Lab Web Site:  Clapham Laboratory

Research Overview

David Clapham's research focuses on the role of calcium as an intracellular messenger and on the signals that control channels that carry calcium between cells. The identification and characterization of these ion channels may make it possible to develop drugs that alleviate cardiac arrhythmias. The amount of the calcium ion Ca2+ that is admitted to a cell has dramatic consequences for cell function. It determines the cell's motility, proliferation, transcription of genes, growth, secretion, and contraction. The amount of Ca2+ in cells is controlled more tightly than any other ion in the body. Too much, or too little, Ca2+ inside the cell causes cell death. Cell receptors and signaling pathways thus closely guard where, when, and how Ca2+ is admitted through ion channels. The current focus of Clapham's research is to understand the underlying causes of cardiac arrhythmias, through defining the role of transient receptor potential (TRP) ion channels. In humans TRP channels mediate the transmission of and response to sensory stimuli, both throughout the body and at the level of a single cell. 

About David Clapham

David Clapham received MD and PhD from Emory University. He completed his residency in Internal Medicine at Boston's Brigham and Women's Hospital and his postdoctoral fellowship at the Max Planck Institute in Goettingen, Germany. Dr. Clapham is a Howard Hughes Medical Institute Investigator and a member of the National American Academy of Arts and Sciences. He is the recipient of numerous awards and prizes, including the Cole Award for Contributions to Membrane Biophysics of the Biophysical Society, the American Society for Clinical Investigation Award for Research and Contributions to the Biomedical Community, and the American Heart Association Basic Science Award.

More on David Clapham

http://www.hhmi.org/scientists/david-e-clapham
 

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  • Electrophysiology

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PUBLICATIONS

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  1. Clapham DE. Influences: Short circuits. J Gen Physiol. 2018 Apr 02; 150(4):513-515. View abstract
  2. Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE. Structure of full-length human TRPM4. Proc Natl Acad Sci U S A. 2018 Mar 06; 115(10):2377-2382. View abstract
  3. Liu X, Vien T, Duan J, Sheu SH, DeCaen PG, Clapham DE. Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. Elife. 2018 Feb 14; 7. View abstract
  4. Krapivinsky G, Krapivinsky L, Renthal NE, Santa-Cruz A, Manasian Y, Clapham DE. Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proc Natl Acad Sci U S A. 2017 08 22; 114(34):E7092-E7100. View abstract
  5. Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6079-E6088. View abstract
  6. Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. CatSper? regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. Elife. 2017 02 23; 6. View abstract
  7. Platt CD, Chou J, Houlihan P, Badran YR, Kumar L, Bainter W, Poliani PL, Perez CJ, Dent SYR, Clapham DE, Benavides F, Geha RS. Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. J Allergy Clin Immunol. 2017 Dec; 140(6):1651-1659.e1. View abstract
  8. Pablo JL, DeCaen PG, Clapham DE. Progress in ciliary ion channel physiology. J Gen Physiol. 2017 Jan; 149(1):37-47. View abstract
  9. Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell. 2016 Oct 20; 167(3):763-773.e11. View abstract
  10. DeCaen PG, Liu X, Abiria S, Clapham DE. Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife. 2016 06 27; 5. View abstract
  11. Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. Primary cilia are not calcium-responsive mechanosensors. Nature. 2016 Mar 31; 531(7596):656-60. View abstract
  12. Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1872-80. View abstract
  13. Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA. Molecular basis of ion permeability in a voltage-gated sodium channel. EMBO J. 2016 Apr 15; 35(8):820-30. View abstract
  14. Blair NT, Philipson BI, Richards PM, Doerner JF, Segura A, Silver WL, Clapham DE. Naturally Produced Defensive Alkenal Compounds Activate TRPA1. Chem Senses. 2016 05; 41(4):281-92. View abstract
  15. Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI. The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. ACS Chem Biol. 2016 Feb 19; 11(2):452-9. View abstract
  16. Doerner JF, Delling M, Clapham DE. Ion channels and calcium signaling in motile cilia. Elife. 2015 Dec 09; 4. View abstract
  17. Clapham DE. Structural biology: Pain-sensing TRPA1 channel resolved. Nature. 2015 Apr 23; 520(7548):439-41. View abstract
  18. Cai X, Wang X, Patel S, Clapham DE. Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view. Cell Calcium. 2015 Mar; 57(3):166-73. View abstract
  19. DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus. Elife. 2014 Nov 11; 3. View abstract
  20. Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery. 2014 Aug; 61 Suppl 1:214. View abstract
  21. Cai X, Wang X, Clapham DE. Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex. Mol Biol Evol. 2014 Oct; 31(10):2735-40. View abstract
  22. Krapivinsky G, Krapivinsky L, Manasian Y, Clapham DE. The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Cell. 2014 May 22; 157(5):1061-72. View abstract
