Research Overview

Dr. Nurko's research focuses on Gastrointestinal Motility Disorders in children. His main interest is in the areas of mechanisms of defecation and fecal continence, constipation, non-acid reflux , functional bowel disorders, pseudo-obstruction, postoperative problems after GI surgery and Hirschsprung's disease. He is actively involved in a number of clinical trials and outcomes research studies .

The main goals of Dr. Nurko's research, is to:

  • Determine the mechanisms for fecal continence in children
  • Determine the role that non-acid reflux plays in children with gastroesophageal reflux disease
  • Find better treatments for children with motility disorders
  • Genetic mutations in children with gastroparesis and  pseudobstruction
  • mRNA patterns in gastric mucosa of children with gastroparesis, pseudobstruction and constipation
  • Validation of new methods to establish gastric emptying
  • New methods for the study of intestinal motility
  • Use of high resolution manometry in children with motility disorders

About Sam Nurko

Dr. Nurko was awarded his MD from the Universidad Nacional Autonoma de Mexico. Residency and fellowship was completed at Children's Hospital, Boston.

Researcher Services

Researcher Areas

  • Gastrointestinal Motility Disorders

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Graham CD, Rodriguez L, Flores A, Nurko S, Buchmiller TL. Primary placement of a skin-level Cecostomy Tube for Antegrade Colonic Enema Administration Using a Modification of the Laparoscopic-Assisted Percutaneous Endoscopic Cecostomy (LAPEC). J Pediatr Surg. 2018 Oct 02. View abstract
  2. Bonilla S, Nurko S. Focus on the use of antidepressants to treat pediatric functional abdominal pain: current perspectives. Clin Exp Gastroenterol. 2018; 11:365-372. View abstract
  3. Kwatra NS, Nurko S, Stamoulis C, Falone AE, Grant FD, Treves ST. Chronic Acalculous Cholecystitis in Children with Biliary Symptoms: Usefulness of Hepato-Cholescintigraphy. J Pediatr Gastroenterol Nutr. 2018 Sep 25. View abstract
  4. Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018 10; 155(4):1022-1033.e10. View abstract
  5. Hubbard CS, Becerra L, Heinz N, Ludwick A, Rasooly T, Yendiki A, Wu R, Schechter NL, Nurko S, Borsook D. Microstructural White Matter Abnormalities in the Dorsal Cingulum of Adolescents with IBS. eNeuro. 2018 Jul-Aug; 5(4). View abstract
  6. Beinvogl B, Burch E, Snyder J, Schechter N, Hale A, Okazaki Y, Paul F, Warman K, Nurko S. Multidisciplinary Treatment of Pediatric Functional Gastrointestinal Disorders Results in Improved Pain and Functioning. Clin Gastroenterol Hepatol. 2018 Jul 25. View abstract
  7. Duggan EM, Nurko S, Smithers CJ, Rodriguez L, Fox VL, Fishman SJ. Thoracoscopic esophagomyotomy for achalasia in the pediatric population: A retrospective cohort study. J Pediatr Surg. 2018 Jul 24. View abstract
  8. Barnes J, Coleman B, Hwang S, Stolic A, Bousvaros A, Nurko S, Salinas GD. Educational needs in the diagnosis and management of pediatric functional constipation: a US survey of specialist and primary care clinicians. Postgrad Med. 2018 May; 130(4):428-435. View abstract
  9. Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, Di Lorenzo C, Shulman RJ, Hyams JS, Palsson O, van Tilburg MAL. Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria. J Pediatr. 2018 Apr; 195:134-139. View abstract
  10. Singendonk MMJ, Omari TI, Rommel N, van Wijk MP, Benninga MA, Rosen R, Nurko S. Novel Pressure-Impedance Parameters for Evaluating Esophageal Function in Pediatric Achalasia. J Pediatr Gastroenterol Nutr. 2018 Jan; 66(1):37-42. View abstract
  11. Sallis BF, Erkert L, Moñino-Romero S, Acar U, Wu R, Konnikova L, Lexmond WS, Hamilton MJ, Dunn WA, Szepfalusi Z, Vanderhoof JA, Snapper SB, Turner JR, Goldsmith JD, Spencer LA, Nurko S, Fiebiger E. An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. J Allergy Clin Immunol. 2018 Apr; 141(4):1354-1364.e9. View abstract
  12. Beinvogl B, Sabharwal S, McSweeney M, Nurko S. Are We Using Abdominal Radiographs Appropriately in the Management of Pediatric Constipation? J Pediatr. 2017 Dec; 191:179-183. View abstract
  13. Rosen R, Garza JM, Tipnis N, Nurko S. An ANMS-NASPGHAN consensus document on esophageal and antroduodenal manometry in children. Neurogastroenterol Motil. 2018 Mar; 30(3). View abstract
  14. Varni JW, Shulman RJ, Self MM, Saeed SA, Zacur GM, Patel AS, Nurko S, Neigut DA, Franciosi JP, Saps M, Denham JM, Dark CV, Bendo CB, Pohl JF. Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease. Qual Life Res. 2018 01; 27(1):195-204. View abstract
