Research Overview

Dr. Robert Graham's research in health services focuses on clinical outcomes, resource utilization and health-related quality of life for children with chronic respiratory failure (CRF).  Additional clinical investigations include tracheostomy biome studies, nutritional assessment in CRF, and intervention trials in spinal muscular atrophy.

Researcher Services

Researcher Areas

  • Chronic Respiratory Failure
  • Tracheostomy Biome
  • Spinal Muscular Atrophy

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Graham RJ, McManus ML, Rodday AM, Weidner RA, Parsons SK. Pediatric Specialty Care Model for Management of Chronic Respiratory Failure: Cost and Savings Implications and Misalignment With Payment Models. Pediatr Crit Care Med. 2018 May; 19(5):412-420. View abstract
  2. Martinez EE, Quinn N, Arouchon K, Anzaldi R, Tarrant S, Ma NS, Griffin J, Darras BT, Graham RJ, Mehta NM. Comprehensive nutritional and metabolic assessment in patients with spinal muscular atrophy: Opportunity for an individualized approach. Neuromuscul Disord. 2018 Mar 19. View abstract
  3. Burgart AM, Magnus D, Tabor HK, Paquette ED, Frader J, Glover JJ, Jackson BM, Harrison CH, Urion DK, Graham RJ, Brandsema JF, Feudtner C. Ethical Challenges Confronted When Providing Nusinersen Treatment for Spinal Muscular Atrophy. JAMA Pediatr. 2018 Feb 01; 172(2):188-192. View abstract
  4. Mercuri E, Finkel RS, Muntoni F, Wirth B, Montes J, Main M, Mazzone ES, Vitale M, Snyder B, Quijano-Roy S, Bertini E, Davis RH, Meyer OH, Simonds AK, Schroth MK, Graham RJ, Kirschner J, Iannaccone ST, Crawford TO, Woods S, Qian Y, Sejersen T. Diagnosis and management of spinal muscular atrophy: Part 1: Recommendations for diagnosis, rehabilitation, orthopedic and nutritional care. Neuromuscul Disord. 2018 Feb; 28(2):103-115. View abstract
  5. Finkel RS, Mercuri E, Meyer OH, Simonds AK, Schroth MK, Graham RJ, Kirschner J, Iannaccone ST, Crawford TO, Woods S, Muntoni F, Wirth B, Montes J, Main M, Mazzone ES, Vitale M, Snyder B, Quijano-Roy S, Bertini E, Davis RH, Qian Y, Sejersen T. Diagnosis and management of spinal muscular atrophy: Part 2: Pulmonary and acute care; medications, supplements and immunizations; other organ systems; and ethics. Neuromuscul Disord. 2018 Mar; 28(3):197-207. View abstract
  6. Rodday AM, Graham RJ, Weidner RA, Rothrock NE, Dewalt DA, Parsons SK. Leveraging pediatric PROMIS item banks to assess physical functioning in children at risk for severe functional loss. J Patient Rep Outcomes. 2017; 1(1):10. View abstract
  7. Pérez-Losada M, Graham RJ, Coquillette M, Jafarey A, Castro-Nallar E, Aira M, Freishtat RJ, Mansbach JM. The temporal dynamics of the tracheal microbiome in tracheostomised patients with and without lower respiratory infections. PLoS One. 2017; 12(8):e0182520. View abstract
  8. Rodday AM, Terrin N, Leslie LK, Graham RJ, Parsons SK. Understanding the Relationship Between Child Health-Related Quality of Life and Parent Emotional Functioning in Pediatric Hematopoietic Stem Cell Transplant. J Pediatr Psychol. 2017 Aug 01; 42(7):804-814. View abstract
  9. Rodday AM, Graham RJ, Weidner RA, Terrin N, Leslie LK, Parsons SK. Predicting Health Care Utilization for Children With Respiratory Insufficiency Using Parent-Proxy Ratings of Children's Health-Related Quality of Life. J Pediatr Health Care. 2017 Nov - Dec; 31(6):654-662. View abstract
  10. Graham RJ, Rodday AM, Weidner RA, Parsons SK. The Impact on Family of Pediatric Chronic Respiratory Failure in the Home. J Pediatr. 2016 Aug; 175:40-6. View abstract
  11. Graham RJ, McManus ML, Rodday AM, Weidner RA, Parsons SK. Chronic respiratory failure: Utilization of a pediatric specialty integrated care program. Healthc (Amst). 2017 Mar; 5(1-2):23-28. View abstract
  12. Watters K, O'Neill M, Zhu H, Graham RJ, Hall M, Berry J. Two-year mortality, complications, and healthcare use in children with medicaid following tracheostomy. Laryngoscope. 2016 11; 126(11):2611-2617. View abstract
  13. Mehta NM, Newman H, Tarrant S, Graham RJ. Nutritional Status and Nutrient Intake Challenges in Children With Spinal Muscular Atrophy. Pediatr Neurol. 2016 Apr; 57:80-3. View abstract
  14. Haliloglu G, Topaloglu H. Evidence-based guideline summary: Evaluation, diagnosis, and management of congenital muscular dystrophy: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine. Neurology. 2015 Oct 20; 85(16):1432. View abstract
