Research Overview 

Ron Lacro is trained in dysmorphology/clinical genetics as well as pediatric cardiology. As a result, his research interests lie at the intersection of these two disciplines. He is particularly interested in the pathogenesis of congenital cardiovascular malformations and, clinically, on evaluating the management of patients with multiple malformation syndromes such as Williams snydrome and Marfan syndrome and other connective tissue disorders. 

About Ronald Lacro 

Ronald Lacro received his MD from Northwestern University Medical School. He completed an internship, residency, and fellowship in dysmorpholog/genetics at University of California Medical Center, San Diego, and a fellowship in cardiology at Boston Children's Hospital.

Researcher Services

Researcher Areas

  • Noninvasive Cardiology

Research Departments

PUBLICATIONS

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  1. Handisides JC, Hollenbeck-Pringle D, Uzark K, Trachtenberg FL, Pemberton VL, Atz TW, Bradley TJ, Cappella E, De Nobele S, Groh GK, Hamstra MS, Korsin R, Levine JC, Lindauer B, Liou A, Neal MKM, Markham LW, Morrison T, Mussatto KA, Olson AK, Pierpont MEM, Pyeritz RE, Radojewski EA, Roman MJ, Xu M, Lacro RV. Health-Related Quality of Life in Children and Young Adults with Marfan Syndrome. J Pediatr. 2018 Sep 27. View abstract
  2. Jolley MA, Hammer PE, Ghelani SJ, Adar A, Sleeper LA, Lacro RV, Marx GR, Nathan M, Harrild DM. Three-Dimensional Mitral Valve Morphology in Children and Young Adults With Marfan Syndrome. J Am Soc Echocardiogr. 2018 Nov; 31(11):1168-1177.e1. View abstract
  3. Mah DY, Sleeper LA, Crosson JE, Czosek RJ, Love BA, McCrindle BW, Muiño-Mosquera L, Olson AK, Pilcher TA, Tierney ESS, Shah MJ, Wechsler SB, Young LT, Lacro RV. Frequency of Ventricular Arrhythmias and Other Rhythm Abnormalities in Children and Young Adults With the Marfan Syndrome. Am J Cardiol. 2018 Oct 15; 122(8):1429-1436. View abstract
  4. Hoskoppal A, Menon S, Trachtenberg F, Burns KM, De Backer J, Gelb BD, Gleason M, James J, Lai WW, Liou A, Mahony L, Olson AK, Pyeritz RE, Sharkey AM, Stylianou M, Wechsler SB, Young L, Levine JC, Tierney ESS, Lacro RV, Bradley TJ. Predictors of Rapid Aortic Root Dilation and Referral for Aortic Surgery in Marfan Syndrome. Pediatr Cardiol. 2018 Oct; 39(7):1453-1461. View abstract
  5. Selamet Tierney ES, Levine JC, Sleeper LA, Roman MJ, Bradley TJ, Colan SD, Chen S, Campbell MJ, Cohen MS, De Backer J, Heydarian H, Hoskoppal A, Lai WW, Liou A, Marcus E, Nutting A, Olson AK, Parra DA, Pearson GD, Pierpont ME, Printz BF, Pyeritz RE, Ravekes W, Sharkey AM, Srivastava S, Young L, Lacro RV. Influence of Aortic Stiffness on Aortic-Root Growth Rate and Outcome in Patients With the Marfan Syndrome. Am J Cardiol. 2018 May 01; 121(9):1094-1101. View abstract
  6. Merlocco A, Lacro RV, Gauvreau K, Rabideau N, Singh MN, Prakash A. Longitudinal Changes in Segmental Aortic Stiffness Determined by Cardiac Magnetic Resonance in Children and Young Adults With Connective Tissue Disorders (the Marfan, Loeys-Dietz, and Ehlers-Danlos Syndromes, and Nonspecific Connective Tissue Disorders). Am J Cardiol. 2017 Oct 01; 120(7):1214-1219. View abstract