  15. Vadva Z, Nurko S, Hehn R, Vargas SO. Rectal Suction Biopsy in Patients With Previous Anorectal Surgery for Hirschsprung Disease. J Pediatr Gastroenterol Nutr. 2017 Aug; 65(2):173-178. View abstract
  16. Lexmond WS, Goettel JA, Sallis BF, McCann K, Rings EHHM, Jensen-Jarolim E, Nurko S, Snapper SB, Fiebiger E. Spontaneous food allergy in Was-/- mice occurs independent of FceRI-mediated mast cell activation. Allergy. 2017 Dec; 72(12):1916-1924. View abstract
  17. Mahoney LB, Nurko S, Rosen R. The Prevalence of Rome IV Nonerosive Esophageal Phenotypes in Children. J Pediatr. 2017 Oct; 189:86-91. View abstract
  18. Nurko S. Motility Disorders in Children. Pediatr Clin North Am. 2017 06; 64(3):593-612. View abstract
  19. Varni JW, Shulman RJ, Self MM, Saeed SA, Patel AS, Nurko S, Neigut DA, Saps M, Zacur GM, Dark CV, Bendo CB, Pohl JF. Patient Health Communication Mediating Effects Between Gastrointestinal Symptoms and Gastrointestinal Worry in Pediatric Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 05; 23(5):704-711. View abstract
  20. Klages KL, Berlin KS, Silverman AH, Mugie S, Di Lorenzo C, Nurko S, Ponnambalam A, Sanghavi R, Sood MR. Empirically Derived Patterns of Pain, Stooling, and Incontinence and Their Relations to Health-Related Quality of Life Among Youth With Chronic Constipation. J Pediatr Psychol. 2017 04 01; 42(3):325-334. View abstract
  21. Arbizu RA, Nurko S, Heinz N, Amicangelo M, Rodriguez L. Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation. Neurogastroenterol Motil. 2017 Jul; 29(7). View abstract
  22. Koppen IJ, Nurko S, Saps M, Di Lorenzo C, Benninga MA. The pediatric Rome IV criteria: what's new? Expert Rev Gastroenterol Hepatol. 2017 Mar; 11(3):193-201. View abstract
  23. Martinez EE, Pereira LM, Gura K, Stenquist N, Ariagno K, Nurko S, Mehta NM. Gastric Emptying in Critically Ill Children. JPEN J Parenter Enteral Nutr. 2017 09; 41(7):1100-1109. View abstract
  24. Rosen R, Rodriguez L, Nurko S. Pediatric rumination subtypes: A study using high-resolution esophageal manometry with impedance. Neurogastroenterol Motil. 2017 05; 29(5). View abstract
  25. Varni JW, Shulman RJ, Self MM, Saeed SA, Patel AS, Nurko S, Neigut DA, Saps M, Franciosi JP, Denham JM, Zacur GM, Dark CV, Bendo CB, Pohl JF. Gastrointestinal Symptoms Predictors of Health-Related Quality of Life in Patients With Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2016 12; 63(6):e186-e192. View abstract
  26. Varni JW, Shulman RJ, Self MM, Nurko S, Saps M, Saeed SA, Patel AS, Dark CV, Bendo CB, Pohl JF. Gastrointestinal symptoms predictors of health-related quality of life in pediatric patients with functional gastrointestinal disorders. Qual Life Res. 2017 04; 26(4):1015-1025. View abstract
  27. Ambartsumyan L, Flores A, Nurko S, Rodriguez L. Utility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction. Paediatr Drugs. 2016 Oct; 18(5):387-92. View abstract
  28. Mudde AC, Lexmond WS, Blumberg RS, Nurko S, Fiebiger E. Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models. World Allergy Organ J. 2016; 9:23. View abstract
  29. Hubbard CS, Becerra L, Heinz N, Ludwick A, Rasooly T, Wu R, Johnson A, Schechter NL, Borsook D, Nurko S. Abdominal Pain, the Adolescent and Altered Brain Structure and Function. PLoS One. 2016; 11(5):e0156545. View abstract
  30. Venturelli N, Lexmond WS, Ohsaki A, Nurko S, Karasuyama H, Fiebiger E, Oyoshi MK. Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33-basophil axis in mice. J Allergy Clin Immunol. 2016 11; 138(5):1367-1380.e5. View abstract
  31. Ambartsumyan L, Siddiqui A, Bauer S, Nurko S. Simultaneous urodynamic and anorectal manometry studies in children: insights into the relationship between the lower gastrointestinal and lower urinary tracts. Neurogastroenterol Motil. 2016 06; 28(6):924-33. View abstract
  32. Benninga MA, Faure C, Hyman PE, St James Roberts I, Schechter NL, Nurko S. Childhood Functional Gastrointestinal Disorders: Neonate/Toddler. Gastroenterology. 2016 Feb 15. View abstract
  33. Ganesh M, Hertzberg A, Nurko S, Needleman H, Rosen R. Acid Rather Than Nonacid Reflux Burden Is a Predictor of Tooth Erosion. J Pediatr Gastroenterol Nutr. 2016 Feb; 62(2):309-13. View abstract
  34. Martinez EE, Douglas K, Nurko S, Mehta NM. Gastric Dysmotility in Critically Ill Children: Pathophysiology, Diagnosis, and Management. Pediatr Crit Care Med. 2015 Nov; 16(9):828-36. View abstract
  35. Varni JW, Nurko S, Shulman RJ, Self MM, Saps M, Bendo CB, Vaughan Dark C, Pohl JF. Pediatric Functional Constipation Gastrointestinal Symptom Profile Compared With Healthy Controls. J Pediatr Gastroenterol Nutr. 2015 Oct; 61(4):424-30. View abstract
