Research Overview

Dr. Bosquet Enlow’s research program examines the diverse routes by which intergenerational effects influence mental health risk, integrating genetics and epigenetics, neuroscience, biological psychology, and socio-emotional processes. Her studies focus on the impact of maternal and child stress and trauma exposures and maternal psychopathology (depression, anxiety, posttraumatic stress disorder [PTSD]) on child development. She has conducted research examining the ways that mothers’ trauma histories may disrupt development in pregnancy, infancy, and the preschool period and the ways that such disruptions may increase vulnerability to mental health problems in later life. Dr. Bosquet Enlow has a particularly keen interest in understanding risk factors for anxiety disorders. She has also extended her research program to include how early processes may impact child physical health and neurocognitive development. In addition, Dr. Bosquet Enlow has contributed to the development of clinical measures for assessing traumatic stress responses in children, including the Traumatic Events Screening Inventory-Parent Report Revised, the Child Stress Disorders Checklist-Short Form, and an acute stress disorder module adapted from the Diagnostic Interview for Children and Adolescents (DICA).

About the Researcher

Dr. Bosquet Enlow is a developmental and clinical psychologist with specialized training in infant mental health (birth to age 5), the assessment and treatment of traumatic stress in children and adults, the development of child stress regulation, and the etiology and maintenance of anxiety. She received a B.A. in Psychology from Yale University (mentor Dr. Alice Carter) and a Ph.D. from the Developmental Psychopathology and Clinical Science program at the University of Minnesota (mentor Dr. Byron Egeland); she completed an internship in Clinical Psychology and a fellowship in Infant Mental Health at Louisiana State University Health Sciences Center (mentor Dr. Joy Osofsky) and an APA-accredited postdoctoral fellowship in Clinical Psychology through the Boston Consortium in Clinical Psychology (mentor Dr. Glenn Saxe). Dr. Bosquet Enlow is particularly interested in understanding how risk for mental health difficulties throughout life are established in early development. Ultimately, she aims to design interventions that support healthy development and prevent the occurrence of mental health problems, particularly in highly vulnerable populations.

MEDICAL SERVICES

Languages

  • English

Researcher Services

Researcher Areas

  • Anxiety
  • Child Abuse
  • Child Abuse and Neglect
  • Child Development
  • Developmental Origins of Health and Disease
  • Fetal Programming
  • Trauma
  • Intergenerational effects of stress and trauma
  • Etiology of anxiety
  • Infant mental health

