures of his work have been selected as covers in scientific journals. 


Researcher Services

PUBLICATIONS

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  1. Tamilia E, Park EH, Percivati S, Bolton J, Taffoni F, Peters JM, Grant PE, Pearl PL, Madsen JR, Papadelis C. Surgical resection of ripple onset predicts outcome in pediatric epilepsy. Ann Neurol. 2018 Sep; 84(3):331-346. View abstract
  2. Styliadis C, Ioannides AA, Bamidis PD, Papadelis C. Mapping the Spatiotemporal Evolution of Emotional Processing: An MEG Study Across Arousal and Valence Dimensions. Front Hum Neurosci. 2018; 12:322. View abstract
  3. Tanaka N, Papadelis C, Tamilia E, Madsen JR, Pearl PL, Stufflebeam SM. Magnetoencephalographic Mapping of Epileptic Spike Population Using Distributed Source Analysis: Comparison With Intracranial Electroencephalographic Spikes. J Clin Neurophysiol. 2018 Jul; 35(4):339-345. View abstract
  4. Tanaka N, Papadelis C, Tamilia E, AlHilani M, Madsen JR, Pearl PL, Stufflebeam SM. Magnetoencephalographic Spike Analysis in Patients With Focal Cortical Dysplasia: What Defines a "Dipole Cluster"? Pediatr Neurol. 2018 Jun; 83:25-31. View abstract
  5. Mohammadi-Nejad AR, Mahmoudzadeh M, Hassanpour MS, Wallois F, Muzik O, Papadelis C, Hansen A, Soltanian-Zadeh H, Gelovani J, Nasiriavanaki M. Neonatal brain resting-state functional connectivity imaging modalities. Photoacoustics. 2018 Jun; 10:1-19. View abstract
  6. Papadelis C, Butler EE, Rubenstein M, Sun L, Zollei L, Nimec D, Snyder B, Grant PE. Reorganization of the somatosensory cortex in hemiplegic cerebral palsy associated with impaired sensory tracts. Neuroimage Clin. 2018; 17:198-212. View abstract
  7. Adamaszek M, D'Agata F, Ferrucci R, Habas C, Keulen S, Kirkby KC, Leggio M, Mariën P, Molinari M, Moulton E, Orsi L, Van Overwalle F, Papadelis C, Priori A, Sacchetti B, Schutter DJ, Styliadis C, Verhoeven J. Consensus Paper: Cerebellum and Emotion. Cerebellum. 2017 04; 16(2):552-576. View abstract
  8. Capilouto GJ, Cunningham TJ, Mullineaux DR, Tamilia E, Papadelis C, Giannone PJ. Quantifying Neonatal Sucking Performance: Promise of New Methods. Semin Speech Lang. 2017 04; 38(2):147-158. View abstract
  9. Tamilia E, Madsen JR, Grant PE, Pearl PL, Papadelis C. Current and Emerging Potential of Magnetoencephalography in the Detection and Localization of High-Frequency Oscillations in Epilepsy. Front Neurol. 2017; 8:14. View abstract
  10. Papadelis C, Tamilia E, Stufflebeam S, Grant PE, Madsen JR, Pearl PL, Tanaka N. Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy. J Vis Exp. 2016 12 06; (118). View abstract
  11. Papadelis C, Arfeller C, Erla S, Nollo G, Cattaneo L, Braun C. Inferior frontal gyrus links visual and motor cortices during a visuomotor precision grip force task. Brain Res. 2016 11 01; 1650:252-266. View abstract
  12. Papadelis C, Ashkezari SF, Doshi C, Thome-Souza S, Pearl PL, Grant PE, Tasker RC, Loddenkemper T. Real-time multi-channel monitoring of burst-suppression using neural network technology during pediatric status epilepticus treatment. Clin Neurophysiol. 2016 08; 127(8):2820-31. View abstract
  13. Papadelis C, Grant PE, Okada Y, Preissl H. Editorial on emerging neuroimaging tools for studying normal and abnormal human brain development. Front Hum Neurosci. 2015; 9:127. View abstract
  14. Styliadis C, Ioannides AA, Bamidis PD, Papadelis C. Distinct cerebellar lobules process arousal, valence and their interaction in parallel following a temporal hierarchy. Neuroimage. 2015 Apr 15; 110:149-61. View abstract