  36. Varni JW, Shulman RJ, Self MM, Nurko S, Saps M, Saeed SA, Bendo CB, Patel AS, Dark CV, Zacur GM, Pohl JF. Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls. J Pediatr Gastroenterol Nutr. 2015 Sep; 61(3):323-9. View abstract
  37. Rodriguez L, Morley-Fletcher A, Souza A, Rosengaus L, Nurko S. Effect of anesthesia on gastroesophageal reflux in children: a study using BRAVO wireless pH study measurements. Neurogastroenterol Motil. 2015 Nov; 27(11):1553-8. View abstract
  38. Lexmond WS, Hu L, Pardo M, Heinz N, Rooney K, LaRosa J, Dehlink E, Fiebiger E, Nurko S. Accuracy of digital mRNA profiling of oesophageal biopsies as a novel diagnostic approach to eosinophilic oesophagitis. Clin Exp Allergy. 2015 Aug; 45(8):1317-1327. View abstract
  39. Rommel N, Omari TI, Selleslagh M, Kritas S, Cock C, Rosan R, Rodriguez L, Nurko S. High-resolution manometry combined with impedance measurements discriminates the cause of dysphagia in children. Eur J Pediatr. 2015 Dec; 174(12):1629-37. View abstract
  40. Hubert K, Sideridis G, Sherlock R, Queally J, Rosoklija I, Kringle G, Johnson K, Nurko S, Bauer S. Validation of a bowel dysfunction instrument for adolescents with spina bifida. J Pediatr Urol. 2015 Aug; 11(4):199.e1-7. View abstract
  41. Kovacic K, Sood MR, Mugie S, Di Lorenzo C, Nurko S, Heinz N, Ponnambalam A, Beesley C, Sanghavi R, Silverman AH. A multicenter study on childhood constipation and fecal incontinence: effects on quality of life. J Pediatr. 2015 Jun; 166(6):1482-7.e1. View abstract
  42. Varni JW, Franciosi JP, Shulman RJ, Saeed S, Nurko S, Neigut DA, Bendo CB, Patel AS, Self MM, Saps M, Zacur GM, Denham J, Dark CV, Pohl JF. PedsQL gastrointestinal symptoms scales and gastrointestinal worry scales in pediatric patients with inflammatory bowel disease in comparison with healthy controls. Inflamm Bowel Dis. 2015 May; 21(5):1115-24. View abstract
  43. Mallon D, Vernacchio L, Trudell E, Antonelli R, Nurko S, Leichtner AM, Lightdale JR. Shared care: a quality improvement initiative to optimize primary care management of constipation. Pediatrics. 2015 May; 135(5):e1300-7. View abstract
  44. Silverman AH, Berlin KS, Di Lorenzo C, Nurko S, Kamody RC, Ponnambalam A, Mugie S, Gorges C, Sanghavi R, Sood MR. Measuring Health-Related Quality of Life With the Parental Opinions of Pediatric Constipation Questionnaire. J Pediatr Psychol. 2015 Sep; 40(8):814-24. View abstract
  45. Sommers T, Corban C, Sengupta N, Jones M, Cheng V, Bollom A, Nurko S, Kelley J, Lembo A. Emergency department burden of constipation in the United States from 2006 to 2011. Am J Gastroenterol. 2015 Apr; 110(4):572-9. View abstract
  46. Park R, Mikami S, LeClair J, Bollom A, Lembo C, Sethi S, Lembo A, Jones M, Cheng V, Friedlander E, Nurko S. Inpatient burden of childhood functional GI disorders in the USA: an analysis of national trends in the USA from 1997 to 2009. Neurogastroenterol Motil. 2015 May; 27(5):684-92. View abstract
  47. Varni JW, Bendo CB, Shulman RJ, Self MM, Nurko S, Franciosi JP, Saps M, Saeed S, Zacur GM, Vaughan Dark C, Pohl JF. Interpretability of the PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in Pediatric Patients With Functional and Organic Gastrointestinal Diseases. J Pediatr Psychol. 2015 Jul; 40(6):591-601. View abstract
  48. Nurko S, Saps M. Treating constipation with prucalopride: one size does not fit all. Gastroenterology. 2014 Dec; 147(6):1214-6. View abstract
  49. Varni JW, Bendo CB, Nurko S, Shulman RJ, Self MM, Franciosi JP, Saps M, Pohl JF. Health-related quality of life in pediatric patients with functional and organic gastrointestinal diseases. J Pediatr. 2015 Jan; 166(1):85-90. View abstract
  50. Varni JW, Bendo CB, Denham J, Shulman RJ, Self MM, Neigut DA, Nurko S, Patel AS, Franciosi JP, Saps M, Verga B, Smith A, Yeckes A, Heinz N, Langseder A, Saeed S, Zacur GM, Pohl JF. PedsQL gastrointestinal symptoms module: feasibility, reliability, and validity. J Pediatr Gastroenterol Nutr. 2014 Sep; 59(3):347-55. View abstract
  51. Varni JW, Bendo CB, Denham J, Shulman RJ, Self MM, Neigut DA, Nurko S, Patel AS, Franciosi JP, Saps M, Yeckes A, Langseder A, Saeed S, Pohl JF. PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases in comparison to healthy controls. Qual Life Res. 2015 Feb; 24(2):363-78. View abstract
  52. Nurko S, Zimmerman LA. Evaluation and treatment of constipation in children and adolescents. Am Fam Physician. 2014 Jul 15; 90(2):82-90. View abstract