  23. Bagnéris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8428-33. View abstract
  24. Chung JJ, Shim SH, Everley RA, Gygi SP, Zhuang X, Clapham DE. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 2014 May 08; 157(4):808-22. View abstract
  25. Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. JAMA Neurol. 2014 May; 71(5):640-5. View abstract
  26. Chaudhuri D, Clapham DE. Outstanding questions regarding the permeation, selectivity, and regulation of the mitochondrial calcium uniporter. Biochem Biophys Res Commun. 2014 Jul 11; 449(4):367-9. View abstract
  27. Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J. Caspase-11 controls interleukin-1ß release through degradation of TRPC1. Cell Rep. 2014 Mar 27; 6(6):1122-1128. View abstract
  28. Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE. Decreased anxiety-like behavior and Gaq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci. 2014 Mar 05; 34(10):3653-67. View abstract
  29. Tsai MF, Jiang D, Zhao L, Clapham D, Miller C. Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1. J Gen Physiol. 2014 Jan; 143(1):67-73. View abstract
  30. DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12; 504(7479):315-8. View abstract
  31. Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12; 504(7479):311-4. View abstract
  32. Carvacho I, Lee HC, Fissore RA, Clapham DE. TRPV3 channels mediate strontium-induced mouse-egg activation. Cell Rep. 2013 Dec 12; 5(5):1375-86. View abstract
  33. Clapham DE. The mother of all endocytosis. Elife. 2013 Nov 26; 2:e01738. View abstract
  34. Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science. 2013 Dec 13; 342(6164):1379-82. View abstract
  35. Clapham DE. Sperm BerserKers. Elife. 2013 Oct 08; 2:e01469. View abstract
  36. Zeng XH, Navarro B, Xia XM, Clapham DE, Lingle CJ. Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol. 2013 Sep; 142(3):305-13. View abstract
  37. Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):E3037-46. View abstract
  38. Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME. The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. J Gen Physiol. 2013 Aug; 142(2):113-26. View abstract
  39. Chaudhuri D, Sancak Y, Mootha VK, Clapham DE. MCU encodes the pore conducting mitochondrial calcium currents. Elife. 2013 Jun 04; 2:e00704. View abstract
  40. Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 2013 Jul 09; 128(2):101-14. View abstract
  41. Jiang D, Zhao L, Clish CB, Clapham DE. Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2249-54. View abstract
  42. Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6364-9. View abstract
  43. Miki K, Clapham DE. Rheotaxis guides mammalian sperm. Curr Biol. 2013 Mar 18; 23(6):443-52. View abstract
  44. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell. 2013 Feb 14; 152(4):778-790. View abstract
  45. Lishko P, Clapham DE, Navarro B, Kirichok Y. Sperm patch-clamp. Methods Enzymol. 2013; 525:59-83. View abstract
  46. Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat Commun. 2013; 4:2465. View abstract
  47. Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, DeCaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Res. 2013 Mar; 23(3):409-22. View abstract
  48. Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 2012 Oct 12; 151(2):372-83. View abstract
  49. Stotz SC, Clapham DE. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. PLoS One. 2012; 7(10):e46865. View abstract
  50. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110. View abstract
  51. Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell. 2012 Jun 12; 22(6):1149-62. View abstract
  52. Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012 May 20; 486(7401):130-4. View abstract
  53. Kaczmarek JS, Riccio A, Clapham DE. Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7888-92. View abstract
  54. Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci. 2012 Mar 04; 15(4):565-73. View abstract
  55. Doerner JF, Febvay S, Clapham DE. Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. Nat Commun. 2012; 3:990. View abstract
  56. Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):E225-33. View abstract
  57. Clapham DE, Miller C. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19492-7. View abstract
  58. Krapivinsky G, Krapivinsky L, Stotz SC, Manasian Y, Clapham DE. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19234-9. View abstract
  59. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. Melanopsin signalling in mammalian iris and retina. Nature. 2011 Nov 02; 479(7371):67-73. View abstract
  60. Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):18114-9. View abstract
  61. Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. Annu Rev Physiol. 2012; 74:453-75. View abstract
  62. Navarro B, Miki K, Clapham DE. ATP-activated P2X2 current in mouse spermatozoa. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14342-7. View abstract
  63. Cai X, Clapham DE. Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol. 2012 Jan; 29(1):91-100. View abstract
  64. Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan 11; 2:153. View abstract
  65. Bates-Withers C, Sah R, Clapham DE. TRPM7, the Mg(2+) inhibited channel and kinase. Adv Exp Med Biol. 2011; 704:173-83. View abstract
  66. Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev. 2010 Sep; 62(3):381-404. View abstract
