Research Overview

Dr. Labow's research interests focus on the genetics, pathophysiology, and clinical impact of overgrowth disorders, congenital hand anomalies, as well as the impact and causes of adolescent breast disorders.

Dr. Labow is currently conducting a number of clinical research studies on benign breast disorders in adolescents. The broad goal of this project is to measure the impact and treatment outcomes in adolescent patients with breast disorders such as macromastia, gynecomastia, tuberous breast deformity, and breast asymmetry. Dr. Labow will prospectively study long-term functional and psychosocial outcomes following treatment of male and female adolescents affected by benign breast conditions through the administration of validated questionnaires.

In conjunction with the Orthopedic Research Center, Dr. Labow is currently conducting a prospective translational research study exploring the genetic basis of limb overgrowth disorders, specifically macrodactyly. He has uncovered genetic mutations that lead to overgrowth of limbs in humans, mice, and fish. Clinically, he uses microsurgical and reconstructive techniques to address hand, limb, and breast overgrowth conditions in pediatric patients.  He receives referrals nationally and internationally for patients with a variety of rare overgrowth disorders, including macrodactyly. Over the past 4 years, he has established a tissue repository and database of surgical specimens from these patients that will be a critical tool in the exploration of genotype/phenotype correlations.  

With his experience creating databases at Boston Children’s Hospital and leading several studies examining the impact and outcome of surgical therapies, he hopes to extend his scientific career at the translational interface, providing better understanding—and one day, treatments—to patients with limb overgrowth.  

About Brian Labow

Dr. Labow received his BA and MA in Biochemistry at Brandeis University and his MD in 1993 from Harvard Medical School. He completed his post-graduate training with the Harvard Plastic Surgery Training Program, at Mass General Hospital and Brigham and Women’s Hospital. In addition to completing residencies in both general and plastic surgery, he completed a fellowship in Adult Reconstructive and Microsurgery and Pediatric Hand and Microsurgery at Beth Israel Deaconess Medical Center before joining the Department of Plastic and Oral Surgery at Boston Children’s Hospital in 2004.

Key Publications

  • Webb ML, Rosen H, Taghinia A, McCarty ER, Cerrato F, Upton J, Labow BI. Incidence of Fanconi anemia in children with congenital thumb anomalies referred for diepoxybutane testing.   J Hand Surg Am. 2011 Jun;36(6):1052-7.

  • Lau FH, Xia F, Kaplan A, Cerrato F, Greene AK, Taghinia A, Cowan CA, Labow BI. Expression analysis of macrodactyly identifies pleiotrophin upregulation. PLoS One. 2012;7(7):e40423.

  • Cerrato F, Webb ML, Rosen H, Nuzzi L, McCarty ER, DiVasta AD, Greene AK, Labow BI. The impact of macromastia on adolescents: A cross-sectional study. Pediatrics. 2012 Aug;130(2):e339-46.

  • Cerrato F, Eberlin KR, Waters P, Upton J, Taghinia A, Labow BI. Presentation and treatment of macrodactyly in children. J Hand Surg Am. 2013 Nov;38(11):2112-23.

