Research Overview

Tobias Loddenkemper's research is focused on identifying the factors that determine epileptic encephalopathies and status epilepticus as well as functional outcome later in life. Repetitive seizures and epileptic encephalopathy can impair development, plasticity and cognitive function of eloquent areas including language and memory. Seizure frequency reduction and seizure freedom, in particular after epilepsy surgery, has been shown to improve neurocognitive and developmental outcome. By identifying biomarkers that indicate predictors of cerebral damage and developmental outcome in epileptic encephalopathies and status epilepticus, we intend to reduce the occurrence of brain damage and later developmental disabilities and aim to identify novel therapeutic approaches.

Research Interests

What are we doing?

  • Comparative effectiveness and interventional clinical trials in pediatric status epilepticus and epileptic encephalopathies

How do we do it?

  • Inventing, evaluating and implementing clinically relevant biomarkers and treatment paradigms to assess and benchmark these based on clinical data, neurophysiology, imaging, pharmacogenomics and genetics, in collaboration with basic researcher locally, nationally, and internationally.
  • Developing and evaluating monitoring tools for clinical biomarkers to further clinical epilepsy outcome measures including seizure characterization, neuropsychological outcome assessment, and quality of life assessment by means of seizure sensors and electronic tools including ICISS, the RENCI seizure tracking and outcome prediction modeling software, and novel in- and outpatient monitoring devices and algorithms, and neurophysiological, biochemical and genetic periodicity markers and implement these techniques into clinical workflow.
  • Research networks and collaborations are essential for our work, like the pediatric status epilepticus research group (www.pserg.org), the Pediatric Epilepsy Research Consortium , the pediatric critical care epilepsy research group, the Critical Care EEG consortium, the pediatric neurocritical care research group and other consortia.

Researcher Services

Researcher Areas

  • Epilepsy
  • Clinical Neurophysiology

Research Departments

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ, Saneto RP, Berg AT. Neuroimaging of Early Life Epilepsy. Pediatrics. 2018 Aug 08. View abstract
  2. Vasquez A, Gaínza-Lein M, Sánchez Fernández I, Abend NS, Anderson A, Brenton JN, Carpenter JL, Chapman K, Clark J, Gaillard WD, Glauser T, Goldstein J, Goodkin HP, Lai YC, Loddenkemper T, McDonough TL, Mikati MA, Nayak A, Payne E, Riviello J, Tchapyjnikov D, Topjian AA, Wainwright MS, Tasker RC. Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers. Pediatr Neurol. 2018 Jul 11. View abstract
  3. Gaínza-Lein M, Fernández IS, Ulate-Campos A, Loddenkemper T, Ostendorf AP. Timing in the treatment of status epilepticus: From basics to the clinic. Seizure. 2018 Jun 01. View abstract
  4. Sánchez Fernández I, Sansevere AJ, Gaínza-Lein M, Kapur K, Loddenkemper T. Machine Learning for Outcome Prediction in Electroencephalograph (EEG)-Monitored Children in the Intensive Care Unit. J Child Neurol. 2018 Jul; 33(8):546-553. View abstract
  5. Arya R, Peariso K, Gaínza-Lein M, Harvey J, Bergin A, Brenton JN, Burrows BT, Glauser T, Goodkin HP, Lai YC, Mikati MA, Fernández IS, Tchapyjnikov D, Wilfong AA, Williams K, Loddenkemper T. Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus. Epilepsy Res. 2018 Aug; 144:1-6. View abstract
  6. Goldenholz DM, Rakesh K, Kapur K, Gaínza-Lein M, Hodgeman R, Moss R, Theodore WH, Loddenkemper T. Different as night and day: Patterns of isolated seizures, clusters, and status epilepticus. Epilepsia. 2018 May; 59(5):e73-e77. View abstract
  7. Stredny CM, Abend NS, Loddenkemper T. Towards acute pediatric status epilepticus intervention teams: Do we need "Seizure Codes"? Seizure. 2018 May; 58:133-140. View abstract
  8. Sánchez Fernández I, Gaínza-Lein M, Abend NS, Anderson AE, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Helseth AR, Jackson MC, Kapur K, Lai YC, McDonough TL, Mikati MA, Nayak A, Peariso K, Riviello JJ, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Factors associated with treatment delays in pediatric refractory convulsive status epilepticus. Neurology. 2018 May 08; 90(19):e1692-e1701. View abstract
  9. Gaínza-Lein M, Sánchez Fernández I, Jackson M, Abend NS, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Kapur K, Mikati MA, Peariso K, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus. JAMA Neurol. 2018 Apr 01; 75(4):410-418. View abstract
  10. Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ, Millichap J, Berg AT. Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA Pediatr. 2018 Apr 01; 172(4):352-360. View abstract
  11. Goldenholz DM, Moss R, Jost DA, Crone NE, Krauss G, Picard R, Caborni C, Cavazos JE, Hixson J, Loddenkemper T, Salazar TD, Lubbers L, Harte-Hargrove LC, Whittemore V, Duun-Henriksen J, Dolan E, Kasturia N, Oberemk M, Cook MJ, Lehmkuhle M, Sperling MR, Shafer PO. Common data elements for epilepsy mobile health systems. Epilepsia. 2018 May; 59(5):1020-1026. View abstract
  12. Shamim EA, Mane K, Loddenkemper T, Leviton A. Can a collaborative healthcare network improve the care of people with epilepsy? Epilepsy Behav. 2018 May; 82:189-193. View abstract
  13. Loddenkemper T. Conscious control of breathing: A key to prevention of sudden unexpected death in epilepsy? Ann Neurol. 2018 Mar; 83(3):449-450. View abstract
  14. Berg AT, Chakravorty S, Koh S, Grinspan ZM, Shellhaas RA, Saneto RP, Wirrell EC, Coryell J, Chu CJ, Mytinger JR, Gaillard WD, Valencia I, Knupp KG, Loddenkemper T, Sullivan JE, Poduri A, Millichap JJ, Keator C, Wusthoff C, Ryan N, Dobyns WB, Hegde M. Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms. PLoS One. 2018; 13(3):e0193599. View abstract
  15. Gaspard N, Hirsch LJ, Sculier C, Loddenkemper T, van Baalen A, Lancrenon J, Emmery M, Specchio N, Farias-Moeller R, Wong N, Nabbout R. New-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES): State of the art and perspectives. Epilepsia. 2018 Apr; 59(4):745-752. View abstract
  16. Amengual-Gual M, Sánchez Fernández I, Loddenkemper T. Patterns of epileptic seizure occurrence. Brain Res. 2018 Feb 23. View abstract
  17. Hirsch LJ, Gaspard N, van Baalen A, Nabbout R, Demeret S, Loddenkemper T, Navarro V, Specchio N, Lagae L, Rossetti AO, Hocker S, Gofton TE, Abend NS, Gilmore EJ, Hahn C, Khosravani H, Rosenow F, Trinka E. Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions. Epilepsia. 2018 Apr; 59(4):739-744. View abstract
  18. Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA. Should patients with complex febrile seizure be admitted for further management? Am J Emerg Med. 2018 Aug; 36(8):1386-1390. View abstract
  19. Ulate-Campos A, Tsuboyama M, Loddenkemper T. Devices for Ambulatory Monitoring of Sleep-Associated Disorders in Children with Neurological Diseases. Children (Basel). 2017 Dec 25; 5(1). View abstract