  7. Prakash A, Adlakha H, Rabideau N, Hass CJ, Morris SA, Geva T, Gauvreau K, Singh MN, Lacro RV. Response to Letters Regarding Article "Segmental Aortic Stiffness in Children and Young Adults With Connective Tissue Disorders: Relationships With Age, Aortic Size, Rate of Dilation, and Surgical Root Replacement". Circulation. 2016 Feb 16; 133(7):e405. View abstract
  8. Singh MN, Lacro RV. Recent Clinical Drug Trials Evidence in Marfan Syndrome and Clinical Implications. Can J Cardiol. 2016 Jan; 32(1):66-77. View abstract
  9. Prakash A, Adlakha H, Rabideau N, Hass CJ, Morris SA, Geva T, Gauvreau K, Singh MN, Lacro RV. Segmental Aortic Stiffness in Children and Young Adults With Connective Tissue Disorders: Relationships With Age, Aortic Size, Rate of Dilation, and Surgical Root Replacement. Circulation. 2015 Aug 18; 132(7):595-602. View abstract
  10. Proost D, Vandeweyer G, Meester JA, Salemink S, Kempers M, Ingram C, Peeters N, Saenen J, Vrints C, Lacro RV, Roden D, Wuyts W, Dietz HC, Mortier G, Loeys BL, Van Laer L. Performant Mutation Identification Using Targeted Next-Generation Sequencing of 14 Thoracic Aortic Aneurysm Genes. Hum Mutat. 2015 Aug; 36(8):808-14. View abstract
  11. Wooderchak-Donahue W, VanSant-Webb C, Tvrdik T, Plant P, Lewis T, Stocks J, Raney JA, Meyers L, Berg A, Rope AF, Yetman AT, Bleyl SB, Mesley R, Bull DA, Collins RT, Ojeda MM, Roberts A, Lacro R, Woerner A, Stoler J, Bayrak-Toydemir P. Clinical utility of a next generation sequencing panel assay for Marfan and Marfan-like syndromes featuring aortopathy. Am J Med Genet A. 2015 Aug; 167A(8):1747-57. View abstract
  12. Pierpont ME, Lacro RV. Children with Thoracic Aortic Aneurysm: Challenges in Diagnosis and Therapy. J Pediatr. 2015 Jul; 167(1):14-6. View abstract
  13. Lacro RV, Dietz HC, Mahony L. Atenolol versus Losartan in Marfan's Syndrome. N Engl J Med. 2015 03 05; 372(10):980-1. View abstract
  14. Pitcher A, Emberson J, Lacro RV, Sleeper LA, Stylianou M, Mahony L, Pearson GD, Groenink M, Mulder BJ, Zwinderman AH, De Backer J, De Paepe AM, Arbustini E, Erdem G, Jin XY, Flather MD, Mullen MJ, Child AH, Forteza A, Evangelista A, Chiu HH, Wu MH, Sandor G, Bhatt AB, Creager MA, Devereux RB, Loeys B, Forfar JC, Neubauer S, Watkins H, Boileau C, Jondeau G, Dietz HC, Baigent C. Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration. Am Heart J. 2015 May; 169(5):605-12. View abstract
  15. Quintero-Rivera F, Xi QJ, Keppler-Noreuil KM, Lee JH, Higgins AW, Anchan RM, Roberts AE, Seong IS, Fan X, Lage K, Lu LY, Tao J, Hu X, Berezney R, Gelb BD, Kamp A, Moskowitz IP, Lacro RV, Lu W, Morton CC, Gusella JF, Maas RL. MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus. Hum Mol Genet. 2015 Apr 15; 24(8):2375-89. View abstract
  16. Lacro RV, Dietz HC, Sleeper LA, Yetman AT, Bradley TJ, Colan SD, Pearson GD, Selamet Tierney ES, Levine JC, Atz AM, Benson DW, Braverman AC, Chen S, De Backer J, Gelb BD, Grossfeld PD, Klein GL, Lai WW, Liou A, Loeys BL, Markham LW, Olson AK, Paridon SM, Pemberton VL, Pierpont ME, Pyeritz RE, Radojewski E, Roman MJ, Sharkey AM, Stylianou MP, Wechsler SB, Young LT, Mahony L. Atenolol versus losartan in children and young adults with Marfan's syndrome. N Engl J Med. 2014 Nov 27; 371(22):2061-71. View abstract
  17. Reinstein E, Morris SA, Rimoin DL, Robertson SP, Lacro RV. Arterial tortuosity in patients with Filamin A- associated vascular aneurysms. Am J Med Genet A. 2014 Nov; 164A(11):2961-3. View abstract
