Overview

Dr. Manrai's research group works broadly on two areas:

  1. Statistical and machine learning approaches to improve medical decision making
  2. Meta-science (“science of science”) approaches to model and enhance reproducibility of integrative molecular, clinical, and environmental studies, particularly in the increasingly common setting of communal investigation of large, shared datasets.

A major long-term goal of Dr. Manrai's work is to improve the use of genomic and laboratory data in diagnosing and treating inherited heart disease across demographically diverse populations. Dr. Manrai's research has been published in the New England Journal of Medicine and JAMA, presented at the National Academy of Sciences, and featured in the Wall Street Journal, New York Times, and NPR.

Background

Arjun (Raj) Manrai is an Assistant Professor at Harvard Medical School and Faculty Member in the Computational Health Informatics Program (CHIP) at Boston Children’s Hospital, where he directs the Laboratory for Probabilistic Medical Reasoning.

Manrai received an A.B. in Physics with Highest Honors from Harvard and earned his Ph.D. in Bioinformatics and Integrative Genomics from the Harvard-MIT Division of Health Sciences and Technology.

Researcher Services

Researcher Areas

  • Cardiovascular Medicine
  • Genomics
  • Machine Learning
  • Meta-Science
  • Statistical Methods

Researcher Programs

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Manrai AK, Ioannidis JPA, Patel CJ. Signals Among Signals: Prioritizing Nongenetic Associations in Massive Data Sets. Am J Epidemiol. 2019 May 01; 188(5):846-850. View abstract
  2. Lakhani CM, Tierney BT, Manrai AK, Yang J, Visscher PM, Patel CJ. Author Correction: Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes. Nat Genet. 2019 04; 51(4):764-765. View abstract
  3. Mandl KD, Manrai AK. Potential Excessive Testing at Scale: Biomarkers, Genomics, and Machine Learning. JAMA. 2019 Feb 26; 321(8):739-740. View abstract
  4. Lakhani CM, Tierney BT, Manrai AK, Yang J, Visscher PM, Patel CJ. Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes. Nat Genet. 2019 02; 51(2):327-334. View abstract
  5. Manrai AK, Patel CJ, Ioannidis JPA. Using Big Data to Determine Reference Values for Laboratory Tests-Reply. JAMA. 2018 10 09; 320(14):1496. View abstract
  6. Manrai AK, Patel CJ, Ioannidis JPA. In the Era of Precision Medicine and Big Data, Who Is Normal? JAMA. 2018 May 15; 319(19):1981-1982. View abstract
  7. Diao JA, Kohane IS, Manrai AK. Biomedical informatics and machine learning for clinical genomics. Hum Mol Genet. 2018 05 01; 27(R1):R29-R34. View abstract
  8. Kelly MA, Caleshu C, Morales A, Buchan J, Wolf Z, Harrison SM, Cook S, Dillon MW, Garcia J, Haverfield E, Jongbloed JDH, Macaya D, Manrai A, Orland K, Richard G, Spoonamore K, Thomas M, Thomson K, Vincent LM, Walsh R, Watkins H, Whiffin N, Ingles J, van Tintelen JP, Semsarian C, Ware JS, Hershberger R, Funke B. Adaptation and validation of the ACMG/AMP variant classification framework for MYH7-associated inherited cardiomyopathies: recommendations by ClinGen's Inherited Cardiomyopathy Expert Panel. Genet Med. 2018 03; 20(3):351-359. View abstract
  9. Palmer N, Beam A, Agniel D, Eran A, Manrai A, Spettell C, Steinberg G, Mandl K, Fox K, Nelson SF, Kohane I. Association of Sex With Recurrence of Autism Spectrum Disorder Among Siblings. JAMA Pediatr. 2017 11 01; 171(11):1107-1112. View abstract
