Research Overview

Terry Buchmiller's investigations utilize fetal models for in utero studies of congenital abnormalities. Areas of interest include the surgical implantation of amniotic fluid catheters for supplementation studies in two different arenas. The first involves a fetal rabbit model of in uterine growth retardation (IUGR). Experimental amniotic fluid supplementation with hormones including EGF and gastrin has successfully reversed IUGR by increasing small intestinal nutrient absorption. 

Current studies are underway to elucidate the molecular events controlling these mechanisms. The second involves a large animal model in which we have created mid-gestational obstructive uropathy by both urachal and bladder outlet ligation in fetal sheep, resulting in Potter’s syndrome with subsequent oligohydramnios and pulmonary hypoplasia. Implanted amniotic fluid catheters are used to reconstitute the amniotic fluid during the remainder of gestation. We have reversed the detrimental effects on pulmonary growth by this intra-amniotic supplementation. Additionally we have examined the working collaborative with Dr. Dario Fauza in examining the effect on renal function and potential predictive urinary markers of renal dysfunction. 

Major research goals: Understand the mechanisms underlying fetal small bowel nutrient transport and motility. Define the role of epidermal growth factor in fetal gut development. Design in utero treatments for intrauterine growth retardation utilizing amniotic fluid supplementation. Validate a fetal model of obstructive uropathy with resultant pulmonary hypoplasia which is reversible with amniotic fluid supplementation. 

About Terry Buchmiller

  • MD, University of California, Davis 1988
  • Intern in Surgery, UCLA Medical Center, Los Angeles, CA 1988-1989
  • Resident in Surgery, UCLA Medical Center, Los Angeles, CA 1989-1995
  • Research Fellow, Division of Pediatric Surgery, UCLA Medical Center, Los Angeles, CA  1990-1992
  • Associate Chief Resident in Pediatric Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA 1995-1996
  • Chief Resident in Pediatric Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA 1996-1997

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  1. Tracy S, Buchmiller TL, Ben-Ishay O, Barnewolt CE, Connolly SA, Zurakowski D, Phelps A, Estroff JA. The Distended Fetal Hypopharynx: A Sensitive and Novel Sign for the Prenatal Diagnosis of Esophageal Atresia. J Pediatr Surg. 2018 Jun; 53(6):1137-1141. View abstract
  2. Shieh HF, Barnewolt CE, Wilson JM, Zurakowski D, Connolly SA, Estroff JA, Zalieckas J, Smithers CJ, Buchmiller TL. Percent predicted lung volume changes on fetal magnetic resonance imaging throughout gestation in congenital diaphragmatic hernia. J Pediatr Surg. 2017 Jun; 52(6):933-937. View abstract
  3. Alexander P, Fynn-Thompson F, Buchmiller T, Porras D, Marshall A, Thiagarajan R, Arnold J. 1629: LIQUID FLUOROCARBON LAVAGE FOR AIRWAY THROMBUS AFTER SEVERE HEMOPTYSIS REQUIRING ECMO. Crit Care Med. 2016 Dec; 44(12 Suppl 1):482. View abstract
  4. Shieh HF, Wilson JM, Sheils CA, Smithers CJ, Kharasch VS, Becker RE, Studley M, Morash D, Buchmiller TL. Does the ex utero intrapartum treatment to extracorporeal membrane oxygenation procedure change morbidity outcomes for high-risk congenital diaphragmatic hernia survivors? J Pediatr Surg. 2017 Jan; 52(1):22-25. View abstract
  5. Wolf LL, Nijagal A, Flores A, Buchmiller TL. Late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature. Pediatr Surg Int. 2016 Oct; 32(10):1013-6. View abstract