  15. Reinsberger C, Sarkis R, Papadelis C, Doshi C, Perez DL, Baslet G, Loddenkemper T, Dworetzky BA. Autonomic changes in psychogenic nonepileptic seizures: toward a potential diagnostic biomarker? Clin EEG Neurosci. 2015 Jan; 46(1):16-25. View abstract
  16. Tamè L, Pavani F, Papadelis C, Farnè A, Braun C. Early integration of bilateral touch in the primary somatosensory cortex. Hum Brain Mapp. 2015 Apr; 36(4):1506-23. View abstract
  17. Papadelis C, Ahtam B, Nazarova M, Nimec D, Snyder B, Grant PE, Okada Y. Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study. Front Hum Neurosci. 2014; 8:725. View abstract
  18. Khan S, Lefèvre J, Baillet S, Michmizos KP, Ganesan S, Kitzbichler MG, Zetino M, Hämäläinen MS, Papadelis C, Kenet T. Encoding cortical dynamics in sparse features. Front Hum Neurosci. 2014; 8:338. View abstract
  19. Hunold A, Haueisen J, Ahtam B, Doshi C, Harini C, Camposano S, Warfield SK, Grant PE, Okada Y, Papadelis C. Localization of the epileptogenic foci in tuberous sclerosis complex: a pediatric case report. Front Hum Neurosci. 2014; 8:175. View abstract
  20. Tsigka S, Papadelis C, Braun C, Miceli G. Distinguishable neural correlates of verbs and nouns: a MEG study on homonyms. Neuropsychologia. 2014 Feb; 54:87-97. View abstract
  21. Papadelis C, Harini C, Ahtam B, Doshi C, Grant PE, Okada Y. Current and emerging potential for magnetoencephalography in pediatric epilepsy. J Ped Epilepsy. 2013; 2:1-13. View abstract
  22. Styliadis C, Ioannides AA, Bamidis PD, Papadelis C. Amygdala responses to Valence and its interaction by arousal revealed by MEG. Int J Psychophysiol. 2014 Jul; 93(1):121-33. View abstract
  23. Lithari C, Klados MA, Pappas C, Albani M, Kapoukranidou D, Kovatsi L, Bamidis PD, Papadelis CL. Alcohol affects the brain's resting-state network in social drinkers. PLoS One. 2012; 7(10):e48641. View abstract
  24. Styliadis C, Papadelis C, Konstantinidis E, Ioannides AA, Bamidis P. An MEG compatible system for measuring skin conductance responses. J Neurosci Methods. 2013 Jan 15; 212(1):114-23. View abstract
  25. Papadelis C, Leonardelli E, Staudt M, Braun C. Can magnetoencephalography track the afferent information flow along white matter thalamo-cortical fibers? Neuroimage. 2012 Apr 02; 60(2):1092-105. View abstract
  26. Lithari C, Klados MA, Papadelis C, Pappas C, Albani M, Bamidis PD. How does the metric choice affect brain functional connectivity networks?. Biomedical Signal Processing and Control. 2011; 7(3):228–236. View abstract
  27. Erla S, Faes L, Nollo G, Arfeller C, Braun C, Papadelis C. Multivariate EEG spectral analysis evidences the functional link between motor and visual cortex during integrative sensorimotor tasks. Biomedical Signal Processing & Control. 2011; 7(3):221–227. View abstract
  28. Klados MA, Papadelis C, Braun C, Bamidis PD. REG-ICA: A hybrid methodology combining Blind Source Separation and regression techniques for the rejection of ocular artifacts. Biomedical Signal Processing and Control. 2011; 6(3):291–300. View abstract
  29. Papadelis C, Eickhoff SB, Zilles K, Ioannides AA. BA3b and BA1 activate in a serial fashion after median nerve stimulation: direct evidence from combining source analysis of evoked fields and cytoarchitectonic probabilistic maps. Neuroimage. 2011 Jan 01; 54(1):60-73. View abstract
  30. Frantzidis CA, Bratsas C, Papadelis CL, Konstantinidis E, Pappas C, Bamidis PD. Toward emotion aware computing: an integrated approach using multichannel neurophysiological recordings and affective visual stimuli. IEEE Trans Inf Technol Biomed. 2010 May; 14(3):589-97. View abstract
