Background

Dr. Laura Cornelissen is a systems neuroscientist. Her research focuses on neuronal network dynamics underlying human brain development. She is interested in understanding the immediate and long-term impact of general anesthesia, sedation and pain exposure. Her work integrates electrophysiological

(EMG, EEG, ECG), behavioral and autonomic techniques, combined with advanced signal processing in the clinical environment. She has collaborators within the Harvard-MIT network, and academic institutions across the USA and Europe.

Dr. Laura Cornelissen received her degrees from the University of Bristol, UK (MSci Pharmacology) and University College Londonm UK (PhD in Neuroscience). She carried out her pre-doctoral training under the supervision of Professor Maria Fitzgerald in development of sensory processing pathways in the human infant. Her postdoctoral training included a fellowship at Boston Children's Hospital under the supervision of Professor Charles Berde in the application of perioperative brain monitoring and quantitative sensory testing tools. She now serves as an Instructor in Anesthesia at the Department of Anesthesiology, Critical Care & Pain Medicine at Boston Children's Hospital and Harvard Medical School.

Her publications have been cited > 300 times to date. She has spoken at International and National symposia related to Anesthesia, Pain and Pediatric Neuroscience related research innovations.

A recipient of the International Anesthesia Research Society Mentored Research Award (2015-2018), and the BCH Anesthesia Trailblazer Awards (2014, 2016), for her recent efforts in characterizing the effect of general anesthesia on the infant brain. More details on the Berde lab webpage.

Selected Publications

  1. Cornelissen L, Kim SE, Lee JM, Brown EN, Purdon PL, Berde CB. Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old. Br J Anaesth. 2018 120(6):1274-1286. https://doi.org/10.1016/j.bja.2018.01.037
  2. Cornelissen L, Bergin AM, Lobo K, Donado C, Soul JS, Berde CB. Electroencephalographic discontinuity during sevoflurane anesthesia in infants and children. Paediatr Anaesth. 2017 27(3):251-262. https://doi.org/10.1111/pan.13061
  3. Cornelissen L, Kim SE, Purdon PL, Brown EN, Berde CB. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 4:e06513. https://doi.org/10.7554/eLife.06513
  4. Lobo K, Donado C, Cornelissen L, Kim J, Ortiz R, Peake RW, Kellogg M, Alexander ME, Zurakowski D, Kurgansky KE, Peyton J, Bilge A, Boretsky K, McCann ME, Berde CB, Cravero J. A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia. Anesthesiology. 2015 123(4):873-85. https://doi.org/10.1097/ALN.0000000000000831

Researcher Services

Researcher Areas

  • Anesthesiology
  • Perioperative outcomes and Perioperative pain management
  • Pain
  • Brain Evolution

