Research Overview

Dr. Chen's research concerns the molecular mechanisms of HIV (human immunodeficiency virus) entry -- how HIV enters host cells and how the viral envelope protein interacts with host cellular receptors. The goal is to obtain a structurally accurate “molecular movie” of viral entry and to establish an in vitro system to recapitulate the viral membrane fusion process for mechanistic investigations at the molecular level. Insights gained from these studies will lead to a much deeper understanding of the mechanisms of viral entry and antibody neutralization and will also guide development of vaccines and therapeutics against HIV infection.

About the Researcher

Dr. Chen received his PhD from Ohio State University and received his postgraduate training at Children's Hospital Boston and Harvard Medical School.

Researcher Services

Researcher Areas

  • Molecular Mechanisms of HIV (human immunodeficiency virus) Entry

Research Departments

Research Divisions

PUBLICATIONS

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  1. Chen B. Molecular Mechanism of HIV-1 Entry. Trends Microbiol. 2019 Jun 28. View abstract
  2. Goodwin PJ, Parulekar WR, Gelmon KA, Shepherd LE, Ligibel JA, Hershman DL, Rastogi P, Mayer IA, Hobday TJ, Lemieux J, Thompson AM, Pritchard KI, Whelan TJ, Mukherjee SD, Chalchal HI, Oja CD, Tonkin KS, Bernstein V, Chen BE, Stambolic V. Effect of metformin vs placebo on and metabolic factors in NCIC CTG MA.32. J Natl Cancer Inst. 2015 Mar; 107(3). View abstract