  53. Bromberg MH, Schechter NL, Nurko S, Zempsky WT, Schanberg LE. Persistent pain in chronically ill children without detectable disease activity. Pain Manag. 2014 May; 4(3):211-9. View abstract
  54. Ganesh M, Nurko S. Functional dyspepsia in children. Pediatr Ann. 2014 Apr; 43(4):e101-5. View abstract
  55. Lexmond WS, Neves JF, Nurko S, Olszak T, Exley MA, Blumberg RS, Fiebiger E. Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy. Am J Gastroenterol. 2014 May; 109(5):646-57. View abstract
  56. Rosen R, Amirault J, Giligan E, Khatwa U, Nurko S. Intraesophageal pressure recording improves the detection of cough during multichannel intraluminal impedance testing in children. J Pediatr Gastroenterol Nutr. 2014 Jan; 58(1):22-6. View abstract
  57. Mohammad S, Di Lorenzo C, Youssef NN, Miranda A, Nurko S, Hyman P, Saps M. Assessment of abdominal pain through global outcomes and recent FDA recommendations in children: are we ready for change? J Pediatr Gastroenterol Nutr. 2014 Jan; 58(1):46-50. View abstract
  58. Rosen R, Amirault J, Johnston N, Haver K, Khatwa U, Rubinstein E, Nurko S. The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing. Pediatr Pulmonol. 2014 Nov; 49(11):1090-6. View abstract
  59. Ambartsumyan L, Rodriguez L, Morera C, Nurko S. Longitudinal and radial characteristics of intra-anal pressures in children using 3D high-definition anorectal manometry: new observations. Am J Gastroenterol. 2013 Dec; 108(12):1918-28. View abstract
  60. Ambartsumyan L, Nurko S. Review of organic causes of fecal incontinence in children: evaluation and treatment. Expert Rev Gastroenterol Hepatol. 2013 Sep; 7(7):657-67. View abstract
  61. Lexmond WS, Pardo M, Rooney K, Goettel JA, Snapper SB, Yen EH, Dehlink E, Nurko S, Fiebiger E. Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. Clin Exp Allergy. 2013 Aug; 43(8):902-13. View abstract
  62. Zimmerman LA, Srinath AI, Goyal A, Bousvaros A, Ducharme P, Szigethy E, Nurko S. The overlap of functional abdominal pain in pediatric Crohn's disease. Inflamm Bowel Dis. 2013 Mar-Apr; 19(4):826-31. View abstract
  63. Rodriguez L, Roberts LD, LaRosa J, Heinz N, Gerszten R, Nurko S, Goldstein AM. Relationship between postprandial metabolomics and colon motility in children with constipation. Neurogastroenterol Motil. 2013 May; 25(5):420-6, e299. View abstract
  64. Rodriguez L, Diaz J, Nurko S. Safety and efficacy of cyproheptadine for treating dyspeptic symptoms in children. J Pediatr. 2013 Jul; 163(1):261-7. View abstract
  65. Rodriguez L, Nurko S, Flores A. Factors associated with successful decrease and discontinuation of antegrade continence enemas (ACE) in children with defecation disorders: a study evaluating the effect of ACE on colon motility. Neurogastroenterol Motil. 2013 Feb; 25(2):140-e81. View abstract
  66. Chogle A, Sztainberg M, Bass L, Youssef NN, Miranda A, Nurko S, Hyman P, Cocjin J, Di Lorenzo C, Saps M. Accuracy of pain recall in children. J Pediatr Gastroenterol Nutr. 2012 Sep; 55(3):288-91. View abstract
  67. Bannert C, Bidmon-Fliegenschnee B, Stary G, Hotzy F, Stift J, Nurko S, Szépfalusi Z, Fiebiger E, Dehlink E. Fc-epsilon-RI, the high affinity IgE-receptor, is robustly expressed in the upper gastrointestinal tract and modulated by mucosal inflammation. PLoS One. 2012; 7(7):e42066. View abstract
  68. Rodriguez L, Siddiqui A, Nurko S. Internal anal sphincter relaxation associated with bisacodyl-induced colonic high amplitude propagating contractions in children with constipation: a colo-anal reflex? Neurogastroenterol Motil. 2012 Nov; 24(11):1023-e545. View abstract
  69. Rodriguez L, Rosen R, Manfredi M, Nurko S. Endoscopic intrapyloric injection of botulinum toxin A in the treatment of children with gastroparesis: a retrospective, open-label study. Gastrointest Endosc. 2012 Feb; 75(2):302-9. View abstract
  70. Morera C, Nurko S. Heterogeneity of lower esophageal sphincter function in children with achalasia. J Pediatr Gastroenterol Nutr. 2012 Jan; 54(1):34-40. View abstract
  71. Rosen R, Johnston N, Hart K, Khatwa U, Nurko S. The presence of pepsin in the lung and its relationship to pathologic gastro-esophageal reflux. Neurogastroenterol Motil. 2012 Feb; 24(2):129-33, e84-5. View abstract
  72. Nurko S. Eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2011 Dec; 53 Suppl 2:S13-5. View abstract
  73. Nurko S. Extra-esophageal symptoms: how do we treat them? J Pediatr Gastroenterol Nutr. 2011 Dec; 53 Suppl 2:S22-3. View abstract
