Research Overview

Kosuke Kawai received his doctorate degree from the Harvard School of Public Health. As a senior biostatistician and epidemiologist in the Department of Otolaryngology at Boston Children’s Hospital, he actively collaborates with clinical faculty members and research staff. He is interested in innovative application of advanced statistical methods. Exemplary in this respect is his employment of a three-level hierarchical mixed-effects model to account for the correlation between ears in a longitudinal study of children with cochlear implants. He also conducts research on herpes zoster epidemiology to identify risk factors and appropriate strategies for prevention. We demonstrated that the incidence of herpes zoster has increased by more than 4-fold from 1945 to 2007.

MEDICAL SERVICES

Languages

  • English

PUBLICATIONS

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  1. Irace AL, Dombrowski ND, Kawai K, Watters K, Choi S, Perez J, Dodrill P, Hernandez K, Davidson K, Rahbar R. Evaluation of Aspiration in Infants With Laryngomalacia and Recurrent Respiratory and Feeding Difficulties. JAMA Otolaryngol Head Neck Surg. 2018 Dec 27. View abstract
  2. Hseu A, Ayele N, Dombrowski N, Irace A, Kawai K, Woodnorth G, Watters K, Nuss R, Rahbar R. Prevalence of voice disturbances in pediatric airway patients: Are we missing anything? Int J Pediatr Otorhinolaryngol. 2019 Mar; 118:59-61. View abstract
  3. Kawai K, Yawn BP. Risk of Herpes Zoster in Cancer Patients and the Promise of New Vaccines. J Infect Dis. 2018 Dec 13. View abstract
  4. McKeon M, Kirsh E, Kawai K, Roberson D, Watters K. Risk Factors for Multiple Hemorrhages Following Tonsil Surgery in Children. Laryngoscope. 2018 Dec 08. View abstract
  5. Wolter NE, Ayele N, Kawai K, Hseu A, Nuss R. Medialization Laryngoplasty in Pediatric Patients With Unilateral Vocal Fold Immobility: A Case Series. Ann Otol Rhinol Laryngol. 2019 Feb; 128(2):145-151. View abstract
  6. Irace AL, Dombrowski ND, Kawai K, Dodrill P, Perez J, Hernandez K, Davidson K, Hseu A, Nuss R, Rahbar R. Aspiration in children with unilateral vocal fold paralysis. Laryngoscope. 2018 Nov 08. View abstract
  7. Ward BK, Chao WC, Abiola G, Kawai K, Ashry Y, Rasooly T, Poe DS. Twelve-month outcomes of Eustachian tube procedures for management of patulous Eustachian tube dysfunction. Laryngoscope. 2019 Jan; 129(1):222-228. View abstract
  8. Hseu A, Ayele N, Kawai K, Frazier AL, Mack J, Watters K, Nuss R, Rahbar R. Pediatric vincristine-related vocal fold paralysis. Int J Pediatr Otorhinolaryngol. 2018 11; 114:166-169. View abstract
  9. Nelson RW, O'Connell AE, Alroqi F, Kawai K, Young MC, Broyles AD. Duplicate skin prick testing in the assessment of food allergy. J Allergy Clin Immunol Pract. 2019 Feb; 7(2):675-677. View abstract
  10. Heffernan CB, McKeon MG, Molony S, Kawai K, Stiles DJ, Lachenauer CS, Kenna MA, Watters K. Does Clarithromycin Cause Hearing Loss? A 12-Year Review of Clarithromycin Therapy for Nontuberculous Mycobacterial Lymphadenitis in Children. Ann Otol Rhinol Laryngol. 2018 Oct; 127(10):687-693. View abstract
