Research Overview

Dr. Madden has generally focused on clinical research that seeks to identify and potentially address risk factors for more severe critical illness. Her prior focus of research was in vitamin D deficiency and the relationship of the vitamin D pathway to illness severity and organ failure, including vitamin D binding protein levels and polymorphisms.

She has also worked on quality improvement projects addressing response to presentation of severe sepsis and septic shock, as well as the assessment of severe asthma in both the MSICU and the BMC PICU. Current and future work focuses on the diagnosis of delirium in critically ill children, risk factors for that diagnosis, and potentially modifications in sedation practice to decrease risk.

MEDICAL SERVICES

Languages

  • English

Researcher Services

Researcher Areas

  • Critical Care Delirium
  • Medication Burden and Effects in PICU
  • Sepsis Therapies

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Madden K, Burns JP. Reading the Smoke Signals: What Is the Meaning of Burnout Among Pediatric Critical Care Physicians? Crit Care Med. 2018 01; 46(1):168-170. View abstract
  2. Madden K, Tasker RC. The authors reply. Pediatr Crit Care Med. 2018 Jan; 19(1):87-88. View abstract
  3. Madden K, Burns JP. Caring for Long Length of Stay Patients in the Neonatal ICU and PICU: How Do We Ensure Coherent Decisions When the Physicians Are Continuously Rotating? Pediatr Crit Care Med. 2017 Sep; 18(9):907-908. View abstract
  4. Madden K, Burns MM, Tasker RC. Differentiating Delirium From Sedative/Hypnotic-Related Iatrogenic Withdrawal Syndrome: Lack of Specificity in Pediatric Critical Care Assessment Tools. Pediatr Crit Care Med. 2017 Jun; 18(6):580-588. View abstract
  5. Traube C, Silver G, Reeder RW, Doyle H, Hegel E, Wolfe HA, Schneller C, Chung MG, Dervan LA, DiGennaro JL, Buttram SD, Kudchadkar SR, Madden K, Hartman ME, deAlmeida ML, Walson K, Ista E, Baarslag MA, Salonia R, Beca J, Long D, Kawai Y, Cheifetz IM, Gelvez J, Truemper EJ, Smith RL, Peters ME, O'Meara AM, Murphy S, Bokhary A, Greenwald BM, Bell MJ. Delirium in Critically Ill Children: An International Point Prevalence Study. Crit Care Med. 2017 Apr; 45(4):584-590. View abstract
  6. Madsen EC, Levy ER, Madden K, Agan AA, Sullivan RM, Graham DA, Randolph AG. Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections. Pediatr Crit Care Med. 2017 Feb; 18(2):103-111. View abstract
  7. Levy E, Zinter M, Madden K, Randolph A. 1444: MANNOSE-BINDING LECTIN AND PEDIATRIC SEPSIS SUSCEPTIBILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS. Crit Care Med. 2016 Dec; 44(12 Suppl 1):436. View abstract
  8. Gauguet S, Madden K, Wu J, Duncan C, Lee GS, Miller T, Klingensmith WC, Burchett SK, van der Velden M. Case Report of a Child after Hematopoietic Cell Transplantation with Acute Aspergillus Tracheobronchitis as a Cause for Respiratory Failure. Case Rep Pediatr. 2016; 2016:9676234. View abstract
  9. Madden K, Feldman HA, Chun RF, Smith EM, Sullivan RM, Agan AA, Keisling SM, Panoskaltsis-Mortari A, Randolph AG. Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D. Ann Am Thorac Soc. 2015 Nov; 12(11):1654-61. View abstract
  10. Madden K, Feldman HA, Smith EM, Gordon CM, Keisling SM, Sullivan RM, Hollis BW, Agan AA, Randolph AG. Vitamin D deficiency in critically ill children. Pediatrics. 2012 Sep; 130(3):421-8. View abstract
  11. Madden K, Thiagarajan RR, Rycus PT, Rajagopal SK. Survival of neonates with enteroviral myocarditis requiring extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2011 May; 12(3):314-8. View abstract