Researcher Services

Researcher Areas

  • Adolescent breast disorders
  • Congenital Hand Anomalies

Research Departments

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Firriolo JM, Nuzzi LC, Schmidtberg LC, Labow BI. Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction: A Single Surgeon Experience of 500 Consecutive Cases. Plast Reconstr Surg. 2018 Aug 07. View abstract
  2. Ganske IM, Firriolo JM, Nuzzi LC, Ganor O, Hamilton TE, Smithers CJ, Jennings RW, Upton J, Labow BI, Taghinia AH. Double Supercharged Jejunal Interposition for Late Salvage of Long-gap Esophageal Atresia. Ann Plast Surg. 2018 Jun 13. View abstract
  3. Theman TA, Upton J, Taghinia AH, Firriolo JM, Nuzzi LC, Labow BI. Central Coalition Osteotomy of Phalangeal Synostoses in the Management of the Type III Apert Hand. J Hand Surg Am. 2018 Jun 08. View abstract
  4. Resnick CM, Genuth J, Calabrese CE, Taghinia A, Labow BI, Padwa BL. Temporomandibular Joint Ankylosis After Ramus Construction With Free Fibula Flaps in Children With Hemifacial Microsomia. J Oral Maxillofac Surg. 2018 Sep; 76(9):2001.e1-2001.e15. View abstract
  5. Beijnen UEA, Noonan Caillouette C, Flath-Sporn SJ, Maclellan RA, Sanchez K, Labow BI, Meara JG, Taghinia AH. Factors Associated With Late Surgical Cancellations in Pediatric Plastic and Oral Surgery. Ann Plast Surg. 2018 Apr; 80(4):412-415. View abstract
  6. Firriolo JM, Ganske IM, Pike CM, Caillouette C, Faulkner HR, Upton J, Labow BI. Long-term Outcomes After Flap Reconstruction in Pediatric Pressure Ulcers. Ann Plast Surg. 2018 Feb; 80(2):159-163. View abstract
  7. Firriolo JM, Ontiveros NC, Pike CM, Taghinia AH, Rogers-Vizena CR, Ganor O, Greene AK, Meara JG, Labow BI. Pediatric Orbital Floor Fractures: Clinical and Radiological Predictors of Tissue Entrapment and the Effect of Operative Timing on Ocular Outcomes. J Craniofac Surg. 2017 Nov; 28(8):1966-1971. View abstract
  8. Nuzzi LC, Firriolo JM, Pike CM, Cerrato FE, Webb ML, Faulkner HR, DiVasta AD, Labow BI. The Effect of Reduction Mammaplasty on Quality of Life in Adolescents With Macromastia. Pediatrics. 2017 Nov; 140(5). View abstract
  9. Daniels KM, Yorlets RR, Flath-Sporn SJ, Labow BI, Heald RR, Taghinia AH. Physician Courtesy and Patient Satisfaction in a Pediatric Plastic and Oral Surgery Department. J Healthc Manag. 2017 May/Jun; 62(3):211-219. View abstract
  10. Pike CM, Firriolo JM, Ontiveros NC, Kuchibhotla SP, Oppel OK, Monoxelos LC, Greene AK, Labow BI. A Nonsurgical Approach to Adolescent Breast Asymmetry Using External Prostheses. J Adolesc Health. 2017 Aug; 61(2):240-245. View abstract
  11. Yorlets RR, Busa K, Eberlin KR, Raisolsadat MA, Bae DS, Waters PM, Labow BI, Taghinia AH. Fingertip Injuries in Children: Epidemiology, Financial Burden, and Implications for Prevention. Hand (N Y). 2017 Jul; 12(4):342-347. View abstract
  12. Jung O, Smeets R, Hanken H, Friedrich RE, Heiland M, Tagniha A, Labow B. A patient with Charlie M Syndrome: Differential diagnosis of Oromandibular Limb Hypogenesis Syndromes. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Jun; 160(2):310-5. View abstract
  13. Theman TA, Labow BI. Is There Bias against Simulation in Microsurgery Training? J Reconstr Microsurg. 2016 Sep; 32(7):540-5. View abstract
  14. Labow BI, Pike CM, Upton J. Overgrowth of the Hand and Upper Extremity and Associated Syndromes. J Hand Surg Am. 2016 Mar; 41(3):473-82; quiz 482. View abstract
  15. Bairdain S, Foker JE, Smithers CJ, Hamilton TE, Labow BI, Baird CW, Taghinia AH, Feins N, Manfredi M, Jennings RW. Jejunal Interposition after Failed Esophageal Atresia Repair. J Am Coll Surg. 2016 06; 222(6):1001-8. View abstract