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Bosquet Enlow M, Sideridis G, Chiu YM, Nentin F, Howell EA, Le Grand BA, Wright RJ. Associations among maternal socioeconomic status in childhood and pregnancy and hair cortisol in pregnancy. Psychoneuroendocrinology. 2019 Jan; 99:216-224. View abstract
  2. Brunst KJ, Tignor N, Just A, Liu Z, Lin X, Hacker MR, Bosquet Enlow M, Wright RO, Wang P, Baccarelli AA, Wright RJ. Cumulative lifetime maternal stress and epigenome-wide placental DNA methylation in the PRISM cohort. Epigenetics. 2018; 13(6):665-681. View abstract
  3. Bosquet Enlow M, Bollati V, Sideridis G, Flom JD, Hoxha M, Hacker MR, Wright RJ. Sex differences in effects of maternal risk and protective factors in childhood and pregnancy on newborn telomere length. Psychoneuroendocrinology. 2018 Sep; 95:74-85. View abstract
  4. Leppänen JM, Cataldo JK, Bosquet Enlow M, Nelson CA. Early development of attention to threat-related facial expressions. PLoS One. 2018; 13(5):e0197424. View abstract
  5. Morelli N, Fogler J, Tembulkar S, Graber K, Lincoln SH, Bosquet Enlow M, Gonzalez-Heydrich J, D'Angelo EJ. Potentially traumatic events in youth with and at clinical high risk for psychosis. Early Interv Psychiatry. 2018 Mar 25. View abstract
  6. Brunst KJ, Sanchez-Guerra M, Chiu YM, Wilson A, Coull BA, Kloog I, Schwartz J, Brennan KJ, Bosquet Enlow M, Wright RO, Baccarelli AA, Wright RJ. Prenatal particulate matter exposure and mitochondrial dysfunction at the maternal-fetal interface: Effect modification by maternal lifetime trauma and child sex. Environ Int. 2018 03; 112:49-58. View abstract
  7. Brunst KJ, Sanchez Guerra M, Gennings C, Hacker M, Jara C, Bosquet Enlow M, Wright RO, Baccarelli A, Wright RJ. Maternal Lifetime Stress and Prenatal Psychological Functioning and Decreased Placental Mitochondrial DNA Copy Number in the PRISM Study. Am J Epidemiol. 2017 Dec 01; 186(11):1227-1236. View abstract
  8. Lipton LR, Brunst KJ, Kannan S, Ni YM, Ganguri HB, Wright RJ, Bosquet Enlow M. Associations among prenatal stress, maternal antioxidant intakes in pregnancy, and child temperament at age 30 months. J Dev Orig Health Dis. 2017 Dec; 8(6):638-648. View abstract
  9. Bosquet Enlow M, White MT, Hails K, Cabrera I, Wright RJ. The Infant Behavior Questionnaire-Revised: Factor structure in a culturally and sociodemographically diverse sample in the United States. Infant Behav Dev. 2016 05; 43:24-35. View abstract
  10. Bosquet Enlow M, Englund MM, Egeland B. Maternal Childhood Maltreatment History and Child Mental Health: Mechanisms in Intergenerational Effects. J Clin Child Adolesc Psychol. 2016 Apr 12; 1-16. View abstract
  11. Gonzalez-Heydrich J, Enlow MB, D'Angelo E, Seidman LJ, Gumlak S, Kim A, Woodberry KA, Rober A, Tembulkar S, O'Donnell K, Hamoda HM, Kimball K, Rotenberg A, Oberman LM, Pascual-Leone A, Keshavan MS, Duffy FH. N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth. Neural Plast. 2016; 2016:4209831. View abstract
  12. Schreier HM, Enlow MB, Ritz T, Coull BA, Gennings C, Wright RO, Wright RJ. Lifetime exposure to traumatic and other stressful life events and hair cortisol in a multi-racial/ethnic sample of pregnant women. Stress. 2016; 19(1):45-52. View abstract
  13. Gonzalez-Heydrich J, Bosquet Enlow M, D'Angelo E, Seidman LJ, Gumlak S, Kim A, Woodberry KA, Rober A, Tembulkar S, Graber K, O'Donnell K, Hamoda HM, Kimball K, Rotenberg A, Oberman LM, Pascual-Leone A, Keshavan MS, Duffy FH. Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample. Schizophr Res. 2015 Dec; 169(1-3):340-345. View abstract
  14. Schreier HM, Enlow MB, Ritz T, Gennings C, Wright RJ. Childhood abuse is associated with increased hair cortisol levels among urban pregnant women. J Epidemiol Community Health. 2015 Dec; 69(12):1169-74. View abstract
  15. Bosquet Enlow M, King L, Schreier HM, Howard JM, Rosenfield D, Ritz T, Wright RJ. Maternal sensitivity and infant autonomic and endocrine stress responses. Early Hum Dev. 2014 Jul; 90(7):377-85. View abstract
  16. Brunst KJ, Enlow MB, Kannan S, Carroll KN, Coull BA, Wright RJ. Effects of Prenatal Social Stress and Maternal Dietary Fatty Acid Ratio on Infant Temperament: Does Race Matter? Epidemiology (Sunnyvale). 2014; 4(4). View abstract