  18. Prendiville TW, Gauvreau K, Tworog-Dube E, Patkin L, Kucherlapati RS, Roberts AE, Lacro RV. Cardiovascular disease in Noonan syndrome. Arch Dis Child. 2014 Jul; 99(7):629-34. View abstract
  19. Cunningham JW, McElhinney DB, Gauvreau K, Bergersen L, Lacro RV, Marshall AC, Smoot L, Lock JE. Outcomes after primary transcatheter therapy in infants and young children with severe bilateral peripheral pulmonary artery stenosis. Circ Cardiovasc Interv. 2013 Aug; 6(4):460-7. View abstract
  20. Selamet Tierney ES, Levine JC, Chen S, Bradley TJ, Pearson GD, Colan SD, Sleeper LA, Campbell MJ, Cohen MS, De Backer J, Guey LT, Heydarian H, Lai WW, Lewin MB, Marcus E, Mart CR, Pignatelli RH, Printz BF, Sharkey AM, Shirali GS, Srivastava S, Lacro RV. Echocardiographic methods, quality review, and measurement accuracy in a randomized multicenter clinical trial of Marfan syndrome. J Am Soc Echocardiogr. 2013 Jun; 26(6):657-66. View abstract
  21. Lacro RV, Guey LT, Dietz HC, Pearson GD, Yetman AT, Gelb BD, Loeys BL, Benson DW, Bradley TJ, De Backer J, Forbus GA, Klein GL, Lai WW, Levine JC, Lewin MB, Markham LW, Paridon SM, Pierpont ME, Radojewski E, Selamet Tierney ES, Sharkey AM, Wechsler SB, Mahony L. Characteristics of children and young adults with Marfan syndrome and aortic root dilation in a randomized trial comparing atenolol and losartan therapy. Am Heart J. 2013 May; 165(5):828-835.e3. View abstract
  22. Teekakirikul P, Milewicz DM, Miller DT, Lacro RV, Regalado ES, Rosales AM, Ryan DP, Toler TL, Lin AE. Thoracic aortic disease in two patients with juvenile polyposis syndrome and SMAD4 mutations. Am J Med Genet A. 2013 Jan; 161A(1):185-91. View abstract
  23. Fernandes S, Khairy P, Graham DA, Colan SD, Galvin TC, Sanders SP, Singh MN, Bhatt A, Lacro RV. Bicuspid aortic valve and associated aortic dilation in the young. Heart. 2012 Jul; 98(13):1014-9. View abstract
  24. McElhinney DB, Lacro RV, Gauvreau K, O'Brien CM, Yaroglu Kazanci S, Vogel M, Emani S, Brown DW. Dilation of the ascending aorta after balloon valvuloplasty for aortic stenosis during infancy and childhood. Am J Cardiol. 2012 Sep 01; 110(5):702-8. View abstract
  25. Prakash A, Lacro RV, Sleeper LA, Minich LL, Colan SD, McCrindle B, Covitz W, Golding F, Hlavacek AM, Levine JC, Cohen MS. Challenges in echocardiographic assessment of mitral regurgitation in children after repair of atrioventricular septal defect. Pediatr Cardiol. 2012 Feb; 33(2):205-14. View abstract
  26. Kaza AK, Colan SD, Jaggers J, Lu M, Atz AM, Sleeper LA, McCrindle BW, Lambert LM, Margossian R, Lacro RV, Richmond ME, Natarajan S, Minich LL. Surgical interventions for atrioventricular septal defect subtypes: the pediatric heart network experience. Ann Thorac Surg. 2011 Oct; 92(4):1468-75; discussion 1475. View abstract
  27. Baetens M, Van Laer L, De Leeneer K, Hellemans J, De Schrijver J, Van De Voorde H, Renard M, Dietz H, Lacro RV, Menten B, Van Criekinge W, De Backer J, De Paepe A, Loeys B, Coucke PJ. Applying massive parallel sequencing to molecular diagnosis of Marfan and Loeys-Dietz syndromes. Hum Mutat. 2011 Sep; 32(9):1053-62. View abstract