Research Divisions

Researcher Labs

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Pappas I, Cornelissen L, Menon DK, Berde CB, Stamatakis EA. d-Oscillation Correlates of Anesthesia-induced Unconsciousness in Large-scale Brain Networks of Human Infants. Anesthesiology. 2019 Dec; 131(6):1239-1253. View abstract
  2. Kim J, Hu C, Moufawad El Achkar C, Black LE, Douville J, Larson A, Pendergast MK, Goldkind SF, Lee EA, Kuniholm A, Soucy A, Vaze J, Belur NR, Fredriksen K, Stojkovska I, Tsytsykova A, Armant M, DiDonato RL, Choi J, Cornelissen L, Pereira LM, Augustine EF, Genetti CA, Dies K, Barton B, Williams L, Goodlett BD, Riley BL, Pasternak A, Berry ER, Pflock KA, Chu S, Reed C, Tyndall K, Agrawal PB, Beggs AH, Grant PE, Urion DK, Snyder RO, Waisbren SE, Poduri A, Park PJ, Patterson A, Biffi A, Mazzulli JR, Bodamer O, Berde CB, Yu TW. Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. N Engl J Med. 2019 10 24; 381(17):1644-1652. View abstract
  3. Agrawal U, Berde CB, Cornelissen L. Electroencephalographic features of discontinuous activity in anesthetized infants and children. PLoS One. 2019; 14(10):e0223324. View abstract
  4. Soffer OD, Cornelissen L, Cummings C, Berde C. Morphine compared to placebo for procedural pain in preterm infants: safety, efficacy and equipoise. J Perinatol. 2019 Oct; 39(10):1428-1431. View abstract
  5. Chini M, Gretenkord S, Kostka JK, Pöpplau JA, Cornelissen L, Berde CB, Hanganu-Opatz IL, Bitzenhofer SH. Neural Correlates of Anesthesia in Newborn Mice and Humans. Front Neural Circuits. 2019; 13:38. View abstract
  6. Gonzalez-Cano R, Boivin B, Bullock D, Cornelissen L, Andrews N, Costigan M. Up-Down Reader: An Open Source Program for Efficiently Processing 50% von Frey Thresholds. Front Pharmacol. 2018; 9:433. View abstract
  7. Cornelissen L, Kim SE, Lee JM, Brown EN, Purdon PL, Berde CB. Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old. Br J Anaesth. 2018 Jun; 120(6):1274-1286. View abstract
  8. Cornelissen L, Donado C, Lee JM, Liang NE, Mills I, Tou A, Bilge A, Berde CB. Clinical signs and electroencephalographic patterns of emergence from sevoflurane anaesthesia in children: An observational study. Eur J Anaesthesiol. 2018 01; 35(1):49-59. View abstract
  9. Cornelissen L, Bergin AM, Lobo K, Donado C, Soul JS, Berde CB. Electroencephalographic discontinuity during sevoflurane anesthesia in infants and children. Paediatr Anaesth. 2017 Mar; 27(3):251-262. View abstract
  10. Cornelissen L, Berde C. Biomedical science: Protection for anaesthetized mice. Nature. 2016 08 04; 536(7614):36-7. View abstract
  11. Poorun R, Hartley C, Goksan S, Worley A, Boyd S, Cornelissen L, Berde C, Rogers R, Ali T, Slater R. Electroencephalography during general anaesthesia differs between term-born and premature-born children. Clin Neurophysiol. 2016 Feb; 127(2):1216-1222. View abstract
  12. Lobo K, Donado C, Cornelissen L, Kim J, Ortiz R, Peake RW, Kellogg M, Alexander ME, Zurakowski D, Kurgansky KE, Peyton J, Bilge A, Boretsky K, McCann ME, Berde CB, Cravero J. A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia. Anesthesiology. 2015 Oct; 123(4):873-85. View abstract
  13. Cornelissen L, Kim SE, Purdon PL, Brown EN, Berde CB. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23; 4:e06513. View abstract
  14. Garibyan L, Cornelissen L, Sipprell W, Pruessner J, Elmariah S, Luo T, Lerner EA, Jung Y, Evans C, Zurakowski D, Berde CB, Rox Anderson R. Transient Alterations of Cutaneous Sensory Nerve Function by Noninvasive Cryolipolysis. J Invest Dermatol. 2015 Nov; 135(11):2623-2631. View abstract
  15. Cornelissen L, Donado C, Kim J, Chiel L, Zurakowski D, Logan DE, Meier P, Sethna NF, Blankenburg M, Zernikow B, Sundel RP, Berde CB. Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study. Pediatr Rheumatol Online J. 2014; 12:39. View abstract
  16. Cornelissen L, Fabrizi L, Patten D, Worley A, Meek J, Boyd S, Slater R, Fitzgerald M. Postnatal temporal, spatial and modality tuning of nociceptive cutaneous flexion reflexes in human infants. PLoS One. 2013; 8(10):e76470. View abstract
  17. Fabrizi L, Worley A, Patten D, Holdridge S, Cornelissen L, Meek J, Boyd S, Slater R. Electrophysiological measurements and analysis of nociception in human infants. J Vis Exp. 2011 Dec 20; (58). View abstract
  18. Slater R, Cornelissen L, Fabrizi L, Patten D, Yoxen J, Worley A, Boyd S, Meek J, Fitzgerald M. Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial. Lancet. 2010 Oct 09; 376(9748):1225-32. View abstract
  19. Cornelissen LL, Misajet B, Brooks DP, Hicks A. Influence of genetic background and gender on bladder function in the mouse. Auton Neurosci. 2008 Jun; 140(1-2):53-8. View abstract
  20. Cornelissen LL, Brooks DP, Wibberley A. Female, but not male, serotonin reuptake transporter (5-HTT) knockout mice exhibit bladder instability. Auton Neurosci. 2005 Oct 30; 122(1-2):107-10. View abstract