ABOUT THE RESEARCHER

OVERVIEW

Our laboratory works to understand the pathological basis of Sudden Infant Death Syndrome (SIDS) and the means by which biological vulnerabilities intersect with environmental risk factors, putting infants at risk for sudden and unexpected death. We focus predominately on brain and brainstem mechanisms involved in homeostasis including serotonin, a neurotransmitter found by the laboratory to be abnormal in the brainstem of some SIDS infants. We have also reported evidence of hippocampal abnormalities in SIDS infants; abnormalities that we are pursuing with neuropathological and genetic approaches. New directions in our research include the potential role of peripheral and central inflammatory and biochemical mediators in the brainstem dysfunction in SIDS.

Parallel to our work in the brain, we are also working to identify biomarkers of SIDS risk. Most recently, we have reported elevated levels of serum serotonin in SIDS infants, a finding that suggests peripheral serotonin as one such biomarker.

Our laboratory works in close collaboration with clinicians developing translational approaches to Sudden and Unexpected Death in Pediatrics (SUDP) and molecular geneticists and physiologists studying animal models related to SIDS.

 

BACKGROUND

Dr. Robin Haynes received her Ph.D. in Biochemistry from Wake Forest University Medical School where she trained in the mechanisms of oxidative stress and free radical injury. She joined the laboratory of Dr. Hannah Kinney as a post-doctoral fellow to investigate the role of oxidative stress in premature brain injury. She continued in the laboratory of Dr. Kinney as an Instructor to train in the areas of human brain development and neuropathology of Sudden Infant Death Syndrome (SIDS). Upon the retirement of Dr. Kinney, Dr. Haynes assumed the role of Principal Investigator of the laboratory and continues to focus her research on the pathology underlying SIDS.

