Research Overview

Dr. Kourembanas’ research program investigates the molecular and cellular basis of lung inflammation, hypoxic signaling, and developmental lung injury. Using various genetically-modified mouse models, her laboratory has been investigating the pathobiology of pulmonary hypertension and the transcriptional and epigenetic mechanisms by which hypoxia induces chemokine gene expression leading to lung inflammation and lung vascular remodeling.  An active area of research in the lab is the study of stem cell-based therapies, and in particular, the biology and application of mesenchymal stem cell exosomes as a novel therapeutic approach to the treatment of lung diseases including pulmonary hypertension and bronchopulmonary dysplasia. As a PI on several previous and current NIH-funded grants including a SCOR program, she has led several collaborative basic and translational studies that have contributed new knowledge to the field of lung biology.  Most notably, her group was among the first to demonstrate that inflammation plays a critical role in the development of pulmonary hypertension, an area that has recently received wide interest and has become a major focus of study by lung biologists investigating mechanisms of disease and therapeutic strategies targeting lung inflammation.  

Dr. Kourembanas has a long track record of mentoring scientists in lung biology for over 20 years, many of whom are successful independent investigators and program leaders in their own right. She also serves as Program Director of a NIH-funded T32 program training physician-scientists in neonatal-perinatal medicine since 2003.  She is an internationally-recognized expert on the biology of hypoxia and the investigation of stem cell therapies for the treatment of developmental and vascular diseases of the lung. She is an elected member to American Society for Clinical Investigation, the Pediatric Academic Societies, and the Society of Perinatal Research. She has given several State-of-the-Art, Keynote lectures, and named lectureships on her research discoveries at National and International Symposia and has served as standing member of NIH study sections on Lung Biology & Pathology (LBPA) and Respiratory Integrative Biology & Translational Research (RIBT), the Hood Foundation, and the Parker B. Francis Fellowship Program.  

About Stella Kourembanas

Dr. Kourembanas was raised in Brooklyn, New York and attended Barnard College.  She received her M.D. from New York University Medical Center and completed her residency in Pediatrics at Massachusetts General Hospital, Boston.  She subsequently completed a Fellowship in Neonatal-Perinatal Medicine in the Joint Program in Neonatology of Harvard Medical School, and was appointed to the Faculty of the same Program.  She rose through the ranks to Professor at Harvard Medical School, and in 2005, she was appointed Chief of Neonatology at Boston Children’s Hospital and Academic Chair of the Harvard Neonatal-Perinatal Medicine Program.

In addition to her teaching and administrative responsibilities, she is a full time clinical attending in the Neonatal Intensive Care Unit providing care to critically-ill infants.  She has also been the recipient of two teaching awards from the Harvard Programs for excellence in clinical teaching and for mentoring the career development of Pediatric Residents (Janeway Award) and Neonatology Fellows (Bernfield Award). In particular, the Charles A. Janeway Teaching Award is considered the most prestigious distinction for teaching at Boston Children’s Hospital.