  74. Siddiqui A, Rosen R, Nurko S. Anorectal manometry may identify children with spinal cord lesions. J Pediatr Gastroenterol Nutr. 2011 Nov; 53(5):507-11. View abstract
  75. Nurko S. 50 years ago in the journal of pediatrics achalasia in children as a cause of recurrent pulmonary disease. J Pediatr. 2011 Oct; 159(4):632. View abstract
  76. Jadcherla SR, Nurko S. Esophageal disease in pediatrics. Ann N Y Acad Sci. 2011 Sep; 1232:401-4. View abstract
  77. Lexmond W, der Mee Jv, Ruiter F, Platzer B, Stary G, Yen EH, Dehlink E, Nurko S, Fiebiger E. Development and validation of a standardized ELISA for the detection of soluble Fc-epsilon-RI in human serum. J Immunol Methods. 2011 Oct 28; 373(1-2):192-9. View abstract
  78. Rosen R, Johnston N, Hart K, Khatwa U, Katz E, Nurko S. Higher rate of bronchoalveolar lavage culture positivity in children with nonacid reflux and respiratory disorders. J Pediatr. 2011 Sep; 159(3):504-6. View abstract
  79. Chumpitazi BP, Nurko S. Defecation disorders in children after surgery for Hirschsprung disease. J Pediatr Gastroenterol Nutr. 2011 Jul; 53(1):75-9. View abstract
  80. Mousa HM, Rosen R, Woodley FW, Orsi M, Armas D, Faure C, Fortunato J, O'Connor J, Skaggs B, Nurko S. [Esophageal impedance monitoring for gastroesophageal reflux]. Acta Gastroenterol Latinoam. 2011 Jun; 41(2):146-61. View abstract
  81. Chiou E, Rosen R, Jiang H, Nurko S. Diagnosis of supra-esophageal gastric reflux: correlation of oropharyngeal pH with esophageal impedance monitoring for gastro-esophageal reflux. Neurogastroenterol Motil. 2011 Aug; 23(8):717-e326. View abstract
  82. Raphael BP, Nurko S, Jiang H, Hart K, Kamin DS, Jaksic T, Duggan C. Cisapride improves enteral tolerance in pediatric short-bowel syndrome with dysmotility. J Pediatr Gastroenterol Nutr. 2011 May; 52(5):590-4. View abstract
  83. Siddiqui AA, Fishman SJ, Bauer SB, Nurko S. Long-term follow-up of patients after antegrade continence enema procedure. J Pediatr Gastroenterol Nutr. 2011 May; 52(5):574-80. View abstract
  84. Chiou E, Nurko S. Functional abdominal pain and irritable bowel syndrome in children and adolescents. Therapy. 2011 May 01; 8(3):315-331. View abstract
  85. Dehlink E, Platzer B, Baker AH, Larosa J, Pardo M, Dwyer P, Yen EH, Szépfalusi Z, Nurko S, Fiebiger E. A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. PLoS One. 2011 Apr 22; 6(4):e19098. View abstract
  86. Sood MR, Di Lorenzo C, Hyams J, Miranda A, Simpson P, Mousa H, Nurko S. Beliefs and attitudes of general pediatricians and pediatric gastroenterologists regarding functional gastrointestinal disorders: a survey study. Clin Pediatr (Phila). 2011 Oct; 50(10):891-6. View abstract
  87. Rosen R, Hart K, Nurko S. Does reflux monitoring with multichannel intraluminal impedance change clinical decision making? J Pediatr Gastroenterol Nutr. 2011 Apr; 52(4):404-7. View abstract
  88. Chiou E, Rosen R, Nurko S. Effect of different pH criteria on dual-sensor pH monitoring in the evaluation of supraesophageal gastric reflux in children. J Pediatr Gastroenterol Nutr. 2011 Apr; 52(4):399-403. View abstract
  89. Nurko S, Scott SM. Coexistence of constipation and incontinence in children and adults. Best Pract Res Clin Gastroenterol. 2011 Feb; 25(1):29-41. View abstract
  90. Mousa HM, Rosen R, Woodley FW, Orsi M, Armas D, Faure C, Fortunato J, O'connor J, Skaggs B, Nurko S. Esophageal impedance monitoring for gastroesophageal reflux. J Pediatr Gastroenterol Nutr. 2011 Feb; 52(2):129-39. View abstract
  91. Yen EH, Hornick JL, Dehlink E, Dokter M, Baker A, Fiebiger E, Nurko S. Comparative analysis of FceRI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr. 2010 Nov; 51(5):584-92. View abstract
  92. Dehlink E, Baker AH, Yen E, Nurko S, Fiebiger E. Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. PLoS One. 2010 Aug 16; 5(8):e12204. View abstract
  93. Pensabene L, Buonomo C, Fishman L, Chitkara D, Nurko S. Lack of utility of abdominal x-rays in the evaluation of children with constipation: comparison of different scoring methods. J Pediatr Gastroenterol Nutr. 2010 Aug; 51(2):155-9. View abstract
  94. Chiou E, Nurko S. Management of functional abdominal pain and irritable bowel syndrome in children and adolescents. Expert Rev Gastroenterol Hepatol. 2010 Jun; 4(3):293-304. View abstract
  95. Rosen R, Levine P, Lewis J, Mitchell P, Nurko S. Reflux events detected by pH-MII do not determine fundoplication outcome. J Pediatr Gastroenterol Nutr. 2010 Mar; 50(3):251-5. View abstract
  96. Nurko S, Rosen R, Furuta GT. Esophageal dysmotility in children with eosinophilic esophagitis: a study using prolonged esophageal manometry. Am J Gastroenterol. 2009 Dec; 104(12):3050-7. View abstract