  11. Hseu A, Ayele N, Kawai K, Woodnorth G, Nuss R. Voice Abnormalities and Laryngeal Pathology in Preterm Children. Ann Otol Rhinol Laryngol. 2018 Aug; 127(8):508-513. View abstract
  12. Kawai K, Adil EA, Barrett D, Manganella J, Kenna MA. Ambulatory Visits for Otitis Media before and after the Introduction of Pneumococcal Conjugate Vaccination. J Pediatr. 2018 Oct; 201:122-127.e1. View abstract
  13. Kawai K, Yawn BP. In Reply-Human Immunodeficiency Virus and Herpes Zoster: Could the Link Be Ignored? Mayo Clin Proc. 2018 Jun; 93(6):808. View abstract
  14. Manganella JL, Stiles DJ, Kawai K, Barrett DL, O'Brien LB, Kenna MA. Validation of a portable hearing assessment tool: Agilis Health Mobile Audiogram. Int J Pediatr Otorhinolaryngol. 2018 Oct; 113:94-98. View abstract
  15. Irace AL, Shank C, Adil EA, Cunningham MJ, Kawai K, Sideridis G, Rahbar R. Changes in Scope of Procedures Performed by Pediatric Otolaryngologists in the Past Decade. JAMA Otolaryngol Head Neck Surg. 2018 Apr 01; 144(4):322-329. View abstract
  16. Kenna MA, Irace AL, Strychowsky JE, Kawai K, Barrett D, Manganella J, Cunningham MJ. Otolaryngologic Manifestations of Klippel-Feil Syndrome in Children. JAMA Otolaryngol Head Neck Surg. 2018 Mar 01; 144(3):238-243. View abstract
  17. Irace AL, Walker RD, Kawai K, Maddock M, Dombrowski ND, Sideridis G, Ferrari L, Rahbar R. Development and validation of a quality of life instrument for patients with laryngeal cleft. Int J Pediatr Otorhinolaryngol. 2018 May; 108:143-150. View abstract
  18. Londahl M, Irace AL, Kawai K, Dombrowski ND, Jennings R, Rahbar R. Prevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia. JAMA Otolaryngol Head Neck Surg. 2018 Feb 01; 144(2):164-168. View abstract
  19. Bostic K, Lewis RM, Chai B, Manganella JL, Barrett DL, Kawai K, Kenna MA, Stiles DJ, Clark T. Enlarged Vestibular Aqueduct and Cochlear Implants: The Effect of Early Counseling on the Length of Time Between Candidacy and Implantation. Otol Neurotol. 2018 Feb; 39(2):e90-e95. View abstract
  20. Kawai K, Hawkins CA, Hertzmark E, Francis JM, Sando D, Muya AN, Ulenga N, Fawzi WW. Impact of Antiretroviral Therapy on the Risk of Herpes Zoster among Human Immunodeficiency Virus-Infected Individuals in Tanzania. Am J Trop Med Hyg. 2018 02; 98(2):396-401. View abstract
  21. Velayutham P, Irace AL, Kawai K, Dodrill P, Perez J, Londahl M, Mundy L, Dombrowski ND, Rahbar R. Silent aspiration: Who is at risk? Laryngoscope. 2018 08; 128(8):1952-1957. View abstract
  22. Kawai K, Yawn BP. Risk Factors for Herpes Zoster: A Systematic Review and Meta-analysis. Mayo Clin Proc. 2017 Dec; 92(12):1806-1821. View abstract
  23. Ashry Y, Kawai K, Poe D. Utility of Adjunctive Procedures With Balloon Dilation of the Eustachian Tube. Laryngoscope Investig Otolaryngol. 2017 12; 2(6):337-343. View abstract
  24. Kawai K, Kawai AT, Wollan P, Yawn BP. Adverse impacts of chronic pain on health-related quality of life, work productivity, depression and anxiety in a community-based study. Fam Pract. 2017 11 16; 34(6):656-661. View abstract
  25. Sobin L, Kawai K, Irace AL, Gergin O, Cunningham M, Sawicki GS, Adil EA. Microbiology of the Upper and Lower Airways in Pediatric Cystic Fibrosis Patients. Otolaryngol Head Neck Surg. 2017 08; 157(2):302-308. View abstract
