Lab Web Site:  The D'Andrea Laboratory

Research Overview

The D'Andrea laboratory is interested in the molecular events involved in normal blood cell formation and in the molecular cause of leukemia and other cancers. A major focus of the lab is the normal, physiologic activation of the cell surface receptor for erythropoietin, particularly in the early signal transduction events that follow cytokine activation, such as activation of JAK kinases and STAT transcription factors, and in later events, such as the induction of cytokine-specific genes. 

D'Andrea and colleagues have identified and cloned a family of cytokine-inducible deubiquitinating enzymes that regulate hematopoietic cell growth by controlling the ubiquitin-mediated proteolysis of intracellular growth regulatory proteins. The lab is also pursuing the molecular cause of Fanconi anemia--a human autosomal recessive disease characterized by spontaneous chromosome breakage, bone marrow failure, and cancer susceptibility. Cells from FA patients are hypersensitive to ionizing radiation (IR) and to the DNA crosslinking agent, mitomycin C (MMC). These cells have a defect in DNA repair. The researchers have isolated cDNAs corresponding to six of the eight Fanconi anemia complementation groups. 

About Alan D'Andrea

Alan D'Andrea received his MD from Harvard Medical School. He completed a residency in pediatrics at Children's Hospital of Philadelphia, a fellowship at Children's Hospital Boston and Dana-Farber Cancer Institute, and a research fellowship at the Whitehead Institute of Biomedical Research. 

Dr. D'Andrea has received the Award of Merit, Fanconi Anemia Scientific Symposium, 2002; E. Mead Johnson Award for Research in Pediatrics; Society for Pediatric Research, 2001;Scholar Award, Leukemia Society of America, 1995; Markey Scholar Award, 1990; and Excellence in Research Award, American Academy of Pediatrics, 1997.

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  • Fanconi Anemia

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