Researcher Services

Researcher Areas

  • Lung Vascular Biology

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Mitsialis SA, Willis GR, Fernandez-Gonzalez A, Kourembanas S. Reply to Muraca et al.: Exosome Treatment of Bronchopulmonary Dysplasia: How Pure Should Your Exosome Preparation Be? Am J Respir Crit Care Med. 2018 Apr 01; 197(7):970. View abstract
  2. Willis GR, Fernandez-Gonzalez A, Anastas J, Vitali SH, Liu X, Ericsson M, Kwong A, Mitsialis SA, Kourembanas S. Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation. Am J Respir Crit Care Med. 2018 Jan 01; 197(1):104-116. View abstract
  3. Christou H, Hudalla H, Michael Z, Filatava EJ, Li J, Zhu M, Possomato-Vieira JS, Dias-Junior C, Kourembanas S, Khalil RA. Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model. J Pharmacol Exp Ther. 2018 Feb; 364(2):258-274. View abstract
  4. Willis GR, Mitsialis SA, Kourembanas S. "Good things come in small packages": application of exosome-based therapeutics in neonatal lung injury. Pediatr Res. 2018 Jan; 83(1-2):298-307. View abstract
  5. Willis GR, Kourembanas S, Mitsialis SA. Toward Exosome-Based Therapeutics: Isolation, Heterogeneity, and Fit-for-Purpose Potency. Front Cardiovasc Med. 2017; 4:63. View abstract
  6. Thébaud B, Kourembanas S. Can We Cure Bronchopulmonary Dysplasia? J Pediatr. 2017 Dec; 191:12-14. View abstract
  7. Willis GR, Kourembanas S, Mitsialis SA. Therapeutic Applications of Extracellular Vesicles: Perspectives from Newborn Medicine. Methods Mol Biol. 2017; 1660:409-432. View abstract
  8. Mitsialis SA, Kourembanas S. Stem cell-based therapies for the newborn lung and brain: Possibilities and challenges. Semin Perinatol. 2016 Apr; 40(3):138-51. View abstract
  9. Cruz FF, Borg ZD, Goodwin M, Sokocevic D, Wagner DE, Coffey A, Antunes M, Robinson KL, Mitsialis SA, Kourembanas S, Thane K, Hoffman AM, McKenna DH, Rocco PR, Weiss DJ. Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice. Stem Cells Transl Med. 2015 Nov; 4(11):1302-16. View abstract
  10. Vitali SH, Hansmann G, Rose C, Fernandez-Gonzalez A, Scheid A, Mitsialis SA, Kourembanas S. The Sugen 5416/hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up. Pulm Circ. 2014 Dec; 4(4):619-29. View abstract
  11. Kourembanas S. Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu Rev Physiol. 2015; 77:13-27. View abstract
  12. Hale A, Lee C, Annis S, Min PK, Pande R, Creager MA, Julian CG, Moore LG, Mitsialis SA, Hwang SJ, Kourembanas S, Chan SY. An Argonaute 2 switch regulates circulating miR-210 to coordinate hypoxic adaptation across cells. Biochim Biophys Acta. 2014 Nov; 1843(11):2528-42. View abstract
  13. Kourembanas S. Expanding the pool of stem cell therapy for lung growth and repair. Circulation. 2014 May 27; 129(21):2091-3. View abstract
  14. Kourembanas S. Stem cell-based therapy for newborn lung and brain injury: feasible, safe, and the next therapeutic breakthrough? J Pediatr. 2014 May; 164(5):954-6. View abstract
  15. Sdrimas K, Kourembanas S. MSC microvesicles for the treatment of lung disease: a new paradigm for cell-free therapy. Antioxid Redox Signal. 2014 Nov 01; 21(13):1905-15. View abstract
  16. Xiao Y, Christou H, Liu L, Visner G, Mitsialis SA, Kourembanas S, Liu H. Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension. Am J Respir Crit Care Med. 2013 Aug 15; 188(4):482-91. View abstract
  17. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 01; 188(3):370-5. View abstract