  26. Gergin O, Adil E, Kawai K, Watters K, Moritz E, Rahbar R. Routine airway surveillance in pediatric tracheostomy patients. Int J Pediatr Otorhinolaryngol. 2017 Jun; 97:1-4. View abstract
  27. Yuen S, Kawai K, Roberson DW, Murray R. Do post-tonsillectomy patients who report bleeding require observation if no bleeding is present on exam? Int J Pediatr Otorhinolaryngol. 2017 Apr; 95:75-79. View abstract
  28. Rampakakis E, Stutz M, Kawai K, Tsai TF, Cheong HJ, Dhitavat J, Ortiz-Covarrubias A, Cashat-Cruz M, Monsanto H, Johnson KD, Sampalis JS, Acosta CJ. Association between work time loss and quality of life in patients with Herpes Zoster: a pooled analysis of the MASTER studies. Health Qual Life Outcomes. 2017 Jan 18; 15(1):11. View abstract
  29. Chang DT, Irace AL, Kawai K, Rogers-Vizena CR, Nuss R, Adil EA. Nasal septal perforation in children: Presentation, etiology, and management. Int J Pediatr Otorhinolaryngol. 2017 Jan; 92:176-180. View abstract
  30. Yuen SN, Leung PP, Funamura J, Kawai K, Roberson DW, Adil EA. Complications of turbinate reduction surgery in combination with tonsillectomy in pediatric patients. Laryngoscope. 2017 08; 127(8):1920-1923. View abstract
  31. Funamura JL, Yuen S, Kawai K, Gergin O, Adil E, Rahbar R, Watters K. Characterizing mortality in pediatric tracheostomy patients. Laryngoscope. 2017 07; 127(7):1701-1706. View abstract
  32. Hseu A, Sandler M, Ericson D, Ayele N, Kawai K, Nuss R. Paradoxical vocal fold motion in children presenting with exercise induced dyspnea. Int J Pediatr Otorhinolaryngol. 2016 Nov; 90:165-169. View abstract
  33. Adil EA, Kawai K, Dombrowski N, Irace AL, Cunningham MJ. Nasal versus tracheobronchial biopsies to diagnose primary ciliary dyskinesia: A meta-analysis. Laryngoscope. 2017 01; 127(1):6-13. View abstract
  34. Gergin O, Adil EA, Kawai K, Watters K, Moritz E, Rahbar R. Indications of pediatric tracheostomy over the last 30 years: Has anything changed? Int J Pediatr Otorhinolaryngol. 2016 Aug; 87:144-7. View abstract
  35. Johnson BH, Palmer L, Gatwood J, Lenhart G, Kawai K, Acosta CJ. Healthcare resource utilization and costs associated with herpes zoster in the US. J Med Econ. 2016 Oct; 19(10):928-35. View abstract
  36. Kawai K, Yawn BP, Wollan P, Harpaz R. Increasing Incidence of Herpes Zoster Over a 60-year Period From a Population-based Study. Clin Infect Dis. 2016 07 15; 63(2):221-6. View abstract
  37. Adil E, Gergin O, Kawai K, Rahbar R, Watters K. Usefulness of Upper Airway Endoscopy in the Evaluation of Pediatric Pulmonary Aspiration. JAMA Otolaryngol Head Neck Surg. 2016 Apr; 142(4):339-43. View abstract
  38. Gergin O, Kawai K, MacDougall RD, Robson CD, Moritz E, Cunningham M, Adil E. Sinus Computed Tomography Imaging in Pediatric Cystic Fibrosis: Added Value? Otolaryngol Head Neck Surg. 2016 07; 155(1):160-5. View abstract
  39. McLaughlin EJ, Cunningham MJ, Kazahaya K, Hsing J, Kawai K, Adil EA. Endoscopic Radiofrequency Ablation-Assisted Resection of Juvenile Nasopharyngeal Angiofibroma: Comparison with Traditional Endoscopic Technique. Otolaryngol Head Neck Surg. 2016 06; 154(6):1145-8. View abstract