PUBLICATIONS

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  1. Haynes RL. Editorial: New insights into the role of central serotonin in the maintenance of homeostasis, autonomic control, and sleep. Exp Neurol. 2020 Jun; 328:113263. View abstract
  2. Elliott AJ, Kinney HC, Haynes RL, Dempers JD, Wright C, Fifer WP, Angal J, Boyd TK, Burd L, Burger E, Folkerth RD, Groenewald C, Hankins G, Hereld D, Hoffman HJ, Holm IA, Myers MM, Nelsen LL, Odendaal HJ, Petersen J, Randall BB, Roberts DJ, Robinson F, Schubert P, Sens MA, Sullivan LM, Tripp T, Van Eerden P, Wadee S, Willinger M, Zaharie D, Dukes KA. Concurrent prenatal drinking and smoking increases risk for SIDS: Safe Passage Study report. EClinicalMedicine. 2020 Feb; 19:100247. View abstract
  3. Donnelly WT, Haynes RL, Commons KG, Erickson DJ, Panzini CM, Xia L, Han QJ, Leiter JC. Prenatal intermittent hypoxia sensitizes the laryngeal chemoreflex, blocks serotoninergic shortening of the reflex, and reduces 5-HT3 receptor binding in the NTS in anesthetized rat pups. Exp Neurol. 2020 Apr; 326:113166. View abstract
  4. Kinney HC, Haynes RL. The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome. J Neuropathol Exp Neurol. 2019 09 01; 78(9):765-779. View abstract
  5. Brownstein CA, Goldstein RD, Thompson CH, Haynes RL, Giles E, Sheidley B, Bainbridge M, Haas EA, Mena OJ, Lucas J, Schaber B, Holm IA, George AL, Kinney HC, Poduri AH. SCN1A variants associated with sudden infant death syndrome. Epilepsia. 2018 04; 59(4):e56-e62. View abstract
  6. Haynes RL, Frelinger AL, Giles EK, Goldstein RD, Tran H, Kozakewich HP, Haas EA, Gerrits AJ, Mena OJ, Trachtenberg FL, Paterson DS, Berry GT, Adeli K, Kinney HC, Michelson AD. High serum serotonin in sudden infant death syndrome. Proc Natl Acad Sci U S A. 2017 07 18; 114(29):7695-7700. View abstract
  7. Goldstein IS, Erickson DJ, Sleeper LA, Haynes RL, Kinney HC. The Lateral Temporal Lobe in Early Human Life. J Neuropathol Exp Neurol. 2017 Jun 01; 76(6):424-438. View abstract
  8. McAdams RM, Fleiss B, Traudt C, Schwendimann L, Snyder JM, Haynes RL, Natarajan N, Gressens P, Juul SE. Long-Term Neuropathological Changes Associated with Cerebral Palsy in a Nonhuman Primate Model of Hypoxic-Ischemic Encephalopathy. Dev Neurosci. 2017; 39(1-4):124-140. View abstract
  9. Haynes RL, Folkerth RD, Paterson DS, Broadbelt KG, Dan Zaharie S, Hewlett RH, Dempers JJ, Burger E, Wadee S, Schubert P, Wright C, Sens MA, Nelsen L, Randall BB, Tran H, Geldenhuys E, Elliott AJ, Odendaal HJ, Kinney HC. Serotonin Receptors in the Medulla Oblongata of the Human Fetus and Infant: The Analytic Approach of the International Safe Passage Study. J Neuropathol Exp Neurol. 2016 Nov 01; 75(11):1048-1057. View abstract
  10. Kinney HC, Poduri AH, Cryan JB, Haynes RL, Teot L, Sleeper LA, Holm IA, Berry GT, Prabhu SP, Warfield SK, Brownstein C, Abram HS, Kruer M, Kemp WL, Hargitai B, Gastrang J, Mena OJ, Haas EA, Dastjerdi R, Armstrong DD, Goldstein RD. Hippocampal Formation Maldevelopment and Sudden Unexpected Death across the Pediatric Age Spectrum. J Neuropathol Exp Neurol. 2016 Oct; 75(10):981-997. View abstract
  11. Hefti MM, Trachtenberg FL, Haynes RL, Hassett C, Volpe JJ, Kinney HC. A Century of Germinal Matrix Intraventricular Hemorrhage in Autopsied Premature Infants: A Historical Account. Pediatr Dev Pathol. 2016 Mar-Apr; 19(2):108-14. View abstract
  12. Kinney HC, Cryan JB, Haynes RL, Paterson DS, Haas EA, Mena OJ, Minter M, Journey KW, Trachtenberg FL, Goldstein RD, Armstrong DD. Dentate gyrus abnormalities in sudden unexplained death in infants: morphological marker of underlying brain vulnerability. Acta Neuropathol. 2015 Jan; 129(1):65-80. View abstract
  13. Wisnowski JL, Schmithorst VJ, Rosser T, Paquette L, Nelson MD, Haynes RL, Painter MJ, Blüml S, Panigrahy A. Magnetic resonance spectroscopy markers of axons and astrogliosis in relation to specific features of white matter injury in preterm infants. Neuroradiology. 2014 Sep; 56(9):771-9. View abstract
  14. Rognum IJ, Tran H, Haas EA, Hyland K, Paterson DS, Haynes RL, Broadbelt KG, Harty BJ, Mena O, Krous HF, Kinney HC. Serotonin metabolites in the cerebrospinal fluid in sudden infant death syndrome. J Neuropathol Exp Neurol. 2014 Feb; 73(2):115-22. View abstract
  15. Haynes RL, Sleeper LA, Volpe JJ, Kinney HC. Neuropathologic studies of the encephalopathy of prematurity in the late preterm infant. Clin Perinatol. 2013 Dec; 40(4):707-22. View abstract
  16. Massey CA, Kim G, Corcoran AE, Haynes RL, Paterson DS, Cummings KJ, Dymecki SM, Richerson GB, Nattie EE, Kinney HC, Commons KG. Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice. J Neurochem. 2013 Sep; 126(6):749-57. View abstract
  17. Edlow BL, Haynes RL, Takahashi E, Klein JP, Cummings P, Benner T, Greer DM, Greenberg SM, Wu O, Kinney HC, Folkerth RD. Disconnection of the ascending arousal system in traumatic coma. J Neuropathol Exp Neurol. 2013 Jun; 72(6):505-23. View abstract
  18. Haynes RL, van Leyen K. 12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia. Dev Neurosci. 2013; 35(2-3):140-54. View abstract
