Research Overview

Web Site:  Fetal-Neonatal Neuroimaging and Developmental Science Center

Christos Papadelis is Assistant Professor in Pediatrics at Harvard Medical School, Research Associate at Children’s Hospital Boston and Manager of the BabyMEG laboratory. He has received the Diploma in Electrical Engineering from the Aristotle University of Thessaloniki, Greece, in 1998, and his MSc and PhD in Medical Informatics, in 2001 and 2005 respectively, from the same institute. During his graduate studies, he worked in a number of research projects funded from the European Union and the Greek Secretariat for Research and Technology. After his PhD graduation, he worked as Post-Doc Researcher in the Laboratory of Human Brain Dynamics at Brain Science Institute (BSI) of RIKEN, Japan, from June 2005 to August 2008, and in the Center for Mind/Brain Sciences (CIMeC) of University of Trento, Italy, from September 2008 to August 2011.

His main research activities include:

Presurgical Mapping in Childhood Epilepsy: A large proportion of pediatric epileptic patients become medically intractable and require resective surgery. To be successful, epilepsy surgery requires a comprehensive preoperative evaluation for defining the epileptogenic zone. A battery of presurgical diagnostic tests is used to assess the epileptogenic zone. However, the results of these tests are often insufficiently concordant or inconclusive. Dr. Papadelis works on the development of a non-invasively acquired robust biomarker that identifies the epileptogenic zone and eventually improves the outcome of surgical treatment in pediatric patients with epilepsy. 

Anatomical and Functional Deficits in the Brain of Children with Cerebral Palsy: Although cerebral palsy is among the most common causes of physical disability in early childhood, we know little about the functional and structural changes of this disorder in the developing brain. Dr. Papadelis investigates with different neuroimaging modalities whether spastic cerebral palsy is associated with functional and anatomical abnormalities in the sensorimotor network. This research has important implications for the diagnosis and the rehabilitation of patients with spastic cerebral palsy. Such interventions should be applied early in life when the brain demonstrates the ability to plasticity, allowing it to readily reorganize in the face of injury. 

Involvement of Cerebellum in the Processing of Emotions: Despite findings that a wide variety of psychiatric disorders have been associated with abnormalities in the cerebellum, this brain structure is often overlooked as a contributor to the neural basis of emotion. Dr. Papadelis’ goal is to examine the functional role of cerebellum in the processing of emotional stimuli. This kind of knowledge could aid in the development of novel therapies to detect and treat early manifestations of psychiatric disorders, such as those affecting mood and anxiety. 

Dr. Papadelis is Guest Associate Editor in the Frontiers in Human Neuroscience, Associate Editor in the Journal of Information Technology Research (JITR), Guest Editor in Biomedical Signal Processing and Control, and ad-hoc reviewer in more than twenty peer-reviewed journals such as Neuroimage, Brain Research, Journal of Sleep Research, and others. He has published more than 30 papers in peer-reviewed journals, while figures of his work have been selected as covers in scientific journals. 