  6. Baird CW, Prabhu S, Buchmiller TL, Smithers C, Jennings R. Direct Tracheobronchopexy and Posterior Descending Aortopexy for Severe Left Mainstem Bronchomalacia Associated With Congenital Pulmonary Airway Malformation and Left Circumflex Aortic Arch. Ann Thorac Surg. 2016 Jul; 102(1):e1-4. View abstract
  7. Ardestani A, Sheu EG, Nepomnayshy D, Rubin MS, Buchmiller TL, Jaklitsch MT, Tavakkoli A. Surgical skills competitions at ACS chapter meetings can increase resident engagement. Bull Am Coll Surg. 2016 May; 101(5):44-5. View abstract
  8. Lally KP, Lasky RE, Lally PA, Bagolan P, Davis CF, Frenckner BP, Hirschl RM, Langham MR, Buchmiller TL, Usui N, Tibboel D, Wilson JM. Standardized reporting for congenital diaphragmatic hernia--an international consensus. J Pediatr Surg. 2013 Dec; 48(12):2408-15. View abstract
  9. Brown SD, Donelan K, Martins Y, Sayeed SA, Mitchell C, Buchmiller TL, Burmeister K, Ecker JL. Does professional orientation predict ethical sensitivities? Attitudes of paediatric and obstetric specialists toward fetuses, pregnant women and pregnancy termination. J Med Ethics. 2014 Feb; 40(2):117-22. View abstract
  10. Ben-Ishay O, Connolly SA, Buchmiller TL. Multiple duplication cysts diagnosed prenatally: case report and review of the literature. Pediatr Surg Int. 2013 Apr; 29(4):397-400. View abstract
  11. Ben-Ishay O, Johnson VM, Wilson JM, Buchmiller TL. Congenital diaphragmatic hernia associated with esophageal atresia: incidence, outcomes, and determinants of mortality. J Am Coll Surg. 2013 Jan; 216(1):90-95.e2. View abstract
  12. Brown SD, Donelan K, Martins Y, Burmeister K, Buchmiller TL, Sayeed SA, Mitchell C, Ecker JL. Differing attitudes toward fetal care by pediatric and maternal-fetal medicine specialists. Pediatrics. 2012 Dec; 130(6):e1534-40. View abstract
  13. Ben-Ishay O, Nicksa GA, Wilson JM, Buchmiller TL. Management of giant congenital pulmonary airway malformations requiring pneumonectomy. Ann Thorac Surg. 2012 Oct; 94(4):1073-8. View abstract
  14. Stoffan AP, Wilson JM, Jennings RW, Wilkins-Haug LE, Buchmiller TL. Does the ex utero intrapartum treatment to extracorporeal membrane oxygenation procedure change outcomes for high-risk patients with congenital diaphragmatic hernia? J Pediatr Surg. 2012 Jun; 47(6):1053-7. View abstract
  15. Brown SD, Ecker JL, Ward JR, Halpern EF, Sayeed SA, Buchmiller TL, Mitchell C, Donelan K. Prenatally diagnosed fetal conditions in the age of fetal care: does who counsels matter? Am J Obstet Gynecol. 2012 May; 206(5):409.e1-11. View abstract
  16. Nicksa GA, Yu DC, Kalish BT, Klein JD, Turner CG, Zurakowski D, Barnewolt CE, Fauza DO, Buchmiller TL. Serial amnioinfusions prevent fetal pulmonary hypoplasia in a large animal model of oligohydramnios. J Pediatr Surg. 2011 Jan; 46(1):67-71. View abstract
  17. Beuling E, Kerkhof IM, Nicksa GA, Giuffrida MJ, Haywood J, aan de Kerk DJ, Piaseckyj CM, Pu WT, Buchmiller TL, Dawson PA, Krasinski SD. Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine. Gut. 2010 Jul; 59(7):888-95. View abstract
  18. Nicksa GA, O'Neil E, Yu DC, Curatolo AS, McNeish BL, Barnewolt CE, Zurakowski D, Buchmiller TL, Moses MA, Rosen S, Fauza DO. Correlation between prenatal urinary matrix metalloproteinase activity and the degree of kidney damage in a large animal model of congenital obstructive uropathy. J Pediatr Surg. 2010 Jun; 45(6):1120-5. View abstract
  19. Nicksa GA, Yu DC, Curatolo AS, McNeish BL, Barnewolt CE, Valim C, Buchmiller TL, Moses MA, Fauza DO. Prenatal urinary matrix metalloproteinase profiling as a potential diagnostic tool in fetal obstructive uropathy. J Pediatr Surg. 2010 Jan; 45(1):70-3. View abstract
  20. Nicksa GA, Christensen EP, Buchmiller TL. A case report of a congenital left subcostal hernia in a neonate. J Pediatr Surg. 2009 Aug; 44(8):1653-5. View abstract