  18. Hamvas A, Deterding R, Balch WE, Schwartz DA, Albertine KH, Whitsett JA, Cardoso WV, Kotton DN, Kourembanas S, Hagood JS. Diffuse lung disease in children: summary of a scientific conference. Pediatr Pulmonol. 2014 Apr; 49(4):400-9. View abstract
  19. Lee C, Mitsialis SA, Aslam M, Vitali SH, Vergadi E, Konstantinou G, Sdrimas K, Fernandez-Gonzalez A, Kourembanas S. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation. 2012 Nov 27; 126(22):2601-11. View abstract
  20. Angelidou A, Asadi S, Alysandratos KD, Karagkouni A, Kourembanas S, Theoharides TC. Perinatal stress, brain inflammation and risk of autism-review and proposal. BMC Pediatr. 2012 Jul 02; 12:89. View abstract
  21. Hansmann G, Fernandez-Gonzalez A, Aslam M, Vitali SH, Martin T, Mitsialis SA, Kourembanas S. Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. Pulm Circ. 2012 Apr-Jun; 2(2):170-81. View abstract
  22. Anversa P, Perrella MA, Kourembanas S, Choi AM, Loscalzo J. Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest. 2012 Aug; 42(8):900-13. View abstract
  23. Tropea KA, Leder E, Aslam M, Lau AN, Raiser DM, Lee JH, Balasubramaniam V, Fredenburgh LE, Alex Mitsialis S, Kourembanas S, Kim CF. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L829-37. View abstract
  24. Fernandez-Gonzalez A, Alex Mitsialis S, Liu X, Kourembanas S. Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 15; 302(8):L775-84. View abstract
  25. Christou H, Reslan OM, Mam V, Tanbe AF, Vitali SH, Touma M, Arons E, Mitsialis SA, Kourembanas S, Khalil RA. Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L875-90. View abstract
  26. Vergadi E, Chang MS, Lee C, Liang OD, Liu X, Fernandez-Gonzalez A, Mitsialis SA, Kourembanas S. Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension. Circulation. 2011 May 10; 123(18):1986-95. View abstract
  27. Liang OD, Mitsialis SA, Chang MS, Vergadi E, Lee C, Aslam M, Fernandez-Gonzalez A, Liu X, Baveja R, Kourembanas S. Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension. Stem Cells. 2011 Jan; 29(1):99-107. View abstract
  28. Kourembanas S, Steinhorn R. In-house neonatology: what are we waiting for? Am J Respir Crit Care Med. 2010 Sep 15; 182(6):728-9. View abstract
  29. Aslam M, Baveja R, Liang OD, Fernandez-Gonzalez A, Lee C, Mitsialis SA, Kourembanas S. Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. Am J Respir Crit Care Med. 2009 Dec 01; 180(11):1122-30. View abstract
  30. Vitali SH, Mitsialis SA, Liang OD, Liu X, Fernandez-Gonzalez A, Christou H, Wu X, McGowan FX, Kourembanas S. Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. PLoS One. 2009 Jun 19; 4(6):e5978. View abstract
  31. Fernandez-Gonzalez A, Kourembanas S, Wyatt TA, Mitsialis SA. Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):305-13. View abstract
  32. Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA. Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation. 2008 Apr 22; 117(16):2114-22. View abstract
  33. Fredenburgh L, Liang O, Macias A, Polte T, Riascos D, Chung SW, Schissel S, Ingber D, Mitsialis SA, Kourembanas S, Perella M. Absence of COX-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. J Clin Invest. Submitted. 2007. View abstract
  34. Wu X, Chang, MS, Mitsialis, SA, Kourembanas, S. Hypoxia regulates bone morphogenetic protein signaling in vascular smooth muscle cells through CtBP-1. Circ. Res. 2006; 99:240-247. View abstract
  35. Wu X, Chang MS, Mitsialis SA, Kourembanas S. Hypoxia regulates bone morphogenetic protein signaling through C-terminal-binding protein 1. Circ Res. 2006 Aug 04; 99(3):240-7. View abstract