  20. Manganaro S, Loddenkemper T, Rotenberg A. The Need for Antiepileptic Drug Chronotherapy to Treat Selected Childhood Epilepsy Syndromes and Avert the Harmful Consequences of Drug Resistance. J Cent Nerv Syst Dis. 2017; 9:1179573516685883. View abstract
  21. Cohen S, Fulcher BD, Rajaratnam SMW, Conduit R, Sullivan JP, St Hilaire MA, Phillips AJK, Loddenkemper T, Kothare SV, McConnell K, Braga-Kenyon P, Ahearn W, Shlesinger A, Potter J, Bird F, Cornish KM, Lockley SW. Sleep patterns predictive of daytime challenging behavior in individuals with low-functioning autism. Autism Res. 2018 Feb; 11(2):391-403. View abstract
  22. Jafarpour S, Hodgeman RM, De Marchi Capeletto C, de Lima MTA, Kapur K, Tasker RC, Loddenkemper T. New-Onset Status Epilepticus in Pediatric Patients: Causes, Characteristics, and Outcomes. Pediatr Neurol. 2018 Mar; 80:61-69. View abstract
  23. Vega C, Sánchez Fernández I, Peters J, Thome-Souza MS, Jackson M, Takeoka M, Wilkening GN, Pearl PL, Chapman K, Loddenkemper T. Response to clobazam in continuous spike-wave during sleep. Dev Med Child Neurol. 2018 03; 60(3):283-289. View abstract
  24. Sánchez Fernández I, Sansevere AJ, Gaínza-Lein M, Buraniqi E, Tasker RC, Loddenkemper T. Time to continuous electroencephalogram in repeated admissions to the pediatric intensive care unit. Seizure. 2018 Jan; 54:19-26. View abstract
  25. Demarest ST, Shellhaas RA, Gaillard WD, Keator C, Nickels KC, Hussain SA, Loddenkemper T, Patel AD, Saneto RP, Wirrell E, Sánchez Fernández I, Chu CJ, Grinspan Z, Wusthoff CJ, Joshi S, Mohamed IS, Stafstrom CE, Stack CV, Yozawitz E, Bluvstein JS, Singh RK, Knupp KG. The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium. Epilepsia. 2017 12; 58(12):2098-2103. View abstract
  26. Cohen S, Fulcher BD, Rajaratnam SMW, Conduit R, Sullivan JP, Hilaire MAS, Phillips AJ, Loddenkemper T, Kothare SV, McConnell K, Ahearn W, Braga-Kenyon P, Shlesinger A, Potter J, Bird F, Cornish KM, Lockley SW. Behaviorally-determined sleep phenotypes are robustly associated with adaptive functioning in individuals with low functioning autism. Sci Rep. 2017 Oct 27; 7(1):14228. View abstract
  27. Gaínza-Lein M, Benjamin R, Stredny C, McGurl M, Kapur K, Loddenkemper T. Rescue Medications in Epilepsy Patients: A Family Perspective. Seizure. 2017 Nov; 52:188-194. View abstract
  28. Onorati F, Regalia G, Caborni C, Migliorini M, Bender D, Poh MZ, Frazier C, Kovitch Thropp E, Mynatt ED, Bidwell J, Mai R, LaFrance WC, Blum AS, Friedman D, Loddenkemper T, Mohammadpour-Touserkani F, Reinsberger C, Tognetti S, Picard RW. Multicenter clinical assessment of improved wearable multimodal convulsive seizure detectors. Epilepsia. 2017 11; 58(11):1870-1879. View abstract
  29. Sansevere AJ, Duncan ED, Libenson MH, Loddenkemper T, Pearl PL, Tasker RC. Continuous EEG in Pediatric Critical Care: Yield and Efficiency of Seizure Detection. J Clin Neurophysiol. 2017 Sep; 34(5):421-426. View abstract
  30. Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ, Koh S. Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA Pediatr. 2017 Sep 01; 171(9):863-871. View abstract
  31. Sachdev M, Gaínza-Lein M, Tchapyjnikov D, Jiang YH, Loddenkemper T, Mikati MA. Novel clinical manifestations in patients with KCNA2 mutations. Seizure. 2017 Oct; 51:74-76. View abstract
  32. Sánchez Fernández I, Stephen C, Loddenkemper T. Disparities in epilepsy surgery in the United States of America. J Neurol. 2017 Aug; 264(8):1735-1745. View abstract
  33. Jackson MC, Jafarpour S, Klehm J, Thome-Souza S, Coughlin F, Kapur K, Loddenkemper T. Effect of vigabatrin on seizure control and safety profile in different subgroups of children with epilepsy. Epilepsia. 2017 09; 58(9):1575-1585. View abstract
  34. Buraniqi E, Sansevere AJ, Kapur K, Bergin AM, Pearl PL, Loddenkemper T. Electrographic Seizures in Preterm Neonates in the Neonatal Intensive Care Unit. J Child Neurol. 2017 Sep; 32(10):880-885. View abstract
  35. Sánchez Fernández I, Loddenkemper T. A Question Worth Asking. J Clin Neurophysiol. 2017 Jul; 34(4):392. View abstract
  36. Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD. Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatr Neurol. 2017 Oct; 75:73-79. View abstract
  37. Sánchez Fernández I, Gaínza-Lein M, Loddenkemper T. Nonintravenous rescue medications for pediatric status epilepticus: A cost-effectiveness analysis. Epilepsia. 2017 08; 58(8):1349-1359. View abstract
  38. Sansevere AJ, Avalone J, Strauss LD, Patel AA, Pinto A, Ramachandran M, Fernandez IS, Bergin AM, Kimia A, Pearl PL, Loddenkemper T. Diagnostic and Therapeutic Management of a First Unprovoked Seizure in Children and Adolescents With a Focus on the Revised Diagnostic Criteria for Epilepsy. J Child Neurol. 2017 Jul; 32(8):774-788. View abstract
  39. Gaínza-Lein M, Sánchez Fernández I, Loddenkemper T. Use of EEG in critically ill children and neonates in the United States of America. J Neurol. 2017 Jun; 264(6):1165-1173. View abstract
  40. Wolff M, Johannesen KM, Hedrich UBS, Masnada S, Rubboli G, Gardella E, Lesca G, Ville D, Milh M, Villard L, Afenjar A, Chantot-Bastaraud S, Mignot C, Lardennois C, Nava C, Schwarz N, Gérard M, Perrin L, Doummar D, Auvin S, Miranda MJ, Hempel M, Brilstra E, Knoers N, Verbeek N, van Kempen M, Braun KP, Mancini G, Biskup S, Hörtnagel K, Döcker M, Bast T, Loddenkemper T, Wong-Kisiel L, Baumeister FM, Fazeli W, Striano P, Dilena R, Fontana E, Zara F, Kurlemann G, Klepper J, Thoene JG, Arndt DH, Deconinck N, Schmitt-Mechelke T, Maier O, Muhle H, Wical B, Finetti C, Brückner R, Pietz J, Golla G, Jillella D, Linnet KM, Charles P, Moog U, Õiglane-Shlik E, Mantovani JF, Park K, Deprez M, Lederer D, Mary S, Scalais E, Selim L, Van Coster R, Lagae L, Nikanorova M, Hjalgrim H, Korenke GC, Trivisano M, Specchio N, Ceulemans B, Dorn T, Helbig KL, Hardies K, Stamberger H, de Jonghe P, Weckhuysen S, Lemke JR, Krägeloh-Mann I, Helbig I, Kluger G, Lerche H, Møller RS. Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders. Brain. 2017 May 01; 140(5):1316-1336. View abstract
  41. Keros S, Buraniqi E, Alex B, Antonetty A, Fialho H, Hafeez B, Jackson MC, Jawahar R, Kjelleren S, Stewart E, Morgan LA, Wainwright MS, Sogawa Y, Patel AD, Loddenkemper T, Grinspan ZM. Increasing Ketamine Use for Refractory Status Epilepticus in US Pediatric Hospitals. J Child Neurol. 2017 06; 32(7):638-646. View abstract
  42. Olson HE, Kelly M, LaCoursiere CM, Pinsky R, Tambunan D, Shain C, Ramgopal S, Takeoka M, Libenson MH, Julich K, Loddenkemper T, Marsh ED, Segal D, Koh S, Salman MS, Paciorkowski AR, Yang E, Bergin AM, Sheidley BR, Poduri A. Genetics and genotype-phenotype correlations in early onset epileptic encephalopathy with burst suppression. Ann Neurol. 2017 Mar; 81(3):419-429. View abstract
  43. Donner EJ, Camfield P, Brooks L, Buchhalter J, Camfield C, Loddenkemper T, Wirrell E. Understanding Death in Children With Epilepsy. Pediatr Neurol. 2017 May; 70:7-15. View abstract