  21. Nicksa GA, Pigula FA, Giuffrida MJ, Buchmiller TL. Removal of a sewing needle from an occult esophageal ingestion in a 9-month-old. J Pediatr Surg. 2009 Jul; 44(7):1450-3. View abstract
  22. Alomari AI, Chaudry G, Fox VL, Fishman SJ, Buchmiller TL. Atypical manifestation of patent ductus venosus in a child: intervening against a paradoxical presentation. J Vasc Interv Radiol. 2009 Apr; 20(4):537-42. View abstract
  23. Waters KJ, Levine D, Lee EY, Buonomo C, Buchmiller TL. Segmental dilatation of the ileum: diagnostic clarification by prenatal and postnatal imaging. J Ultrasound Med. 2007 Sep; 26(9):1251-6. View abstract
  24. Kunisaki SM, Barnewolt CE, Estroff JA, Myers LB, Fauza DO, Wilkins-Haug LE, Grable IA, Ringer SA, Benson CB, Nemes LP, Morash D, Buchmiller TL, Wilson JM, Jennings RW. Ex utero intrapartum treatment with extracorporeal membrane oxygenation for severe congenital diaphragmatic hernia. J Pediatr Surg. 2007 Jan; 42(1):98-104; discussion 104-6. View abstract
  25. Cellini C, Xu J, Buchmiller TL. Effect of esophageal ligation on small intestinal development in normal and growth-retarded fetal rabbits. J Pediatr Gastroenterol Nutr. 2006 Sep; 43(3):291-8. View abstract
  26. Buchmiller TL. Intercostal lung hernia in a 7-year-old boy. J Pediatr Surg. 2005 Sep; 40(9):1508-9. View abstract
  27. Sase M, Lee JJ, Ross MG, Buchmiller TL. Maternal steroid enhancement of fetal rabbit gastrointestinal motility. J Obstet Gynaecol Res. 2005 Jun; 31(3):263-7. View abstract
  28. Cellini C, Xu J, Arriaga A, Buchmiller-Crair TL. Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development. J Pediatr Surg. 2004 Jun; 39(6):891-7; discussion 891-7. View abstract
  29. Oyachi N, Acosta R, Cho MH, Atkinson JB, Buchmiller-Crair TL, Ross MG. Ontogeny of cholinergic regulation of fetal upper gastrointestinal motility. J Matern Fetal Neonatal Med. 2003 Aug; 14(2):102-6. View abstract
  30. Thakur A, Yang I, Lin A, Buchmiller-Crair T, Fonkalsrud EW. Management of ovarian cysts in women undergoing restorative proctocolectomy for ulcerative colitis. Am Surg. 2003 Apr; 69(4):339-42. View abstract
  31. Buchmiller-Crair TL. Initial presentation of coccidioidomycosis during inguinal herniorrhaphy. Hernia. 2003 Jun; 7(2):92-4. View abstract
  32. Acosta R, Lee JJ, Oyachi N, Buchmiller-Crair TL, Atkinson JB, Ross MG. Anticholinergic suppression of fetal rabbit upper gastrointestinal motility. J Matern Fetal Neonatal Med. 2002 Mar; 11(3):153-7. View abstract
  33. Thakur A, Fedorka P, Ko C, Buchmiller-Crair TL, Atkinson JB, Fonkalsrud EW. Impact of mentor guidance in surgical career selection. J Pediatr Surg. 2001 Dec; 36(12):1802-4. View abstract
  34. Sase M, Lee JJ, Park JY, Thakur A, Ross MG, Buchmiller-Crair TL. Ontogeny of fetal rabbit upper gastrointestinal motility. J Surg Res. 2001 Nov; 101(1):68-72. View abstract
  35. Buchmiller-Crair TL, Gregg JP, Rivera FA, Choi RS, Diamond JM, Fonkalsrud EW. Delayed disaccharidase development in a rabbit model of intrauterine growth retardation. Pediatr Res. 2001 Oct; 50(4):520-4. View abstract
  36. Thakur A, Buchmiller T, Hiyama D, Shaw A, Atkinson J. Scrotal abscess following appendectomy. Pediatr Surg Int. 2001 Sep; 17(7):569-71. View abstract
  37. Buchmiller-Crair TL, Kim CS, Won NH, Chopourian HL, Shaw KS, Fonkalsrud EW. Effect of acute anemia on the healing of intestinal anastomoses in the rabbit. J Trauma. 2001 Aug; 51(2):363-8. View abstract
  38. Sase M, Lee JJ, Ross MG, Buchmiller-Crair TL. Effect of hypoxia on fetal rabbit gastrointestinal motility. J Surg Res. 2001 Aug; 99(2):347-51. View abstract