  67. Ramsey IS, Mokrab Y, Carvacho I, Sands ZA, Sansom MSP, Clapham DE. An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1. Nat Struct Mol Biol. 2010 Jul; 17(7):869-875. View abstract
  68. Febvay S, Marini DM, Belcher AM, Clapham DE. Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption. Nano Lett. 2010 Jun 09; 10(6):2211-9. View abstract
  69. Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE, Xu H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010 Apr 16; 141(2):331-43. View abstract
  70. Jiang D, Zhao L, Clapham DE. Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science. 2009 Oct 02; 326(5949):144-7. View abstract
  71. Zhou H, Clapham DE. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15750-5. View abstract
  72. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15; 137(4):761-72. View abstract
  73. Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE. TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal. 2009 May 12; 2(70):ra21. View abstract
  74. Blair NT, Kaczmarek JS, Clapham DE. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol. 2009 May; 133(5):525-46. View abstract
  75. Ramsey IS, Ruchti E, Kaczmarek JS, Clapham DE. Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7642-7. View abstract
  76. Clapham DE. A STIMulus Package puts orai calcium channels to work. Cell. 2009 Mar 06; 136(5):814-6. View abstract
  77. Zimmermann K, Hein A, Hager U, Kaczmarek JS, Turnquist BP, Clapham DE, Reeh PW. Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc. 2009; 4(2):174-96. View abstract
  78. Jin J, Desai BN, Navarro B, Donovan A, Andrews NC, Clapham DE. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. 2008 Oct 31; 322(5902):756-60. View abstract
  79. Cai X, Clapham DE. Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. PLoS One. 2008; 3(10):e3569. View abstract
  80. Brauchi S, Krapivinsky G, Krapivinsky L, Clapham DE. TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8304-8. View abstract
  81. Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 07; 3(5):e2082. View abstract
  82. Musset B, Cherny VV, Morgan D, Okamura Y, Ramsey IS, Clapham DE, DeCoursey TE. Detailed comparison of expressed and native voltage-gated proton channel currents. J Physiol. 2008 May 15; 586(10):2477-86. View abstract
  83. Rama S, Krapivinsky G, Clapham DE, Medina I. The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP. Mol Cell Neurosci. 2008 Jun; 38(2):183-8. View abstract
  84. Navarro B, Kirichok Y, Chung JJ, Clapham DE. Ion channels that control fertility in mammalian spermatozoa. Int J Dev Biol. 2008; 52(5-6):607-13. View abstract
  85. Clapham DE. Calcium signaling. Cell. 2007 Dec 14; 131(6):1047-58. View abstract
  86. Fujinami S, Sato T, Trimmer JS, Spiller BW, Clapham DE, Krulwich TA, Kawagishi I, Ito M. The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. Microbiology. 2007 Dec; 153(Pt 12):4027-38. View abstract
  87. Xu H, Delling M, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18321-6. View abstract
  88. Liu J, Xia J, Cho KH, Clapham DE, Ren D. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. J Biol Chem. 2007 Jun 29; 282(26):18945-52. View abstract
  89. Navarro B, Kirichok Y, Clapham DE. KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7688-92. View abstract
  90. Clapham DE. SnapShot: mammalian TRP channels. Cell. 2007 Apr 06; 129(1):220. View abstract
  91. Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1219-23. View abstract
  92. Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 2006 Dec 15; 127(6):1137-50. View abstract
  93. Krapivinsky G, Mochida S, Krapivinsky L, Cibulsky SM, Clapham DE. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron. 2006 Nov 09; 52(3):485-96. View abstract
  94. Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem. 2006 Oct 06; 281(40):29897-904. View abstract
  95. Lambers TT, Mahieu F, Oancea E, Hoofd L, de Lange F, Mensenkamp AR, Voets T, Nilius B, Clapham DE, Hoenderop JG, Bindels RJ. Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J. 2006 Jul 12; 25(13):2978-88. View abstract
  96. Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT. CACNA1H mutations in autism spectrum disorders. J Biol Chem. 2006 Aug 04; 281(31):22085-91. View abstract
  97. Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May; 9(5):628-35. View abstract
  98. Ramsey IS, Moran MM, Chong JA, Clapham DE. A voltage-gated proton-selective channel lacking the pore domain. Nature. 2006 Apr 27; 440(7088):1213-6. View abstract
  99. Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 2006 Feb 09; 439(7077):737-40. View abstract
  100. Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu Rev Physiol. 2006; 68:619-47. View abstract
  101. Oancea E, Wolfe JT, Clapham DE. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ Res. 2006 Feb 03; 98(2):245-53. View abstract
  102. Clapham DE, Garbers DL. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. Pharmacol Rev. 2005 Dec; 57(4):451-4. View abstract
  103. Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev. 2005 Dec; 57(4):427-50. View abstract
  104. Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev. 2005 Dec; 57(4):509-26. View abstract
  105. Xu H, Blair NT, Clapham DE. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci. 2005 Sep 28; 25(39):8924-37. View abstract