  44. Sánchez Fernández I, Sansevere AJ, Guerriero RM, Buraniqi E, Pearl PL, Tasker RC, Loddenkemper T. Time to electroencephalography is independently associated with outcome in critically ill neonates and children. Epilepsia. 2017 03; 58(3):420-428. View abstract
  45. Sánchez Fernández I, Peters JM, Akhondi-Asl A, Klehm J, Warfield SK, Loddenkemper T. Reduced thalamic volume in patients with Electrical Status Epilepticus in Sleep. Epilepsy Res. 2017 02; 130:74-80. View abstract
  46. Sánchez Fernández I, Jackson MC, Abend NS, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Helseth A, Kapur K, McDonough TL, Mikati MA, Peariso K, Riviello J, Tasker RC, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Refractory status epilepticus in children with and without prior epilepsy or status epilepticus. Neurology. 2017 Jan 24; 88(4):386-394. View abstract
  47. Sánchez Fernández I, Loddenkemper T. Seizures caused by brain tumors in children. Seizure. 2017 Jan; 44:98-107. View abstract
  48. Tomko S, Loddenkemper T, Pearl PL. Texting Rhythm With Temporal Predominance. J Clin Neurophysiol. 2016 Dec; 33(6):570. View abstract
  49. Tasker RC, Goodkin HP, Sánchez Fernández I, Chapman KE, Abend NS, Arya R, Brenton JN, Carpenter JL, Gaillard WD, Glauser TA, Goldstein J, Helseth AR, Jackson MC, Kapur K, Mikati MA, Peariso K, Wainwright MS, Wilfong AA, Williams K, Loddenkemper T. Refractory Status Epilepticus in Children: Intention to Treat With Continuous Infusions of Midazolam and Pentobarbital. Pediatr Crit Care Med. 2016 10; 17(10):968-975. View abstract
  50. Knupp KG, Leister E, Coryell J, Nickels KC, Ryan N, Juarez-Colunga E, Gaillard WD, Mytinger JR, Berg AT, Millichap J, Nordli DR, Joshi S, Shellhaas RA, Loddenkemper T, Dlugos D, Wirrell E, Sullivan J, Hartman AL, Kossoff EH, Grinspan ZM, Hamikawa L. Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia. 2016 11; 57(11):1834-1842. View abstract
  51. Sánchez Fernández I, Loddenkemper T. Interictal epileptiform discharges and cognition. Dev Med Child Neurol. 2017 01; 59(1):13-14. View abstract
  52. Mohammadpour Touserkani F, Gaínza-Lein M, Jafarpour S, Brinegar K, Kapur K, Loddenkemper T. HHV-6 and seizure: A systematic review and meta-analysis. J Med Virol. 2017 01; 89(1):161-169. View abstract
  53. Reuber M, Helmstaedter C, Liao W, Loddenkemper T, Thomas R, Kälviäinen R, Mann M. Editorial. Seizure. 2016 Oct; 41:42. View abstract
  54. Ulate-Campos A, Coughlin F, Gaínza-Lein M, Fernández IS, Pearl PL, Loddenkemper T. Automated seizure detection systems and their effectiveness for each type of seizure. Seizure. 2016 Aug; 40:88-101. View abstract
  55. Papadelis C, Ashkezari SF, Doshi C, Thome-Souza S, Pearl PL, Grant PE, Tasker RC, Loddenkemper T. Real-time multi-channel monitoring of burst-suppression using neural network technology during pediatric status epilepticus treatment. Clin Neurophysiol. 2016 08; 127(8):2820-31. View abstract
  56. Thome-Souza S, Klehm J, Jackson M, Kadish NE, Manganaro S, Fernández IS, Loddenkemper T. Clobazam higher-evening differential dosing as an add-on therapy in refractory epilepsy. Seizure. 2016 Aug; 40:1-6. View abstract
  57. Dlugos D, Worrell G, Davis K, Stacey W, Szaflarski J, Kanner A, Sunderam S, Rogawski M, Jackson-Ayotunde P, Loddenkemper T, Diehl B, Fureman B, Dingledine R. 2014 Epilepsy Benchmarks Area III: Improve Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects. Epilepsy Curr. 2016 May-Jun; 16(3):192-7. View abstract
  58. Hodgeman RM, Kapur K, Paris A, Marti C, Can A, Kimia A, Loddenkemper T, Bergin A, Poduri A, Libenson M, Lamb N, Jafarpour S, Harini C. Effectiveness of once-daily high-dose ACTH for infantile spasms. Epilepsy Behav. 2016 06; 59:4-8. View abstract
  59. Lee JW, LaRoche S, Choi H, Rodriguez Ruiz AA, Fertig E, Politsky JM, Herman ST, Loddenkemper T, Sansevere AJ, Korb PJ, Abend NS, Goldstein JL, Sinha SR, Dombrowski KE, Ritzl EK, Westover MB, Gavvala JR, Gerard EE, Schmitt SE, Szaflarski JP, Ding K, Haas KF, Buchsbaum R, Hirsch LJ, Wusthoff CJ, Hopp JL, Hahn CD. Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research. J Clin Neurophysiol. 2016 Apr; 33(2):133-40. View abstract
  60. Knupp KG, Coryell J, Nickels KC, Ryan N, Leister E, Loddenkemper T, Grinspan Z, Hartman AL, Kossoff EH, Gaillard WD, Mytinger JR, Joshi S, Shellhaas RA, Sullivan J, Dlugos D, Hamikawa L, Berg AT, Millichap J, Nordli DR, Wirrell E. Response to treatment in a prospective national infantile spasms cohort. Ann Neurol. 2016 Mar; 79(3):475-84. View abstract
  61. Lotte J, Bast T, Borusiak P, Coppola A, Cross JH, Dimova P, Fogarasi A, Graneß I, Guerrini R, Hjalgrim H, Keimer R, Korff CM, Kurlemann G, Leiz S, Linder-Lucht M, Loddenkemper T, Makowski C, Mühe C, Nicolai J, Nikanorova M, Pellacani S, Philip S, Ruf S, Sánchez Fernández I, Schlachter K, Striano P, Sukhudyan B, Valcheva D, Vermeulen RJ, Weisbrod T, Wilken B, Wolf P, Kluger G. Effectiveness of antiepileptic therapy in patients with PCDH19 mutations. Seizure. 2016 Feb; 35:106-10. View abstract
  62. Lyons TW, Johnson KB, Michelson KA, Nigrovic LE, Loddenkemper T, Prabhu SP, Kimia AA. Yield of emergent neuroimaging in children with new-onset seizure and status epilepticus. Seizure. 2016 Feb; 35:4-10. View abstract
  63. Sánchez Fernández I, Loddenkemper T. aEEG and cEEG: Two complementary techniques to assess seizures and encephalopathy in neonates: Editorial on "Amplitude-integrated EEG for detection of neonatal seizures: A systematic review" by Rakshasbhuvankar et al. Seizure. 2015 Dec; 33:88-9. View abstract
  64. Harini C, Nagarajan E, Kimia AA, de Carvalho RM, An S, Bergin AM, Takeoka M, Pearl PL, Loddenkemper T. Utility of initial EEG in first complex febrile seizure. Epilepsy Behav. 2015 Nov; 52(Pt A):200-4. View abstract
  65. van den Munckhof B, van Dee V, Sagi L, Caraballo RH, Veggiotti P, Liukkonen E, Loddenkemper T, Sánchez Fernández I, Buzatu M, Bulteau C, Braun KP, Jansen FE. Treatment of electrical status epilepticus in sleep: A pooled analysis of 575 cases. Epilepsia. 2015 Nov; 56(11):1738-46. View abstract
  66. Ullrich NJ, Pomeroy SL, Kapur K, Manley PE, Goumnerova LC, Loddenkemper T. Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors. Epilepsia. 2015 Oct; 56(10):1599-604. View abstract
  67. Sánchez Fernández I, Loddenkemper T, Galanopoulou AS, Moshé SL. Should epileptiform discharges be treated? Epilepsia. 2015 Oct; 56(10):1492-504. View abstract
  68. Jafarpour S, Loddenkemper T. Outcomes in pediatric patients with nonconvulsive status epilepticus. Epilepsy Behav. 2015 Aug; 49:98-103. View abstract
  69. Dhamne SC, Ekstein D, Zhuo Z, Gersner R, Zurakowski D, Loddenkemper T, Pascual-Leone A, Jensen FE, Rotenberg A. Acute seizure suppression by transcranial direct current stimulation in rats. Ann Clin Transl Neurol. 2015 Aug; 2(8):843-56. View abstract