  15. Kang PB, Morrison L, Iannaccone ST, Graham RJ, Bönnemann CG, Rutkowski A, Hornyak J, Wang CH, Christi C, North K. Author response. Neurology. 2015 Oct 20; 85(16):1432-3. View abstract
  16. Martinez EE, Bechard LJ, Smallwood CD, Duggan CP, Graham RJ, Mehta NM. Impact of Individualized Diet Intervention on Body Composition and Respiratory Variables in Children With Respiratory Insufficiency: A Pilot Intervention Study. Pediatr Crit Care Med. 2015 Jul; 16(6):e157-64. View abstract
  17. Kang PB, Morrison L, Iannaccone ST, Graham RJ, Bönnemann CG, Rutkowski A, Hornyak J, Wang CH, North K, Oskoui M, Getchius TS, Cox JA, Hagen EE, Gronseth G, Griggs RC. Evidence-based guideline summary: evaluation, diagnosis, and management of congenital muscular dystrophy: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine. Neurology. 2015 Mar 31; 84(13):1369-78. View abstract
  18. Martinez EE, Smallwood CD, Bechard LJ, Graham RJ, Mehta NM. Metabolic assessment and individualized nutrition in children dependent on mechanical ventilation at home. J Pediatr. 2015 Feb; 166(2):350-7. View abstract
  19. Casavant DW, McManus ML, Parsons SK, Zurakowski D, Graham RJ. Trial of telemedicine for patients on home ventilator support: feasibility, confidence in clinical management and use in medical decision-making. J Telemed Telecare. 2014 Dec; 20(8):441-9. View abstract
  20. Mehta NM, Smallwood CD, Graham RJ. Current applications of metabolic monitoring in the pediatric intensive care unit. Nutr Clin Pract. 2014 Jun; 29(3):338-47. View abstract
  21. Graham RJ, Rodday AM, Parsons SK. Family-centered assessment and function for children with chronic mechanical respiratory support. J Pediatr Health Care. 2014 Jul-Aug; 28(4):295-304. View abstract
  22. Graham RJ. Long-term ventilation: charting a pathway home. Arch Dis Child. 2013 Sep; 98(9):653. View abstract
  23. LaRovere KL, Graham RJ, Tasker RC. Pediatric neurocritical care: a neurology consultation model and implication for education and training. Pediatr Neurol. 2013 Mar; 48(3):206-11. View abstract
  24. Edwards JD, Houtrow AJ, Vasilevskis EE, Rehm RS, Markovitz BP, Graham RJ, Dudley RA. Chronic conditions among children admitted to U.S. pediatric intensive care units: their prevalence and impact on risk for mortality and prolonged length of stay*. Crit Care Med. 2012 Jul; 40(7):2196-203. View abstract
  25. Edwards JD, Kun SS, Graham RJ, Keens TG. End-of-life discussions and advance care planning for children on long-term assisted ventilation with life-limiting conditions. J Palliat Care. 2012; 28(1):21-7. View abstract
  26. Puri AS, Rahbar R, Dearden J, Graham RJ, Lillehei C, Orbach DB. Stretched and sheared microcatheter retained after onyx embolization of infantile myofibromatosis. Interv Neuroradiol. 2011 Jun; 17(2):261-6. View abstract
  27. Edwards JD, Davidson EJ, Houtrow AJ, Graham RJ. Pediatric resident attitudes toward caring for children with severe disabilities. Am J Phys Med Rehabil. 2010 Sep; 89(9):765-71. View abstract
  28. Berry JG, Graham RJ, Roberson DW, Rhein L, Graham DA, Zhou J, O'Brien J, Putney H, Goldmann DA. Patient characteristics associated with in-hospital mortality in children following tracheotomy. Arch Dis Child. 2010 Sep; 95(9):703-10. View abstract
  29. Berry JG, Graham DA, Graham RJ, Zhou J, Putney HL, O'Brien JE, Roberson DW, Goldmann DA. Predictors of clinical outcomes and hospital resource use of children after tracheotomy. Pediatrics. 2009 Aug; 124(2):563-72. View abstract
  30. Graham RJ, Athiraman U, Laubach AE, Sethna NF. Anesthesia and perioperative medical management of children with spinal muscular atrophy. Paediatr Anaesth. 2009 Nov; 19(11):1054-63. View abstract
  31. Graham RJ, Pemstein DM, Curley MA. Experiencing the pediatric intensive care unit: perspective from parents of children with severe antecedent disabilities. Crit Care Med. 2009 Jun; 37(6):2064-70. View abstract
  32. Graham RJ, Wachendorf MT, Burns JP, Mancuso TJ. Successful and safe delivery of anesthesia and perioperative care for children with complex special health care needs. J Clin Anesth. 2009 May; 21(3):165-72. View abstract
  33. Graham RJ. Medicine and children with special health care needs: conflict with the cult of cure. J Dev Behav Pediatr. 2008 Aug; 29(4):309-10. View abstract