  16. Inverso G, Flath-Sporn SJ, Monoxelos L, Labow BI, Padwa BL, Resnick CM. What Is the Cost of Meaningful Use? J Oral Maxillofac Surg. 2016 Feb; 74(2):227-9. View abstract
  17. Pike CM, Nuzzi LC, DiVasta AD, Greene AK, Labow BI. Weight Changes After Reduction Mammaplasty in Adolescents. J Adolesc Health. 2015 Sep; 57(3):277-81. View abstract
  18. Nuzzi LC, Cerrato FE, Webb ML, Faulkner HR, Walsh EM, DiVasta AD, Greene AK, Labow BI. Reply: Psychological Impact of Breast Asymmetry on Adolescents: A Prospective Cohort. Plast Reconstr Surg. 2015 Jul; 136(1):109e-110e. View abstract
  19. Cerrato FE, Pruthi S, Boughey JC, Simmons PS, Salje B, Nuzzi LC, Lemaine V, Labow BI. Intermediate and Long-term Outcomes of Giant Fibroadenoma Excision in Adolescent and Young Adult Patients. Breast J. 2015 May-Jun; 21(3):254-9. View abstract
  20. Eberlin KR, Busa K, Bae DS, Waters PM, Labow BI, Taghinia AH. Composite grafting for pediatric fingertip injuries. Hand (N Y). 2015 Mar; 10(1):28-33. View abstract
  21. Nuzzi LC, Greene AK, Meara JG, Taghinia A, Labow BI. Surgical Site Infection After Skin Excisions in Children: Is Field Sterility Sufficient? Pediatr Dermatol. 2016 Mar-Apr; 33(2):136-41. View abstract
  22. Nuzzi LC, Pike CM, Lewine EB, Cerrato FE, Alexander ME, Ferrari LR, Bae DS, Taghinia A, Waters PM, Labow BI. Preoperative electrocardiograms for nonsyndromic children with hand syndactyly. J Hand Surg Am. 2015 Mar; 40(3):452-5. View abstract
  23. Nuzzi LC, Cerrato FE, Webb ML, Faulkner HR, Walsh EM, DiVasta AD, Greene AK, Labow BI. Psychological impact of breast asymmetry on adolescents: a prospective cohort study. Plast Reconstr Surg. 2014 Dec; 134(6):1116-23. View abstract
  24. Theman TA, Labow BI, Taghinia A. Discrepancies between meeting abstracts and subsequent full text publications in hand surgery. J Hand Surg Am. 2014 Aug; 39(8):1585-90.e3. View abstract
  25. Cerrato FE, Nuzzi LC, Theman TA, Taghinia A, Upton J, Labow BI. Upper extremity anomalies in Pfeiffer syndrome and mutational correlations. Plast Reconstr Surg. 2014 May; 133(5):654e-661e. View abstract
  26. Cerrato F, Eberlin KR, Waters P, Upton J, Taghinia A, Labow BI. Presentation and treatment of macrodactyly in children. J Hand Surg Am. 2013 Nov; 38(11):2112-23. View abstract
  27. Benoit MM, Vargas SO, Bhattacharyya N, McGill TA, Robson CD, Ferraro N, Didas AE, Labow BI, Upton J, Taghinia A, Meara JG, Marcus KJ, Mack J, Rodriguez-Galindo C, Rahbar R. The presentation and management of mandibular tumors in the pediatric population. Laryngoscope. 2013 Aug; 123(8):2035-42. View abstract
  28. Nuzzi LC, Cerrato FE, Erickson CR, Erikson CR, Webb ML, Rosen H, Walsh EM, DiVasta AD, Greene AK, Labow BI. Psychosocial impact of adolescent gynecomastia: a prospective case-control study. Plast Reconstr Surg. 2013 Apr; 131(4):890-6. View abstract
  29. Marneros AG, Beck AE, Turner EH, McMillin MJ, Edwards MJ, Field M, de Macena Sobreira NL, Perez AB, Fortes JA, Lampe AK, Giovannucci Uzielli ML, Gordon CT, Plessis G, Le Merrer M, Amiel J, Reichenberger E, Shively KM, Cerrato F, Labow BI, Tabor HK, Smith JD, Shendure J, Nickerson DA, Bamshad MJ. Mutations in KCTD1 cause scalp-ear-nipple syndrome. Am J Hum Genet. 2013 Apr 04; 92(4):621-6. View abstract
  30. Cerrato F, Labow BI. Diagnosis and management of fibroadenomas in the adolescent breast. Semin Plast Surg. 2013 Feb; 27(1):23-5. View abstract
  31. Rogers GF, Maclellan RA, Liu AS, Taghinia AH, Labow BI, Meara JG, Greene AK. Extremity fasciotomy wound closure: comparison of skin grafting to staged linear closure. J Plast Reconstr Aesthet Surg. 2013 Mar; 66(3):e90-1. View abstract