  70. Sarkis RA, Thome-Souza S, Poh MZ, Llewellyn N, Klehm J, Madsen JR, Picard R, Pennell PB, Dworetzky BA, Loddenkemper T, Reinsberger C. Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy. Epilepsy Res. 2015 Sep; 115:113-8. View abstract
  71. Sedigh-Sarvestani M, Blumenfeld H, Loddenkemper T, Bateman LM. Seizures and brain regulatory systems: consciousness, sleep, and autonomic systems. J Clin Neurophysiol. 2015 Jun; 32(3):188-93. View abstract
  72. Sánchez Fernández I, Abend NS, Agadi S, An S, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goodkin HP, Kapur K, Mikati MA, Peariso K, Ream M, Riviello J, Tasker RC, Loddenkemper T. Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology. 2015 Jun 09; 84(23):2304-11. View abstract
  73. Sánchez Fernández I, Loddenkemper T. Therapeutic choices in convulsive status epilepticus. Expert Opin Pharmacother. 2015 Mar; 16(4):487-500. View abstract
  74. Sánchez Fernández I, An S, Loddenkemper T. Pediatric refractory epilepsy: A decision analysis comparing medical versus surgical treatment. Epilepsia. 2015 Feb; 56(2):263-72. View abstract
  75. Reinsberger C, Sarkis R, Papadelis C, Doshi C, Perez DL, Baslet G, Loddenkemper T, Dworetzky BA. Autonomic changes in psychogenic nonepileptic seizures: toward a potential diagnostic biomarker? Clin EEG Neurosci. 2015 Jan; 46(1):16-25. View abstract
  76. Harini C, Das RR, Prabhu SP, Singh K, Haldar A, Takeoka M, Bergin AM, Loddenkemper T, Kothare SV. Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. J Neuroimaging. 2015 Sep-Oct; 25(5):824-31. View abstract
  77. Abend NS, Loddenkemper T. Pediatric status epilepticus management. Curr Opin Pediatr. 2014 Dec; 26(6):668-74. View abstract
  78. Loddenkemper T. Febrile status epilepticus: time is of the essence. Epilepsy Curr. 2014 Nov-Dec; 14(6):345-7. View abstract
  79. Yang A, Arndt DH, Berg RA, Carpenter JL, Chapman KE, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, Nash KB, Payne ET, Sánchez Fernández I, Shults J, Topjian AA, Williams K, Wusthoff CJ, Abend NS. Development and validation of a seizure prediction model in critically ill children. Seizure. 2015 Feb; 25:104-11. View abstract
  80. Suarez RO, Taimouri V, Boyer K, Vega C, Rotenberg A, Madsen JR, Loddenkemper T, Duffy FH, Prabhu SP, Warfield SK. Passive fMRI mapping of language function for pediatric epilepsy surgical planning: validation using Wada, ECS, and FMAER. Epilepsy Res. 2014 Dec; 108(10):1874-88. View abstract
  81. Sánchez Fernández I, Loddenkemper T. Subunit composition of neurotransmitter receptors in the immature and in the epileptic brain. Biomed Res Int. 2014; 2014:301950. View abstract
  82. Ramgopal S, Thome-Souza S, Jackson M, Kadish NE, Sánchez Fernández I, Klehm J, Bosl W, Reinsberger C, Schachter S, Loddenkemper T. Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy. Epilepsy Behav. 2014 Aug; 37:291-307. View abstract
  83. Pinto AL, Fernández IS, Peters JM, Manganaro S, Singer JM, Vendrame M, Prabhu SP, Loddenkemper T, Kothare SV. Localization of sleep spindles, k-complexes, and vertex waves with subdural electrodes in children. J Clin Neurophysiol. 2014 Aug; 31(4):367-74. View abstract
  84. Thome-Souza S, Kadish NE, Ramgopal S, Sánchez Fernández I, Bergin AM, Bolton J, Harini C, Libenson M, Olson H, Peters J, Poduri A, Rotenberg A, Takeoka M, Kothare SV, Kapur K, Bourgeois BF, Loddenkemper T. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View abstract
  85. Abend NS, Loddenkemper T. Management of pediatric status epilepticus. Curr Treat Options Neurol. 2014 Jul; 16(7):301. View abstract
  86. Sánchez Fernández I, Vendrame M, Kapur K, Klehm J, Uysal S, Gedik M, An S, Jillella D, Zelener J, Syed S, Gooty V, Rotenberg A, Loddenkemper T. Comparison of pediatric patients with status epilepticus lasting 5-29 min versus =30 min. Epilepsy Behav. 2014 Aug; 37:1-6. View abstract
  87. Olson H, Shen Y, Avallone J, Sheidley BR, Pinsky R, Bergin AM, Berry GT, Duffy FH, Eksioglu Y, Harris DJ, Hisama FM, Ho E, Irons M, Jacobsen CM, James P, Kothare S, Khwaja O, Lipton J, Loddenkemper T, Markowitz J, Maski K, Megerian JT, Neilan E, Raffalli PC, Robbins M, Roberts A, Roe E, Rollins C, Sahin M, Sarco D, Schonwald A, Smith SE, Soul J, Stoler JM, Takeoka M, Tan WH, Torres AR, Tsai P, Urion DK, Weissman L, Wolff R, Wu BL, Miller DT, Poduri A. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. View abstract
  88. Sánchez Fernández I, Chapman K, Peters JM, Klehm J, Jackson MC, Berg AT, Loddenkemper T. Treatment for continuous spikes and waves during sleep (CSWS): survey on treatment choices in North America. Epilepsia. 2014 Jul; 55(7):1099-108. View abstract
  89. Sánchez Fernández I, Klehm J, An S, Jillella D, Kapur K, Zelener J, Rotenberg A, Loddenkemper T. Comparison of risk factors for pediatric convulsive status epilepticus when defined as seizures = 5 min versus seizures = 30 min. Seizure. 2014 Oct; 23(9):692-8. View abstract
  90. Johnson KB, Michelson KA, Lyons TW, Nigrovic LE, Landschaft A, Loddenkemper T, Kimia AA. Pediatric status epilepticus: how common is cerebrospinal fluid pleocytosis in the absence of infection? Seizure. 2014 Aug; 23(7):573-5. View abstract
  91. Ramgopal S, Powell C, Zarowski M, Alexopoulos AV, Kothare SV, Loddenkemper T. Predicting diurnal and sleep/wake seizure patterns in paediatric patients of different ages. Epileptic Disord. 2014 Mar; 16(1):56-66. View abstract
  92. Loddenkemper T, Talos DM, Cleary RT, Joseph A, Sánchez Fernández I, Alexopoulos A, Kotagal P, Najm I, Jensen FE. Subunit composition of glutamate and gamma-aminobutyric acid receptors in status epilepticus. Epilepsy Res. 2014 May; 108(4):605-15. View abstract
  93. Klehm J, Thome-Souza S, Sánchez Fernández I, Bergin AM, Bolton J, Harini C, Kadish NE, Libenson M, Peters J, Poduri A, Rotenberg A, Takeoka M, Bourgeois B, Loddenkemper T. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View abstract
  94. Maski KP, Loddenkemper T, An S, Allred EN, Urion DK, Leviton A. Development and implementation of a quality improvement curriculum for child neurology residents: lessons learned. Pediatr Neurol. 2014 May; 50(5):452-7. View abstract
  95. Berg AT, Loddenkemper T, Baca CB. Diagnostic delays in children with early onset epilepsy: impact, reasons, and opportunities to improve care. Epilepsia. 2014 Jan; 55(1):123-32. View abstract
  96. Fernández IS, Loddenkemper T. Electrocorticography for seizure foci mapping in epilepsy surgery. J Clin Neurophysiol. 2013 Dec; 30(6):554-70. View abstract
  97. Sánchez Fernández I, Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Matsumoto JH, McBain K, Nash KB, Payne E, Sánchez SM, Williams K, Loddenkemper T. Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter study. J Pediatr. 2014 Feb; 164(2):339-46.e1-2. View abstract
  98. Yu C, Ramgopal S, Libenson M, Abdelmoumen I, Powell C, Remy K, Madsen JR, Rotenberg A, Loddenkemper T. Outcomes of vagal nerve stimulation in a pediatric population: a single center experience. Seizure. 2014 Feb; 23(2):105-11. View abstract