  28. Morris SA, Orbach DB, Geva T, Singh MN, Gauvreau K, Lacro RV. Increased vertebral artery tortuosity index is associated with adverse outcomes in children and young adults with connective tissue disorders. Circulation. 2011 Jul 26; 124(4):388-96. View abstract
  29. Li JS, Colan SD, Sleeper LA, Newburger JW, Pemberton VL, Atz AM, Cohen MS, Golding F, Klein GL, Lacro RV, Radojewski E, Richmond ME, Minich LL. Lessons learned from a pediatric clinical trial: the Pediatric Heart Network angiotensin-converting enzyme inhibition in mitral regurgitation study. Am Heart J. 2011 Feb; 161(2):233-40. View abstract
  30. Yusupov R, Roberts AE, Lacro RV, Sandstrom M, Ligon AH. Potocki-Lupski syndrome: an inherited dup(17)(p11.2p11.2) with hypoplastic left heart. Am J Med Genet A. 2011 Feb; 155A(2):367-71. View abstract
  31. Atz AM, Hawkins JA, Lu M, Cohen MS, Colan SD, Jaggers J, Lacro RV, McCrindle BW, Margossian R, Mosca RS, Sleeper LA, Minich LL. Surgical management of complete atrioventricular septal defect: associations with surgical technique, age, and trisomy 21. J Thorac Cardiovasc Surg. 2011 Jun; 141(6):1371-9. View abstract
  32. Minich LL, Atz AM, Colan SD, Sleeper LA, Mital S, Jaggers J, Margossian R, Prakash A, Li JS, Cohen MS, Lacro RV, Klein GL, Hawkins JA. Partial and transitional atrioventricular septal defect outcomes. Ann Thorac Surg. 2010 Feb; 89(2):530-6. View abstract
  33. Radbill AE, Brown DW, Lacro RV, Cecchin F, Berul CI, Triedman JK, Bevilacqua LM, Walsh EP, Alexander ME. Ascending aortic dilation in patients with congenital complete heart block. Heart Rhythm. 2008 Dec; 5(12):1704-8. View abstract
  34. Khemani E, McElhinney DB, Rhein L, Andrade O, Lacro RV, Thomas KC, Mullen MP. Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics. 2007 Dec; 120(6):1260-9. View abstract
  35. Lacro RV, Dietz HC, Wruck LM, Bradley TJ, Colan SD, Devereux RB, Klein GL, Li JS, Minich LL, Paridon SM, Pearson GD, Printz BF, Pyeritz RE, Radojewski E, Roman MJ, Saul JP, Stylianou MP, Mahony L. Rationale and design of a randomized clinical trial of beta-blocker therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome. Am Heart J. 2007 Oct; 154(4):624-31. View abstract
  36. Larrazabal LA, del Nido PJ, Jenkins KJ, Gauvreau K, Lacro R, Colan SD, Pigula F, Benavidez OJ, Fynn-Thompson F, Mayer JE, Bacha EA. Measurement of technical performance in congenital heart surgery: a pilot study. Ann Thorac Surg. 2007 Jan; 83(1):179-84. View abstract
  37. Anttila V, Piaszczynski M, Mora B, Hagino I, Lacro RV, Zurakowski D, Jonas RA. Improved outcome with composite graft versus homograft root replacement for children with aortic root aneurysms. Eur J Cardiothorac Surg. 2005 Mar; 27(3):420-4. View abstract
  38. Sokol J, Bohn D, Lacro RV, Ryan G, Stephens D, Rabinovitch M, Smallhorn J, Hornberger LK. Fetal pulmonary artery diameters and their association with lung hypoplasia and postnatal outcome in congenital diaphragmatic hernia. Am J Obstet Gynecol. 2002 May; 186(5):1085-90. View abstract
  39. Satou GM, Lacro RV, Chung T, Gauvreau K, Jenkins KJ. Heart size on chest x-ray as a predictor of cardiac enlargement by echocardiography in children. Pediatr Cardiol. 2001 May-Jun; 22(3):218-22. View abstract
  40. Abdullah MM, Lacro RV, Smallhorn J, Chitayat D, van der Velde ME, Yoo SJ, Oman-Ganes L, Hornberger LK. Fetal cardiac dextroposition in the absence of an intrathoracic mass: sign of significant right lung hypoplasia. J Ultrasound Med. 2000 Oct; 19(10):669-76. View abstract
