Research Overview

Dr. Madden conducts clinical research with a focus on finding risk factors for critical illness and its complications. This has included vitamin D deficiency and its relationship to illness severity and organ failure, quality improvement in severe sepsis and septic shock management, sedation management, early mobilization from critical illness, and delirium assessment. Current clinical research focuses on causes of delirium in critically ill children, as well as its assessment and management.

About the Researcher

Dr. Madden graduated from Brown University and Washington University Medical School at Saint Louis. She completed pediatrics residency, chief residency and pediatric critical care fellowship at Boston Children’s Hospital. She is currently an associate in the division of Pediatric Critical Care, and an Instructor in Anaesthesia at Harvard Medical School. Dr. Madden has studied various areas of clinical research, including vitamin D deficiency in critically ill children, sepsis management, delirium, and sedation in pediatric critical illness. After completing a clinical research fellowship at Harvard Medical School in 2012 with a Master’s of Medical Science, she has been involved in quality improvement initiatives in the division, as well as conducting clinical research projects. Dr. Madden serves as the physician lead for critical care on her hospital’s steering committee of a national “Improving Pediatric Sepsis Outcomes” collaborative (Children’s Hospital Association.)

Researcher Services

Researcher Areas

  • Critical Care Delirium
  • Medication Burden and Effects in PICU
  • Sepsis Therapies

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Madden K, Hussain K, Tasker RC. Anticholinergic Medication Burden in Pediatric Prolonged Critical Illness: A Potentially Modifiable Risk Factor for Delirium. Pediatr Crit Care Med. 2018 10; 19(10):917-924. View abstract
  2. Madden K, Burns JP. Reading the Smoke Signals: What Is the Meaning of Burnout Among Pediatric Critical Care Physicians? Crit Care Med. 2018 01; 46(1):168-170. View abstract
  3. Madden K, Tasker RC. The authors reply. Pediatr Crit Care Med. 2018 01; 19(1):87-88. View abstract
  4. Madden K, Burns JP. Caring for Long Length of Stay Patients in the Neonatal ICU and PICU: How Do We Ensure Coherent Decisions When the Physicians Are Continuously Rotating? Pediatr Crit Care Med. 2017 09; 18(9):907-908. View abstract
  5. Madden K, Burns MM, Tasker RC. Differentiating Delirium From Sedative/Hypnotic-Related Iatrogenic Withdrawal Syndrome: Lack of Specificity in Pediatric Critical Care Assessment Tools. Pediatr Crit Care Med. 2017 Jun; 18(6):580-588. View abstract
  6. Traube C, Silver G, Reeder RW, Doyle H, Hegel E, Wolfe HA, Schneller C, Chung MG, Dervan LA, DiGennaro JL, Buttram SD, Kudchadkar SR, Madden K, Hartman ME, deAlmeida ML, Walson K, Ista E, Baarslag MA, Salonia R, Beca J, Long D, Kawai Y, Cheifetz IM, Gelvez J, Truemper EJ, Smith RL, Peters ME, O'Meara AM, Murphy S, Bokhary A, Greenwald BM, Bell MJ. Delirium in Critically Ill Children: An International Point Prevalence Study. Crit Care Med. 2017 Apr; 45(4):584-590. View abstract
  7. Madsen EC, Levy ER, Madden K, Agan AA, Sullivan RM, Graham DA, Randolph AG. Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections. Pediatr Crit Care Med. 2017 02; 18(2):103-111. View abstract
  8. Levy E, Zinter M, Madden K, Randolph A. 1444: MANNOSE-BINDING LECTIN AND PEDIATRIC SEPSIS SUSCEPTIBILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS. Crit Care Med. 2016 Dec; 44(12 Suppl 1):436. View abstract
  9. Gauguet S, Madden K, Wu J, Duncan C, Lee GS, Miller T, Klingensmith WC, Burchett SK, van der Velden M. Case Report of a Child after Hematopoietic Cell Transplantation with Acute Aspergillus Tracheobronchitis as a Cause for Respiratory Failure. Case Rep Pediatr. 2016; 2016:9676234. View abstract
  10. Madden K, Feldman HA, Chun RF, Smith EM, Sullivan RM, Agan AA, Keisling SM, Panoskaltsis-Mortari A, Randolph AG. Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D. Ann Am Thorac Soc. 2015 Nov; 12(11):1654-61. View abstract
  11. Madden K, Feldman HA, Smith EM, Gordon CM, Keisling SM, Sullivan RM, Hollis BW, Agan AA, Randolph AG. Vitamin D deficiency in critically ill children. Pediatrics. 2012 Sep; 130(3):421-8. View abstract
  12. Madden K, Thiagarajan RR, Rycus PT, Rajagopal SK. Survival of neonates with enteroviral myocarditis requiring extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2011 May; 12(3):314-8. View abstract