  36. Fernandez-Gonzalez A, Naghshineh S, Mitsialis SA, Kourembanas S. Heme oxygenase-1 (HO-1) overexpression prevents fibrosis and iron deposition in developmental lung injury. American Thoracic Society International Conference Proceedings. 2006; 3:A254. View abstract
  37. Liang OD, Mitsialis SA, Kourembanas S. . Bone marrow derived mesenchymal stem cells expressing human heme oxygenase-1 (HO-1) reverse hypoxic pulmonary hypertension in HO-1 null mice. American Thoracic Society International Conference Proceedings. 2006; 3:A25. View abstract
  38. Fredenburgh LE, Liang OD, Macias AA, Mitsialis SA, Kourembanas S , Perrella MA. Exacerbation of hypoxia-induced pulmonary hypertension and vascular remodeling in COX-2 deficient mice. American Thoracic Society International Conference Proceedings. 2006; 3:A278. View abstract
  39. Vitali SH, Mitsialis SA, Christou H, Fernandez-Gonzalez A, Liu X, Kourembanas S. Mechanisms of heme oxygenase-1-mediated cardiac and pulmonary vascular protection in chronic hypoxia: roles of carbon monoxide and bilirubin. Chest. 2005 Dec; 128(6 Suppl):578S-579S. View abstract
  40. Danhaive O, Margossian R, Geva T, Kourembanas S. Pulmonary hypertension and right ventricular dysfunction in growth-restricted, extremely low birth weight neonates. J Perinatol. 2005 Jul; 25(7):495-9. View abstract
  41. Christou H, Bailey N, Kluger MS, Mitsialis SA, Kourembanas S. Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2647-52. View abstract
  42. Vitali S, Mitsialis SA, Christou H, Kluger M, Liu X, Kourembanas S. . HO-1 mediated cardiac protection in chronic hypoxia: Role of carbon monoxide and bilirubin. 4th International HO Conference, Boston, MA. 2005. View abstract
  43. Liang O, Mitsialis SA, Kourembanas S. . Bone-marrow derived mesenchymal stem cells expressing human HO-1 reverse hypoxic pulmonary hypertension in HO-1 null mice. 4th International HO Conference, Boston, MA. 2005. View abstract
  44. Fernandez-Gonzalez A, Naghshineh S, Mitsialis SA, Kourembanas S. . Heme Oxygenase-1 overexpression decreases alveolar remodeling and iron deposition in developmental lung injury. 4th International CO Conference, Boston, MA. 2005. View abstract
  45. Zampetaki A, Mitsialis SA, Pfeilschifter J, Kourembanas S. Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/ p44 and PI3 kinase pathways. FASEB J. 2004 Jul; 18(10):1090-2. View abstract
  46. Wu X, Kourembanas S . Hypoxia suppresses bone morphogenetic protein mediated Id1 gene activation n human pulmonary artery smooth muscle cells. Am. J. Respir. Crit. Care Med. 2004; A510. View abstract
  47. Vitali S, Mitsialis SA, Christou H, Kourembanas S . Mechanisms of HO-1 cytoprotection in hypoxic pulmonary hypertension. Pediatric Research. 2004; 55(4):A2683. View abstract
  48. Kourembanas S. Shock. Manual of Neonatal Care(Cloherty JP, Eichenwald E, Stark AR, eds.). 2004; 181-185. View abstract
  49. Zampetaki A, Minamino T, Mitsialis SA, Kourembanas S. Effect of heme oxygenase-1 overexpression in two models of lung inflammation. Exp Biol Med (Maywood). 2003 May; 228(5):442-6. View abstract
  50. Christou H, Mitsialis SA, Kourembanas S. Regulation of heme oxygenase-1 (HO-1) gene expression in vascular smooth muscle cells by extracellular acidosis. Pediatric Research. 2003; 53(4):A3220. View abstract
  51. Kourembanas S. Hypoxia and carbon monoxide in the vasculature. Antioxid Redox Signal. 2002 Apr; 4(2):291-9. View abstract
  52. Kourembanas S, Minamino T, Christou H, Hsieh C-M, Liu Y, Dhawan V, Atwater L, Abraham NG, Perrella MA, Mitsialis SA. Targeted expression of heme oxygenase-1 and pulmonary responses to hypoxia. Heme Oxygenase in Biology and Medicine. 2002; 193-204. View abstract