  106. Desai BN, Clapham DE. TRP channels and mice deficient in TRP channels. Pflugers Arch. 2005 Oct; 451(1):11-8. View abstract
  107. Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005 Jul; 37(7):739-44. View abstract
  108. Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Mol Cell Biol. 2005 Apr; 25(7):2632-43. View abstract
  109. Zhuang ZY, Xu H, Clapham DE, Ji RR. Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci. 2004 Sep 22; 24(38):8300-9. View abstract
  110. Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron. 2004 Aug 19; 43(4):563-74. View abstract
  111. Legin A, Rudnitskaya A, Clapham D, Seleznev B, Lord K, Vlasov Y. Electronic tongue for pharmaceutical analytics: quantification of tastes and masking effects. Anal Bioanal Chem. 2004 Sep; 380(1):36-45. View abstract
  112. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol. 2004 Aug; 6(8):709-20. View abstract
  113. Ito M, Xu H, Guffanti AA, Wei Y, Zvi L, Clapham DE, Krulwich TA. The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10566-71. View abstract
  114. Moran MM, Xu H, Clapham DE. TRP ion channels in the nervous system. Curr Opin Neurobiol. 2004 Jun; 14(3):362-9. View abstract
  115. Xu H, Jin J, DeFelice LJ, Andrews NC, Clapham DE. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol. 2004 Mar; 2(3):E50. View abstract
  116. Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 2004 Jan 22; 427(6972):360-4. View abstract
  117. Khositseth, A, Clapham DE, and Ackerman, M. Intracellular signaling and regulation of cardiac ion channels. Cardiac Electrophysiology. 2004; 33-41. View abstract
  118. 80. Ackerman, M, and Clapham DE. Excitability and Conduction. The Molecular Basis of Heart Disease. 2004; 311-335. View abstract
  119. Clapham DE. Symmetry, selectivity, and the 2003 Nobel Prize. Cell. 2003 Dec 12; 115(6):641-6. View abstract
  120. Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE. A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem. 2004 Mar 05; 279(10):9532-8. View abstract
  121. Clapham DE. TRP channels as cellular sensors. Nature. 2003 Dec 04; 426(6966):517-24. View abstract
  122. Clapham DE, Montell C, Schultz G, Julius D. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev. 2003 Dec; 55(4):591-6. View abstract
  123. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 2003 Dec; 55(4):583-6. View abstract
  124. Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14864-8. View abstract
  125. Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, Ben-Ari Y, Clapham DE, Medina I. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron. 2003 Nov 13; 40(4):775-84. View abstract
  126. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci. 2003 Aug; 6(8):837-45. View abstract
  127. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem. 2003 Oct 03; 278(40):39014-9. View abstract
  128. Footitt S, Ingouff M, Clapham D, von Arnold S. Expression of the viviparous 1 (Pavp1) and p34cdc2 protein kinase (cdc2Pa) genes during somatic embryogenesis in Norway spruce (Picea abies [L.] Karst). J Exp Bot. 2003 Jul; 54(388):1711-9. View abstract
  129. Oancea E, Bezzerides VJ, Greka A, Clapham DE. Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell. 2003 Apr; 4(4):561-74. View abstract
  130. Wei X, Henke VG, Strübing C, Brown EB, Clapham DE. Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophys J. 2003 Feb; 84(2 Pt 1):1317-27. View abstract
  131. Catterall, WA, Chandy, KG, Clapham, DE, Gutman, GA, Hofmann, F, Harmar, AJ, Abernethy, DR, and M. Spedding. International Union of Pharmacology: Approaches to the nomenclature of voltage-gated ion channels. Pharmacological Reviews. 2003; 55:572-574. View abstract
  132. Sandler VM, Wang S, Angelo K, Lo HG, Breakefield XO, Clapham DE. Modified herpes simplex virus delivery of enhanced GFP into the central nervous system. J Neurosci Methods. 2002 Dec 15; 121(2):211-9. View abstract
  133. Yue L, Navarro B, Ren D, Ramos A, Clapham DE. The cation selectivity filter of the bacterial sodium channel, NaChBac. J Gen Physiol. 2002 Dec; 120(6):845-53. View abstract
  134. Clapham DE. Sorting out MIC, TRP, and CRAC ion channels. J Gen Physiol. 2002 Aug; 120(2):217-20. View abstract
  135. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature. 2002 Jul 11; 418(6894):181-6. View abstract
  136. Runnels LW, Yue L, Clapham DE. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol. 2002 May; 4(5):329-36. View abstract
  137. Clapham DE. Signal transduction. Hot and cold TRP ion channels. Science. 2002 Mar 22; 295(5563):2228-9. View abstract
  138. Wickman K, Pu WT, Clapham DE. Structural characterization of the mouse Girk genes. Gene. 2002 Feb 06; 284(1-2):241-50. View abstract
  139. Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX. A unified nomenclature for the superfamily of TRP cation channels. Mol Cell. 2002 Feb; 9(2):229-31. View abstract
  140. Roberson, C, and Clapham, DE. . G protein-coupled receptor signaling through ion channels. GPCRs in the CNS- The GPCR Superfamily. 2002; 108-123. View abstract
  141. Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE. A prokaryotic voltage-gated sodium channel. Science. 2001 Dec 14; 294(5550):2372-5. View abstract
  142. Quill TA, Ren D, Clapham DE, Garbers DL. A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12527-31. View abstract
