Research Overview

Dr Fu’s research interest is in the understanding of basic mechanism of retinal neurovascular biology, particularly the metabolic effects on diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration.

About the Researcher

Dr. Fu graduated from the Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong with a Ph.D. in Ophthalmology in 2012 and joined Prof. Lois Smith’s group in Sep 2012 for postdoctoral training. Dr. Fu’s current focus is to investigate the effects of diets, hormones, glucose/lipid metabolism on the progression of retinopathies.

Awards:

  1. Asia-ARVO 2017 Travel Grant

2016: Knights Templar Eye Foundation Pediatric Ophthalmology Competitive Renewal Research Award

2015: The Bernadotte Foundation Travel Award, New York, USA.

2015: Knights Templar Eye Foundation Pediatric Ophthalmology Career-starter Research Award, Flower Mound, TX, USA.

Key Publications

First-authored:

  1. Z Fu, Y Gong, R Liegl, Z Wang, CH Liu, S Meng, S Burnim, N Saba, TW Fredrick, PC Morss, A Hellstrom, S Talukdar, LEH Smith. FGF21 administration suppresses retinal and choroidal neovascularization. Cell Reports. 2017 Feb 14;18(7):1606-1613. PMID: 28199833.
  2. Z Fu, SS Meng, SS Burnim, LEH Smith, ACY Lo, Lutein facilitates physiological revascularization in a mouse model of oxygen-induced retinopathy. Clinical and Experimental Ophthalmology. 2017 Dec. PMID: 28002872.
  3. Z Fu, Y Gong, C Lofqvist, A Hellstrom, LEH Smith. Review: adiponectin in retinopathy. BBA – Molecular Basis of Disease. 2016 May 4;1862(8):1392-1400. PMID: 27155572.
  4. Z Fu, S Nian, SY Li, D Wong, SK Chung and ACY Lo. Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity. Graefe's Archive for Clinical and Experimental Ophthalmology 2015. Sep;253(9):1503-13. PMID: 25921391.
  5. Z Fu, C. Lofqvist, Z Shao, Y Sun, JS Joyal, C Hurst, R Cui, L Evans, K Tian, J SanGiovanni, J Chen, D Ley, IH Pupp, A Hellstrom, LEH. Smith. Dietary ω3 polyunsaturated-fatty-acid decreases retinal neovascularization by adipose-ER-stress reduction to increase adiponectin. The American Journal of Clinical Nutrition. 2015 Apr;101(4):879-88. PMID: 25833984
  6. Z Shao*, Z Fu*, A Stahl, JS Joyal, C Hatton, A Juan, C Hurst, L Evans, Z Cui, D Pei, Y Gong, D Xu, K Tian, H Bogardus, ML Edin, F Lih, P Sapieha, J Chen, D Panigrahy, A Hellstrom, DC Zeldin, LEH Smith. Cytochrome P450 2C8 ω3LCPUFA metabolites increase mouse retinal pathologic neovascularization. Arteriosclerosis, Thrombosis, and Vascular Biology, Brief Report, 34(3):581-6. PMID: 24458713 (* Equal Contribution)
  7. Z Fu, SY Li, N Kociok, D Wong, SK Chung and ACY Lo. Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy. Investigative Ophthalmology & Visual Science 2012 53(9):5698-712. PMID: 22836764

Co-authored:

  1. Gong, Z. Shao, Z Fu, ML. Edin, Y. Sun, RG. Liegl, Z. Wang, CH. Liu, SB. Burnim, SS. Meng, FB, Lih, JP SanGiovannie, DC. Zeldin, A. Hellstrom, LEH. Smith. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov;13:201-211. PMID: 27720395.
  2. Gong, Z Fu, ML. Edin, CH. Liu, Z. Wang, Z. Shao, TW. Fredrick, NJ. Saba, PC, Morss, SB. Burnim, SS. Meng, FB, Lih, KSS. Lee, EP. Moran, JP SanGiovannie, A. Hellstrom, BD. Hammock, DC. Zeldin, LEH. Smith. Cytochrome P450 oxidase 2C inhibition adds to omega-3 long-chain polyunsaturated fatty acids protection against retinal and choroidal angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016. Sep;36(9):1919-27. PMID:27417579.
  3. JS Joyal, Y Sun, M Gantner, Z Shao, L Evans, N Saba, T Fredrick, S Burnim, JS Kim, G Patel, A Juan, C Hurst, C Hatton, Z Cui, K Pierce, P Bherer, E Aguilar, M Powner, K Vevis, M Boisvert, Z Fu, E Levy, M Fruttiger, A Packard, F Rezende, B Maranda,, P Sapieha, J Chen, M Friedlander, CB. Clish and LEH Smith. Retinal lipid and glucose metabolism dictates angiogenesis through lipid sensor Ffar1. Nature Medicine. Apr;22(4):439-45. PMID: 26974308.
  4. Y Gong, J Li, Y Sun, Z Fu, CH Liu, L Evans, K Tian, N Saba, T Fredrick, P Morss, J Chen, LEH Smith. Optimization of an Image-guided Laser-induced Choroidal Neovascularization Model in Mice. PloS One. 2015. Jul 10;10(7). PMID: 26161975.
  5. J Li, C Liu, Y Sun, Y Gong, Z Fu, L Evans, K Tian, A Juan, Christian Hurst, A Mammoto, J Chen. Endothelial Twist1 promotes pathological ocular angiogenesis. Investigative Ophthalmology & Visual Science Nov 20;55(12):8267-77. PMID: 25414194
  6. AKW Lai, Z Fu, ACY Lo. Stem cell therapy for retinopathy of prematurity. Anatomy & Physiology. 2013. 3(126), 2161-0940.
  7. SY Li, Z Fu, ACY Lo. Hypoxia-induced oxidative stress in ischemic retinopathy. Oxidative Medicine and Cellular Longevity. Review. Vol Article number 426769. PMID: 23125893
  8. SY Li, FKC Fung, Z Fu, HHL Chan, ACY Lo. Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro Investigative Ophthalmology & Visual Science 2012. 53(10):5976-84. PMID: 22871829
  9. SY Li, D Yang, Z Fu, T Woo, D Wong and ACY Lo. Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiology of Disease 45(1): 624-632. PMID: 22024715
  10. SY Li, Z Fu, H Ma, WC Jang, KF So, D Wong and ACY Lo. Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Investigative Ophthalmology & Visual Science 50(2): 836-842. PMID: 18936152.

