Research Overview

Dr. Meléndez' research aims to understand and modify outcomes in children with severe sepsis and septic shock. His research involves the analysis of specific biomarkers and how they evolve over time the course of septic shock. His work preliminarily shows that particular biomarkers are elevated and are associated with worse outcomes, as a result allowing for planning of future studies to see if these biomarkers will allow for focused interventions. In addition, Dr. Meléndez performs quality improvement research to improve the timeliness of key process measures in the management of septic shock. He is an advisor for the American Academy of Pediatrics, Pediatric Septic Shock Collaborative.

About Elliot Meléndez, MD

Dr. Meléndez is a graduate of Harvard Medical School. He trained in pediatrics at Boston Children's Hospital. Following residency , he completed two subspecialty fellowships, those being Pediatric Critical Care and Pediatric Emergency Medicine. Dr. Meléndez serves as the associate director of quality and safety in Division of Medicine Critical Care and oversees multiple quality and safety initiatives. He is active in clinical research and quality improvement in children presenting with severe sepsis and shock, and is a member of a national collaborative to improve sepsis management. His academic work revolves around the study of specific biomarkers in sepsis to assist in prognosticating outcomes. He is also a member of the Diversity and Cultural Competency Council. He has been honored with multiple teaching and mentoring awards, and most recently by the "Milagros para Nino's" Award for clinical excellence.

Key Publications

  1. Gaeta TJ, LaPolla C, Meléndez E. AIDS in the Elderly: New York City Vital Statistics. The Journal of Emergency Medicine. 14(1): 19-23, January 1996.
  2. Meléndez E, Harper M. Utility of Sepsis Work-Ups in Infants Aged 90 days or Younger with Fever and Bronchiolitis. Pediatric Infectious Disease Journal. 22(12):1053-1056, December 2003
  3. Meléndez E, Bachur R. Serious Adverse Events during Procedural Sedation with Ketamine. Pediatric Emergency Care. 25(5):325-328. May 2009.
  4. Meléndez E, Harper M. Risk of Serious Bacterial Infection in Isolated and Unsuspected Neutropenia. Academic Emergency Medicine. 17:163-167. Jan 2010.
  5. Paul R, Neuman MI, Monuteaux MC, Meléndez E. Adherence to PALS Sepsis Guidelines and Hospital Length of Stay. Pediatrics. 130(2):e273-80. Aug 2012.
  6. Paul R, Meléndez E, Stack A, Capraro A, Monuteaux MC, Neuman MI. Improving Adherence to PALS Septic Shock Guidelines. Pediatrics. 133(5): e1358-1366. May 2014
  7. Meléndez E, Bachur R. Advances in the Emergency Management of Pediatric Sepsis. Current Opinion in Pediatrics. 18(3):245-253. June 2006
  8. Gupta P, Tobias JD, Goyal S, Miller MD, Meléndez E, Noviski N, Demoor MM, Mehta V. Sudden Cardiac Death under anesthesia in a pediatric patient with William’s syndrome. A case report and review of the literature. Annals of Cardiac Anesthesia. 13(1): 32-36. Jan-Apr 2010
  9. Scott H, Meléndez E, Cruz AT. Correspondence. Mortality after Fluid Bolus in African Children with Sepsis. NEJM. 365: 1348-1353. Oct 6, 2011.
  10. Meléndez E, Goldstein A, Sagar P, Badizadigan K. Case 3-2012: A Newborn Boy with Vomiting, Diarrhea, and Abdominal Distention. NEJM. 366: 361-372. Jan 26, 2012

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