  143. Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11; 413(6856):603-9. View abstract
  144. Clapham D, Michel T, Seidman C. In memorium. J Mol Cell Cardiol. 2001 Aug; 33(8):1393-4. View abstract
  145. Kovoor P, Wickman K, Maguire CT, Pu W, Gehrmann J, Berul CI, Clapham DE. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. J Am Coll Cardiol. 2001 Jun 15; 37(8):2136-43. View abstract
  146. Clapham DE, Runnels LW, Strübing C. The TRP ion channel family. Nat Rev Neurosci. 2001 Jun; 2(6):387-96. View abstract
  147. Lindroth AM, Saarikoski P, Flygh G, Clapham D, Grönroos R, Thelander M, Ronne H, von Arnold S. Two S-adenosylmethionine synthetase-encoding genes differentially expressed during adventitious root development in Pinus contorta. Plant Mol Biol. 2001 Jun; 46(3):335-46. View abstract
  148. O'Connell PJ, Klyachko VA, Badminton MN, Thomson AW, Jackson MB, Clapham DE, Ahern GP. Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway. J Immunol. 2001 May 15; 166(10):6126-33. View abstract
  149. Yue L, Peng JB, Hediger MA, Clapham DE. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature. 2001 Apr 05; 410(6829):705-9. View abstract
  150. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron. 2001 Mar; 29(3):645-55. View abstract
  151. Runnels LW, Yue L, Clapham DE. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science. 2001 Feb 09; 291(5506):1043-7. View abstract
  152. Corey S, Clapham DE. The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs). J Biol Chem. 2001 Apr 06; 276(14):11409-13. View abstract
  153. Clapham D. How to lose your hippocampus by working on chloride channels. Neuron. 2001 Jan; 29(1):1-3. View abstract
  154. Clapham DE. . Intracellular calcium signaling. Roger Eckert Memorial Lecture. 2001. View abstract
  155. Jelacic TM, Kennedy ME, Wickman K, Clapham DE. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. J Biol Chem. 2000 Nov 17; 275(46):36211-6. View abstract
  156. Medina I, Krapivinsky G, Arnold S, Kovoor P, Krapivinsky L, Clapham DE. A switch mechanism for G beta gamma activation of I(KACh). J Biol Chem. 2000 Sep 22; 275(38):29709-16. View abstract
  157. Wickman K, Karschin C, Karschin A, Picciotto MR, Clapham DE. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. J Neurosci. 2000 Aug 01; 20(15):5608-15. View abstract
  158. Franco-Obregón A, Wang HW, Clapham DE. Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines. Biophys J. 2000 Jul; 79(1):202-14. View abstract
  159. Pu WT, Wickman K, Clapham DE. ICln is essential for cellular and early embryonic viability. J Biol Chem. 2000 Apr 28; 275(17):12363-6. View abstract
  160. Sabala I, Elfstrand M, Farbos I, Clapham D, von Arnold S. Tissue-specific expression of Pa18, a putative lipid transfer protein gene, during embryo development in Norway spruce (Picea abies). Plant Mol Biol. 2000 Feb; 42(3):461-78. View abstract
  161. Clapham DE. Remembering Eva Neer. Cell. 2000. View abstract
  162. Clapham DE. More pieces of the K+ ion channel puzzle. Nat Struct Biol. 1999 Sep; 6(9):807-10. View abstract
  163. Wang H, Clapham DE. Conformational changes of the in situ nuclear pore complex. Biophys J. 1999 Jul; 77(1):241-7. View abstract
  164. Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE. pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol. 1999 Jun; 19(6):4113-20. View abstract
  165. Clapham DE. Unlocking family secrets: K+ channel transmembrane domains. Cell. 1999 May 28; 97(5):547-50. View abstract
  166. Jelacic TM, Sims SM, Clapham DE. Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3. J Membr Biol. 1999 May 15; 169(2):123-9. View abstract
  167. Arnold DB, Clapham DE. Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. Neuron. 1999 May; 23(1):149-57. View abstract
  168. Wickman K, Krapivinsky G, Corey S, Kennedy M, Nemec J, Medina I, Clapham DE. Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh. Ann N Y Acad Sci. 1999 Apr 30; 868:386-98. View abstract
  169. Strübing C, Clapham DE. Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells. J Gen Physiol. 1999 Feb; 113(2):239-48. View abstract
  170. Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE. GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. J Biol Chem. 1999 Jan 22; 274(4):2571-82. View abstract
  171. Nemec J, Wickman K, Clapham DE. Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sites. Biophys J. 1999 Jan; 76(1 Pt 1):246-52. View abstract
  172. Ackerman, M, and Clapham DE. G proteins and ion channels. Cardiac Electrophysiology. 1999; 112-118. View abstract
  173. Navarro, B, Corey, S, Kennedy, M, and Clapham DE. G-protein-gated potassium channels: Implications for the weaver mouse. Potassium Ion Channels: Molecular Structure, Function, and Diseases. 1999; 46:295-320. View abstract
  174. Franco-Obregón A, Clapham DE. Touch channels sense blood pressure. Neuron. 1998 Dec; 21(6):1224-6. View abstract
  175. Corey S, Clapham DE. Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. J Biol Chem. 1998 Oct 16; 273(42):27499-504. View abstract
  176. Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L, Clapham DE. Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. J Biol Chem. 1998 Jul 03; 273(27):16946-52. View abstract
  177. Clapham DE. Not so funny anymore: pacing channels are cloned. Neuron. 1998 Jul; 21(1):5-7. View abstract
