Dr. Mazumdar’s program focuses on the role environmental hazards play in the development of neural tube defects.  Neural tube defects, including anencephaly and spina bifida, are birth defects caused by failure of the developing neural plate for fold in the first few weeks of gestations, causing death and disability in surviving children.  The study of neural tube defects also provides a unique opportunity to learn about how environmental hazards affect the developing nervous system.  Neural tube defects are flagrantly visible in newborns, and represent a severe form of injury that is likely common with those in many other neurological disorders that are more difficult to detect and classify.  Better understanding of the environmental influences that increase neural tube risk has the potential to lead to more focused interrogation of biological processes of other disorders of the developing nervous system that may have important environmental factors.

Dr. Mazumdar’s studies take place in Bangladesh, where an estimated 70 million people have been chronically exposed to high concentrations of arsenic through contaminated drinking water, beginning in the 1980s.

Researcher Services

Researcher Areas

  • Spina Bifida
  • Environmental Health

Research Departments

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Sun R, Wang Z, Henn BC, Su L, Lu Q, Lin X, Wright RO, Bellinger DC, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Identification of novel loci associated with infant cognitive ability. Mol Psychiatry. 2018 Aug 17. View abstract
  2. Lee JJ, Valeri L, Kapur K, Ibne Hasan MOS, Quamruzzaman Q, Wright RO, Bellinger DC, Christiani DC, Mazumdar M. Growth parameters at birth mediate the relationship between prenatal manganese exposure and cognitive test scores among a cohort of 2- to 3-year-old Bangladeshi children. Int J Epidemiol. 2018 Aug 01; 47(4):1169-1179. View abstract
  3. Rahman ML, Kile ML, Rodrigues EG, Valeri L, Raj A, Mazumdar M, Mostofa G, Quamruzzaman Q, Rahman M, Hauser R, Baccarelli A, Liang L, Christiani DC. Prenatal arsenic exposure, child marriage, and pregnancy weight gain: Associations with preterm birth in Bangladesh. Environ Int. 2018 Mar; 112:23-32. View abstract
  4. Kancherla V, Ibne Hasan MOS, Hamid R, Paul L, Selhub J, Oakley G, Quamruzzaman Q, Mazumdar M. Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh. PLoS One. 2017; 12(11):e0188726. View abstract
  5. Rahman ML, Valeri L, Kile ML, Mazumdar M, Mostofa G, Qamruzzaman Q, Rahman M, Baccarelli A, Liang L, Hauser R, Christiani DC. Investigating causal relation between prenatal arsenic exposure and birthweight: Are smaller infants more susceptible? Environ Int. 2017 11; 108:32-40. View abstract
  6. Wang Z, Claus Henn B, Wang C, Wei Y, Su L, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright R, Bellinger D, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health. 2017 07 28; 16(1):81. View abstract
  7. Lee JJ, Kapur K, Rodrigues EG, Ibne Hasan MOS, Quamruzzaman Q, Wright RO, Bellinger DC, Christiani DC, Mazumdar M. Anthropometric measures at birth and early childhood are associated with neurodevelopmental outcomes among Bangladeshi children aged 2-3years. Sci Total Environ. 2017 Dec 31; 607-608:475-482. View abstract
  8. Valeri L, Mazumdar MM, Bobb JF, Claus Henn B, Rodrigues E, Sharif OIA, Kile ML, Quamruzzaman Q, Afroz S, Golam M, Amarasiriwardena C, Bellinger DC, Christiani DC, Coull BA, Wright RO. The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20-40 Months of Age: Evidence from Rural Bangladesh. Environ Health Perspect. 2017 06 26; 125(6):067015. View abstract
  9. Tauheed J, Sanchez-Guerra M, Lee JJ, Paul L, Ibne Hasan MOS, Quamruzzaman Q, Selhub J, Wright RO, Christiani DC, Coull BA, Baccarelli AA, Mazumdar M. Associations between post translational histone modifications, myelomeningocele risk, environmental arsenic exposure, and folate deficiency among participants in a case control study in Bangladesh. Epigenetics. 2017 06 03; 12(6):484-491. View abstract
  10. Mazumdar M. Does arsenic increase the risk of neural tube defects among a highly exposed population? A new case-control study in Bangladesh. Birth Defects Res. 2017 Jan 30; 109(2):92-98. View abstract
