Research Overview

Dr. Kantor is pursuing 2 main research areas:

Gene-environment interactions that contribute to illness severity. The susceptibility to and severity of many diseases in the ICU are likely subject to gene-environment interactions in which inter-individual variation in disease manifestation is influenced both by host genetic background and environmental exposure. Our overall goal is to use genetic association methods to identify genes that explain inter-individual variation in disease manifestation following environmental exposure. We are using rhinovirus triggered asthma exacerbation as a model because:

  1. rhinovirus-triggered acute asthma exacerbation is a dominant cause of morbidity among children with asthm
  2. there is marked inter-individual variation in the susceptibility to and severity of rhinovirus-triggered asthma exacerbation, ranging from mild symptoms to life-threatening episodes
  3. accumulating evidence suggests that variation in asthma severity is likely influenced by host genetic background. Characterizing the genetic basis of inter-individual variation in the clinical phenotype of rhinovirus infection will provide insights into the biological mechanisms that pre-dispose some children to severe episodes of rhinovirus-triggered asthma exacerbation, and ultimately will improve risk stratification and treatment. Further, we expect that our approach can be used more broadly to study the genetics of severe disease in the intensive care unit.

 

Point of care ultrasound in the pediatric intensive care unit. Point of care ultrasound in the critical care setting comprises a set of focused applications utilized to monitor physiological states, guide invasive procedures, and diagnose potentially life-threatening conditions. Accumulating evidence in adults demonstrates point of care ultrasound alters clinical management, improves the safety and efficacy of invasive procedures, and may potentially improve the outcomes of critically ill patients. We are broadly interested in investigating the utility of point of care ultrasound in the pediatric intensive care unit. Current projects include:

  1. using ultrasound to measure anterior thigh muscle thickness as a proxy for muscle mass and nutritional statu
  2. nvestigating ultrasound-based physiological parameters that might predict volume responsiveness
  3. using ultrasound to assess lung recruitment of patients on ECMO. In addition, we are collaborating with a number of other academic centers to investigate how ultrasound-derived data alters the timing and nature of clinical management decisions in the pediatric intensive care unit.

About the Researcher

David B. Kantor obtained his MD and PhD from the Johns Hopkins University School of Medicine. His PhD work focused on using genetic techniques to identify and characterize genes involved in early brain development. He subsequently completed his internship and residency in Pediatrics at Boston Children’s Hospital, followed by a fellowship in Pediatric Critical Care, also at Boston Children’s Hospital. Dr. Kantor is a past scholar in the Pediatric Critical Care and Trauma Scientist Development K12 Program and is currently funded through a National Heart, Lung, and Blood Institute K23 career development award.

Key Publications

  1. A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Kantor DB, Lanzrein M, Stary SJ, Sandoval GM, Smith WB, et al. Science (New York, N.Y.). 1996; 274(5293):1744-8. PubMed [journal]PMID: 8939872
  2. Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. Ouyang Y, Kantor D, Harris KM, Schuman EM, Kennedy MB. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1997; 17(14):5416-27. PubMed [journal]PMID: 9204925
  3. Recombinant adenovirus-mediated expression in nervous system of genes coding for ion channels and other molecules involved in synaptic function. Ehrengruber MU, Lanzrein M, Xu Y, Jasek MC, Kantor DB, et al. Methods in enzymology. 1998; 293:483-503. PubMed [journal]PMID: 9711625
  4. Curbing the excesses of youth: molecular insights into axonal pruning. Kantor DB, Kolodkin AL. Neuron. 2003; 38(6):849-52. PubMed [journal]PMID: 12818170
  5. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, et al. Neuron. 2004; 44(6):961-75. PubMed [journal]PMID: 15603739
  6. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, et al. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005; 25(4):808-22. PubMed [journal]PMID: 15673660 
  7. Replication and fine mapping of asthma-associated loci in individuals of African ancestry. Kantor DB, Palmer CD, Young TR, Meng Y, Gajdos ZK, et al. Human genetics. 2013; 132(9):1039-47. NIHMSID: NIHMS497079 PubMed [journal]PMID: 23666277 PMCID: PMC3975655
  8. Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Duvall MG, Pikman Y, Kantor DB, Ariagno K, Summers L, et al. Pediatrics. 2013; 132(6):e1699-703. PubMed [journal]PMID: 24190688
  9. Intravenous β agonists and severe pediatric asthma exacerbation: time for a closer look at terbutaline? Kantor DB, Phipatanakul W. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology. 2014; 112(3):187. PubMed [journal]PMID: 24565592
  10. Establishing intensivist-driven ultrasound at the PICU bedside--it's about time*. Su E, Pustavoitau A, Hirshberg EL, Nishisaki A, Conlon T, et al. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2014; 15(7):649-52. PubMed [journal]PMID: 24977438

