Research Overview

Dr. Brennan-Krohn’s research involves the evaluation of antimicrobial combinations for synergistic activity against multidrug-resistant Gram-negative bacteria, specifically carbapenem-resistant Enterobacteriaceae (CRE). These pathogens, which are increasing in frequency worldwide, are very challenging to treat and tend to affect patients critically ill patients, in whom antibiotic selection may be complicated by factors including underlying illness and drug-drug interactions. Combination therapy is frequently used to treat such infections, with the goal of achieving synergistic activity between two drugs, but much remains to be understood about the mechanisms of action of antimicrobial combinations and about how to determine which combinations, if any, are likely to be effective against which pathogens. Dr. Brennan-Krohn’s research aims to identify promising combination regimens and to improve diagnostic methods for synergy testing.

About Thea Brennan-Krohn

Dr. Brennan-Krohn earned her BA in Classics from Brown University and her MD from Stanford University School of Medicine, then completed a Pediatrics residency and pediatric Infectious Diseases fellowship at Boston Children’s Hospital. She also completed a medical microbiology fellowship at Beth Israel Deaconess Medical Center and is a diplomate of the American Board of Medical Microbiology. Dr. Brennan-Krohn joined the division of Infectious Diseases as faculty in 2017. Her research is performed in the laboratory of Dr. James Kirby at Beth Israel Deaconess Medical Center.


Researcher Services

Researcher Areas

  • Antibiotic synergy
  • Antimicrobial resistance

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Brennan-Krohn T, Pironti A, Kirby JE. Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2018 Oct; 62(10). View abstract
  2. Truelson KA, Brennan-Krohn T, Smith KP, Kirby JE. Evaluation of apramycin activity against methicillin-resistant, methicillin-sensitive, and vancomycin-intermediate Staphylococcus aureus clinical isolates. Diagn Microbiol Infect Dis. 2018 Oct; 92(2):168-171. View abstract
  3. Brennan-Krohn T, Ozonoff A, Sandora TJ. Adherence to guidelines for testing and treatment of children with pharyngitis: a retrospective study. BMC Pediatr. 2018 02 09; 18(1):43. View abstract
  4. Brennan-Krohn T, Truelson KA, Smith KP, Kirby JE. Screening for synergistic activity of antimicrobial combinations against carbapenem-resistant Enterobacteriaceae using inkjet printer-based technology. J Antimicrob Chemother. 2017 10 01; 72(10):2775-2781. View abstract
  5. Smith KP, Richmond DL, Brennan-Krohn T, Elliott HL, Kirby JE. Development of MAST: A Microscopy-Based Antimicrobial Susceptibility Testing Platform. SLAS Technol. 2017 12; 22(6):662-674. View abstract
  6. Brennan-Krohn T, Yoon E, Nishino M, Kirby JE, Riedel S. Arthroconidia in lung tissue: an unusual histopathological finding in pulmonary coccidioidomycosis. Hum Pathol. 2018 01; 71:55-59. View abstract
  7. Brennan-Krohn T, Smith KP, Kirby JE. The Poisoned Well: Enhancing the Predictive Value of Antimicrobial Susceptibility Testing in the Era of Multidrug Resistance. J Clin Microbiol. 2017 08; 55(8):2304-2308. View abstract
  8. Smith KP, Brennan-Krohn T, Weir S, Kirby JE. Improved Accuracy of Cefepime Susceptibility Testing for Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae with an On-Demand Digital Dispensing Method. J Clin Microbiol. 2017 02; 55(2):470-478. View abstract
  9. Brennan-Krohn T, Pica N, Sandora TJ, McAdam A. The Brief Case: Safe To Go Back in the Water? Vibrio parahaemolyticus Wound Infection Associated with Brackish Water. J Clin Microbiol. 2016 06; 54(6):1414-1415. View abstract
  10. Brennan-Krohn T, Pica N, Sandora TJ, McAdam A. Closing the Brief Case: Safe To Go Back in the Water? Vibrio parahaemolyticus Wound Infection Associated with Brackish Water. J Clin Microbiol. 2016 06; 54(6):1672. View abstract
  11. Brennan-Krohn T, Salloway S, Correia S, Dong M, de la Monte SM. Glial vascular degeneration in CADASIL. J Alzheimers Dis. 2010; 21(4):1393-402. View abstract
  12. Grant JE, Correia S, Brennan-Krohn T, Malloy PF, Laidlaw DH, Schulz SC. Frontal white matter integrity in borderline personality disorder with self-injurious behavior. J Neuropsychiatry Clin Neurosci. 2007; 19(4):383-90. View abstract
  13. Grant JE, Correia S, Brennan-Krohn T. White matter integrity in kleptomania: a pilot study. Psychiatry Res. 2006 Oct 30; 147(2-3):233-7. View abstract