  97. Saps M, Youssef N, Miranda A, Nurko S, Hyman P, Cocjin J, Di Lorenzo C. Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. Gastroenterology. 2009 Oct; 137(4):1261-9. View abstract
  98. Mallory LA, Shaw JG, Burgess SL, Estrella E, Nurko S, Burpee TM, Agus MS, Darras BT, Kunkel LM, Kang PB. Congenital myasthenic syndrome with episodic apnea. Pediatr Neurol. 2009 Jul; 41(1):42-5. View abstract
  99. Chumpitazi BP, Fishman SJ, Nurko S. Long-term clinical outcome after botulinum toxin injection in children with nonrelaxing internal anal sphincter. Am J Gastroenterol. 2009 Apr; 104(4):976-83. View abstract
  100. Nurko S. The tip of the iceberg: the prevalence of functional gastrointestinal diseases in children. J Pediatr. 2009 Mar; 154(3):313-5. View abstract
  101. Modi BP, Ching YA, Langer M, Donovan K, Fauza DO, Kim HB, Jaksic T, Nurko S. Preservation of intestinal motility after the serial transverse enteroplasty procedure in a large animal model of short bowel syndrome. J Pediatr Surg. 2009 Jan; 44(1):229-35; discussion 235. View abstract
  102. Nurko S, Di Lorenzo C. Functional abdominal pain: time to get together and move forward. J Pediatr Gastroenterol Nutr. 2008 Nov; 47(5):679-80. View abstract
  103. Pai SY, Levy O, Jabara HH, Glickman JN, Stoler-Barak L, Sachs J, Nurko S, Orange JS, Geha RS. Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. J Allergy Clin Immunol. 2008 Dec; 122(6):1113-1118.e1. View abstract
  104. Pensabene L, Nurko S. Approach to the child who has persistent dysphagia after surgical treatment for esophageal achalasia. J Pediatr Gastroenterol Nutr. 2008 Jul; 47(1):92-7. View abstract
  105. Berde C, Nurko S. Opioid side effects--mechanism-based therapy. N Engl J Med. 2008 May 29; 358(22):2400-2. View abstract
  106. Rosen R, Furuta G, Fritz J, Donovan K, Nurko S. Role of acid and nonacid reflux in children with eosinophilic esophagitis compared with patients with gastroesophageal reflux and control patients. J Pediatr Gastroenterol Nutr. 2008 May; 46(5):520-3. View abstract
  107. Rosen R, Fritz J, Nurko A, Simon D, Nurko S. Lipid-laden macrophage index is not an indicator of gastroesophageal reflux-related respiratory disease in children. Pediatrics. 2008 Apr; 121(4):e879-84. View abstract
  108. Nurko S, Youssef NN, Sabri M, Langseder A, McGowan J, Cleveland M, Di Lorenzo C. PEG3350 in the treatment of childhood constipation: a multicenter, double-blinded, placebo-controlled trial. J Pediatr. 2008 Aug; 153(2):254-61, 261.e1. View abstract
  109. Chumpitazi B, Nurko S. Pediatric gastrointestinal motility disorders: challenges and a clinical update. Gastroenterol Hepatol (N Y). 2008 Feb; 4(2):140-8. View abstract
  110. Nurko S, Rosen R. Esophageal dysmotility in patients who have eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008 Jan; 18(1):73-89; ix. View abstract
  111. Rosen R, Lord C, Nurko S. The sensitivity of multichannel intraluminal impedance and the pH probe in the evaluation of gastroesophageal reflux in children. Clin Gastroenterol Hepatol. 2006 Feb; 4(2):167-72. View abstract
  112. Nurko S. What's the value of diagnostic tools in defecation disorders? J Pediatr Gastroenterol Nutr. 2005 Sep; 41 Suppl 1:S53-5. View abstract
  113. Nurko S, Rosen R. Use of multi-channel intraluminal impedance (MII) in the evaluation of children with respiratory symptoms: a new phenomenon? J Pediatr Gastroenterol Nutr. 2005 Aug; 41(2):166-8. View abstract
  114. Benninga M, Candy DC, Catto-Smith AG, Clayden G, Loening-Baucke V, Di Lorenzo C, Nurko S, Staiano A. The Paris Consensus on Childhood Constipation Terminology (PACCT) Group. J Pediatr Gastroenterol Nutr. 2005 Mar; 40(3):273-5. View abstract
  115. Chitkara DK, Fortunato C, Nurko S. Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis. J Pediatr Gastroenterol Nutr. 2005 Jan; 40(1):70-5. View abstract
  116. Rosen R, Nurko S. The importance of multichannel intraluminal impedance in the evaluation of children with persistent respiratory symptoms. Am J Gastroenterol. 2004 Dec; 99(12):2452-8. View abstract
  117. Pensabene L, Nurko S. Management of Fecal Incontinence in Children Without Functional Fecal Retention. Curr Treat Options Gastroenterol. 2004 Oct; 7(5):381-390. View abstract
  118. Rosen R, Buonomo C, Andrade R, Nurko S. Incidence of spinal cord lesions in patients with intractable constipation. J Pediatr. 2004 Sep; 145(3):409-11. View abstract
  119. Fishman L, Lenders C, Fortunato C, Noonan C, Nurko S. Increased prevalence of constipation and fecal soiling in a population of obese children. J Pediatr. 2004 Aug; 145(2):253-4. View abstract