  40. Johnson BH, Palmer L, Gatwood J, Lenhart G, Kawai K, Acosta CJ. Annual incidence rates of herpes zoster among an immunocompetent population in the United States. BMC Infect Dis. 2015 Nov 06; 15:502. View abstract
  41. Adil E, Al Shemari H, Kacprowicz A, Perez J, Larson K, Hernandez K, Kawai K, Cowenhoven J, Urion D, Rahbar R. Evaluation and Management of Chronic Aspiration in Children With Normal Upper Airway Anatomy. JAMA Otolaryngol Head Neck Surg. 2015 Nov; 141(11):1006-11. View abstract
  42. Brodsky JR, Cusick BA, Kawai K, Kenna M, Zhou G. Peripheral vestibular loss detected in pediatric patients using a smartphone-based test of the subjective visual vertical. Int J Pediatr Otorhinolaryngol. 2015 Dec; 79(12):2094-8. View abstract
  43. Strychowsky JE, Kawai K, Moritz E, Rahbar R, Adil EA. To stent or not to stent? A meta-analysis of endonasal congenital bilateral choanal atresia repair. Laryngoscope. 2016 Jan; 126(1):218-27. View abstract
  44. Kawai K, Rampakakis E, Tsai TF, Cheong HJ, Dhitavat J, Covarrubias AO, Yang L, Cashat-Cruz M, Monsanto H, Johnson K, Sampalis JS, Acosta CJ. Predictors of postherpetic neuralgia in patients with herpes zoster: a pooled analysis of prospective cohort studies from North and Latin America and Asia. Int J Infect Dis. 2015 May; 34:126-31. View abstract
  45. Chen Q, Hsu T, Chan R, Kawai K, Acosta CJ, Walia A, Pan JY. Clinical and economic burden of herpes zoster and postherpetic neuralgia in patients from the National Skin Centre, Singapore. Dermatologica Sinica. 2015; 4(33):201-205. View abstract
  46. Tsai TF, Yao CA, Yu HS, Lan CC, Chao SC, Yang JH, Yang KC, Chen CY, White RR, Psaradellis E, Rampakakis E, Kawai K, Acosta CJ, Sampalis JS. Herpes zoster-associated severity and duration of pain, health-related quality of life, and healthcare utilization in Taiwan: a prospective observational study. Int J Dermatol. 2015; 54(5):529-36. View abstract
  47. Kawai K, Gebremeskel BG, Acosta CJ. Systematic review of incidence and complications of herpes zoster: towards a global perspective. BMJ Open. 2014 Jun 10; 4(6):e004833. View abstract
  48. Kawai K, Preaud E, Baron-Papillon F, Largeron N, Acosta CJ. Cost-effectiveness of vaccination against herpes zoster and postherpetic neuralgia: a critical review. Vaccine. 2014 Mar 26; 32(15):1645-53. View abstract
  49. Song H, Lee J, Lee M, Choi WS, Choi JH, Lee MS, Hashemi M, Rampakakis E, Kawai K, White R, Acosta C, Sampalis JS, Cheong HJ. Burden of illness, quality of life, and healthcare utilization among patients with herpes zoster in South Korea: a prospective clinical-epidemiological study. Int J Infect Dis. 2014 Mar; 20:23-30. View abstract
  50. Lemos EV, de la Hoz FP, Einarson TR, McGhan WF, Quevedo E, Castañeda C, Kawai K. Carbapenem resistance and mortality in patients with Acinetobacter baumannii infection: systematic review and meta-analysis. Clin Microbiol Infect. 2014 May; 20(5):416-23. View abstract
  51. Kawai K, Meydani SN, Urassa W, Wu D, Mugusi FM, Saathoff E, Bosch RJ, Villamor E, Spiegelman D, Fawzi WW. Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania. Epidemiol Infect. 2014 Jul; 142(7):1505-9. View abstract