MEDICAL SERVICES

Languages

  • English

Researcher Services

Researcher Areas

  • Retinopathy of prematurity
  • Diabetic Retinopathy
  • Age Related Macular Degeneration

Research Departments

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Fu Z, Wang Z, Liu CH, Gong Y, Cakir B, Liegl R, Sun Y, Meng SS, Burnim SB, Arellano I, Moran E, Duran R, Poblete A, Cho SS, Talukdar S, Akula JD, Hellström A, Smith LEH. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. View abstract
  2. Fu Z, Löfqvist CA, Liegl R, Wang Z, Sun Y, Gong Y, Liu CH, Meng SS, Burnim SB, Arellano I, Chouinard MT, Duran R, Poblete A, Cho SS, Akula JD, Kinter M, Ley D, Pupp IH, Talukdar S, Hellström A, Smith LE. Photoreceptor glucose metabolism determines normal retinal vascular growth. EMBO Mol Med. 2018 01; 10(1):76-90. View abstract
  3. Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, Smith LEH, Ma JX. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. View abstract
  4. Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y, Sodhi A, Smith L, Hong M, Huo Y. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017 09 19; 8(1):584. View abstract
  5. Fu Z, Liegl R, Wang Z, Gong Y, Liu CH, Sun Y, Cakir B, Burnim SB, Meng SS, Löfqvist C, SanGiovanni JP, Hellström A, Smith LEH. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. View abstract
  6. Gong Y, Fu Z, Liegl R, Chen J, Hellström A, Smith LE. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017 Jul; 106(1):16-26. View abstract
  7. Fu Z, Gong Y, Liegl R, Wang Z, Liu CH, Meng SS, Burnim SB, Saba NJ, Fredrick TW, Morss PC, Hellstrom A, Talukdar S, Smith LE. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017 02 14; 18(7):1606-1613. View abstract
  8. Fu Z, Meng SS, Burnim SB, Smith LE, Lo AC. Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity. Clin Exp Ophthalmol. 2017 Jul; 45(5):529-538. View abstract
  9. Gong Y, Shao Z, Fu Z, Edin ML, Sun Y, Liegl RG, Wang Z, Liu CH, Burnim SB, Meng SS, Lih FB, SanGiovanni JP, Zeldin DC, Hellström A, Smith LEH. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov; 13:201-211. View abstract
  10. Gong Y, Fu Z, Edin ML, Liu CH, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellström A, Hammock BD, Zeldin DC, Smith LE. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1919-27. View abstract
  11. Fu Z, Gong Y, Löfqvist C, Hellström A, Smith LE. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016 08; 1862(8):1392-400. View abstract
  12. Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View abstract
  13. Gong Y, Li J, Sun Y, Fu Z, Liu CH, Evans L, Tian K, Saba N, Fredrick T, Morss P, Chen J, Smith LE. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View abstract
  14. Fu Z, Nian S, Li SY, Wong D, Chung SK, Lo AC. Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2015 Sep; 253(9):1503-13. View abstract
  15. Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP, Chen J, Ley D, Hansen Pupp I, Hellstrom A, Smith LE. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View abstract
  16. Li J, Liu CH, Sun Y, Gong Y, Fu Z, Evans LP, Tian KT, Juan AM, Hurst CG, Mammoto A, Chen J. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. View abstract
  17. Shao Z, Fu Z, Stahl A, Joyal JS, Hatton C, Juan A, Hurst C, Evans L, Cui Z, Pei D, Gong Y, Xu D, Tian K, Bogardus H, Edin ML, Lih F, Sapieha P, Chen J, Panigrahy D, Hellstrom A, Zeldin DC, Smith LE. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. View abstract
  18. Lai AKW, Fu Z, Lo ACY. Stem cell therapy for retinopathy of prematurity. Anatomy & Physiology. 2013; 126(3):2161-0940. View abstract
  19. Li SY, Fu ZJ, Lo AC. Hypoxia-induced oxidative stress in ischemic retinopathy. Oxid Med Cell Longev. 2012; 2012:426769. View abstract
  20. Li SY, Fung FK, Fu ZJ, Wong D, Chan HH, Lo AC. Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro studies. Invest Ophthalmol Vis Sci. 2012 Sep 06; 53(10):5976-84. View abstract
  21. Fu ZJ, Li SY, Kociok N, Wong D, Chung SK, Lo AC. Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 Aug 20; 53(9):5698-712. View abstract
  22. Li SY, Yang D, Fu ZJ, Woo T, Wong D, Lo AC. Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiol Dis. 2012 Jan; 45(1):624-32. View abstract
  23. Li SY, Fu ZJ, Ma H, Jang WC, So KF, Wong D, Lo AC. Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):836-43. View abstract