  53. Brodsky D, Christou H, Bernfield M, Kourembanas S. Response of the developing lung to injury (Haddad GG, Abman S, Chernik V, eds.). Basic Mechanisms of Pediatric Respiratory Disease. 2002; 102-123. View abstract
  54. Zampetaki A, Mitsialis SA, Pfeilschifter J, Kourembanas, S. Regulation of macrophage inflammatory protein-2 (MIP-2) gene expression by hypoxia. Am. J. Respir. Crit. Care Med. 2002; 165(8):A546. View abstract
  55. Minamino T, Kourembanas S. Mechanisms of telomerase induction during vascular smooth muscle cell proliferation. Circ Res. 2001 Aug 03; 89(3):237-43. View abstract
  56. Minamino T, Christou H, Hsieh CM, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA, Kourembanas S. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8798-803. View abstract
  57. Ellington M, O'Reilly D, Allred EN, McCormick MC, Wessel DL, Kourembanas S. Child health status, neurodevelopmental outcome, and parental satisfaction in a randomized, controlled trial of nitric oxide for persistent pulmonary hypertension of the newborn. Pediatrics. 2001 Jun; 107(6):1351-6. View abstract
  58. Minamino T, Mitsialis SA, Kourembanas S. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol. 2001 May; 21(10):3336-42. View abstract
  59. Christou H, Van Marter LJ, Wessel DL, Allred EN, Kane JW, Thompson JE, Stark AR, Kourembanas S. Inhaled nitric oxide reduces the need for extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the newborn. Crit Care Med. 2000 Nov; 28(11):3722-7. View abstract
  60. Christou H, Morita T, Hsieh CM, Koike H, Arkonac B, Perrella MA, Kourembanas S. Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res. 2000 Jun 23; 86(12):1224-9. View abstract
  61. Christou H, Minamino T, Hsieh C-M, Liu Y, Lynch L, Mitsialis SA, Perrella MA, Kourembanas S. Transgenic mice overexpressing heme oxygenase-1 (HO-1) in the lung are protected from development of hypoxia-induced pulmonary hypertension: Evidence of antiinflammatory effects of HO-1. Pediatric Research. 2000; 47(4):A385. View abstract
  62. Kourembanas S, Minamino T, Christou H, Hsieh C-M, Liu Y, Dhawan V, Lynch L, Abraham NG, Perrella MA, Mitsialis SA. Heme oxygenase and pulmonary responses to hypoxia. Acta Haematologica. 2000; 103(1):A247. View abstract
  63. Brodsky S, Mitsialis SA, Minamino T, Kourembanas S. Herbimycin A and geldanamycin inhibit the hypoxic induction of the vascular endothelial growth factor (VEGF) gene in pulmonary artery endothelial cells. Pediatric Research. 2000; 47(4):A380. View abstract
  64. Christou H, Minamino T, Mitsialis SA, Kourembanas S. Extracellular acidosis induces heme oxygenase-1 (HO-1) gene expression in vascular smooth muscle cells. Pediatric Research. 2000; 47(4):A386. View abstract
  65. Yet S-F, Perrella MA, Christou H, Tian R, Ingwall J, Kourembanas S, Lee M-E. The role of heme oxygenase-1 in the regulation of cardiomyocyte death during ischemia/reperfusion. Acta Haematologica. 2000; 103(1):A276. View abstract
  66. Maemura K, Hsieh CM, Jain MK, Fukumoto S, Layne MD, Liu Y, Kourembanas S, Yet SF, Perrella MA, Lee ME. Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain. J Biol Chem. 1999 Oct 29; 274(44):31565-70. View abstract
  67. Yet SF, Perrella MA, Layne MD, Hsieh CM, Maemura K, Kobzik L, Wiesel P, Christou H, Kourembanas S, Lee ME. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999 Apr; 103(8):R23-9. View abstract