Researcher Services


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  1. Mohammadi-Nejad AR, Mahmoudzadeh M, Hassanpour MS, Wallois F, Muzik O, Papadelis C, Hansen A, Soltanian-Zadeh H, Gelovani J, Nasiriavanaki M. Neonatal brain resting-state functional connectivity imaging modalities. Photoacoustics. 2018 Jun; 10:1-19. View abstract
  2. Papadelis C, Butler EE, Rubenstein M, Sun L, Zollei L, Nimec D, Snyder B, Grant PE. Reorganization of the somatosensory cortex in hemiplegic cerebral palsy associated with impaired sensory tracts. Neuroimage Clin. 2018; 17:198-212. View abstract
  3. Adamaszek M, D'Agata F, Ferrucci R, Habas C, Keulen S, Kirkby KC, Leggio M, Mariën P, Molinari M, Moulton E, Orsi L, Van Overwalle F, Papadelis C, Priori A, Sacchetti B, Schutter DJ, Styliadis C, Verhoeven J. Consensus Paper: Cerebellum and Emotion. Cerebellum. 2017 Apr; 16(2):552-576. View abstract
  4. Capilouto GJ, Cunningham TJ, Mullineaux DR, Tamilia E, Papadelis C, Giannone PJ. Quantifying Neonatal Sucking Performance: Promise of New Methods. Semin Speech Lang. 2017 Apr; 38(2):147-158. View abstract
  5. Tamilia E, Madsen JR, Grant PE, Pearl PL, Papadelis C. Current and Emerging Potential of Magnetoencephalography in the Detection and Localization of High-Frequency Oscillations in Epilepsy. Front Neurol. 2017; 8:14. View abstract
  6. Papadelis C, Tamilia E, Stufflebeam S, Grant PE, Madsen JR, Pearl PL, Tanaka N. Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy. J Vis Exp. 2016 Dec 06; (118). View abstract
  7. Papadelis C, Arfeller C, Erla S, Nollo G, Cattaneo L, Braun C. Inferior frontal gyrus links visual and motor cortices during a visuomotor precision grip force task. Brain Res. 2016 11 01; 1650:252-266. View abstract
  8. Papadelis C, Ashkezari SF, Doshi C, Thome-Souza S, Pearl PL, Grant PE, Tasker RC, Loddenkemper T. Real-time multi-channel monitoring of burst-suppression using neural network technology during pediatric status epilepticus treatment. Clin Neurophysiol. 2016 08; 127(8):2820-31. View abstract
  9. Papadelis C, Grant PE, Okada Y, Preissl H. Editorial on emerging neuroimaging tools for studying normal and abnormal human brain development. Front Hum Neurosci. 2015; 9:127. View abstract
  10. Styliadis C, Ioannides AA, Bamidis PD, Papadelis C. Distinct cerebellar lobules process arousal, valence and their interaction in parallel following a temporal hierarchy. Neuroimage. 2015 Apr 15; 110:149-61. View abstract
  11. Reinsberger C, Sarkis R, Papadelis C, Doshi C, Perez DL, Baslet G, Loddenkemper T, Dworetzky BA. Autonomic changes in psychogenic nonepileptic seizures: toward a potential diagnostic biomarker? Clin EEG Neurosci. 2015 Jan; 46(1):16-25. View abstract
  12. Tamè L, Pavani F, Papadelis C, Farnè A, Braun C. Early integration of bilateral touch in the primary somatosensory cortex. Hum Brain Mapp. 2015 Apr; 36(4):1506-23. View abstract
  13. Papadelis C, Ahtam B, Nazarova M, Nimec D, Snyder B, Grant PE, Okada Y. Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study. Front Hum Neurosci. 2014; 8:725. View abstract
  14. Khan S, Lefèvre J, Baillet S, Michmizos KP, Ganesan S, Kitzbichler MG, Zetino M, Hämäläinen MS, Papadelis C, Kenet T. Encoding cortical dynamics in sparse features. Front Hum Neurosci. 2014; 8:338. View abstract
  15. Hunold A, Haueisen J, Ahtam B, Doshi C, Harini C, Camposano S, Warfield SK, Grant PE, Okada Y, Papadelis C. Localization of the epileptogenic foci in tuberous sclerosis complex: a pediatric case report. Front Hum Neurosci. 2014; 8:175. View abstract
  16. Tsigka S, Papadelis C, Braun C, Miceli G. Distinguishable neural correlates of verbs and nouns: a MEG study on homonyms. Neuropsychologia. 2014 Feb; 54:87-97. View abstract
  17. Papadelis C, Harini C, Ahtam B, Doshi C, Grant PE, Okada Y. Current and emerging potential for magnetoencephalography in pediatric epilepsy. J Ped Epilepsy. 2013; 2:1-13. View abstract
  18. Styliadis C, Ioannides AA, Bamidis PD, Papadelis C. Amygdala responses to Valence and its interaction by arousal revealed by MEG. Int J Psychophysiol. 2014 Jul; 93(1):121-33. View abstract
  19. Lithari C, Klados MA, Pappas C, Albani M, Kapoukranidou D, Kovatsi L, Bamidis PD, Papadelis CL. Alcohol affects the brain's resting-state network in social drinkers. PLoS One. 2012; 7(10):e48641. View abstract
  20. Styliadis C, Papadelis C, Konstantinidis E, Ioannides AA, Bamidis P. An MEG compatible system for measuring skin conductance responses. J Neurosci Methods. 2013 Jan 15; 212(1):114-23. View abstract
  21. Papadelis C, Leonardelli E, Staudt M, Braun C. Can magnetoencephalography track the afferent information flow along white matter thalamo-cortical fibers? Neuroimage. 2012 Apr 02; 60(2):1092-105. View abstract
