Research Summary

My research goal is to understand how host genetic variation and environmental exposures (such as infection) interact to influence the severity of acute disease in children.  We are currently focused on rhinovirus triggered acute asthma exacerbation.  In a separate research track, I am also interested in investigating how point of care ultrasound imaging can be utilized in the intensive care unit to improve patient care.

Key Publications

A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Kantor DB, Lanzrein M, Stary SJ, Sandoval GM, Smith WB, et al. Science (New York, N.Y.). 1996; 274(5293):1744-8. PubMed [journal]PMID: 8939872

Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. Ouyang Y, Kantor D, Harris KM, Schuman EM, Kennedy MB. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1997; 17(14):5416-27. PubMed [journal]PMID: 9204925

Recombinant adenovirus-mediated expression in nervous system of genes coding for ion channels and other molecules involved in synaptic function. Ehrengruber MU, Lanzrein M, Xu Y, Jasek MC, Kantor DB, et al. Methods in enzymology. 1998; 293:483-503. PubMed [journal]PMID: 9711625

Curbing the excesses of youth: molecular insights into axonal pruning. Kantor DB, Kolodkin AL. Neuron. 2003; 38(6):849-52. PubMed [journal]PMID: 12818170

Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, et al. Neuron. 2004; 44(6):961-75. PubMed [journal]PMID: 15603739

The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, et al. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005; 25(4):808-22. PubMed [journal]PMID: 15673660 

Replication and fine mapping of asthma-associated loci in individuals of African ancestry. Kantor DB, Palmer CD, Young TR, Meng Y, Gajdos ZK, et al. Human genetics. 2013; 132(9):1039-47. NIHMSID: NIHMS497079 PubMed [journal]PMID: 23666277 PMCID: PMC3975655

Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Duvall MG, Pikman Y, Kantor DB, Ariagno K, Summers L, et al. Pediatrics. 2013; 132(6):e1699-703. PubMed [journal]PMID: 24190688

Intravenous β agonists and severe pediatric asthma exacerbation: time for a closer look at terbutaline? Kantor DB, Phipatanakul W. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology. 2014; 112(3):187. PubMed [journal]PMID: 24565592

Establishing intensivist-driven ultrasound at the PICU bedside--it's about time*. Su E, Pustavoitau A, Hirshberg EL, Nishisaki A, Conlon T, et al. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2014; 15(7):649-52. PubMed [journal]PMID: 24977438