MEDICAL SERVICES

Languages

  • English

Researcher Services

Researcher Areas

  • Asthma
  • Genetics
  • Point of Care Ultrasound

Research Departments

Research Divisions

Researcher Labs

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Conlon TW, Kantor DB, Su ER, Nishisaki A. The authors reply. Pediatr Crit Care Med. 2019 Jun; 20(6):592-593. View abstract
  2. Conlon TW, Kantor DB, Su ER, Basu S, Boyer DL, Haileselassie B, Petersen TL, Su F, Nishisaki A. Diagnostic Bedside Ultrasound Program Development in Pediatric Critical Care Medicine: Results of a National Survey. Pediatr Crit Care Med. 2018 11; 19(11):e561-e568. View abstract
  3. Kantor DB, Hirshberg EL, McDonald MC, Griffin J, Buccigrosso T, Stenquist N, Smallwood CD, Nelson KA, Zurakowski D, Phipatanakul W, Hirschhorn JN. Fluid Balance Is Associated with Clinical Outcomes and Extravascular Lung Water in Children with Acute Asthma Exacerbation. Am J Respir Crit Care Med. 2018 May 01; 197(9):1128-1135. View abstract
  4. Kantor DB, Petty CR, Phipatanakul W, Gaffin JM. Transcutaneous CO-oximetry differentiates asthma exacerbation and convalescence in children. J Allergy Clin Immunol. 2018 Aug; 142(2):676-678.e5. View abstract
  5. Kantor DB, Phipatanakul W, Hirschhorn JN. Gene-Environment Interactions Associated with the Severity of Acute Asthma Exacerbation in Children. Am J Respir Crit Care Med. 2018 Mar 01; 197(5):545-547. View abstract
  6. Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliövaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kähönen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Marenholz I, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Melén E, Meyers D, Michel S, Mohamdi H, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Pershagen G, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Schlünssen V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Siroux V, Smith LJ, Solodilova M, Standl M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Tiesler CMT, Torgerson DG, Tsunoda T, Uitterlinden AG, van der Valk RJP, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Widén E, Willemsen G, Williams LK, Wouters IM, Yang JJ, Zhao JH, Moffatt MF, Ober C, Nicolae DL. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018 01; 50(1):42-53. View abstract
  7. Kantor DB, Mehta NM. Ultrasound Measurement of Muscle Thickness: A Novel Biomarker for the PICU? Pediatr Crit Care Med. 2017 08; 18(8):817-819. View abstract
  8. Kantor DB, Phipatanakul W, Hirschhorn JN. Reply. J Allergy Clin Immunol. 2017 05; 139(5):1717-1718. View abstract
  9. Kantor DB, McDonald MC, Stenquist N, Schultz BJ, Smallwood CD, Nelson KA, Phipatanakul W, Hirschhorn JN. Omalizumab Is Associated with Reduced Acute Severity of Rhinovirus-triggered Asthma Exacerbation. Am J Respir Crit Care Med. 2016 12 15; 194(12):1552-1555. View abstract
  10. Conlon T, Su E, Hirshberg E, Burzynski J, Godshall A, Kantor D, Sanchez-de-Toledo J, Nishisaki A. 395: BENEFITS AND BARRIERS TO BEDSIDE ULTRASOUND: A SURVEY OF THE SCCM PEDIATRIC ULTRASOUND COURSE. Crit Care Med. 2016 Dec; 44(12 Suppl 1):175. View abstract
  11. Kantor DB, Su E, Milliren CE, Conlon TW. Ultrasound Guidance and Other Determinants of Successful Peripheral Artery Catheterization in Critically Ill Children. Pediatr Crit Care Med. 2016 12; 17(12):1124-1130. View abstract
  12. Bairdain S, Zurakowski D, Vargas SO, Stenquist N, McDonald M, Towne MC, Miller DT, Jennings RW, Kantor DB, Agrawal PB. Long-Gap Esophageal Atresia Is a Unique Entity within the Esophageal Atresia Defect Spectrum. Neonatology. 2017; 111(2):140-144. View abstract
  13. Kantor DB, Stenquist N, McDonald MC, Schultz BJ, Hauptman M, Smallwood CD, Nelson KA, Perzanowski MS, Matsui EC, Phipatanakul W, Hirschhorn JN. Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children. J Allergy Clin Immunol. 2016 11; 138(5):1467-1471.e9. View abstract
  14. Su E, Kantor DB, Conlon T. Looking for Tips on Central Venous Catheter Insertion? Try Ultrasound. Pediatr Crit Care Med. 2015 Nov; 16(9):891-3. View abstract