  19. Xu G, Takahashi E, Folkerth RD, Haynes RL, Volpe JJ, Grant PE, Kinney HC. Radial coherence of diffusion tractography in the cerebral white matter of the human fetus: neuroanatomic insights. Cereb Cortex. 2014 Mar; 24(3):579-92. View abstract
  20. Haynes RL, Desilva TM, Li J. Mechanisms of perinatal brain injury. Neurol Res Int. 2012; 2012:157858. View abstract
  21. Kinney HC, Haynes RL, Xu G, Andiman SE, Folkerth RD, Sleeper LA, Volpe JJ. Neuron deficit in the white matter and subplate in periventricular leukomalacia. Ann Neurol. 2012 Mar; 71(3):397-406. View abstract
  22. Xu G, Broadbelt KG, Haynes RL, Folkerth RD, Borenstein NS, Belliveau RA, Trachtenberg FL, Volpe JJ, Kinney HC. Late development of the GABAergic system in the human cerebral cortex and white matter. J Neuropathol Exp Neurol. 2011 Oct; 70(10):841-58. View abstract
  23. Kinney HC, Broadbelt KG, Haynes RL, Rognum IJ, Paterson DS. The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis. J Chem Neuroanat. 2011 Jul; 41(4):182-99. View abstract
  24. Haynes RL, Xu G, Folkerth RD, Trachtenberg FL, Volpe JJ, Kinney HC. Potential neuronal repair in cerebral white matter injury in the human neonate. Pediatr Res. 2011 Jan; 69(1):62-7. View abstract
  25. Andiman SE, Haynes RL, Trachtenberg FL, Billiards SS, Folkerth RD, Volpe JJ, Kinney HC. The cerebral cortex overlying periventricular leukomalacia: analysis of pyramidal neurons. Brain Pathol. 2010 Jul; 20(4):803-14. View abstract
  26. Tomycz ND, Haynes RL, Schmidt EF, Ackerson K, Kinney HC. Novel neuropathologic findings in the Haddad syndrome. Acta Neuropathol. 2010 Feb; 119(2):261-9. View abstract
  27. Haynes RL, Folkerth RD, Trachtenberg FL, Volpe JJ, Kinney HC. Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia. Acta Neuropathol. 2009 Sep; 118(3):391-9. View abstract
  28. Ligam P, Haynes RL, Folkerth RD, Liu L, Yang M, Volpe JJ, Kinney HC. Thalamic damage in periventricular leukomalacia: novel pathologic observations relevant to cognitive deficits in survivors of prematurity. Pediatr Res. 2009 May; 65(5):524-9. View abstract
  29. Rognum IJ, Haynes RL, Vege A, Yang M, Rognum TO, Kinney HC. Interleukin-6 and the serotonergic system of the medulla oblongata in the sudden infant death syndrome. Acta Neuropathol. 2009 Oct; 118(4):519-30. View abstract
  30. Folkerth RD, Trachtenberg FL, Haynes RL. Oxidative injury in the cerebral cortex and subplate neurons in periventricular leukomalacia. J Neuropathol Exp Neurol. 2008 Jul; 67(7):677-86. View abstract
  31. Haynes RL, Billiards SS, Borenstein NS, Volpe JJ, Kinney HC. Diffuse axonal injury in periventricular leukomalacia as determined by apoptotic marker fractin. Pediatr Res. 2008 Jun; 63(6):656-61. View abstract
  32. Billiards SS, Haynes RL, Folkerth RD, Borenstein NS, Trachtenberg FL, Rowitch DH, Ligon KL, Volpe JJ, Kinney HC. Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia. Brain Pathol. 2008 Apr; 18(2):153-63. View abstract
  33. Ma Y, Haynes RL, Sidman RL, Vartanian T. TLR8: an innate immune receptor in brain, neurons and axons. Cell Cycle. 2007 Dec 01; 6(23):2859-68. View abstract
  34. Billiards SS, Pierson CR, Haynes RL, Folkerth RD, Kinney HC. Is the late preterm infant more vulnerable to gray matter injury than the term infant? Clin Perinatol. 2006 Dec; 33(4):915-33; abstract x-xi. View abstract
  35. Haynes RL, Folkerth RD, Szweda LI, Volpe JJ, Kinney HC. Lipid peroxidation during human cerebral myelination. J Neuropathol Exp Neurol. 2006 Sep; 65(9):894-904. View abstract
  36. Billiards SS, Haynes RL, Folkerth RD, Trachtenberg FL, Liu LG, Volpe JJ, Kinney HC. Development of microglia in the cerebral white matter of the human fetus and infant. J Comp Neurol. 2006 Jul 10; 497(2):199-208. View abstract
  37. Haynes RL, Baud O, Li J, Kinney HC, Volpe JJ, Folkerth DR. Oxidative and nitrative injury in periventricular leukomalacia: a review. Brain Pathol. 2005 Jul; 15(3):225-33. View abstract
  38. Haynes RL, Borenstein NS, Desilva TM, Folkerth RD, Liu LG, Volpe JJ, Kinney HC. Axonal development in the cerebral white matter of the human fetus and infant. J Comp Neurol. 2005 Apr 04; 484(2):156-67. View abstract
  39. Folkerth RD, Haynes RL, Borenstein NS, Belliveau RA, Trachtenberg F, Rosenberg PA, Volpe JJ, Kinney HC. Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter. J Neuropathol Exp Neurol. 2004 Sep; 63(9):990-9. View abstract
  40. Folkerth RD, Keefe RJ, Haynes RL, Trachtenberg FL, Volpe JJ, Kinney HC. Interferon-gamma expression in periventricular leukomalacia in the human brain. Brain Pathol. 2004 Jul; 14(3):265-74. View abstract
  41. Haynes RL, Folkerth RD, Keefe RJ, Sung I, Swzeda LI, Rosenberg PA, Volpe JJ, Kinney HC. Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia. J Neuropathol Exp Neurol. 2003 May; 62(5):441-50. View abstract
  42. Townsend AJ, Leone-Kabler S, Haynes RL, Wu Y, Szweda L, Bunting KD. Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells. Chem Biol Interact. 2001 Jan 30; 130-132(1-3):261-73. View abstract
  43. Haynes RL, Szweda L, Pickin K, Welker ME, Townsend AJ. Structure-activity relationships for growth inhibition and induction of apoptosis by 4-hydroxy-2-nonenal in raw 264.7 cells. Mol Pharmacol. 2000 Oct; 58(4):788-94. View abstract