  99. Sánchez Fernández I, Abend NS, Agadi S, An S, Arya R, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein DB, Goldstein JL, Goodkin HP, Hahn CD, Heinzen EL, Mikati MA, Peariso K, Pestian JP, Ream M, Riviello JJ, Tasker RC, Williams K, Loddenkemper T. Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). Seizure. 2014 Feb; 23(2):87-97. View abstract
  100. Sánchez Fernández I, Peters JM, An S, Bergin AM, Takeoka M, Rotenberg A, Kothare SV, Riviello JJ, Loddenkemper T. Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep. Pediatr Neurol. 2013 Sep; 49(3):163-170.e4. View abstract
  101. Olson HE, Lechpammer M, Prabhu SP, Ciarlini PD, Poduri A, Gooty VD, Anjum MW, Gorman MP, Loddenkemper T. Clinical application and evaluation of the Bien diagnostic criteria for Rasmussen encephalitis. Epilepsia. 2013 Oct; 54(10):1753-60. View abstract
  102. Khatwa U, Ramgopal S, Singh K, Loddenkemper T, Zarowski M, Kothare SV. The diagnostic yield of pediatric polysomnography based on the professional background of referring physicians. Clin Pediatr (Phila). 2013 Dec; 52(12):1154-60. View abstract
  103. Berg AT, Baca CB, Loddenkemper T, Vickrey BG, Dlugos D. Priorities in pediatric epilepsy research: improving children's futures today. Neurology. 2013 Sep 24; 81(13):1166-75. View abstract
  104. Sánchez Fernández I, Chapman KE, Peters JM, Harini C, Rotenberg A, Loddenkemper T. Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management. Epilepsy Res Treat. 2013; 2013:583531. View abstract
  105. Sánchez SM, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, McBain K, Nash KB, Payne E, Sánchez Fernández I, Shults J, Williams K, Yang A, Abend NS. Electroencephalography monitoring in critically ill children: current practice and implications for future study design. Epilepsia. 2013 Aug; 54(8):1419-27. View abstract
  106. Taimouri V, Akhondi-Asl A, Tomas-Fernandez X, Peters JM, Prabhu SP, Poduri A, Takeoka M, Loddenkemper T, Bergin AM, Harini C, Madsen JR, Warfield SK. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View abstract
  107. Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, McBain K, Nash KB, Payne E, Sánchez SM, Fernández IS, Shults J, Williams K, Yang A, Dlugos DJ. Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality. Neurology. 2013 Jul 23; 81(4):383-91. View abstract
  108. Gaspard N, Foreman B, Judd LM, Brenton JN, Nathan BR, McCoy BM, Al-Otaibi A, Kilbride R, Fernández IS, Mendoza L, Samuel S, Zakaria A, Kalamangalam GP, Legros B, Szaflarski JP, Loddenkemper T, Hahn CD, Goodkin HP, Claassen J, Hirsch LJ, Laroche SM. Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study. Epilepsia. 2013 Aug; 54(8):1498-503. View abstract
  109. Mane KK, Loddenkemper T, Fernández IS, Mikati MA, Tennison M, Schmitt C, Wilhelmsen K, Leviton A. Visual aids to medical data and computational diagnostics: new frontiers in pediatric neurology. Epilepsy Behav. 2013 Aug; 28(2):258-60. View abstract
  110. Glauser TA, Loddenkemper T. Management of childhood epilepsy. Continuum (Minneap Minn). 2013 Jun; 19(3 Epilepsy):656-81. View abstract
  111. Harini C, Singh K, Takeoka M, Parulkar I, Bergin AM, Loddenkemper T, Kothare SV. Predictors of seizure occurrence in children undergoing pre-surgical monitoring. Seizure. 2013 Oct; 22(8):640-6. View abstract
  112. Fernández IS, Loddenkemper T, Datta A, Kothare S, Riviello JJ, Rotenberg A. Electroencephalography in the pediatric emergency department: when is it most useful? J Child Neurol. 2014 Apr; 29(4):475-82. View abstract
  113. Leviton A, Loddenkemper T, Pomeroy SL. Clinical practice guidelines and practice parameters for the child neurologist. J Child Neurol. 2013 Jul; 28(7):917-25. View abstract
  114. Singh K, Katz ES, Zarowski M, Loddenkemper T, Llewellyn N, Manganaro S, Gregas M, Pavlova M, Kothare SV. Cardiopulmonary complications during pediatric seizures: a prelude to understanding SUDEP. Epilepsia. 2013 Jun; 54(6):1083-91. View abstract
  115. Ramgopal S, Thome-Souza S, Loddenkemper T. Chronopharmacology of anti-convulsive therapy. Curr Neurol Neurosci Rep. 2013 Apr; 13(4):339. View abstract
  116. Sanchez SM, Carpenter J, Chapman KE, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Kessler SK, Loddenkemper T, Riviello JJ, Abend NS. Pediatric ICU EEG monitoring: current resources and practice in the United States and Canada. J Clin Neurophysiol. 2013 Apr; 30(2):156-60. View abstract
  117. Allred E, An S, Leviton A, Loddenkemper T, McCrave J, Nichol SM. Should readmission within 30 days after discharge of children hospitalized for a neurologic disorder be considered a quality assurance failure? J Child Neurol. 2013 Jun; 28(6):758-61. View abstract
  118. Abend NS, Chapman KE, Gallentine WB, Goldstein J, Hyslop AE, Loddenkemper T, Nash KB, Riviello JJ, Hahn CD. Electroencephalographic monitoring in the pediatric intensive care unit. Curr Neurol Neurosci Rep. 2013 Mar; 13(3):330. View abstract
  119. Fogarasi A, Loddenkemper T, Mellado C, Tuxhorn I, Evers G, Sarco D, Burgess RC, Halász P, Barsis P, Gyorsok Z, Gyimesi C, Kóbor J, Siegler Z, Janszky J, Jakus R, Rásonyi G, Ebner A, Woermann FG, Sahin M. Sturge-Weber syndrome: clinical and radiological correlates in 86 patients. Ideggyogy Sz. 2013 Jan 30; 66(1-2):53-7. View abstract
  120. Chavakula V, Sánchez Fernández I, Peters JM, Popli G, Bosl W, Rakhade S, Rotenberg A, Loddenkemper T. Automated quantification of spikes. Epilepsy Behav. 2013 Feb; 26(2):143-52. View abstract
  121. Sánchez Fernández I, Loddenkemper T, Peters JM, Kothare SV. Electrical status epilepticus in sleep: clinical presentation and pathophysiology. Pediatr Neurol. 2012 Dec; 47(6):390-410. View abstract
  122. Fernández IS, Chapman KE, Peters JM, Kothare SV, Nordli DR, Jensen FE, Berg AT, Loddenkemper T. The tower of Babel: survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America. Epilepsia. 2013 Apr; 54(4):741-50. View abstract
  123. Loddenkemper T, Syed TU, Ramgopal S, Gulati D, Thanaviratananich S, Kothare SV, Alshekhlee A, Koubeissi MZ. Risk factors associated with death in in-hospital pediatric convulsive status epilepticus. PLoS One. 2012; 7(10):e47474. View abstract
  124. Sánchez Fernández I, Ramgopal S, Powell C, Gregas M, Zarowski M, Shah A, Vendrame M, Alexopoulos AV, Kothare SV, Loddenkemper T. Clinical evolution of seizures: distribution across time of day and sleep/wakefulness cycle. J Neurol. 2013 Feb; 260(2):549-57. View abstract
  125. Sánchez Fernández I, Loddenkemper T. Pediatric focal epilepsy syndromes. J Clin Neurophysiol. 2012 Oct; 29(5):425-40. View abstract
  126. Blumberg J, Fernández IS, Vendrame M, Oehl B, Tatum WO, Schuele S, Alexopoulos AV, Poduri A, Kellinghaus C, Schulze-Bonhage A, Loddenkemper T. Dacrystic seizures: demographic, semiologic, and etiologic insights from a multicenter study in long-term video-EEG monitoring units. Epilepsia. 2012 Oct; 53(10):1810-9. View abstract
  127. Loddenkemper T. Chrono-epileptology: time to reconsider seizure timing. Seizure. 2012 Jul; 21(6):411. View abstract