  68. Maemura K, Mukesh JK, Hsieh C-M, Fukumoto S, Kourembanas S, Yet S-F, Perrella MA, Lee M-E. Functional analysis of endothelial PAS domain Protein 1: Generation of a dominant negative mutant by deleting C-terminal potent transactivation domain. Circulation. 1999; 100(18):A193. View abstract
  69. Christou H, Magnani B, Morse DS, Allred EN, Van Marter LJ, Wessel DL, Kourembanas S. Inhaled nitric oxide does not affect adenosine 5'-diphosphate-dependent platelet activation in infants with persistent pulmonary hypertension of the newborn. Pediatrics. 1998 Dec; 102(6):1390-3. View abstract
  70. Kourembanas S, Morita T, Christou H, Liu Y, Koike H, Brodsky D, Arthur V, Mitsial SA. Hypoxic responses of vascular cells. Chest. 1998 Jul; 114(1 Suppl):25S-28S. View abstract
  71. Liu Y, Christou H, Morita T, Laughner E, Semenza GL, Kourembanas S. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer. J Biol Chem. 1998 Jun 12; 273(24):15257-62. View abstract
  72. Christou H, Yoshida A, Arthur V, Morita T, Kourembanas S. Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension. Am J Respir Cell Mol Biol. 1998 Jun; 18(6):768-76. View abstract
  73. Christou H, Van Marter LJ, Wessel DL, Allred EN, Kane JW, Thompson JE, Stark AR, Kourembanas S. Combination of inhaled nitric oxide with high frequency ventilation reduces the need for extracorporeal membrane oxygenation in infants with persistant pulmonary hypertension of the newborn: Results from a single center trial. Pediatric Research. 1998; 43(4):169A. View abstract
  74. Kourembanas S. Shock. Manual of Neonatal Care (Cloherty JP and Stark AR, eds.). 1998; 171-173. View abstract
  75. Maemura K, Jain MK, Decarie LA, Liu Y, Kourembanas S, Milstone DS, Lee S-L, Perrella MA, Yet S-F, Lee M-E. Activation of KDR/flk-1 promoter by endothelial PAS domain protein-1: Potential role of endothelial PAS domain protein-1 in endothelial cell differentiation. Circulation. 1998. View abstract
  76. Maemura K, Fukumoto S, Jain MK, Kourembanas S, Perrella MA, Yet S-F, Lee M-E. Characterization of functional domains of endothelial PAS domain protein-1 and generation of a dominant negative mutant. Circulation. 1998. View abstract
  77. Morita T, Mitsialis SA, Koike H, Liu Y, Kourembanas S. Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells. J Biol Chem. 1997 Dec 26; 272(52):32804-9. View abstract
  78. Wessel DL, Adatia I, Van Marter LJ, Thompson JE, Kane JW, Stark AR, Kourembanas S. Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent pulmonary hypertension of the newborn. Pediatrics. 1997 Nov; 100(5):E7. View abstract
  79. Hammerman SI, Kourembanas S, Conca TJ, Tucci M, Brauer M, Farber HW. Endothelin-1 production during the acute chest syndrome in sickle cell disease. Am J Respir Crit Care Med. 1997 Jul; 156(1):280-5. View abstract
  80. Christou H, Adatia I, Van Marter LJ, Kane JW, Thompson JE, Stark AR, Wessel DL, Kourembanas S. Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5'-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension. J Pediatr. 1997 Apr; 130(4):603-11. View abstract
  81. Kourembanas S, Morita T, Liu Y, Christou H. Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature. Kidney Int. 1997 Feb; 51(2):438-43. View abstract
  82. Christou H, Morita T, Koike H, Hsieh, CM, Perrella M, Kourembanas S. Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Pediatric Research. 1997; 41:A238. View abstract
  83. Morita T, Kourembanas S, Togashi A, Negishi K, Katayama S. Endogenous carbon monoxide regulates tube formation by human microvascular endothelial cells under high glucose. Circulation. 1997; 96(8):A4067. View abstract