  120. Nurko S, Teitelbaum JE, Husain K, Buonomo C, Fox VL, Antonioli D, Fortunato C, Badizadegan K, Furuta GT. Association of Schatzki ring with eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr. 2004 Apr; 38(4):436-41. View abstract
  121. Prasad C, Nurko S, Borovoy J, Korson MS. The importance of gut motility in the metabolic control of propionic acidemia. J Pediatr. 2004 Apr; 144(4):532-5. View abstract
  122. Chitkara DK, Fortunato C, Nurko S. Prolonged monitoring of esophageal motor function in healthy children. J Pediatr Gastroenterol Nutr. 2004 Feb; 38(2):192-7. View abstract
  123. Köhler H, Nurko S, Glickman J, Furuta GT. Acute myeloid leukemia presenting as non-neutropenic colitis in an infant. J Pediatr Gastroenterol Nutr. 2003 Nov; 37(5):631-3. View abstract
  124. Ciamarra P, Nurko S, Barksdale E, Fishman S, Di Lorenzo C. Internal anal sphincter achalasia in children: clinical characteristics and treatment with Clostridium botulinum toxin. J Pediatr Gastroenterol Nutr. 2003 Sep; 37(3):315-9. View abstract
  125. Rosen R, Nurko S, Furuta GT. Impeding gastroesophageal refluxate: a new application of an old medication. Gastroenterology. 2003 Sep; 125(3):984-5; discussion 985-6. View abstract
  126. Hadigan C, Fishman SJ, Connolly LP, Treves ST, Nurko S. Stimulation with fatty meal (Lipomul) to assess gallbladder emptying in children with chronic acalculous cholecystitis. J Pediatr Gastroenterol Nutr. 2003 Aug; 37(2):178-82. View abstract
  127. Morera C, Nurko S. Rectal manometry in patients with isolated sacral agenesis. J Pediatr Gastroenterol Nutr. 2003 Jul; 37(1):47-52. View abstract
  128. Fishman L, Rappaport L, Schonwald A, Nurko S. Trends in referral to a single encopresis clinic over 20 years. Pediatrics. 2003 May; 111(5 Pt 1):e604-7. View abstract
  129. Chitkara DK, Nurko S, Shoffner JM, Buie T, Flores A. Abnormalities in gastrointestinal motility are associated with diseases of oxidative phosphorylation in children. Am J Gastroenterol. 2003 Apr; 98(4):871-7. View abstract
  130. Kim HB, Fauza D, Garza J, Oh JT, Nurko S, Jaksic T. Serial transverse enteroplasty (STEP): a novel bowel lengthening procedure. J Pediatr Surg. 2003 Mar; 38(3):425-9. View abstract
  131. Fox VL, Nurko S, Teitelbaum JE, Badizadegan K, Furuta GT. High-resolution EUS in children with eosinophilic "allergic" esophagitis. Gastrointest Endosc. 2003 Jan; 57(1):30-6. View abstract
  132. Heuschkel RB, Fletcher K, Hill A, Buonomo C, Bousvaros A, Nurko S. Isolated neonatal swallowing dysfunction: a case series and review of the literature. Dig Dis Sci. 2003 Jan; 48(1):30-5. View abstract
  133. Teitelbaum JE, Berde CB, Nurko S, Buonomo C, Perez-Atayde AR, Fox VL. Diagnosis and management of MNGIE syndrome in children: case report and review of the literature. J Pediatr Gastroenterol Nutr. 2002 Sep; 35(3):377-83. View abstract
  134. Fox VL, Nurko S, Furuta GT. Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc. 2002 Aug; 56(2):260-70. View abstract
  135. Di Lorenzo C, Hillemeier C, Hyman P, Loening-Baucke V, Nurko S, Rosenberg A, Taminiau J. Manometry studies in children: minimum standards for procedures. Neurogastroenterol Motil. 2002 Aug; 14(4):411-20. View abstract
  136. Rakhit A, Nurko S, Gauvreau K, Mayer JE, Blume ED. Gastrointestinal complications after pediatric cardiac transplantation. J Heart Lung Transplant. 2002 Jul; 21(7):751-9. View abstract
  137. Simanovsky N, Buonomo C, Nurko S. The infant with chronic vomiting: the value of the upper GI series. Pediatr Radiol. 2002 Aug; 32(8):549-50; discussion 551. View abstract
  138. Orange JS, Brodeur SR, Jain A, Bonilla FA, Schneider LC, Kretschmer R, Nurko S, Rasmussen WL, Köhler JR, Gellis SE, Ferguson BM, Strominger JL, Zonana J, Ramesh N, Ballas ZK, Geha RS. Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. J Clin Invest. 2002 Jun; 109(11):1501-9. View abstract
  139. Teitelbaum JE, Fox VL, Twarog FJ, Nurko S, Antonioli D, Gleich G, Badizadegan K, Furuta GT. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology. 2002 May; 122(5):1216-25. View abstract
  140. Fishman L, Rappaport L, Cousineau D, Nurko S. Early constipation and toilet training in children with encopresis. J Pediatr Gastroenterol Nutr. 2002 Apr; 34(4):385-8. View abstract
  141. Lyons J, Rauh-Pfeiffer A, Ming-Yu Y, Lu XM, Zurakowski D, Curley M, Collier S, Duggan C, Nurko S, Thompson J, Ajami A, Borgonha S, Young VR, Castillo L. Cysteine metabolism and whole blood glutathione synthesis in septic pediatric patients. Crit Care Med. 2001 Apr; 29(4):870-7. View abstract