  128. Bateman LM, Begley CE, Ben-Menachem E, Berg AT, Berkovic SF, Cascino GD, Drazkowski J, Edwards JC, Engel J, French JA, Gilliam FD, Hoerth MT, Jehi LE, Kanner AM, Krauss GL, Labiner DM, Loddenkemper T, Luders HO, McKhann GM, McLachlan R, Modi A, Pennell PB, Shafer PO, Sirven JI, Stern JM, Szaflarski JP, Theodore WH. Overcoming barriers to successful epilepsy management. Epilepsy Curr. 2012 Jul; 12(4):158-60. View abstract
  129. Ramgopal S, Vendrame M, Shah A, Gregas M, Zarowski M, Rotenberg A, Alexopoulos AV, Wyllie E, Kothare SV, Loddenkemper T. Circadian patterns of generalized tonic-clonic evolutions in pediatric epilepsy patients. Seizure. 2012 Sep; 21(7):535-9. View abstract
  130. Segal E, Vendrame M, Gregas M, Loddenkemper T, Kothare SV. Effect of treatment of obstructive sleep apnea on seizure outcomes in children with epilepsy. Pediatr Neurol. 2012 Jun; 46(6):359-62. View abstract
  131. Ramgopal S, Shah A, Zarowski M, Vendrame M, Gregas M, Alexopoulos AV, Loddenkemper T, Kothare SV. Diurnal and sleep/wake patterns of epileptic spasms in different age groups. Epilepsia. 2012 Jul; 53(7):1170-7. View abstract
  132. Fernández IS, Peters JM, Hadjiloizou S, Prabhu SP, Zarowski M, Stannard KM, Takeoka M, Rotenberg A, Kothare SV, Loddenkemper T. Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep. Epilepsia. 2012 Jul; 53(7):1185-95. View abstract
  133. Vendrame M, Guilhoto LM, Loddenkemper T, Gregas M, Bourgeois BF, Kothare SV. Outcomes of epileptic spasms in patients aged less than 3 years: single-center United States experience. Pediatr Neurol. 2012 May; 46(5):276-80. View abstract
  134. Sánchez Fernández I, Hadjiloizou S, Eksioglu Y, Peters JM, Takeoka M, Tas E, Abdelmoumen I, Rotenberg A, Kothare SV, Riviello JJ, Loddenkemper T. Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. Pediatr Neurol. 2012 May; 46(5):312-8. View abstract
  135. Sánchez Fernández I, Takeoka M, Tas E, Peters JM, Prabhu SP, Stannard KM, Gregas M, Eksioglu Y, Rotenberg A, Riviello JJ, Kothare SV, Loddenkemper T. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29; 78(22):1721-7. View abstract
  136. Poh MZ, Loddenkemper T, Reinsberger C, Swenson NC, Goyal S, Madsen JR, Picard RW. Autonomic changes with seizures correlate with postictal EEG suppression. Neurology. 2012 Jun 05; 78(23):1868-76. View abstract
  137. Fernández IS, Peters J, Takeoka M, Rotenberg A, Prabhu S, Gregas M, Riviello JJ, Kothare S, Loddenkemper T. Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity. J Child Neurol. 2013 Jan; 28(1):83-9. View abstract
  138. Poh MZ, Loddenkemper T, Reinsberger C, Swenson NC, Goyal S, Sabtala MC, Madsen JR, Picard RW. Convulsive seizure detection using a wrist-worn electrodermal activity and accelerometry biosensor. Epilepsia. 2012 May; 53(5):e93-7. View abstract
  139. Vendrame M, Loddenkemper T, Zarowski M, Gregas M, Shuhaiber H, Sarco DP, Morales A, Nespeca M, Sharpe C, Haas K, Barnes G, Glaze D, Kothare SV. Analysis of EEG patterns and genotypes in patients with Angelman syndrome. Epilepsy Behav. 2012 Mar; 23(3):261-5. View abstract
  140. Peters JM, Tomas-Fernandez M, van Putten MJ, Loddenkemper T. Behavioral measures and EEG monitoring using the Brain Symmetry Index during the Wada test in children. Epilepsy Behav. 2012 Mar; 23(3):247-53. View abstract
  141. Stamoulis C, Fernández IS, Chang BS, Loddenkemper T. Signal subspace integration for improved seizure localization. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:1016-9. View abstract
  142. Loddenkemper T, Wyllie E, Hirsch E. Epileptic syndromes with focal seizures of childhood and adolescence. Handb Clin Neurol. 2012; 107:195-208. View abstract
  143. McLaughlin BL, Mariano LJ, Prakash SR, Kindle AL, Czarnecki A, Modarres MH, Rotenberg A, Loddenkemper T, Shoeb A, Schachter SC. An electroencephalographic recording platform for real-time seizure detection. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:875-8. View abstract
  144. Loddenkemper T, Goodkin HP. Treatment of pediatric status epilepticus. Curr Treat Options Neurol. 2011 Dec; 13(6):560-73. View abstract
  145. Pinto A, Miller-Horn J, Guilhoto L, Harini C, Morrison P, Prabhu SP, Kothare S, Loddenkemper T. Teaching NeuroImages: mesial temporal sclerosis after a prolonged unprovoked seizure in an infant. Neurology. 2011 Nov 08; 77(19):e112-3. View abstract
  146. Leviton A, Nichol SM, Allred EN, Loddenkemper T. What is quality improvement and why should child neurologists care? J Child Neurol. 2012 Feb; 27(2):251-7. View abstract
  147. Pestana Knight EM, Loddenkemper T, Lachhwani D, Kotagal P, Wyllie E, Bingaman W, Gupta A. Outcome of no resection after long-term subdural electroencephalography evaluation in children with epilepsy. J Neurosurg Pediatr. 2011 Sep; 8(3):269-78. View abstract
  148. Vendrame M, Zarowski M, Loddenkemper T, Steinborn B, Kothare SV. Selective serotonin reuptake inhibitors and periodic limb movements of sleep. Pediatr Neurol. 2011 Sep; 45(3):175-7. View abstract
  149. Ghosh PS, Ghosh D, Loddenkemper T, Prayson RA, Tekautz T, Sriram CS, Danziger-Isakov L. Necrotizing granulomatous meningoencephalitis due to Balamuthia in an immunocompetent child. Neurology. 2011 Aug 23; 77(8):801-2. View abstract
  150. Vendrame M, Auerbach S, Loddenkemper T, Kothare S, Montouris G. Effect of continuous positive airway pressure treatment on seizure control in patients with obstructive sleep apnea and epilepsy. Epilepsia. 2011 Nov; 52(11):e168-71. View abstract
  151. Kaleyias J, Loddenkemper T, Vendrame M, Das R, Syed TU, Alexopoulos AV, Wyllie E, Kothare SV. Sleep-wake patterns of seizures in children with lesional epilepsy. Pediatr Neurol. 2011 Aug; 45(2):109-13. View abstract
  152. Guilhoto LM, Loddenkemper T, Gooty VD, Rotenberg A, Takeoka M, Duffy FH, Coulter D, Urion D, Bourgeois BF, Kothare SV. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol. 2011 Jun; 44(6):414-9. View abstract
  153. Vendrame M, Kaleyias J, Loddenkemper T, Smith E, McClain C, Rockoff M, Manganaro S, McKenzie B, Gao L, Scott M, Bourgeois B, Kothare SV. Electroencephalogram monitoring during intracranial surgery for moyamoya disease. Pediatr Neurol. 2011 Jun; 44(6):427-32. View abstract
  154. Sundaram P, Mulkern RV, Wells WM, Triantafyllou C, Loddenkemper T, Bubrick EJ, Orbach DB. An empirical investigation of motion effects in eMRI of interictal epileptiform spikes. Magn Reson Imaging. 2011 Dec; 29(10):1401-9. View abstract
  155. Vendrame M, Zarowski M, Alexopoulos AV, Wyllie E, Kothare SV, Loddenkemper T. Localization of pediatric seizure semiology. Clin Neurophysiol. 2011 Oct; 122(10):1924-8. View abstract
  156. Loddenkemper T, Fernández IS, Peters JM. Continuous spike and waves during sleep and electrical status epilepticus in sleep. J Clin Neurophysiol. 2011 Apr; 28(2):154-64. View abstract
  157. Loddenkemper T, Lockley SW, Kaleyias J, Kothare SV. Chronobiology of epilepsy: diagnostic and therapeutic implications of chrono-epileptology. J Clin Neurophysiol. 2011 Apr; 28(2):146-53. View abstract