  31. Frantzidis CA, Bratsas C, Klados MA, Konstantinidis E, Lithari CD, Vivas AB, Papadelis CL, Kaldoudi E, Pappas C, Bamidis PD. On the classification of emotional biosignals evoked while viewing affective pictures: an integrated data-mining-based approach for healthcare applications. IEEE Trans Inf Technol Biomed. 2010 Mar; 14(2):309-18. View abstract
  32. Lithari C, Frantzidis CA, Papadelis C, Vivas AB, Klados MA, Kourtidou-Papadeli C, Pappas C, Ioannides AA, Bamidis PD. Are females more responsive to emotional stimuli? A neurophysiological study across arousal and valence dimensions. Brain Topogr. 2010 Mar; 23(1):27-40. View abstract
  33. Papadelis C, Poghosyan V, Fenwick PBC, Ioannides AA. MEG's ability to localise accurately weak transient neural sources. Clin Neurophysiol. 2009 Nov; 120(11):1958-1970. View abstract
  34. Klados MA, Frantzidis C, Vivas AB, Papadelis C, Lithari C, Pappas C, Bamidis PD. A framework combining delta Event-Related Oscillations (EROs) and Synchronisation Effects (ERD/ERS) to study emotional processing. Comput Intell Neurosci. 2009; 549419. View abstract
  35. Bamidis PD, Konstantinidis S, Papadelis CL, Perantoni E, Styliadis C, Kourtidou-Papadeli C, Kourtidou-Papadeli C, Pappas C. An e-learning platform for aerospace medicine. Hippokratia. 2008 Aug; 12 Suppl 1:15-22. View abstract
  36. Kourtidou-Papadeli C, Papadelis C, Koutsonikolas D, Boutzioukas S, Styliadis C, Guiba-Tziampiri O. High altitude cognitive performance and COPD interaction. Hippokratia. 2008 Aug; 12 Suppl 1:84-90. View abstract
  37. Kourtidou-Papadeli C, Papadelis CL, Vernikos J, Bamidis PD, Hitoglou-Antoniadou M, Perantoni E, Vlachogiannis E. The therapeutic benefits of gravity in space and on earth. Hippokratia. 2008 Aug; 12(Suppl 1):28-31. View abstract
  38. Papadelis C, Chen Z, Kourtidou-Papadeli C, Bamidis PD, Chouvarda I, Bekiaris E, Maglaveras N. Monitoring sleepiness with on-board electrophysiological recordings for preventing sleep-deprived traffic accidents. Clin Neurophysiol. 2007 Sep; 118(9):1906-22. View abstract
  39. Papadelis C, Kourtidou-Papadeli C, Bamidis P, Albani M. Effects of imagery training on cognitive performance and use of physiological measures as an assessment tool of mental effort. Brain Cogn. 2007 Jun; 64(1):74-85. View abstract
  40. Papadelis C, Kourtidou-Papadeli C, Bamidis PD, Maglaveras N, Pappas K. The effect of hypobaric hypoxia on multichannel EEG signal complexity. Clin Neurophysiol. 2007 Jan; 118(1):31-52. View abstract
  41. Papadelis C, Maglaveras N, Kourtidou-Papadeli C, Bamidis P, Albani M, Chatzinikolaou K, Pappas K. Quantitative multichannel EEG measure predicting the optimal weaning from ventilator in ICU patients with acute respiratory failure. Clin Neurophysiol. 2006 Apr; 117(4):752-70. View abstract
  42. Kourtidou-Papadeli C, Kyparos A, Albani M, Frossinis A, Papadelis CL, Bamidis P, Vivas A, Guiba-Tziampiri O. Electrophysiological, histochemical, and hormonal adaptation of rat muscle after prolonged hindlimb suspension. Acta Astronaut. 2004 May; 54(10):737-47. View abstract
  43. Papadelis C, Kourtidou-Papadeli C, Vlachogiannis E, Skepastianos P, Bamidis P, Maglaveras N, Pappas K. Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain Cogn. 2003 Feb; 51(1):143-54. View abstract
  44. Kourtidou-Papadeli C, Papadelis C, Louizos AL, Guiba-Tziampiri O. Maximum cognitive performance and physiological time trend measurements after caffeine intake. Brain Res Cogn Brain Res. 2002 May; 13(3):407-15. View abstract