  84. Christou H, Magnani B, Morse D, Allred E, Van Marter L, Wessel D, Kourembanas S. Inhaled nitric oxide does not inhibit platelet activation in infants with persistent pulmonary hypertension of the newborn (PPHN). Pediatric Research. 1997; 41:A844. View abstract
  85. Wessel D, Adatia I, Thompson J, Kane J, Van Marter L, Stark A, Kourembanas S. Improved oxygenation in a randomized trial of inhaled nitric oxide for PPHN. Pediatric Research. 1996; 39(4):A1498. View abstract
  86. Kourembanas S. Regulation of Carbon Monoxide Producation and Vascular Responses. Ketsuatsu - Japanese Journal of Blood Pressure. 1996; 3(2):260-268. View abstract
  87. Morita T, Kourembanas S. Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J Clin Invest. 1995 Dec; 96(6):2676-82. View abstract
  88. Kostyk SK, Kourembanas S, Wheeler EL, Medeiros D, McQuillan LP, D'Amore PA, Braunhut SJ. Basic fibroblast growth factor increases nitric oxide synthase production in bovine endothelial cells. Am J Physiol. 1995 Nov; 269(5 Pt 2):H1583-9. View abstract
  89. Liu Y, Cox SR, Morita T, Kourembanas S. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer. Circ Res. 1995 Sep; 77(3):638-43. View abstract
  90. Morita T, Perrella MA, Lee ME, Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1475-9. View abstract
  91. Itoh A, Levinson SF, Morita T, Kourembanas S, Brody JS, Mitsialis SA. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. Cell Mol Biol Res. 1995; 41(3):147-54. View abstract
  92. Christou H, Yoshida H, Morita T, Kourembanas S. Increased epithelial cell expression of vascular endothelial growth factor (VEGF) in the lungs of animals with hypoxia-induced pulmonary hypertension. Am. J. Resp. Crit. Care Med. 1995; 151(4):A732. View abstract
  93. Kourembanas S, Stark AR. Inhaled NO for PPHN: Basic Biology to Clinical Application (Fanaroff AA and Klaus MH, eds.). 1995 Year Book of Neonatal and Perinatal Medicine. 1995; xvii-xxxvi. View abstract
  94. Liu Y, Cox S, Kourembanas S. Hypoxia upregulates the transcription of human vascular endothelial growth factor gene via a 28-bp enhancer. FASEB J. 1995; 9(3):A611. View abstract
  95. Morita T, Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of endothelial cell gene expression and cGMP content. Circulation. 1995; 92(8):110. View abstract
  96. Kourembanas S. Persistent pulmonary hypertension of the newborn: Role of nitric oxide. J. Int. Care Medicine. 1995; 10:270-282. View abstract
  97. Morita T, Perrella MA, Lee M-E, Kourembanas S. Hypoxia increases cGMP levels in rat vascular smooth muscle cells via inducation of heme oxygenase-1. 67th Scientific Sessions of the American Heart Assocation, Dallas, TX. 1994. View abstract
  98. McQuillan LP, Leung GK, Marsden PA, Kostyk SK, Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am J Physiol. 1994 Nov; 267(5 Pt 2):H1921-7. View abstract
  99. Kourembanas S, Bernfield M. Hypoxia and endothelial-smooth muscle cell interactions in the lung. Am J Respir Cell Mol Biol. 1994 Oct; 11(4):373-4. View abstract
  100. Perrella MA, Yoshizumi M, Fen Z, Tsai JC, Hsieh CM, Kourembanas S, Lee ME. Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells. J Biol Chem. 1994 May 20; 269(20):14595-600. View abstract
  101. Kourembanas S, McQuillan L, Christou H, Adatia I, Van Marter L, Kane J, Thompson J, Fackler J, Wessel D, Stark A. Inhaled nitric oxide (NO) alters endogenous endothelin-1 (ET-1) and cGMP levels in newborns with persistent pulmonary hypertension (PPHN). Pediatric Research. 1994; 35(4):234A. View abstract