  158. Zarowski M, Loddenkemper T, Vendrame M, Alexopoulos AV, Wyllie E, Kothare SV. Circadian distribution and sleep/wake patterns of generalized seizures in children. Epilepsia. 2011 Jun; 52(6):1076-83. View abstract
  159. Syed TU, LaFrance WC, Kahriman ES, Hasan SN, Rajasekaran V, Gulati D, Borad S, Shahid A, Fernandez-Baca G, Garcia N, Pawlowski M, Loddenkemper T, Amina S, Koubeissi MZ. Can semiology predict psychogenic nonepileptic seizures? A prospective study. Ann Neurol. 2011 Jun; 69(6):997-1004. View abstract
  160. Vendrame M, Poduri A, Loddenkemper T, Kluger G, Coppola G, Kothare SV. Treatment of malignant migrating partial epilepsy of infancy with rufinamide: report of five cases. Epileptic Disord. 2011 Mar; 13(1):18-21. View abstract
  161. Olson HE, Loddenkemper T, Vendrame M, Poduri A, Takeoka M, Bergin AM, Libenson MH, Duffy FH, Rotenberg A, Coulter D, Bourgeois BF, Kothare SV. Rufinamide for the treatment of epileptic spasms. Epilepsy Behav. 2011 Feb; 20(2):344-8. View abstract
  162. Loddenkemper T, Vendrame M, Zarowski M, Gregas M, Alexopoulos AV, Wyllie E, Kothare SV. Circadian patterns of pediatric seizures. Neurology. 2011 Jan 11; 76(2):145-53. View abstract
  163. Tas E, Tracy M, Sarco DP, Eksioglu YZ, Prabhu SP, Loddenkemper T. Septo-optic dysplasia complicated by infantile spasms and bilateral choroidal fissure arachnoid cysts. J Neuroimaging. 2011 Jan; 21(1):89-91. View abstract
  164. Guilhoto LM, Loddenkemper T, Vendrame M, Bergin A, Bourgeois BF, Kothare SV. Higher evening antiepileptic drug dose for nocturnal and early-morning seizures. Epilepsy Behav. 2011 Feb; 20(2):334-7. View abstract
  165. Das RR, Alexopoulos AV, Loddenkemper T. Incidence and clinical decision making for the Wada test over one decade: 1997-2007. Epileptic Disord. 2010 Dec; 12(4):249-54. View abstract
  166. Vendrame M, Loddenkemper T, Gooty VD, Takeoka M, Rotenberg A, Bergin AM, Eksioglu YZ, Poduri A, Duffy FH, Libenson M, Bourgeois BF, Kothare SV. Experience with rufinamide in a pediatric population: a single center's experience. Pediatr Neurol. 2010 Sep; 43(3):155-8. View abstract
  167. Vendrame M, Loddenkemper T. Surgical treatment of refractory status epilepticus in children: candidate selection and outcome. Semin Pediatr Neurol. 2010 Sep; 17(3):182-9. View abstract
  168. Loddenkemper T, Nichol SM, Allred EN, Leviton A. Fears and promises of comparative effectiveness research. Acta Paediatr. 2010 Sep; 99(9):1311-3. View abstract
  169. Vendrame M, Tracy M, Das R, Duffy F, Loddenkemper T, Kothare SV. Clinical correlations of midline spikes in children. Epilepsy Behav. 2010 Aug; 18(4):460-5. View abstract
  170. Tatum WO, Loddenkemper T. Crying with left temporal lobe seizures and Wada testing. Epilepsy Behav. 2010 Jul; 18(3):303-5. View abstract
  171. Sarkis R, Wyllie E, Burgess RC, Loddenkemper T. Neuroimaging findings in children with benign focal epileptiform discharges. Epilepsy Res. 2010 Jun; 90(1-2):91-8. View abstract
  172. Kovac S, Möddel G, Reinholz J, Alexopoulos AV, Syed T, Koubeissi MZ, Schuele SU, Lineweaver T, Busch RM, Loddenkemper T. Visual naming performance after ATL resection: impact of atypical language dominance. Neuropsychologia. 2010 Jun; 48(7):2221-5. View abstract
  173. Khandelwal DC, Syed TU, Loddenkemper T, Alexopoulos AV. A self-administered screening instrument for psychogenic nonepileptic seizures. Neurology. 2010 Jan 19; 74(3):270; author reply 271. View abstract
  174. Poh MZ, Loddenkemper T, Swenson NC, Goyal S, Madsen JR, Picard RW. Continuous monitoring of electrodermal activity during epileptic seizures using a wearable sensor. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:4415-8. View abstract
  175. Sarkis RA, Loddenkemper T, Burgess RC, Wyllie E. Childhood absence epilepsy in patients with benign focal epileptiform discharges. Pediatr Neurol. 2009 Dec; 41(6):428-34. View abstract
  176. Loddenkemper T, Möddel G, Dinner DS, Kim H, Schuele SU, Alexopoulos AV, Kotagal P, Lüders HO. Language assessment in Wada test: comparison of methohexital and amobarbital. Seizure. 2009 Nov; 18(9):656-9. View abstract
  177. Vendrame M, Alexopoulos AV, Boyer K, Gregas M, Haut J, Lineweaver T, Wyllie E, Loddenkemper T. Longer duration of epilepsy and earlier age at epilepsy onset correlate with impaired cognitive development in infancy. Epilepsy Behav. 2009 Nov; 16(3):431-5. View abstract
  178. Kovac S, Möddel G, Reinholz J, Alexopoulos AV, Syed T, Schuele SU, Lineweaver T, Loddenkemper T. Memory performance is related to language dominance as determined by the intracarotid amobarbital procedure. Epilepsy Behav. 2009 Sep; 16(1):145-9. View abstract
  179. Ghosh PS, Loddenkemper T, Blanco MB, Marks M, Sabella C, Ghosh D. Holocord spinal epidural abscess. J Child Neurol. 2009 Jun; 24(6):768-71. View abstract
  180. Syed TU, Arozullah AM, Loparo KL, Jamasebi R, Suciu GP, Griffin C, Mani R, Syed I, Loddenkemper T, Alexopoulos AV. A self-administered screening instrument for psychogenic nonepileptic seizures. Neurology. 2009 May 12; 72(19):1646-52. View abstract
  181. Möddel G, Lineweaver T, Schuele SU, Reinholz J, Loddenkemper T. Atypical language lateralization in epilepsy patients. Epilepsia. 2009 Jun; 50(6):1505-16. View abstract
  182. Loddenkemper T, Cosmo G, Kotagal P, Haut J, Klaas P, Gupta A, Lachhwani DK, Bingaman W, Wyllie E. Epilepsy surgery in children with electrical status epilepticus in sleep. Neurosurgery. 2009 Feb; 64(2):328-37; discussion 337. View abstract
  183. Loddenkemper T, Alexopoulos AV, Kotagal P, Moosa A, Lachhwani DK, Gupta A, Bingaman W, Wyllie E. Epilepsy surgery in epidermal nevus syndrome variant with hemimegalencephaly and intractable seizures. J Neurol. 2008 Nov; 255(11):1829-31. View abstract
  184. Kellinghaus C, Skidmore C, Loddenkemper T. Lateralizing value of epileptic nystagmus. Epilepsy Behav. 2008 Nov; 13(4):700-2. View abstract
  185. Loddenkemper T, Morris HH, Möddel G. Complications during the Wada test. Epilepsy Behav. 2008 Oct; 13(3):551-3. View abstract
  186. Loddenkemper T. Quo vadis Wada? Epilepsy Behav. 2008 Jul; 13(1):1-2. View abstract
  187. Lachhwani DK, Loddenkemper T, Holland KD, Kotagal P, Mascha E, Bingaman W, Wyllie E. Discontinuation of medications after successful epilepsy surgery in children. Pediatr Neurol. 2008 May; 38(5):340-4. View abstract
  188. Loddenkemper T, Friedman NR, Ruggieri PM, Marcotty A, Sears J, Traboulsi EI. Pituitary stalk duplication in association with moya moya disease and bilateral morning glory disc anomaly - broadening the clinical spectrum of midline defects. J Neurol. 2008 Jun; 255(6):885-90. View abstract
  189. Loddenkemper T, Burgess RC, Syed T, Pestana EM. Lateralization of interictal EEG findings. J Clin Neurophysiol. 2007 Oct; 24(5):379-85. View abstract