  39. Thakur A, Lansford R, Thakur V, Narone JN, Atkinson JB, Buchmiller-Crair T, Fraser SE. Gene transfer to the embryo: strategies for the delivery and expression of proteins at 48 to 56 hours postfertilization. J Pediatr Surg. 2001 Aug; 36(8):1304-7. View abstract
  40. Thakur A, Fonkalsrud EW, Buchmiller T, French S. Surgical treatment of severe colonic inertia with restorative proctocolectomy. Am Surg. 2001 Jan; 67(1):36-40. View abstract
  41. Thakur A, Buchmiller T, Atkinson J. Bronchial perforation after closed-tube endotracheal suction. J Pediatr Surg. 2000 Sep; 35(9):1353-5. View abstract
  42. Thakur A, Sase M, Lee JJ, Thakur V, Buchmiller TL. Ontogeny of insulin-like growth factor 1 in a rabbit model of growth retardation. J Surg Res. 2000 Jun 15; 91(2):135-40. View abstract
  43. Thakur A, Sase M, Lee JJ, Thakur V, Buchmiller TL. Effect of dexamethasone on insulin-like growth factor-1 expression in a rabbit model of growth retardation. J Pediatr Surg. 2000 Jun; 35(6):898-904; discussion 904-5. View abstract
  44. Thakur A, Thakur V, Fonkalsrud EW, Singh S, Buchmiller TL. The outcome of research training during surgical residency. J Surg Res. 2000 May 01; 90(1):10-2. View abstract
  45. Kling K, Applebaum H, Dunn J, Buchmiller T, Atkinson J. A novel technique for correction of intestinal atresia at the ligament of Treitz. J Pediatr Surg. 2000 Feb; 35(2):353-5; discussion 356. View abstract
  46. Wu SS, Buchmiller TL, Close P, Gershman GB, Peng SK, French SW. Congenital gastrointestinal pacemaker cell tumor. Arch Pathol Lab Med. 1999 Sep; 123(9):842-5. View abstract
  47. Braun RA, Buchmiller TL, Khankhanian N. Pulmonary arteriovenous malformation complicating coccidioidal pneumonia. Ann Thorac Surg. 1995 Aug; 60(2):454-7. View abstract
  48. Buchmiller TL, Shaw KS, Lam ML, Stokes R, Diamond JS, Fonkalsrud EW. Effect of prenatal dexamethasone administration: fetal rabbit intestinal nutrient uptake and disaccharidase development. J Surg Res. 1994 Aug; 57(2):274-9. View abstract
  49. Buchmiller TL, Kim CS, Chopourian HL, Fonkalsrud EW. Transamniotic fetal feeding: enhancement of growth in a rabbit model of intrauterine growth retardation. Surgery. 1994 Jul; 116(1):36-41. View abstract
  50. Shaw K, Buchmiller TL, Curr M, Lam MM, Habib R, Chopourian HL, Diamond JM, Fonkalsrud EW. Impairment of nutrient uptake in a rabbit model of gastroschisis. J Pediatr Surg. 1994 Mar; 29(3):376-8. View abstract
  51. Buchmiller TL, Curr M, Fonkalsrud EW. Assessment of alkaline reflux in children after Nissen fundoplication and pyloroplasty. J Am Coll Surg. 1994 Jan; 178(1):1-5. View abstract
  52. Fonkalsrud EW, Buchmiller TL. Reduction of wound infection in high-risk surgical patients. Am Surg. 1993 Dec; 59(12):838-41. View abstract
  53. Buchmiller TL, Gregg J, Rivera FA, Diamond JM, Fonkalsrud EW. Effect of esophageal ligation on the development of fetal rabbit intestinal lactase. J Pediatr Surg. 1993 Nov; 28(11):1473-7. View abstract
  54. Buchmiller TL, Shaw KS, Chopourian HL, Lloyd KC, Gregg JP, Rivera FA, Lam ML, Diamond JM, Fonkalsrud EW. Effect of transamniotic administration of epidermal growth factor on fetal rabbit small intestinal nutrient transport and disaccharidase development. J Pediatr Surg. 1993 Oct; 28(10):1239-44. View abstract
  55. Kim CS, Buchmiller TL, Fonkalsrud EW, Phillips JD. The effect of anabolic steroids on ameliorating the adverse effects of chronic corticosteroids on intestinal anastomotic healing in rabbits. Surg Gynecol Obstet. 1993 Jan; 176(1):73-9. View abstract
  56. Buchmiller TL, Fonkalsrud EW, Kim CS, Chopourian HL, Shaw KS, Lam MM, Diamond JM. Upregulation of nutrient transport in fetal rabbit intestine by transamniotic substrate administration. J Surg Res. 1992 May; 52(5):443-7. View abstract