  41. Lin AE, Herring AH, Amstutz KS, Westgate MN, Lacro RV, Al-Jufan M, Ryan L, Holmes LB. Cardiovascular malformations: changes in prevalence and birth status, 1972-1990. Am J Med Genet. 1999 May 21; 84(2):102-10. View abstract
  42. Lin AE, Westgate MN, van der Velde ME, Lacro RV, Holmes LB. Adams-Oliver syndrome associated with cardiovascular malformations. Clin Dysmorphol. 1998 Oct; 7(4):235-41. View abstract
  43. Bird LM, Billman GF, Lacro RV, Spicer RL, Jariwala LK, Hoyme HE, Zamora-Salinas R, Morris C, Viskochil D, Frikke MJ, Jones MC. Sudden death in Williams syndrome: report of ten cases. J Pediatr. 1996 Dec; 129(6):926-31. View abstract
  44. Schwartz ML, Cox GF, Lin AE, Korson MS, Perez-Atayde A, Lacro RV, Lipshultz SE. Clinical approach to genetic cardiomyopathy in children. Circulation. 1996 Oct 15; 94(8):2021-38. View abstract
  45. Pober BR, Lacro RV, Rice C, Mandell V, Teele RL. Renal findings in 40 individuals with Williams syndrome. Am J Med Genet. 1993 May 15; 46(3):271-4. View abstract
  46. Lee YS, Marks AR, Gureckas N, Lacro R, Nadal-Ginard B, Kim DH. Purification, characterization, and molecular cloning of a 60-kDa phosphoprotein in rabbit skeletal sarcoplasmic reticulum which is an isoform of phosphoglucomutase. J Biol Chem. 1992 Oct 15; 267(29):21080-8. View abstract
  47. Takahashi T, Allen PD, Lacro RV, Marks AR, Dennis AR, Schoen FJ, Grossman W, Marsh JD, Izumo S. Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. J Clin Invest. 1992 Sep; 90(3):927-35. View abstract
  48. Jones KL, Lacro RV, Johnson KA, Adams J. Pattern of malformations in the children of women treated with carbamazepine during pregnancy. N Engl J Med. 1989 Jun 22; 320(25):1661-6. View abstract
  49. Lacro RV, Jones KL, Benirschke K. Coarctation of the aorta in Turner syndrome: a pathologic study of fetuses with nuchal cystic hygromas, hydrops fetalis, and female genitalia. Pediatrics. 1988 Mar; 81(3):445-51. View abstract
  50. Villegas-Camargo I, Lacro RV, Lyons-Jones K. [Brachmann-de Lange syndrome: report of 4 cases in Mexican children]. Bol Med Hosp Infant Mex. 1987 Dec; 44(12):766-70. View abstract
  51. Lacro RV, Jones KL. The Gorlin syndrome: a genetically determined disorder associated with cardiac tumor. J Thorac Cardiovasc Surg. 1987 Dec; 94(6):919-20. View abstract
  52. Lacro RV, Jones KL, Benirschke K. The umbilical cord twist: origin, direction, and relevance. Am J Obstet Gynecol. 1987 Oct; 157(4 Pt 1):833-8. View abstract
  53. Mathias RS, Lacro RV, Jones KL. X-linked laterality sequence: situs inversus, complex cardiac defects, splenic defects. Am J Med Genet. 1987 Sep; 28(1):111-6. View abstract
  54. Fujimoto A, Lipson M, Lacro RV, Shinno NW, Boelter WD, Jones KL, Wilson MG. New autosomal dominant branchio-oculo-facial syndrome. Am J Med Genet. 1987 Aug; 27(4):943-51. View abstract
  55. Lacro RV, Jones KL, Mascarello JT, Jones OW, Wilson N, Jones MC. Duplication of distal 15q: report of five new cases from two different translocation kindreds. Am J Med Genet. 1987 Mar; 26(3):719-28. View abstract
  56. McNamara JJ, Lacro RV, Yee M, Smith GT. Hemorrhagic infarction and coronary reperfusion. J Thorac Cardiovasc Surg. 1981 Apr; 81(4):498-501. View abstract