  190. Loddenkemper T, Sharma P, Katzan I, Plant GT. Risk factors for early visual deterioration in temporal arteritis. J Neurol Neurosurg Psychiatry. 2007 Nov; 78(11):1255-9. View abstract
  191. Loddenkemper T, Holland KD, Stanford LD, Kotagal P, Bingaman W, Wyllie E. Developmental outcome after epilepsy surgery in infancy. Pediatrics. 2007 May; 119(5):930-5. View abstract
  192. Loddenkemper T, Morris HH, Lineweaver TT, Kellinghaus C. Repeated intracarotid amobarbital tests. Epilepsia. 2007 Mar; 48(3):553-8. View abstract
  193. Loddenkemper T, Möddel G, Schuele SU, Wyllie E, Morris HH. Seizures during intracarotid methohexital and amobarbital testing. Epilepsy Behav. 2007 Feb; 10(1):49-54. View abstract
  194. Tamma P, Migeon C, Ghosh D, Loddenkemper T, Wright B, Phillips S, Levien MG, Prayson RA, Hashkes P, Dixon R. Index of suspicion. Pediatr Rev. 2006 Sep; 27(9):351-7. View abstract
  195. Kellinghaus C, Loddenkemper T, Wyllie E, Najm I, Gupta A, Rosenow F, Baumgartner C, Boesebeck F, Diehl B, Drees C, Ebner A, Hamer H, Knake S, Meencke JH, Merschhemke M, Möddel G, Noachtar S, Rona S, Schuele SU, Steinhoff BJ, Tuxhorn I, Werhahn K, Lüders HO. [Suggestion for a new, patient-oriented epilepsy classification]. Nervenarzt. 2006 Aug; 77(8):961-9. View abstract
  196. Alexopoulos AV, Kotagal P, Loddenkemper T, Hammel J, Bingaman WE. Long-term results with vagus nerve stimulation in children with pharmacoresistant epilepsy. Seizure. 2006 Oct; 15(7):491-503. View abstract
  197. Kellinghaus C, Loddenkemper T. Double-blind, randomized controlled study of bilateral cerebellar stimulation. Epilepsia. 2006 Jul; 47(7):1247; author reply 1248-9. View abstract
  198. Loddenkemper T, Morris HH, Diehl B, Lachhwani DK. Intracranial lipomas and epilepsy. J Neurol. 2006 May; 253(5):590-3. View abstract
  199. Lüders HO, Acharya J, Alexopoulos A, Baumgartner C, Bautista J, Burgess R, Carreño M, Diehl B, Dinner D, Ebner A, Foldvary N, Godoy J, Hamer H, Ikeda A, Källén K, Kellinghaus C, Kotagal P, Lachhwani D, Loddenkemper T, Mani J, Matsumoto R, Möddel G, Nair D, Noachtar S, O'Donovan CA, Rona S, Rosenow F, Schuele S, Szabo CA, Tandon N, Tanner A, Widdess-Walsh P. Are epilepsy classifications based on epileptic syndromes and seizure types outdated? Epileptic Disord. 2006 Mar; 8(1):81-5. View abstract
  200. Loddenkemper T, Kellinghaus C, Wyllie E, Najm IM, Gupta A, Rosenow F, Lüders HO. A proposal for a five-dimensional patient-oriented epilepsy classification. Epileptic Disord. 2005 Dec; 7(4):308-16. View abstract
  201. Weitemeyer L, Kellinghaus C, Weckesser M, Matheja P, Loddenkemper T, Schuierer G, Schober O, Ringelstein EB, Lüdemann P. The prognostic value of [F]FDG-PET in nonrefractory partial epilepsy. Epilepsia. 2005 Oct; 46(10):1654-60. View abstract
  202. Loddenkemper T, Kotagal P. Lateralizing signs during seizures in focal epilepsy. Epilepsy Behav. 2005 Aug; 7(1):1-17. View abstract
  203. Schuele SU, Kellinghaus C, Shook SJ, Boulis N, Bethoux FA, Loddenkemper T. Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen. Neurology. 2005 Mar 22; 64(6):1086-7. View abstract
  204. Kellinghaus C, Loddenkemper T. Acute repetitive pilomotor seizures. Clin Neurophysiol. 2005 Apr; 116(4):989-90; author reply 990. View abstract
  205. Loddenkemper T. Temporal arteritis. 1932. Arch Neurol. 2004 Oct; 61(10):1620-2. View abstract
  206. Loddenkemper T, Evers S, Hahn M, Reichelt D, Husstedt IW. Mononeuropathy of the laryngeal recurrent nerve as possible manifestation of human immunodeficiency virus infection. Otolaryngol Head Neck Surg. 2004 Oct; 131(4):556-7. View abstract
  207. Schulze-Bonhage A, Quiske A, Loddenkemper T, Dinner DS, Wyllie E. Validity of language lateralisation by unilateral intracarotid Wada test. J Neurol Neurosurg Psychiatry. 2004 Sep; 75(9):1367; author reply 1367-8. View abstract
  208. Loddenkemper T, Wyllie E, Neme S, Kotagal P, Lüders HO. Lateralizing signs during seizures in infants. J Neurol. 2004 Sep; 251(9):1075-9. View abstract
  209. Loddenkemper T, Kellinghaus C, Gandjour J, Nair DR, Najm IM, Bingaman W, Lüders HO. Localising and lateralising value of ictal piloerection. J Neurol Neurosurg Psychiatry. 2004 Jun; 75(6):879-83. View abstract
  210. Kellinghaus C, Loddenkemper T, Dinner DS, Lachhwani D, Lüders HO. Non-epileptic seizures of the elderly. J Neurol. 2004 Jun; 251(6):704-9. View abstract
  211. Kellinghaus C, Loddenkemper T, Najm IM, Wyllie E, Lineweaver T, Nair DR, Lüders HO. Specific epileptic syndromes are rare even in tertiary epilepsy centers: a patient-oriented approach to epilepsy classification. Epilepsia. 2004 Mar; 45(3):268-75. View abstract
  212. Kellinghaus C, Loddenkemper T, Dinner DS, Lachhwani D, Lüders HO. Seizure semiology in the elderly: a video analysis. Epilepsia. 2004 Mar; 45(3):263-7. View abstract
  213. Loddenkemper T, Dinner DS, Kubu C, Prayson R, Bingaman W, Dagirmanjian A, Wyllie E. Aphasia after hemispherectomy in an adult with early onset epilepsy and hemiplegia. J Neurol Neurosurg Psychiatry. 2004 Jan; 75(1):149-51. View abstract
  214. Loddenkemper T, Wyllie E, Kaplan B, Lachhwani DK. Stool-withholding activity mimicking epilepsy. Neurology. 2003 Nov 25; 61(10):1454-5. View abstract
  215. Kellinghaus C, Loddenkemper T, Kotagal P. Ictal spitting: clinical and electroencephalographic features. Epilepsia. 2003 Aug; 44(8):1064-9. View abstract
  216. Kellinghaus C, Loddenkemper T, Möddel G, Tergau F, Lüders J, Lüdemann P, Nair DR, Lüders HO. [Electric brain stimulation for epilepsy therapy]. Nervenarzt. 2003 Aug; 74(8):664-76. View abstract
  217. Kellinghaus C, Loddenkemper T, Lüders HO. Epileptic monocular nystagmus. Neurology. 2003 Jul 08; 61(1):145-7; author reply 147. View abstract
  218. Loddenkemper T, Wyllie E, Lardizabal D, Stanford LD, Bingaman W. Late language transfer in patients with Rasmussen encephalitis. Epilepsia. 2003 Jun; 44(6):870-1. View abstract
  219. Loddenkemper T, Kellinghaus C, Lüders HO. Effects of subthalamic nucleus (STN) stimulation on motor cortex excitability. Neurology. 2003 Mar 11; 60(5):885-6; author reply 885-6. View abstract
  220. Loddenkemper T, Foldvary N, Raja S, Neme S, Lüders HO. Ictal urinary urge: further evidence for lateralization to the nondominant hemisphere. Epilepsia. 2003 Jan; 44(1):124-6. View abstract
  221. Loddenkemper T, Morris HH, Perl J. Carotid artery dissection after the intracarotid amobarbital test. Neurology. 2002 Dec 10; 59(11):1797-8. View abstract
  222. Loddenkemper T, Grote K, Evers S, Oelerich M, Stögbauer F. Neurological manifestations of the oculodentodigital dysplasia syndrome. J Neurol. 2002 May; 249(5):584-95. View abstract
  223. Loddenkemper T, Pan A, Neme S, Baker KB, Rezai AR, Dinner DS, Montgomery EB, Lüders HO. Deep brain stimulation in epilepsy. J Clin Neurophysiol. 2001 Nov; 18(6):514-32. View abstract
  224. Kellinghaus C, Loddenkemper T, Weitemeyer L, Lüdemann P. [Experience with tiagabine in the clinical practice; new insights as to the efficacy and safety profile]. Nervenarzt. 2001 Oct; 72(10):764-9. View abstract