Lab website: http://donglab.hms.harvard.edu

Researcher Services

Researcher Areas

  • botulinum neurotoxins
  • bacterial toxins
  • synaptic vesicles
  • Membrane Trafficking
  • clostridium difficile toxins
  • protein engineering and therapeutics

Research Departments

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, Doxey AC, Dong M. Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium. Cell Host Microbe. 2018 Feb 14; 23(2):169-176.e6. View abstract
  2. Zhang S, Berntsson RP, Tepp WH, Tao L, Johnson EA, Stenmark P, Dong M. Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC. Nat Commun. 2017 11 21; 8(1):1637. View abstract
  3. Huang NJ, Pishesha N, Mukherjee J, Zhang S, Deshycka R, Sudaryo V, Dong M, Shoemaker CB, Lodish HF. Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin. Nat Commun. 2017 09 04; 8(1):423. View abstract
  4. Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark P. Identification and characterization of a novel botulinum neurotoxin. Nat Commun. 2017 Aug 03; 8:14130. View abstract
  5. Tao L, Peng L, Berntsson RP, Liu SM, Park S, Yu F, Boone C, Palan S, Beard M, Chabrier PE, Stenmark P, Krupp J, Dong M. Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors. Nat Commun. 2017 07 03; 8(1):53. View abstract
  6. Ma Y, Yang AC, Duan Y, Dong M, Yeung AS. Quality and readability of online information resources on insomnia. Front Med. 2017 Sep; 11(3):423-431. View abstract
  7. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355. View abstract
  8. Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M. Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathog. 2014 Jul; 10(7):e1004177. View abstract
  9. Lü J, Yang J, Dong M, Sahin O. Nanomechanical spectroscopy of synthetic and biological membranes. Nanoscale. 2014 Jul 07; 6(13):7604-8. View abstract
  10. Zhang Z, Song J, Besenbacher F, Dong M, Gothelf KV. Self-assembly of DNA origami and single-stranded tile structures at room temperature. Angew Chem Int Ed Engl. 2013 Aug 26; 52(35):9219-23. View abstract
  11. Song J, Zhang Z, Zhang S, Liu L, Li Q, Xie E, Gothelf KV, Besenbacher F, Dong M. Isothermal hybridization kinetics of DNA assembly of two-dimensional DNA origami. Small. 2013 Sep 09; 9(17):2954-9. View abstract
  12. Zhang S, Andreasen M, Nielsen JT, Liu L, Nielsen EH, Song J, Ji G, Sun F, Skrydstrup T, Besenbacher F, Nielsen NC, Otzen DE, Dong M. Coexistence of ribbon and helical fibrils originating from hIAPP(20-29) revealed by quantitative nanomechanical atomic force microscopy. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2798-803. View abstract
  13. Peng L, Liu H, Ruan H, Tepp WH, Stoothoff WH, Brown RH, Johnson EA, Yao WD, Zhang SC, Dong M. Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival. Nat Commun. 2013; 4:1472. View abstract
  14. Pfeffer C, Larsen S, Song J, Dong M, Besenbacher F, Meyer RL, Kjeldsen KU, Schreiber L, Gorby YA, El-Naggar MY, Leung KM, Schramm A, Risgaard-Petersen N, Nielsen LP. Filamentous bacteria transport electrons over centimetre distances. Nature. 2012 Nov 08; 491(7423):218-21. View abstract
  15. Song J, Arbona JM, Zhang Z, Liu L, Xie E, Elezgaray J, Aime JP, Gothelf KV, Besenbacher F, Dong M. Direct visualization of transient thermal response of a DNA origami. J Am Chem Soc. 2012 Jun 20; 134(24):9844-7. View abstract
  16. Chen M, Gao S, Dong M, Song J, Yang C, Howard KA, Kjems J, Besenbacher F. Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery. ACS Nano. 2012 Jun 26; 6(6):4835-44. View abstract
  17. Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong M. Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. J Cell Sci. 2012 Jul 01; 125(Pt 13):3233-42. View abstract
  18. Song J, Kahveci D, Chen M, Guo Z, Xie E, Xu X, Besenbacher F, Dong M. Enhanced catalytic activity of lipase encapsulated in PCL nanofibers. Langmuir. 2012 Apr 10; 28(14):6157-62. View abstract
  19. Song J, Chen M, Olesen MB, Wang C, Havelund R, Li Q, Xie E, Yang R, Bøggild P, Wang C, Besenbacher F, Dong M. Direct electrospinning of Ag/polyvinylpyrrolidone nanocables. Nanoscale. 2011 Dec; 3(12):4966-71. View abstract
  20. Peng L, Tepp WH, Johnson EA, Dong M. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathog. 2011 Mar; 7(3):e1002008. View abstract
  21. Dong M, Sahin O. A nanomechanical interface to rapid single-molecule interactions. Nat Commun. 2011; 2:247. View abstract
  22. Liu H, Tørring T, Dong M, Rosen CB, Besenbacher F, Gothelf KV. DNA-templated covalent coupling of G4 PAMAM dendrimers. J Am Chem Soc. 2010 Dec 29; 132(51):18054-6. View abstract
  23. Michelow IC, Dong M, Mungall BA, Yantosca LM, Lear C, Ji X, Karpel M, Rootes CL, Brudner M, Houen G, Eisen DP, Kinane TB, Takahashi K, Stahl GL, Olinger GG, Spear GT, Ezekowitz RA, Schmidt EV. A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus. J Biol Chem. 2010 Aug 06; 285(32):24729-39. View abstract
  24. Dong M, Husale S, Sahin O. Determination of protein structural flexibility by microsecond force spectroscopy. Nat Nanotechnol. 2009 Aug; 4(8):514-7. View abstract