  32. Lau FH, Xia F, Kaplan A, Cerrato F, Greene AK, Taghinia A, Cowan CA, Labow BI. Expression analysis of macrodactyly identifies pleiotrophin upregulation. PLoS One. 2012; 7(7):e40423. View abstract
  33. Cerrato F, Webb ML, Rosen H, Nuzzi L, McCarty ER, DiVasta AD, Greene AK, Labow BI. The impact of macromastia on adolescents: a cross-sectional study. Pediatrics. 2012 Aug; 130(2):e339-46. View abstract
  34. Eberlin KR, Labow BI, Upton J, Taghinia AH. High-impact articles in hand surgery. Hand (N Y). 2012 Jun; 7(2):157-62. View abstract
  35. Webb ML, Cerrato F, Rosen H, DiVasta AD, Greene AK, Labow BI. The effect of obesity on early outcomes in adolescents undergoing reduction mammaplasty. Ann Plast Surg. 2012 Mar; 68(3):257-60. View abstract
  36. Cerrato F, Wallins JS, Webb ML, McCarty ER, Schmidt BA, Labow BI. Outcomes in pediatric atypical spitz tumors treated without sentinel lymph node biopsy. Pediatr Dermatol. 2012 Jul-Aug; 29(4):448-53. View abstract
  37. McCarthy JG, Warren SM, Bernstein J, Burnett W, Cunningham ML, Edmond JC, Figueroa AA, Kapp-Simon KA, Labow BI, Peterson-Falzone SJ, Proctor MR, Rubin MS, Sze RW, Yemen TA. Parameters of care for craniosynostosis. Cleft Palate Craniofac J. 2012 Jan; 49 Suppl:1S-24S. View abstract
  38. Webb ML, Rosen H, Taghinia A, McCarty ER, Cerrato F, Upton J, Labow BI. Incidence of Fanconi anemia in children with congenital thumb anomalies referred for diepoxybutane testing. J Hand Surg Am. 2011 Jun; 36(6):1052-7. View abstract
  39. Rosen H, Webb ML, DiVasta AD, Greene AK, Weldon CB, Kozakewich H, Perez-Atayde AR, Labow BI. Adolescent gynecomastia: not only an obesity issue. Ann Plast Surg. 2010 May; 64(5):688-90. View abstract
  40. Upton J, Guo L, Labow BI. Pediatric free-tissue transfer. Plast Reconstr Surg. 2009 Dec; 124(6 Suppl):e313-26. View abstract
  41. Clune JE, Kozakewich HP, VanBeek CA, Labow BI, Greene AK. Nipple adenoma in infancy. J Pediatr Surg. 2009 Nov; 44(11):2219-22. View abstract
  42. Rosen H, Schmidt B, Lam HP, Meara JG, Labow BI. Management of nevus sebaceous and the risk of Basal cell carcinoma: an 18-year review. Pediatr Dermatol. 2009 Nov-Dec; 26(6):676-81. View abstract
  43. Labow BI, Rosen H, Pap SA, Upton J. Microsurgical reconstruction: a more conservative method of managing large scalp defects? J Reconstr Microsurg. 2009 Nov; 25(8):465-74. View abstract
  44. Glotzbecker MP, Shin EK, Chen NC, Labow BI, Waters PM. Salvage reconstruction of congenital pseudarthrosis of the clavicle with vascularized fibular graft after failed operative treatment: a case report. J Pediatr Orthop. 2009 Jun; 29(4):411-5. View abstract
  45. Greene AK, Karnes J, Padua HM, Schmidt BA, Kasser JR, Labow BI. Diffuse lipofibromatosis of the lower extremity masquerading as a vascular anomaly. Ann Plast Surg. 2009 Jun; 62(6):703-6. View abstract
  46. Upton J, Guo L, Labow BI. Pediatric Microsurgery. Plastic and Reconstructive Surgery (in press). 2008. View abstract
  47. BI Labow, H Rosen, AK Greene, WPA Lee, J Upton . Soft Tissue Sarcomas of the Hand: Functional Reconstruction and Outcome Analysis. HAND. 2008; 3(3):229-36. View abstract
  48. Labow BI, Rosen H, Greene AK, Lee WP, Upton J. Soft tissue sarcomas of the hand: functional reconstruction and outcome analysis. Hand (N Y). 2008 Sep; 3(3):229-36. View abstract
  49. MP Glotzbecker, EK Shin, NC Chen, BI Labow, PM Waters . Salvage Reconstruction of Congenital Pseudarthrosis of the Clavicle With Vascularized Fibular Graft After Failed Operative Treatment. Journal of Bone and Joint Surgery. 2008; (In press). View abstract