  10. Jasny BR, Wigginton N, McNutt M, Bubela T, Buck S, Cook-Deegan R, Gardner T, Hanson B, Hustad C, Kiermer V, Lazer D, Lupia A, Manrai A, McConnell L, Noonan K, Phimister E, Simon B, Strandburg K, Summers Z, Watts D. Fostering reproducibility in industry-academia research. Science. 2017 08 25; 357(6353):759-761. View abstract
  11. Patel CJ, Manrai AK, Corona E, Kohane IS. Systematic correlation of environmental exposure and physiological and self-reported behaviour factors with leukocyte telomere length. Int J Epidemiol. 2017 02 01; 46(1):44-56. View abstract
  12. Karczewski KJ, Tatonetti NP, Manrai AK, Patel CJ, Titus Brown C, Ioannidis JPA. METHODS TO ENSURE THE REPRODUCIBILITY OF BIOMEDICAL RESEARCH. Pac Symp Biocomput. 2017; 22:117-119. View abstract
  13. Manrai AK, Cui Y, Bushel PR, Hall M, Karakitsios S, Mattingly CJ, Ritchie M, Schmitt C, Sarigiannis DA, Thomas DC, Wishart D, Balshaw DM, Patel CJ. Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health. Annu Rev Public Health. 2017 Mar 20; 38:279-294. View abstract
  14. Manrai AK, Funke BH, Rehm HL, Olesen MS, Maron BA, Szolovits P, Margulies DM, Loscalzo J, Kohane IS. Genetic Misdiagnoses and the Potential for Health Disparities. N Engl J Med. 2016 Aug 18; 375(7):655-65. View abstract
  15. Manrai AK, Ioannidis JP, Kohane IS. Clinical Genomics: From Pathogenicity Claims to Quantitative Risk Estimates. JAMA. 2016 Mar 22-29; 315(12):1233-4. View abstract
  16. Manrai AK, Patel CJ, Gehlenborg N, Tatonetti NP, Ioannidis JP, Kohane IS. METHODS TO ENHANCE THE REPRODUCIBILITY OF PRECISION MEDICINE. Pac Symp Biocomput. 2016; 21:180-2. View abstract
  17. Manrai AK, Wang BL, Patel CJ, Kohane IS. REPRODUCIBLE AND SHAREABLE QUANTIFICATIONS OF PATHOGENICITY. Pac Symp Biocomput. 2016; 21:231-42. View abstract
  18. Manrai AK, Patel CJ, Gehlenborg N, Tatonetti NP, Ioannidis JP, Kohane IS. METHODS TO ENHANCE THE REPRODUCIBILITY OF PRECISION MEDICINE. Pac Symp Biocomput. 2016; 21:180-182. View abstract
  19. Patel CJ, Manrai AK. Development of exposome correlation globes to map out environment-wide associations. Pac Symp Biocomput. 2015; 231-42. View abstract
  20. Manrai AK, Bhatia G, Strymish J, Kohane IS, Jain SH. Medicine's uncomfortable relationship with math: calculating positive predictive value. JAMA Intern Med. 2014 Jun; 174(6):991-3. View abstract
  21. Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Yarmush J, Jiao Y, Fletcher A, Lee J, Cima MJ, Yarmush ML, Parekkadan B. Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol Ther. 2014 May; 22(5):999-1007. View abstract
  22. Manrai AK, Kohane IS, Szolovits P. Urinary-cell mRNA and acute kidney-transplant rejection. N Engl J Med. 2013 11 07; 369(19):1859. View abstract
  23. Shin H, Liu T, Manrai AK, Liu XS. CEAS: cis-regulatory element annotation system. Bioinformatics. 2009 Oct 01; 25(19):2605-6. View abstract
  24. Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Jänne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS, Brown M. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell. 2009 Jul 23; 138(2):245-56. View abstract
  25. Manrai AK, Gunawardena J. The geometry of multisite phosphorylation. Biophys J. 2008 Dec 15; 95(12):5533-43. View abstract
  26. Song JS, Johnson WE, Zhu X, Zhang X, Li W, Manrai AK, Liu JS, Chen R, Liu XS. Model-based analysis of two-color arrays (MA2C). Genome Biol. 2007; 8(8):R178. View abstract