  15. Su E, Pustavoitau A, Hirshberg EL, Nishisaki A, Conlon T, Kantor DB, Weber MD, Godshall AJ, Burzynski JH, Thompson AE. Establishing intensivist-driven ultrasound at the PICU bedside--it's about time*. Pediatr Crit Care Med. 2014 Sep; 15(7):649-52. View abstract
  16. Kantor DB, Phipatanakul W. Intravenous ß agonists and severe pediatric asthma exacerbation: time for a closer look at terbutaline? Ann Allergy Asthma Immunol. 2014 Mar; 112(3):187. View abstract
  17. Duvall MG, Pikman Y, Kantor DB, Ariagno K, Summers L, Sectish TC, Mullen MP. Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Pediatrics. 2013 Dec; 132(6):e1699-703. View abstract
  18. Kantor DB, Palmer CD, Young TR, Meng Y, Gajdos ZK, Lyon H, Price AL, Pollack S, London SJ, Loehr LR, Smith LJ, Kumar R, Jacobs DR, Petrini MF, O'Connor GT, White WB, Papanicolaou G, Burkart KM, Heckbert SR, Barr RG, Hirschhorn JN. Replication and fine mapping of asthma-associated loci in individuals of African ancestry. Hum Genet. 2013 Sep; 132(9):1039-47. View abstract
  19. Firtha F, Fekete A, Kaszab T, Gillay B, Nogula-Nagy M, Kovács Z, Kantor DB. Methods for Improving Image Quality and Reducing Data Load of NIR Hyperspectral Images. Sensors (Basel). 2008 May 19; 8(5):3287-3298. View abstract
  20. Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, Newman BA, Mage R, Rader C, Giger RJ. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. J Neurosci. 2005 Jan 26; 25(4):808-22. View abstract
  21. David B. Kantor. Functional Regulation of the Axon Guidance Cue Semaphorin 5A by Sulfated Proteoglycans. 2005. View abstract
  22. Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ, Flanagan JG, Yamaguchi Y, Sretavan DW, Giger RJ, Kolodkin AL. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Neuron. 2004 Dec 16; 44(6):961-75. View abstract
  23. Kantor DB, Kolodkin AL. Curbing the excesses of youth: molecular insights into axonal pruning. Neuron. 2003 Jun 19; 38(6):849-52. View abstract
  24. Kantor, D.B., Giger, R.J., and Kolodkin, A.L. Sema5A affects axon outgrowth from the habenular nucleus. Keystone symposia, Axonal connections: molecular cues for development and regeneration. 2003. View abstract
  25. Ehrengruber MU, Lanzrein M, Xu Y, Jasek MC, Kantor DB, Schuman EM, Lester HA, Davidson N. Recombinant adenovirus-mediated expression in nervous system of genes coding for ion channels and other molecules involved in synaptic function. Methods Enzymol. 1998; 293:483-503. View abstract
  26. Ouyang Y, Kantor D, Harris KM, Schuman EM, Kennedy MB. Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. J Neurosci. 1997 Jul 15; 17(14):5416-27. View abstract
  27. Kantor, D.B., Zirlinger, M., Smith, W.B., Lanzrein, M., Sullivan, B.M., Davidson, N., and Schuman, E.M. The effect of endothelial nitric oxide synthase subcellular localization on nitric oxide release and long-term potentiation. Society for Neuroscience abstracts. 1997; 23:47.18. View abstract
  28. Potter, S., Kantor, D.B., Mamelak, A.N., Fraser, S.E., and Schuman, E.M. 3D time-lapse imaging of hippocampal dendritic spine plasticity using 2-photon microscopy. Society for Neuroscience abstracts. 1997; 23:136.5. View abstract
  29. Kantor DB, Lanzrein M, Stary SJ, Sandoval GM, Smith WB, Sullivan BM, Davidson N, Schuman EM. A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Science. 1996 Dec 06; 274(5293):1744-8. View abstract
  30. Kantor, D.B., Stary, S.J., Smith, W.B., Sullivan, B.M., Davidson, N., and Schuman, E.M. Expression of a mutant endothelial nitric oxide synthase (eNOS) blocks long-term potentiation (LTP). Society for Neuroscience abstracts. 1996; 22:598.16. View abstract
  31. Kantor, D.B., Sandoval, G.M.R., and Schuman, E.M. . A potential role for protein myristoylation and an endothelial nitric oxide synthase (eNOS) in long-term potentiation (LTP). Society for Neuroscience abstracts 21, 711.14. 1995; 21:711.14. View abstract