  142. Fishman SJ, Islam S, Buonomo C, Nurko S. Nonfixation of an atretic colon predicts Hirschsprung's disease. J Pediatr Surg. 2001 Jan; 36(1):202-4. View abstract
  143. Furuta GT, Nurko S, Bousvaros A, Antonioli D, Badizadegan K. The spectrum of pediatric gastroesophageal reflux. JAMA. 2000 Dec 27; 284(24):3125-6. View abstract
  144. Reid JR, Buonomo C, Moreira C, Kozakevich H, Nurko SJ. The barium enema in constipation: comparison with rectal manometry and biopsy to exclude Hirschsprung's disease after the neonatal period. Pediatr Radiol. 2000 Oct; 30(10):681-4. View abstract
  145. Nurko S. Advances in the management of pediatric constipation. Curr Gastroenterol Rep. 2000 Jun; 2(3):234-40. View abstract
  146. Nurko S. The efficacy of cisapride: what is needed for digestion? J Pediatr Gastroenterol Nutr. 2000 Mar; 30(3):230-1. View abstract
  147. Nurko S, Garcia-Aranda JA, Worona LB, Zlochisty O. Cisapride for the treatment of constipation in children: A double-blind study. J Pediatr. 2000 Jan; 136(1):35-40. View abstract
  148. Baker SS, Liptak GS, Colletti RB, Croffie JM, Di Lorenzo C, Ector W, Nurko S. Constipation in infants and children: evaluation and treatment. A medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1999 Nov; 29(5):612-26. View abstract
  149. Vazquez JL, Buonomo C, Nurko S. Barrett's esophagus in a teenager with a ringed esophagus. Pediatr Radiol. 1999 Aug; 29(8):641. View abstract
  150. Nurko S. Cisapride for the treatment of gastroesophageal reflux disease in children. J Pediatr Gastroenterol Nutr. 1999 Jul; 29(1):7. View abstract
  151. Bloom DA, Buonomo C, Fishman SJ, Furuta G, Nurko S. Allergic colitis: a mimic of Hirschsprung disease. Pediatr Radiol. 1999 Jan; 29(1):37-41. View abstract
  152. Guzman C, Bousvaros A, Buonomo C, Nurko S. Intraduodenal hematoma complicating intestinal biopsy: case reports and review of the literature. Am J Gastroenterol. 1998 Dec; 93(12):2547-50. View abstract
  153. Buckley K, Buonomo C, Husain K, Nurko S. Schatzki ring in children and young adults: clinical and radiologic findings. Pediatr Radiol. 1998 Nov; 28(11):884-6. View abstract
  154. Borovoy J, Furuta L, Nurko S. Benefit of uncooked cornstarch in the management of children with dumping syndrome fed exclusively by gastrostomy. Am J Gastroenterol. 1998 May; 93(5):814-8. View abstract
  155. Siafakas C, Fox VL, Nurko S. Use of octreotide for the treatment of severe gastrointestinal bleeding in children. J Pediatr Gastroenterol Nutr. 1998 Mar; 26(3):356-9. View abstract
  156. Duggan C, Nurko S. "Feeding the gut": the scientific basis for continued enteral nutrition during acute diarrhea. J Pediatr. 1997 Dec; 131(6):801-8. View abstract
  157. Nurko S, García-Aranda JA, Fishbein E, Pérez-Zúñiga MI. Successful use of a chicken-based diet for the treatment of severely malnourished children with persistent diarrhea: a prospective, randomized study. J Pediatr. 1997 Sep; 131(3):405-12. View abstract
  158. Nurko S. Botulinum toxin for achalasia: are we witnessing the birth of a new era? J Pediatr Gastroenterol Nutr. 1997 Apr; 24(4):447-9. View abstract
  159. Nurko S, Garcia-Aranda JA, Guerrero VY, Worona LB. Treatment of intractable constipation in children: experience with cisapride. J Pediatr Gastroenterol Nutr. 1996 Jan; 22(1):38-44. View abstract
  160. Shamberger RC, Lillehei CW, Nurko S, Winter HS. Anorectal function in children after ileoanal pull-through. J Pediatr Surg. 1994 Feb; 29(2):329-32; discussion 332-3. View abstract
  161. Nurko S, Rattan S. Role of neuropeptide Y in opossum internal anal sphincter. Am J Physiol. 1990 Jan; 258(1 Pt 1):G59-64. View abstract
  162. Nurko S, Dunn BM, Rattan S. Peptide histidine isoleucine and vasoactive intestinal polypeptide cause relaxation of opossum internal anal sphincter via two distinct receptors. Gastroenterology. 1989 Feb; 96(2 Pt 1):403-13. View abstract
  163. Nurko S, Rattan S. Role of vasoactive intestinal polypeptide in the internal anal sphincter relaxation of the opossum. J Clin Invest. 1988 Apr; 81(4):1146-53. View abstract
  164. Peña A, Pérez L, Nurko S, Dorenbaum D. Pectus carinatum and pectus excavatum: are they the same disease? Am Surg. 1981 May; 47(5):215-8. View abstract
  165. Lazar Moussali F, Dorenbaum D, Nurko S. [Neurogenic bladder in children. Analysis of the most adequate method for the treatment in our area (review of 6 years of experience at the Hospital del Niño DIF)]. Actas Urol Esp. 1979 Nov-Dec; 3(6):337-44. View abstract