  22. Lithari C, Klados MA, Papadelis C, Pappas C, Albani M, Bamidis PD. How does the metric choice affect brain functional connectivity networks?. Biomedical Signal Processing and Control. 2011; 7(3):228–236. View abstract
  23. Erla S, Faes L, Nollo G, Arfeller C, Braun C, Papadelis C. Multivariate EEG spectral analysis evidences the functional link between motor and visual cortex during integrative sensorimotor tasks. Biomedical Signal Processing & Control. 2011; 7(3):221–227. View abstract
  24. Klados MA, Papadelis C, Braun C, Bamidis PD. REG-ICA: A hybrid methodology combining Blind Source Separation and regression techniques for the rejection of ocular artifacts. Biomedical Signal Processing and Control. 2011; 6(3):291–300. View abstract
  25. Papadelis C, Eickhoff SB, Zilles K, Ioannides AA. BA3b and BA1 activate in a serial fashion after median nerve stimulation: direct evidence from combining source analysis of evoked fields and cytoarchitectonic probabilistic maps. Neuroimage. 2011 Jan 01; 54(1):60-73. View abstract
  26. Frantzidis CA, Bratsas C, Papadelis CL, Konstantinidis E, Pappas C, Bamidis PD. Toward emotion aware computing: an integrated approach using multichannel neurophysiological recordings and affective visual stimuli. IEEE Trans Inf Technol Biomed. 2010 May; 14(3):589-97. View abstract
  27. Frantzidis CA, Bratsas C, Klados MA, Konstantinidis E, Lithari CD, Vivas AB, Papadelis CL, Kaldoudi E, Pappas C, Bamidis PD. On the classification of emotional biosignals evoked while viewing affective pictures: an integrated data-mining-based approach for healthcare applications. IEEE Trans Inf Technol Biomed. 2010 Mar; 14(2):309-18. View abstract
  28. Lithari C, Frantzidis CA, Papadelis C, Vivas AB, Klados MA, Kourtidou-Papadeli C, Pappas C, Ioannides AA, Bamidis PD. Are females more responsive to emotional stimuli? A neurophysiological study across arousal and valence dimensions. Brain Topogr. 2010 Mar; 23(1):27-40. View abstract
  29. Papadelis C, Poghosyan V, Fenwick PB, Ioannides AA. MEG's ability to localise accurately weak transient neural sources. Clin Neurophysiol. 2009 Nov; 120(11):1958-70. View abstract
  30. Klados MA, Frantzidis C, Vivas AB, Papadelis C, Lithari C, Pappas C, Bamidis PD. A framework combining delta Event-Related Oscillations (EROs) and Synchronisation Effects (ERD/ERS) to study emotional processing. Comput Intell Neurosci. 2009; 549419. View abstract
  31. Bamidis PD, Konstantinidis S, Papadelis CL, Perantoni E, Styliadis C, Kourtidou-Papadeli C, Kourtidou-Papadeli C, Pappas C. An e-learning platform for aerospace medicine. Hippokratia. 2008 Aug; 12 Suppl 1:15-22. View abstract
  32. Kourtidou-Papadeli C, Papadelis C, Koutsonikolas D, Boutzioukas S, Styliadis C, Guiba-Tziampiri O. High altitude cognitive performance and COPD interaction. Hippokratia. 2008 Aug; 12 Suppl 1:84-90. View abstract
  33. Kourtidou-Papadeli C, Papadelis CL, Vernikos J, Bamidis PD, Hitoglou-Antoniadou M, Perantoni E, Vlachogiannis E. The therapeutic benefits of gravity in space and on earth. Hippokratia. 2008 Aug; 12(Suppl 1):28-31. View abstract
  34. Papadelis C, Chen Z, Kourtidou-Papadeli C, Bamidis PD, Chouvarda I, Bekiaris E, Maglaveras N. Monitoring sleepiness with on-board electrophysiological recordings for preventing sleep-deprived traffic accidents. Clin Neurophysiol. 2007 Sep; 118(9):1906-22. View abstract
  35. Papadelis C, Kourtidou-Papadeli C, Bamidis P, Albani M. Effects of imagery training on cognitive performance and use of physiological measures as an assessment tool of mental effort. Brain Cogn. 2007 Jun; 64(1):74-85. View abstract
  36. Papadelis C, Kourtidou-Papadeli C, Bamidis PD, Maglaveras N, Pappas K. The effect of hypobaric hypoxia on multichannel EEG signal complexity. Clin Neurophysiol. 2007 Jan; 118(1):31-52. View abstract
  37. Papadelis C, Maglaveras N, Kourtidou-Papadeli C, Bamidis P, Albani M, Chatzinikolaou K, Pappas K. Quantitative multichannel EEG measure predicting the optimal weaning from ventilator in ICU patients with acute respiratory failure. Clin Neurophysiol. 2006 Apr; 117(4):752-70. View abstract
  38. Kourtidou-Papadeli C, Kyparos A, Albani M, Frossinis A, Papadelis CL, Bamidis P, Vivas A, Guiba-Tziampiri O. Electrophysiological, histochemical, and hormonal adaptation of rat muscle after prolonged hindlimb suspension. Acta Astronaut. 2004 May; 54(10):737-47. View abstract
  39. Papadelis C, Kourtidou-Papadeli C, Vlachogiannis E, Skepastianos P, Bamidis P, Maglaveras N, Pappas K. Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain Cogn. 2003 Feb; 51(1):143-54. View abstract
  40. Kourtidou-Papadeli C, Papadelis C, Louizos AL, Guiba-Tziampiri O. Maximum cognitive performance and physiological time trend measurements after caffeine intake. Brain Res Cogn Brain Res. 2002 May; 13(3):407-15. View abstract