  11. Gleason KM, Valeri L, Shankar AH, Hasan MO, Quamruzzaman Q, Rodrigues EG, Christiani DC, Wright RO, Bellinger DC, Mazumdar M. Stunting is associated with blood lead concentration among Bangladeshi children aged 2-3 years. Environ Health. 2016 11 04; 15(1):103. View abstract
  12. Rodrigues EG, Bellinger DC, Valeri L, Hasan MO, Quamruzzaman Q, Golam M, Kile ML, Christiani DC, Wright RO, Mazumdar M. Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environ Health. 2016 Mar 12; 15:44. View abstract
  13. Kile ML, Cardenas A, Rodrigues E, Mazumdar M, Dobson C, Golam M, Quamruzzaman Q, Rahman M, Christiani DC. Estimating Effects of Arsenic Exposure During Pregnancy on Perinatal Outcomes in a Bangladeshi Cohort. Epidemiology. 2016 Mar; 27(2):173-81. View abstract
  14. Mazumdar M, Valeri L, Rodrigues EG, Ibne Hasan MO, Hamid R, Paul L, Selhub J, Silva F, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC. Polymorphisms in maternal folate pathway genes interact with arsenic in drinking water to influence risk of myelomeningocele. Birth Defects Res A Clin Mol Teratol. 2015 Sep; 103(9):754-62. View abstract
  15. Mazumdar M, Ibne Hasan MO, Hamid R, Valeri L, Paul L, Selhub J, Rodrigues EG, Silva F, Mia S, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC. Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh. Environ Health. 2015 Apr 10; 14:34. View abstract
  16. Mazumdar M, Christiani DC, Biswas SK, Ibne-Hasan OS, Kapur K, Hug C. Elevated sweat chloride levels due to arsenic toxicity. N Engl J Med. 2015 Feb 05; 372(6):582-4. View abstract
  17. Bobb JF, Valeri L, Claus Henn B, Christiani DC, Wright RO, Mazumdar M, Godleski JJ, Coull BA. Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics. 2015 Jul; 16(3):493-508. View abstract
  18. Gleason K, Shine JP, Shobnam N, Rokoff LB, Suchanda HS, Ibne Hasan MO, Mostofa G, Amarasiriwardena C, Quamruzzaman Q, Rahman M, Kile ML, Bellinger DC, Christiani DC, Wright RO, Mazumdar M. Contaminated turmeric is a potential source of lead exposure for children in rural Bangladesh. J Environ Public Health. 2014; 2014:730636. View abstract
  19. Bernson-Leung ME, Mazumdar M. Journal club: pretreatment EEG in childhood absence epilepsy. Neurology. 2014 May 06; 82(18):e158-60. View abstract
  20. Kile ML, Rodrigues EG, Mazumdar M, Dobson CB, Diao N, Golam M, Quamruzzaman Q, Rahman M, Christiani DC. A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh. Environ Health. 2014 Apr 16; 13(1):29. View abstract
  21. Mazumdar M, Xia W, Hofmann O, Gregas M, Ho Sui S, Hide W, Yang T, Needleman HL, Bellinger DC. Prenatal lead levels, plasma amyloid ß levels, and gene expression in young adulthood. Environ Health Perspect. 2012 May; 120(5):702-7. View abstract
  22. Mazumdar M, Bellinger DC, Gregas M, Abanilla K, Bacic J, Needleman HL. Low-level environmental lead exposure in childhood and adult intellectual function: a follow-up study. Environ Health. 2011 Mar 30; 10:24. View abstract
  23. Mazumdar M. Risk of death is not increased in children with simple febrile seizures. J Pediatr. 2009 Jan; 154(1):150-1. View abstract
  24. Mazumdar M. Febrile seizures and risk of death. Lancet. 2008 Aug 09; 372(9637):429-30. View abstract
  25. Mazumdar M, Liu CY, Wang SF, Pan PC, Wu MT, Christiani DC. No association between parental or subject occupation and brain tumor risk. Cancer Epidemiol Biomarkers Prev. 2008 Jul; 17(7):1835-7. View abstract
  26. Mazumdar M, Heeney MM, Sox CM, Lieu TA. Preventing stroke among children with sickle cell anemia: an analysis of strategies that involve transcranial Doppler testing and chronic transfusion. Pediatrics. 2007 Oct; 120(4):e1107-16. View abstract
  27. Mazumdar M, Pandharipande P, Poduri A. Does albendazole affect seizure remission and computed tomography response in children with neurocysticercosis? A Systematic review and meta-analysis. J Child Neurol. 2007 Feb; 22(2):135-42. View abstract
  28. Anselm IA, Anselm IM, Alkuraya FS, Salomons GS, Jakobs C, Fulton AB, Mazumdar M, Rivkin M, Frye R, Poussaint TY, Marsden D. X-linked creatine transporter defect: a report on two unrelated boys with a severe clinical phenotype. J Inherit Metab Dis. 2006 Feb; 29(1):214-9. View abstract
  29. Mazumdar M, Rivkin, M. Creatine deficiency syndrome: A case of defective creatine transport presenting with episodic dystonia. Annals of Neurology. 2003; 54(Suppl. 7):S157. View abstract