  178. Schiller J, Schiller Y, Clapham DE. NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation. Nat Neurosci. 1998 Jun; 1(2):114-8. View abstract
  179. Clapham DE. The list of potential volume-sensitive chloride currents continues to swell (and shrink). J Gen Physiol. 1998 May; 111(5):623-4. View abstract
  180. Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J Biol Chem. 1998 May 01; 273(18):10811-4. View abstract
  181. Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE. A novel inward rectifier K+ channel with unique pore properties. Neuron. 1998 May; 20(5):995-1005. View abstract
  182. Clapham DE. At last, the structure of an ion-selective channel. Nat Struct Biol. 1998 May; 5(5):342-4. View abstract
  183. Lorenz E, Alekseev AE, Krapivinsky GB, Carrasco AJ, Clapham DE, Terzic A. Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel. Mol Cell Biol. 1998 Mar; 18(3):1652-9. View abstract
  184. Corey S, Krapivinsky G, Krapivinsky L, Clapham DE. Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. J Biol Chem. 1998 Feb 27; 273(9):5271-8. View abstract
  185. Lee MA, Dunn RC, Clapham DE, Stehno-Bittel L. Calcium regulation of nuclear pore permeability. Cell Calcium. 1998 Feb-Mar; 23(2-3):91-101. View abstract
  186. Wickman K, Nemec J, Gendler SJ, Clapham DE. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron. 1998 Jan; 20(1):103-14. View abstract
  187. Clapham DE. Some like it hot: spicing up ion channels. Nature. 1997 Oct 23; 389(6653):783-4. View abstract
  188. Perez-Terzic C, Jaconi M, Clapham DE. Nuclear calcium and the regulation of the nuclear pore complex. Bioessays. 1997 Sep; 19(9):787-92. View abstract
  189. Jaconi M, Pyle J, Bortolon R, Ou J, Clapham D. Calcium release and influx colocalize to the endoplasmic reticulum. Curr Biol. 1997 Aug 01; 7(8):599-602. View abstract
  190. Ackerman MJ, Clapham DE. Ion channels--basic science and clinical disease. N Engl J Med. 1997 May 29; 336(22):1575-86. View abstract
  191. Perez-Terzic C, Stehno-Bittel L, Clapham DE. Nucleoplasmic and cytoplasmic differences in the fluorescence properties of the calcium indicator Fluo-3. Cell Calcium. 1997 Apr; 21(4):275-82. View abstract
  192. Wickman K, Seldin MF, James MR, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Icln gene. Genomics. 1997 Mar 15; 40(3):402-8. View abstract
  193. Wickman K, Seldin MF, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Girk4 gene. Genomics. 1997 Mar 15; 40(3):395-401. View abstract
  194. Clapham DE, Neer EJ. G protein beta gamma subunits. Annu Rev Pharmacol Toxicol. 1997; 37:167-203. View abstract
  195. Clapham DE. The molecular control of cardiac ion channels. Heart Vessels. 1997; Suppl 12:168-9. View abstract
  196. Perez-Terzic C, Pyle J, Jaconi M, Stehno-Bittel L, Clapham DE. Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores. Science. 1996 Sep 27; 273(5283):1875-7. View abstract
  197. Clapham DE. Intracellular signalling: more jobs for G beta gamma. Curr Biol. 1996 Jul 01; 6(7):814-6. View abstract
  198. Navarro B, Kennedy ME, Velimirovíc B, Bhat D, Peterson AS, Clapham DE. Nonselective and G betagamma-insensitive weaver K+ channels. Science. 1996 Jun 28; 272(5270):1950-3. View abstract
  199. Saarikoski P, Clapham D, von Arnold S. A wound-inducible gene from Salix viminalis coding for a trypsin inhibitor. Plant Mol Biol. 1996 Jun; 31(3):465-78. View abstract
  200. Aleksandrov A, Velimirovic B, Clapham DE. Inward rectification of the IRK1 K+ channel reconstituted in lipid bilayers. Biophys J. 1996 Jun; 70(6):2680-7. View abstract
  201. Clapham DE. TRP is cracked but is CRAC TRP? Neuron. 1996 Jun; 16(6):1069-72. View abstract
  202. Hedin KE, Lim NF, Clapham DE. Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes. Neuron. 1996 Feb; 16(2):423-9. View abstract
  203. Clapham DE. The G-protein nanomachine. Nature. 1996 Jan 25; 379(6563):297-9. View abstract
  204. Velimirovic BM, Gordon EA, Lim NF, Navarro B, Clapham DE. The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-gated K+ channel. FEBS Lett. 1996 Jan 22; 379(1):31-7. View abstract
  205. Kennedy ME, Nemec J, Clapham DE. Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits. Neuropharmacology. 1996; 35(7):831-9. View abstract
  206. Stehno-Bittel L, Perez-Terzic C, Luckhoff A, Clapham DE. Nuclear ion channels and regulation of the nuclear pore. Soc Gen Physiol Ser. 1996; 51:195-207. View abstract
  207. Perez-Terzic CM, Chini EN, Shen SS, Dousa TP, Clapham DE. Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. Biochem J. 1995 Dec 15; 312 ( Pt 3):955-9. View abstract
  208. Stehno-Bittel L, Krapivinsky G, Krapivinsky L, Perez-Terzic C, Clapham DE. The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes. J Biol Chem. 1995 Dec 15; 270(50):30068-74. View abstract
  209. Stehno-Bittel L, Perez-Terzic C, Clapham DE. Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store. Science. 1995 Dec 15; 270(5243):1835-8. View abstract
  210. Krapivinsky G, Krapivinsky L, Wickman K, Clapham DE. G beta gamma binds directly to the G protein-gated K+ channel, IKACh. J Biol Chem. 1995 Dec 08; 270(49):29059-62. View abstract
  211. Krapivinsky G, Krapivinsky L, Velimirovic B, Wickman K, Navarro B, Clapham DE. The cardiac inward rectifier K+ channel subunit, CIR, does not comprise the ATP-sensitive K+ channel, IKATP. J Biol Chem. 1995 Dec 01; 270(48):28777-9. View abstract