  34. Jay Berry Robert Graham Dionne Graham. Clinical Outcomes and Hospital Use of Children Following Tracheostomy. Pediatric Academic Societies. 2008. View abstract
  35. Graham RJ, Pemstein DM, Palfrey JS. Included but isolated: early intervention programmes provision for children and families with chronic respiratory support needs. Child Care Health Dev. 2008 May; 34(3):373-9. View abstract
  36. Graham RJ. Specialty services for children with special health care needs: supplement not supplant the medical home. Arch Dis Child. 2008 Jan; 93(1):2-4. View abstract
  37. Graham RJ, Fleegler EW, Robinson WM. Chronic ventilator need in the community: a 2005 pediatric census of Massachusetts. Pediatrics. 2007 Jun; 119(6):e1280-7. View abstract
  38. Graham RJ, Stein P. Gastric outlet obstruction in an infant: lactobezoar. Am J Emerg Med. 2007 Jan; 25(1):98-9. View abstract
  39. O'Brien JE, Birnkrant DJ, Dumas HM, Haley SM, Burke SA, Graham RJ, Kharasch VS. Weaning children from mechanical ventilation in a post-acute care setting. Pediatr Rehabil. 2006 Oct-Dec; 9(4):365-72. View abstract
  40. The informed patient (column - Laura Landro): Pediatric hospitals teach doctors ways to convey tragic news. Cited in article. Wall Street Journal. 2006. View abstract
  41. Jeff Edwards, MD, MA, Emily J. Davidson, MD, MPH, Robert J. Graham, MD. Resident Attitudes Toward Caring for Children with Severe Disabilities. 2006. View abstract
  42. Graham RJ. Acute respiratory distress syndrome in children with severe motor and intellectual disabilities. Brain Dev. 2006 Jun; 28(5):342. View abstract
  43. Graham R Dussel V Wolfe J. Research. Oxford Textbook of Palliative Care for Children, Goldman A, Hain R, Liben S (eds). 2006; 615-647. View abstract
  44. Graham RJ, Robinson WM. Integrating palliative care into chronic care for children with severe neurodevelopmental disabilities. J Dev Behav Pediatr. 2005 Oct; 26(5):361-5. View abstract
  45. Graham RJ. An opportunity: critical care beyond the intensive care unit. Pediatr Crit Care Med. 2005 May; 6(3):327-8. View abstract
  46. Graham RJ. Jading. Pediatr Crit Care Med. 2005 Jan; 6(1):93; author reply 93. View abstract
  47. O'Brien JE, Graham RJ, Dumas HM, and Kjarasch VS. Inpatient pediatric pulmonary rehabilitation: development of a minimum data set. Advance for Directors in Rehabilitation. 2005; 14(2):57-68. View abstract
  48. Graham RJ, Dumas HM, O'Brien JE, Burns JP. Congenital neurodevelopmental diagnoses and an intensive care unit: defining a population. Pediatr Crit Care Med. 2004 Jul; 5(4):321-8. View abstract
  49. Haley SM, Graham RJ, Dumas HM. Outcome rating scales for pediatric head injury. J Intensive Care Med. 2004 Jul-Aug; 19(4):205-19. View abstract
  50. Tracy Magee PhD, CPNP, RN, Robert J. Graham MD, Jane E O'Brien MD, Stephen M. Haley PhD, Helene M. Dumas MS, Virginia S. Kharasch MD. Developing a pediatric pulmonary multidisciplinary data set: meeting everyone's needs, clinician, patient, and researcher. 2004. View abstract
  51. Graham R. Evidence-based medicine, predictive model review of Robertson CMT, Joffe AR, Moore AJ, Watt JM. Neurodevelopmental outcome of young pediatric intensive care survivors of serious brain injury. (Pediatric Critical Care Medicine 2002; 3(4):345-350) http://pedsccm.wustl.edu/EBJournal_club.html. 2003. View abstract
  52. Randolph AG and Graham R. Measuring the health status of pediatric ICU survivors. Surviving Intensive Care. 2003; 107-115. View abstract
  53. Graham R. Evidence-based medicine, predictive models review of Hatherill M, McIntyre AG, Wattie M, Murdoch IA. Early hyperlactatemia in critically ill children. (Intensive Care Medicine 2000; 26:314-318) http://pedsccm.wustl.edu/EBJournal_club.html. 2001. View abstract
  54. Graham R. Evidence-based medicine, quality of life review of Sheridan RL et al. Longterm outcomes of children surviving massive burns (JAMA 2000; 283:69-73) http://pedsccm.wustl.edu/EBJournal_club.html. 2001. View abstract
  55. Babl, FE and Graham R. A pain in the heel: sneaker puncture wounds. Infectious Diseases in Children. 1999; 12(2):32. View abstract
  56. Peacock WJ and Graham R. Advances in pediatric neurosurgery - surgical management of epileptic surgery. Headlines. 1993; 12-14. View abstract