  52. Uusküla A, Müürsepp A, Kawai K, Raag M, Jürisson M, Pillsbury M. The epidemiological and economic impact of a quadrivalent human papillomavirus (hpv) vaccine in Estonia. BMC Infect Dis. 2013 Jul 03; 13:304. View abstract
  53. Lemos EV, de la Hoz FP, Alvis N, Einarson TR, Quevedo E, Castañeda C, Leon Y, Amado C, Cañon O, Kawai K. Impact of carbapenem resistance on clinical and economic outcomes among patients with Acinetobacter baumannii infection in Colombia. Clin Microbiol Infect. 2014 Feb; 20(2):174-80. View abstract
  54. Kawai K, O'Brien MA, Conway JH, Marshall GS, Kuter BJ. Factors associated with receipt of two doses of varicella vaccine among adolescents in the United States. Pediatr Infect Dis J. 2013 May; 32(5):538-42. View abstract
  55. Lemos EV, De la Hoz F, Alvis N, Quevedo E, Einarson TR, Castañeda C, Kawai K. Healthcare costs in patients with Acinetobacter baumannii infection in Colombia. Infectio. 2013; 4(17):185-192. View abstract
  56. Kawai K, de Araujo GT, Fonseca M, Pillsbury M, Singhal PK. Estimated health and economic impact of quadrivalent HPV (types 6/11/16/18) vaccination in Brazil using a transmission dynamic model. BMC Infect Dis. 2012 Oct 09; 12:250. View abstract
  57. Kawai K, O'Brien MA, Goveia MG, Mast TC, El Khoury AC. Burden of rotavirus gastroenteritis and distribution of rotavirus strains in Asia: a systematic review. Vaccine. 2012 Feb 08; 30(7):1244-54. View abstract
  58. Kawai K, Villamor E, Mugusi FM, Saathoff E, Urassa W, Bosch RJ, Spiegelman D, Fawzi WW. Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania. Int J Tuberc Lung Dis. 2011 Oct; 15(10):1380-9. View abstract
  59. Kawai K, Spiegelman D, Shankar AH, Fawzi WW. Maternal multiple micronutrient supplementation and pregnancy outcomes in developing countries: meta-analysis and meta-regression. Bull World Health Organ. 2011 Jun 01; 89(6):402-411B. View abstract
  60. Stone CA, Kawai K, Kupka R, Fawzi WW. Role of selenium in HIV infection. Nutr Rev. 2010 Nov; 68(11):671-81. View abstract
  61. Kawai K, Msamanga G, Manji K, Villamor E, Bosch RJ, Hertzmark E, Fawzi WW. Sex differences in the effects of maternal vitamin supplements on mortality and morbidity among children born to HIV-infected women in Tanzania. Br J Nutr. 2010 Jun; 103(12):1784-91. View abstract
  62. Kawai K, Kupka R, Mugusi F, Aboud S, Okuma J, Villamor E, Spiegelman D, Fawzi WW. A randomized trial to determine the optimal dosage of multivitamin supplements to reduce adverse pregnancy outcomes among HIV-infected women in Tanzania. Am J Clin Nutr. 2010 Feb; 91(2):391-7. View abstract
  63. Kawai K, Saathoff E, Antelman G, Msamanga G, Fawzi WW. Geophagy (Soil-eating) in relation to Anemia and Helminth infection among HIV-infected pregnant women in Tanzania. Am J Trop Med Hyg. 2009 Jan; 80(1):36-43. View abstract
  64. Kawai K, Kaaya SF, Kajula L, Mbwambo J, Kilonzo GP, Fawzi WW. Parents' and teachers' communication about HIV and sex in relation to the timing of sexual initiation among young adolescents in Tanzania. Scand J Public Health. 2008 Nov; 36(8):879-88. View abstract