MEDICAL SERVICES

Languages

Researcher Services

Researcher Areas

  • Asthma
  • Genetics

Research Departments

Research Divisions

Researcher Labs

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Kantor DB, Hirshberg EL, McDonald MC, Griffin J, Buccigrosso T, Stenquist N, Smallwood CD, Nelson KA, Zurakowski D, Phipatanakul W, Hirschhorn JN. Fluid Balance Is Associated with Clinical Outcomes and Extravascular Lung Water in Children with Acute Asthma Exacerbation. Am J Respir Crit Care Med. 2018 May 01; 197(9):1128-1135. View abstract
  2. Kantor DB, Petty CR, Phipatanakul W, Gaffin JM. Transcutaneous CO-oximetry differentiates asthma exacerbation and convalescence in children. J Allergy Clin Immunol. 2018 Apr 16. View abstract
  3. Kantor DB, Phipatanakul W, Hirschhorn JN. Gene-Environment Interactions Associated with the Severity of Acute Asthma Exacerbation in Children. Am J Respir Crit Care Med. 2018 Mar 01; 197(5):545-547. View abstract
  4. Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliövaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kähönen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Marenholz I, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Melén E, Meyers D, Michel S, Mohamdi H, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Pershagen G, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Schlünssen V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Siroux V, Smith LJ, Solodilova M, Standl M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Tiesler CMT, Torgerson DG, Tsunoda T, Uitterlinden AG, van der Valk RJP, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Widén E, Willemsen G, Williams LK, Wouters IM, Yang JJ, Zhao JH, Moffatt MF, Ober C, Nicolae DL. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018 Jan; 50(1):42-53. View abstract
  5. Kantor DB, Mehta NM. Ultrasound Measurement of Muscle Thickness: A Novel Biomarker for the PICU? Pediatr Crit Care Med. 2017 Aug; 18(8):817-819. View abstract
  6. Kantor DB, Phipatanakul W, Hirschhorn JN. Reply. J Allergy Clin Immunol. 2017 May; 139(5):1717-1718. View abstract
  7. Kantor DB, McDonald MC, Stenquist N, Schultz BJ, Smallwood CD, Nelson KA, Phipatanakul W, Hirschhorn JN. Omalizumab Is Associated with Reduced Acute Severity of Rhinovirus-triggered Asthma Exacerbation. Am J Respir Crit Care Med. 2016 12 15; 194(12):1552-1555. View abstract
  8. Conlon T, Su E, Hirshberg E, Burzynski J, Godshall A, Kantor D, Sanchez-de-Toledo J, Nishisaki A. 395: BENEFITS AND BARRIERS TO BEDSIDE ULTRASOUND: A SURVEY OF THE SCCM PEDIATRIC ULTRASOUND COURSE. Crit Care Med. 2016 Dec; 44(12 Suppl 1):175. View abstract
  9. Kantor DB, Su E, Milliren CE, Conlon TW. Ultrasound Guidance and Other Determinants of Successful Peripheral Artery Catheterization in Critically Ill Children. Pediatr Crit Care Med. 2016 Dec; 17(12):1124-1130. View abstract
  10. Bairdain S, Zurakowski D, Vargas SO, Stenquist N, McDonald M, Towne MC, Miller DT, Jennings RW, Kantor DB, Agrawal PB. Long-Gap Esophageal Atresia Is a Unique Entity within the Esophageal Atresia Defect Spectrum. Neonatology. 2017; 111(2):140-144. View abstract
  11. Kantor DB, Stenquist N, McDonald MC, Schultz BJ, Hauptman M, Smallwood CD, Nelson KA, Perzanowski MS, Matsui EC, Phipatanakul W, Hirschhorn JN. Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children. J Allergy Clin Immunol. 2016 Nov; 138(5):1467-1471.e9. View abstract
  12. Su E, Kantor DB, Conlon T. Looking for Tips on Central Venous Catheter Insertion? Try Ultrasound. Pediatr Crit Care Med. 2015 Nov; 16(9):891-3. View abstract
  13. Su E, Pustavoitau A, Hirshberg EL, Nishisaki A, Conlon T, Kantor DB, Weber MD, Godshall AJ, Burzynski JH, Thompson AE. Establishing intensivist-driven ultrasound at the PICU bedside--it's about time*. Pediatr Crit Care Med. 2014 Sep; 15(7):649-52. View abstract
  14. Kantor DB, Phipatanakul W. Intravenous ß agonists and severe pediatric asthma exacerbation: time for a closer look at terbutaline? Ann Allergy Asthma Immunol. 2014 Mar; 112(3):187. View abstract
  15. Duvall MG, Pikman Y, Kantor DB, Ariagno K, Summers L, Sectish TC, Mullen MP. Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Pediatrics. 2013 Dec; 132(6):e1699-703. View abstract
  16. Kantor DB, Palmer CD, Young TR, Meng Y, Gajdos ZK, Lyon H, Price AL, Pollack S, London SJ, Loehr LR, Smith LJ, Kumar R, Jacobs DR, Petrini MF, O'Connor GT, White WB, Papanicolaou G, Burkart KM, Heckbert SR, Barr RG, Hirschhorn JN. Replication and fine mapping of asthma-associated loci in individuals of African ancestry. Hum Genet. 2013 Sep; 132(9):1039-47. View abstract
  17. Firtha F, Fekete A, Kaszab T, Gillay B, Nogula-Nagy M, Kovács Z, Kantor DB. Methods for Improving Image Quality and Reducing Data Load of NIR Hyperspectral Images. Sensors (Basel). 2008 May 19; 8(5):3287-3298. View abstract
  18. Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, Newman BA, Mage R, Rader C, Giger RJ. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. J Neurosci. 2005 Jan 26; 25(4):808-22. View abstract
  19. David B. Kantor. Functional Regulation of the Axon Guidance Cue Semaphorin 5A by Sulfated Proteoglycans. 2005. View abstract
  20. Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ, Flanagan JG, Yamaguchi Y, Sretavan DW, Giger RJ, Kolodkin AL. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Neuron. 2004 Dec 16; 44(6):961-75. View abstract
  21. Kantor DB, Kolodkin AL. Curbing the excesses of youth: molecular insights into axonal pruning. Neuron. 2003 Jun 19; 38(6):849-52. View abstract
  22. Kantor, D.B., Giger, R.J., and Kolodkin, A.L. Sema5A affects axon outgrowth from the habenular nucleus. Keystone symposia, Axonal connections: molecular cues for development and regeneration. 2003. View abstract
  23. Ehrengruber MU, Lanzrein M, Xu Y, Jasek MC, Kantor DB, Schuman EM, Lester HA, Davidson N. Recombinant adenovirus-mediated expression in nervous system of genes coding for ion channels and other molecules involved in synaptic function. Methods Enzymol. 1998; 293:483-503. View abstract
  24. Ouyang Y, Kantor D, Harris KM, Schuman EM, Kennedy MB. Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. J Neurosci. 1997 Jul 15; 17(14):5416-27. View abstract
  25. Kantor, D.B., Zirlinger, M., Smith, W.B., Lanzrein, M., Sullivan, B.M., Davidson, N., and Schuman, E.M. The effect of endothelial nitric oxide synthase subcellular localization on nitric oxide release and long-term potentiation. Society for Neuroscience abstracts. 1997; 23:47.18. View abstract
  26. Potter, S., Kantor, D.B., Mamelak, A.N., Fraser, S.E., and Schuman, E.M. 3D time-lapse imaging of hippocampal dendritic spine plasticity using 2-photon microscopy. Society for Neuroscience abstracts. 1997; 23:136.5. View abstract
  27. Kantor DB, Lanzrein M, Stary SJ, Sandoval GM, Smith WB, Sullivan BM, Davidson N, Schuman EM. A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Science. 1996 Dec 06; 274(5293):1744-8. View abstract
  28. Kantor, D.B., Stary, S.J., Smith, W.B., Sullivan, B.M., Davidson, N., and Schuman, E.M. Expression of a mutant endothelial nitric oxide synthase (eNOS) blocks long-term potentiation (LTP). Society for Neuroscience abstracts. 1996; 22:598.16. View abstract
  29. Kantor, D.B., Sandoval, G.M.R., and Schuman, E.M. . A potential role for protein myristoylation and an endothelial nitric oxide synthase (eNOS) in long-term potentiation (LTP). Society for Neuroscience abstracts 21, 711.14. 1995; 21:711.14. View abstract