Overview

My research and training to date highlight my commitment to advancing the field of neurosurgery. I graduated from Yale with a B.A. in political science and a focus on neurovascular research. Interested in understanding the molecular biologic basis for cerebrovascular anomalies, I studied the proteins encoded by the 3 genes known to be mutated in familial cerebral cavernous malformations-Krit1, Malcalvernin, and PDCD10 in the Gunel Lab. As a medical student at Stanford University, I studied vascular injury and repair through stem cell homing and recruitment in the Rabinovitch Lab and was then awarded a one-year Howard Hughes Research Fellowship at the NIH to focus on mesenchymal stem cell biology in the Tuan Lab. As a neurosurgery resident at Massachusetts General Hospital, my clinical interest in vascular injury and dysregulation extended beyond primary vascular pathologies to oncologic processes as well.

As a post-doctoral fellow in the Boston Children’s Vascular Biology Program at Harvard, I began formulating my research questions with a focus on bench to bedside translation. Under the mentorship of both Edward Smith, M.D. and Marsha Moses, PhD., I studied urinary biomarkers and discovered a urinary biomarker fingerprint unique to juvenile pilocytic astrocytomas. This non-invasive test serves as a potential adjunct tool for long-term clinical follow in low grade glioma. Under the same mentorship, I have studied the role of axonal guidance factors in congenital pediatric neurovascular disease and have demonstrated contributions to pathologic vascular endothelial dysfunction. This work has been presented on a national level at both the International Stroke Conference as well as the AANS/CNS Pediatric section meetings.

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PUBLICATIONS

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  1. See AP, Fehnel KP, Orbach DB, Smith ER. Microsurgical Ligation of Residual Fistulous Arteriovenous Shunt From a Radicular Artery to a Thoracic Arteriovenous Malformation: 2-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2019 Mar 15. View abstract
  2. Choi BD, Fehnel KP, Butler WE. Rare Giant Prevertebral Thoracic Myelomeningocele. World Neurosurg. 2018 Jan; 109:296-297. View abstract
  3. Pricola Fehnel K, Duggins-Warf M, Zurakowski D, McKee-Proctor M, Majumder R, Raber M, Han X, Smith ER. Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature. J Neurosurg Pediatr. 2016 Oct; 18(4):396-407. View abstract
  4. Pricola Fehnel K, Borges LF. Posterior thoracic laminoplasty with dorsal, intradural identification of ventral defect and transdural discectomy for a spontaneous cerebrospinal fluid leak: case report. J Neurosurg Spine. 2015 May; 22(5):478-82. View abstract
  5. Han X, Pricola K, Majumder R, Duggins-Warf M, Raber MR, Smith ER. Columbia softball charity award 195 urinary biomarkers identify pediatric brain tumors noninvasively and correlate with prognostic risk factors. Neurosurgery. 2014 Aug; 61 Suppl 1:225. View abstract
  6. Kim YW, Zipfel GJ, Ogilvy CS, Pricola KL, Welch BG, Shakir N, Patel B, Reavey-Cantwell JF, Kelman CR, Albuquerque FC, Kalani MY, Hoh BL. Preconditioning effect on cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. Neurosurgery. 2014 Apr; 74(4):351-8; discussion 358-9. View abstract
  7. Patil CG, Pricola K, Sarmiento JM, Garg SK, Bryant A, Black KL. Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases. Cochrane Database Syst Rev. 2012 Sep 12; (9):CD006121. View abstract
  8. Pricola KL, Zou H, Chang SD. Successful repair of a gunshot wound to the head with retained bullet in the torcular herophili. World Neurosurg. 2011 Sep-Oct; 76(3-4):362.e1-4. View abstract
  9. Pricola KL, Karamchandani J, Vogel H, Dahl GV, Yeom KW, Edwards MS, Guzman R. Langerhans cell histiocytosis in a 5-month-old presenting with biparietal masses. J Neurosurg Pediatr. 2010 Oct; 6(4):393-7. View abstract
  10. Patil CG, Pricola K, Garg SK, Bryant A, Black KL. Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases. Cochrane Database Syst Rev. 2010 Jun 16; (6):CD006121. View abstract
  11. Pricola KL, Dutta S. Stealth surgery: subcutaneous endoscopic excision of benign lesions of the trunk and lower extremity. J Pediatr Surg. 2010 Apr; 45(4):840-4. View abstract
  12. Pricola KL, Kuhn NZ, Haleem-Smith H, Song Y, Tuan RS. Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism. J Cell Biochem. 2009 Oct 15; 108(3):577-88. View abstract
  13. Tanriover G, Boylan AJ, Diluna ML, Pricola KL, Louvi A, Gunel M. PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit. Neurosurgery. 2008 Apr; 62(4):930-8; discussion 938. View abstract
  14. Spiekerkoetter E, Alvira CM, Kim YM, Bruneau A, Pricola KL, Wang L, Ambartsumian N, Rabinovitch M. Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L276-89. View abstract
  15. Seker A, Pricola KL, Guclu B, Ozturk AK, Louvi A, Gunel M. CCM2 expression parallels that of CCM1. Stroke. 2006 Feb; 37(2):518-23. View abstract
  16. Guclu B, Ozturk AK, Pricola KL, Bilguvar K, Shin D, O'Roak BJ, Gunel M. Mutations in apoptosis-related gene, PDCD10, cause cerebral cavernous malformation 3. Neurosurgery. 2005 Nov; 57(5):1008-13. View abstract
  17. Guclu B, Ozturk AK, Pricola KL, Seker A, Ozek M, Gunel M. Cerebral venous malformations have distinct genetic origin from cerebral cavernous malformations. Stroke. 2005 Nov; 36(11):2479-80. View abstract