Research Overview

Rong Luo's research has been focused on elucidating the cellular and molecular mechanisms by which GPR56, a member of the adhesion G protein-coupled receptor family, regulates brain development. One of her projects was to define the function and signaling pathways of GPR56  in the developing mouse brain. Dr. Piao and Dr. Luo have successfully identified collagen III as the ligand of GPR56, which opens up many avenues for further studies. Dr. Luo's proposed studies cover several areas of research, including: 1) the role of GPR56 in CNS myelination; 2) GPR56 signaling in brain development and malformation; 3) identifying and characterizing the ligands of other adhesion G protein-coupled receptors, such as GPR126. Mouse genetics model and in vitro biochemistry, proteomics techniques are used to accomplish the research goals. 

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  • GPR56 in Brain Development

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PUBLICATIONS

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  1. Giera S, Luo R, Ying Y, Ackerman SD, Jeong SJ, Stoveken HM, Folts CJ, Welsh CA, Tall GG, Stevens B, Monk KR, Piao X. Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Elife. 2018 May 29; 7. View abstract
  2. Salzman GS, Ackerman SD, Ding C, Koide A, Leon K, Luo R, Stoveken HM, Fernandez CG, Tall GG, Piao X, Monk KR, Koide S, Araç D. Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains. Neuron. 2016 Sep 21; 91(6):1292-1304. View abstract
  3. Petersen SC, Luo R, Liebscher I, Giera S, Jeong SJ, Mogha A, Ghidinelli M, Feltri ML, Schöneberg T, Piao X, Monk KR. The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron. 2015 Feb 18; 85(4):755-69. View abstract
  4. Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao X. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015 Jan 21; 6:6121. View abstract
  5. Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Araç D, Piao X. Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. PLoS One. 2014; 9(6):e100043. View abstract
  6. Gao S, Li A, Liu F, Chen F, Williams M, Zhang C, Kelley Z, Wu CL, Luo R, Xiao H. NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell. 2013 Dec 09; 24(6):725-37. View abstract
  7. Jeong SJ, Luo R, Singer K, Giera S, Kreidberg J, Kiyozumi D, Shimono C, Sekiguchi K, Piao X. GPR56 functions together with a3ß1 integrin in regulating cerebral cortical development. PLoS One. 2013; 8(7):e68781. View abstract
  8. Singer K, Luo R, Jeong SJ, Piao X. GPR56 and the developing cerebral cortex: cells, matrix, and neuronal migration. Mol Neurobiol. 2013 Feb; 47(1):186-96. View abstract
  9. Jeong SJ, Luo R, Li S, Strokes N, Piao X. Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. J Comp Neurol. 2012 Sep 01; 520(13):2930-40. View abstract
  10. Luo R, Jin Z, Deng Y, Strokes N, Piao X. Disease-associated mutations prevent GPR56-collagen III interaction. PLoS One. 2012; 7(1):e29818. View abstract
  11. Jeong SJ, Li S, Luo R, Strokes N, Piao X. Loss of Col3a1, the gene for Ehlers-Danlos syndrome type IV, results in neocortical dyslamination. PLoS One. 2012; 7(1):e29767. View abstract
  12. Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X. G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12925-30. View abstract
  13. Luo R, Yang HM, Jin Z, Halley DJ, Chang BS, MacPherson L, Brueton L, Piao X. A novel GPR56 mutation causes bilateral frontoparietal polymicrogyria. Pediatr Neurol. 2011 Jul; 45(1):49-53. View abstract
  14. Chen X, Zhao P, Chen F, Li L, Luo R. Effect and mechanism of 5-aminolevulinic acid-mediated photodynamic therapy in esophageal cancer. Lasers Med Sci. 2011 Jan; 26(1):69-78. View abstract
  15. Jin Z, Luo R, Piao X. GPR56 and its related diseases. Prog Mol Biol Transl Sci. 2009; 89:1-13. View abstract