  212. Wickman K, Clapham DE. Ion channel regulation by G proteins. Physiol Rev. 1995 Oct; 75(4):865-85. View abstract
  213. Clapham DE. Intracellular calcium. Replenishing the stores. Nature. 1995 Jun 22; 375(6533):634-5. View abstract
  214. Wickman KD, Clapham DE. G-protein regulation of ion channels. Curr Opin Neurobiol. 1995 Jun; 5(3):278-85. View abstract
  215. Krapivinsky G, Gordon EA, Wickman K, Velimirovic B, Krapivinsky L, Clapham DE. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 1995 Mar 09; 374(6518):135-41. View abstract
  216. Hedin KE, Appleby MW, Clapham DE. Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes. Immunology. 1995 Feb; 84(2):183-92. View abstract
  217. Clapham DE. Calcium signaling. Cell. 1995 Jan 27; 80(2):259-68. View abstract
  218. Stehno-Bittel L, Lückhoff A, Clapham DE. Calcium release from the nucleus by InsP3 receptor channels. Neuron. 1995 Jan; 14(1):163-7. View abstract
  219. Clapham DE, Sneyd J. Intracellular calcium waves. Adv Second Messenger Phosphoprotein Res. 1995; 30:1-24. View abstract
  220. Clapham DE. Signal transduction. Why testicles are cool. Nature. 1994 Sep 08; 371(6493):109-10. View abstract
  221. Lückhoff A, Clapham DE. Calcium channels activated by depletion of internal calcium stores in A431 cells. Biophys J. 1994 Jul; 67(1):177-82. View abstract
  222. Wickman KD, Iñiguez-Lluhl JA, Davenport PA, Taussig R, Krapivinsky GB, Linder ME, Gilman AG, Clapham DE. Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature. 1994 Mar 17; 368(6468):255-7. View abstract
  223. Krapivinsky GB, Ackerman MJ, Gordon EA, Krapivinsky LD, Clapham DE. Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICln. Cell. 1994 Feb 11; 76(3):439-48. View abstract
  224. Ackerman MJ, Wickman KD, Clapham DE. Hypotonicity activates a native chloride current in Xenopus oocytes. J Gen Physiol. 1994 Feb; 103(2):153-79. View abstract
  225. Girard S, Clapham DE. Simultaneous near ultraviolet and visible excitation confocal microscopy of calcium transients in Xenopus oocytes. Methods Cell Biol. 1994; 40:263-84. View abstract
  226. Clapham DE. Direct G protein activation of ion channels? Annu Rev Neurosci. 1994; 17:441-64. View abstract
  227. Stehno-Bittel L, Amundson J, Clapham D. G-protein-mediated pathways assayed by electrophysiology and confocal microscopy. Methods Enzymol. 1994; 238:321-35. View abstract
  228. Ackerman MJ, Krapivinsky GB, Gordon E, Krapivinsky L, Clapham DC. Characterization of a native swelling-induced chloride current, ICl.swell, and its regulatory protein, pICln, in Xenopus oocytes. Jpn J Physiol. 1994; 44 Suppl 2:S17-24. View abstract
  229. Clapham DE. Mutations in G protein-linked receptors: novel insights on disease. Cell. 1993 Dec 31; 75(7):1237-9. View abstract
  230. Chris Bliton, James Lechleiter, and David Clapham. Confocal imaging system for visible and ultraviolet light. 1993. View abstract
  231. Atri A, Amundson J, Clapham D, Sneyd J. A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte. Biophys J. 1993 Oct; 65(4):1727-39. View abstract
  232. Clapham DE, Neer EJ. New roles for G-protein beta gamma-dimers in transmembrane signalling. Nature. 1993 Sep 30; 365(6445):403-6. View abstract
  233. Hedin KE, Duerson K, Clapham DE. Specificity of receptor-G protein interactions: searching for the structure behind the signal. Cell Signal. 1993 Sep; 5(5):505-18. View abstract
  234. Clapham DE. Cellular calcium. A mysterious new influx factor? Nature. 1993 Aug 26; 364(6440):763-4. View abstract
  235. Clapham DE. Reply. Trends Cardiovasc Med. 1993 Jul-Aug; 3(4):114. View abstract
  236. Duerson K, Carroll R, Clapham D. Alpha-helical distorting substitution disrupt coupling between m3 muscarinic receptor and G proteins. FEBS Lett. 1993 Jun 07; 324(1):103-8. View abstract
  237. Amundson J, Clapham D. Calcium waves. Curr Opin Neurobiol. 1993 Jun; 3(3):375-82. View abstract
  238. Girard S, Clapham D. Acceleration of intracellular calcium waves in Xenopus oocytes by calcium influx. Science. 1993 Apr 09; 260(5105):229-32. View abstract
  239. Sneyd J, Girard S, Clapham D. Calcium wave propagation by calcium-induced calcium release: an unusual excitable system. Bull Math Biol. 1993 Mar; 55(2):315-44. View abstract
  240. Ackerman MJ, Clapham DE. Cardiac chloride channels. Trends Cardiovasc Med. 1993 Jan-Feb; 3(1):23-8. View abstract
  241. Clapham DE, Lechleiter JD, Girard S. Intracellular waves observed by confocal microscopy from Xenopus oocytes. Adv Second Messenger Phosphoprotein Res. 1993; 28:161-5. View abstract
  242. Lechleiter JD, Clapham DE. Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes. Cell. 1992 Apr 17; 69(2):283-94. View abstract
  243. Paulmichl M, Li Y, Wickman K, Ackerman M, Peralta E, Clapham D. New mammalian chloride channel identified by expression cloning. Nature. 1992 Mar 19; 356(6366):238-41. View abstract
  244. Girard S, Lückhoff A, Lechleiter J, Sneyd J, Clapham D. Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes. Biophys J. 1992 Feb; 61(2):509-17. View abstract
  245. Lückhoff A, Clapham DE. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca(2+)-permeable channel. Nature. 1992 Jan 23; 355(6358):356-8. View abstract
  246. Lechleiter JD, Clapham DE. Spiral waves and intracellular calcium signalling. J Physiol Paris. 1992; 86(1-3):123-8. View abstract