  50. AK Greene, J Karnes, HM Padua, BA Schmidt, JR Kasser, BI Labow . Diffuse Lipofibromatosis of the Lower Extremity Masquerading as a Vascular Anomaly . Annals of Plastic Surgery (in press). 2007. View abstract
  51. Liao EC, Labow BI, May JW. Skin banking closure technique in immediate autologous breast reconstruction. Plast Reconstr Surg. 2007 Oct; 120(5):1133-6. View abstract
  52. Labow BI, Greene AK, Upton J. Homocystinuria: an unrecognized cause of microvascular failure. Plast Reconstr Surg. 2007 Jul; 120(1):6e-12e. View abstract
  53. Labow BI, Green AK, Upton J. . Homocystinuria: An Unrecognized Cause of Microvascular Failure. Plastic and Reconstructive Surgery . 2007; 120(1):6e-12e. View abstract
  54. Brian I. Labow. Department of Plastic Surgery Service Guidelines for Rotating Residents and Fellows at Children's Hospital Boston. 2007. View abstract
  55. Rogers GF, Labow BI. Diaphyseal non-union in the distal phalanx of a child. J Hand Surg Eur Vol. 2007 Feb; 32(1):85-7. View abstract
  56. Upton J and Labow BI. Congenital Anomalies of the Upper Extremity. Current Therapy in Plastic Surgery. 2006; 625-639. View abstract
  57. Labow BI, Pap S, Upton J. Microvascular Reconstruction of Large Scalp Defects. Journal of Reconstructive Microsurgery. 2004. View abstract
  58. Labow BI, Souba WW, Abcouwer SF. Mechanisms governing the expression of the enzymes of glutamine metabolism--glutaminase and glutamine synthetase. J Nutr. 2001 09; 131(9 Suppl):2467S-74S; discussion 2486S-7S. View abstract
  59. Labow BI, Souba WW. Glutamine. World J Surg. 2000 Dec; 24(12):1503-13. View abstract
  60. Labow BI, Souba WW, Abcouwer SF. Glutamine synthetase expression in muscle is regulated by transcriptional and posttranscriptional mechanisms. Am J Physiol. 1999 Jun; 276(6 Pt 1):E1136-45. View abstract
  61. Labow BI, Souba, WW. Nurtition. Manual of Clinical Oncology. 1999; 7E. View abstract
  62. Labow BI, Souba WW, Abcouwer SF . Glutamine Synthetase Expression in Muscle is Regulated by Transcriptional and Post-transcriptional Mechanisms. American Journal of Physiology. 1999; 276:E1136-E1145. View abstract
  63. Labow BI, Abcouwer SF, Lin CM, Souba WW. Glutamine synthetase expression in rat lung is regulated by protein stability. Am J Physiol. 1998 Nov; 275(5 Pt 1):L877-86. View abstract
  64. Elgadi KM, Labow BI, Abcouwer SF, Souba WW. Sepsis increases lung glutamine synthetase expression in the tumor-bearing host. J Surg Res. 1998 Jul 15; 78(1):18-22. View abstract
  65. Lukaszewicz G, Abcouwer SF, Labow BI, Souba WW. Glutamine synthetase gene expression in the lungs of endotoxin-treated and adrenalectomized rats. Am J Physiol. 1997 Dec; 273(6 Pt 1):L1182-90. View abstract
  66. Labow BI, Abcouwer SF, Souba WW. Is the Lung an Organ of Nutrition and Metabolism?. Nutrition. 1997; 13(5):492-495. View abstract
  67. Labow BI, Abcouwer SF, Souba WW. Nutritional Modulation of Glutamine Synethase Expression in Stressed Rats. Surgical Forum. 1997. View abstract
  68. Singer S, Corson JM, Gonin R, Labow B, Eberlein TJ. Prognostic factors predictive of survival and local recurrence for extremity soft tissue sarcoma. Ann Surg. 1994 Feb; 219(2):165-73. View abstract
  69. Labow BI, Herschlag D, Jencks WP. Catalysis of the hydrolysis of phosphorylated pyridines by alkaline phosphatase has little or no dependence on the pKa of the leaving group. Biochemistry. 1993 Aug 31; 32(34):8737-41. View abstract
  70. Brian I. Labow. Mechanisms of Catalysis of Phosphoryl-group Transfer Reactions. 1989. View abstract
  71. Keon WJ, Adams GA, Labow BI . Measurement of Thromboembolism: Applications to Patients with A Jarvik Total Artifical Heart. Journal of the Material Research Society. 1989; 110:85-90. View abstract