  102. Kourembanas S, McQuillan LP, Leung GK, Faller DV. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest. 1993 Jul; 92(1):99-104. View abstract
  103. Kourembanas S, Leung GK, McQuillan LP. Hypoxia inhibits nitric oxide synthase (NOS) gene expression and nitric oxide (NO) production in endothelial cells. Pediatric Research. 1993; 33:51A. View abstract
  104. Yoshizumi M, Kourembanas S, Temizer DH, Cambria RP, Quertermous T, Lee ME. Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells. J Biol Chem. 1992 May 15; 267(14):9467-9. View abstract
  105. Kourembanas S. Hypoxic responses of the neonatal endothelium. Semin Perinatol. 1992 Apr; 16(2):140-6. View abstract
  106. Kourembanas S, Marsden P, Faller DV. Feedback loops regulated the production of vasoactive agents by human endothelial cells. Pediatric Research. 1992; 31:46A. View abstract
  107. Kourembanas S, Marsden PA, McQuillan LP, Faller DV. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest. 1991 Sep; 88(3):1054-7. View abstract
  108. Kourembanas S, Marsden P, McQuillan LP, Faller DV. Molecular mechanisms contrbuting to hypoxic vasoconstriction. Pediatric Research. 1991; 29:255A. View abstract
  109. Kourembanas S. Shock. Manual of Neonatal Care (Cloherty JP and Stark AR, eds.). 1991; 68-71. View abstract
  110. Kourembanas S, Hannan RL, Faller DV. Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. J Clin Invest. 1990 Aug; 86(2):670-4. View abstract
  111. Torday JS, Kourembanas S. Fetal rat lung fibroblasts produce a TGF beta homolog that blocks alveolar type II cell maturation. Dev Biol. 1990 May; 139(1):35-41. View abstract
  112. Kourembanas S, Marsden P, Faller DV. Molecular mechanisms contributing to vaso-occlusion in sickle cell disease. Blood. 1990; 76:10S1. View abstract
  113. Kourembanas S, Faller DV. Platelet-derived growth factor production by human umbilical vein endothelial cells is regulated by basic fibroblast growth factor. J Biol Chem. 1989 Mar 15; 264(8):4456-9. View abstract
  114. Kourembanas S, Hannan RL, Faller DV. Hypoxia stimulates platelet-derived growth factor (PDGF) production by human umbilical vein endothelial cells (HUVEC). Pediatric Research. 1989; 25:54A. View abstract
  115. Faller DV, Kourembanas S, Ginsberg D, Hannan R, Collins T, Ewenstein BM, Pober JS, Tantravahi R. Immortalization of human endothelial cells by murine sarcoma viruses, without morphologic transformation. J Cell Physiol. 1988 Jan; 134(1):47-56. View abstract
  116. Hannan RL, Kourembanas S, Flanders KC, Rogelj SJ, Roberts AB, Faller DV, Klagsbrun M. Endothelial cells synthesize basic fibroblast growth factor and transforming growth factor beta. Growth Factors. 1988; 1(1):7-17. View abstract
  117. Kourembanas S, Faller DV. Regulation of platelet-derived growth factor (PDGF) gene expression by basic fibroblast growth factor (bFGF) in human umbilical vein endothelial cells. Pediatric Research. 1988; 23:245A. View abstract
  118. Phelps DS, Church S, Kourembanas S, Taeusch HW, Floros J . Increases in the 35kDa surfactant-associated protein and its mRNA following in vivo dexamethasone treatment of fetal and neonatal rats. Electrophoresis. 1987; 8:235-238. View abstract
  119. Floros J, Phelps DS, Kourembanas S, Taeusch HW. Primary translation products, biosynthesis, and tissue specificity of the major surfactant protein in rat. J Biol Chem. 1986 Jan 15; 261(2):828-31. View abstract
  120. Kourembanas S, Floros J, Phelps DS, Taeusch HW. Developmental profile of surgactant associated protein (Apoprotein A) in the rat lung. Eleventh Annual New England Conference on Perinatal Resesarch. 1985. View abstract