  247. Neer EJ, Clapham DE. Signal transduction through G proteins in the cardiac myocyte. Trends Cardiovasc Med. 1992 Jan-Feb; 2(1):6-11. View abstract
  248. Wallert MA, Ackerman MJ, Kim D, Clapham DE. Two novel cardiac atrial K+ channels, IK.AA and IK.PC. J Gen Physiol. 1991 Nov; 98(5):921-39. View abstract
  249. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, Clapham DE. Cloning and expression of a rat cardiac delayed rectifier potassium channel. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7892-5. View abstract
  250. Tabares L, Mazzanti M, Clapham DE. Chloride channels in the nuclear membrane. J Membr Biol. 1991 Jul; 123(1):49-54. View abstract
  251. Lechleiter J, Girard S, Clapham D, Peralta E. Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors. Nature. 1991 Apr 11; 350(6318):505-8. View abstract
  252. Lechleiter J, Girard S, Peralta E, Clapham D. Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes. Science. 1991 Apr 05; 252(5002):123-6. View abstract
  253. Lechleiter J, Hellmiss R, Duerson K, Ennulat D, David N, Clapham D, Peralta E. Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. EMBO J. 1990 Dec; 9(13):4381-90. View abstract
  254. Lewis DL, Lechleiter JD, Kim D, Nanavati C, Clapham DE. Intracellular regulation of ion channels in cell membranes. Mayo Clin Proc. 1990 Aug; 65(8):1127-43. View abstract
  255. Clapham DE. Arachidonic acid and its metabolites in the regulation of G-protein gated K+ channels in atrial myocytes. Biochem Pharmacol. 1990 Mar 01; 39(5):813-5. View abstract
  256. Nanavati C, Clapham DE, Ito H, Kurachi Y. A comparison of the roles of purified G protein subunits in the activation of the cardiac muscarinic K+ channel. Soc Gen Physiol Ser. 1990; 45:29-41. View abstract
  257. Lechleiter J, Peralta E, Clapham D. Diverse functions of muscarinic acetylcholine receptor subtypes. Trends Pharmacol Sci. 1989 Dec; Suppl:34-8. View abstract
  258. Lewis DL, Clapham DE. Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells. Pflugers Arch. 1989 Aug; 414(4):492-4. View abstract
  259. Kim D, Clapham DE. Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. Science. 1989 Jun 09; 244(4909):1174-6. View abstract
  260. Kim D, Lewis DL, Graziadei L, Neer EJ, Bar-Sagi D, Clapham DE. G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature. 1989 Feb 09; 337(6207):557-60. View abstract
  261. Clapham DE, Kim D. G protein activation mechanisms of the cardiac K+ channel, iK.ACh. Soc Gen Physiol Ser. 1989; 44:55-68. View abstract
  262. Logothetis DE, Kim DH, Northup JK, Neer EJ, Clapham DE. Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):5814-8. View abstract
  263. Clapham D, Neer E. Activation of atrial muscarinic-gated K+ channels by beta gamma-subunits of G proteins. Am J Physiol. 1988 Jun; 254(6 Pt 2):H1224. View abstract
  264. Davies PF, Olesen SP, Clapham DE, Morrel EM, Schoen FJ. Endothelial communication. State of the art lecture. Hypertension. 1988 Jun; 11(6 Pt 2):563-72. View abstract
  265. Olesen SP, Davies PF, Clapham DE. Muscarinic-activated K+ current in bovine aortic endothelial cells. Circ Res. 1988 Jun; 62(6):1059-64. View abstract
  266. Neer EJ, Clapham DE. Roles of G protein subunits in transmembrane signalling. Nature. 1988 May 12; 333(6169):129-34. View abstract
  267. Fish RD, Sperti G, Colucci WS, Clapham DE. Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line. Circ Res. 1988 May; 62(5):1049-54. View abstract
  268. Olesen SP, Clapham DE, Davies PF. Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature. 1988 Jan 14; 331(6152):168-70. View abstract
  269. Clapham DE, Logothetis DE. Delayed rectifier K+ current in embryonic chick heart ventricle. Am J Physiol. 1988 Jan; 254(1 Pt 2):H192-7. View abstract
  270. Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature. 1987 Jan 22-28; 325(6102):321-6. View abstract
  271. Bormann J, Clapham DE. gamma-Aminobutyric acid receptor channels in adrenal chromaffin cells: a patch-clamp study. Proc Natl Acad Sci U S A. 1985 Apr; 82(7):2168-72. View abstract
  272. Clapham DE, Neher E. Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells. J Physiol. 1984 Aug; 353:541-64. View abstract
  273. Ypey DL, Clapham DE. Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages. Proc Natl Acad Sci U S A. 1984 May; 81(10):3083-7. View abstract
  274. Clapham DE, Neher E. Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. J Physiol. 1984 Feb; 347:255-77. View abstract
  275. Clapham DE, Defelice LJ. Voltage-activated k channels in embryonic chick heart. Biophys J. 1984 Jan; 45(1):40-2. View abstract
  276. Clapham DE, DeFelice LJ. Small signal impedance of heart cell membranes. J Membr Biol. 1982; 67(1):63-71. View abstract
  277. Clapham DE, Shrier A, DeHaan RL. Junctional resistance and action potential delay between embryonic heart cell aggregates. J Gen Physiol. 1980 Jun; 75(6):633-54. View abstract
  278. Ypey DL, Clapham DE, DeHaan RL. Development of electrical coupling and action potential synchrony between paired aggregates of embryonic heart cells. J Membr Biol. 1979 Dec 12; 51(1):75-96. View abstract
  279. Clapham DE, De Felice LJ. The theoretical small signal impedance of the frog node, Rana pipiens. Pflugers Arch. 1976 Nov 05; 366(2-3):273-6. View abstract