  17. Brunst KJ, Wright RO, DiGioia K, Enlow MB, Fernandez H, Wright RJ, Kannan S. Racial/ethnic and sociodemographic factors associated with micronutrient intakes and inadequacies among pregnant women in an urban US population. Public Health Nutr. 2014 Sep; 17(9):1960-70. View abstract
  18. Enlow MB, Blood E, Egeland B. Sociodemographic risk, developmental competence, and PTSD symptoms in young children exposed to interpersonal trauma in early life. J Trauma Stress. 2013 Dec; 26(6):686-94. View abstract
  19. Bosquet Enlow M, Egeland B, Carlson E, Blood E, Wright RJ. Mother-infant attachment and the intergenerational transmission of posttraumatic stress disorder. Dev Psychopathol. 2014 Feb; 26(1):41-65. View abstract
  20. Ritz T, Bosquet Enlow M, Schulz SM, Kitts R, Staudenmayer J, Wright RJ. Respiratory sinus arrhythmia as an index of vagal activity during stress in infants: respiratory influences and their control. PLoS One. 2012; 7(12):e52729. View abstract
  21. Enlow MB, Egeland B, Blood EA, Wright RO, Wright RJ. Interpersonal trauma exposure and cognitive development in children to age 8 years: a longitudinal study. J Epidemiol Community Health. 2012 Nov; 66(11):1005-10. View abstract
  22. Bosquet Enlow M, Kitts RL, Blood E, Bizarro A, Hofmeister M, Wright RJ. Maternal posttraumatic stress symptoms and infant emotional reactivity and emotion regulation. Infant Behav Dev. 2011 Dec; 34(4):487-503. View abstract
  23. Suglia SF, Staudenmayer J, Cohen S, Enlow MB, Rich-Edwards JW, Wright RJ. Cumulative Stress and Cortisol Disruption among Black and Hispanic Pregnant Women in an Urban Cohort. Psychol Trauma. 2010 Dec 01; 2(4):326-334. View abstract
  24. Suglia SF, Ryan L, Bellinger DC, Enlow MB, Wright RJ. Children's exposure to violence and distress symptoms: influence of caretakers' psychological functioning. Int J Behav Med. 2011 Mar; 18(1):35-43. View abstract
  25. Bosquet Enlow M, Kassam-Adams N, Saxe G. The Child Stress Disorders Checklist-Short Form: a four-item scale of traumatic stress symptoms in children. Gen Hosp Psychiatry. 2010 May-Jun; 32(3):321-7. View abstract
  26. Miller A, Enlow MB, Reich W, Saxe G. A diagnostic interview for acute stress disorder for children and adolescents. J Trauma Stress. 2009 Dec; 22(6):549-56. View abstract
  27. Sternthal MJ, Enlow MB, Cohen S, Canner MJ, Staudenmayer J, Tsang K, Wright RJ. Maternal interpersonal trauma and cord blood IgE levels in an inner-city cohort: a life-course perspective. J Allergy Clin Immunol. 2009 Nov; 124(5):954-60. View abstract
  28. Enlow MB, Kullowatz A, Staudenmayer J, Spasojevic J, Ritz T, Wright RJ. Associations of maternal lifetime trauma and perinatal traumatic stress symptoms with infant cardiorespiratory reactivity to psychological challenge. Psychosom Med. 2009 Jul; 71(6):607-14. View abstract
  29. Suglia SF, Enlow MB, Kullowatz A, Wright RJ. Maternal intimate partner violence and increased asthma incidence in children: buffering effects of supportive caregiving. Arch Pediatr Adolesc Med. 2009 Mar; 163(3):244-50. View abstract
  30. Wright RJ, Enlow MB. Maternal stress and perinatal programming in the expression of atopy. Expert Rev Clin Immunol. 2008 Sep 01; 4(5):535-538. View abstract
  31. Rifkin-Graboi, A., Borelli, J.L., & Bosquet, M. Neurobiology of stress in infancy . C.H. Zeanah, Jr. (Ed.), Handbook of Infant Mental Health. 2008. View abstract
  32. Saxe G, Geary M, Bedard K, Bosquet M, Miller A, Koenen K, Stoddard F, Moulton S. Separation anxiety as a mediator between acute morphine administration and PTSD symptoms in injured children. Ann N Y Acad Sci. 2006 Jul; 1071:41-5. View abstract
  33. Bosquet M, Egeland B. The development and maintenance of anxiety symptoms from infancy through adolescence in a longitudinal sample. Dev Psychopathol. 2006; 18(2):517-50. View abstract
  34. Koenen KC, Saxe G, Purcell S, Smoller JW, Bartholomew D, Miller A, Hall E, Kaplow J, Bosquet M, Moulton S, Baldwin C. Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children. Mol Psychiatry. 2005 Dec; 10(12):1058-9. View abstract
  35. Saxe GN, Miller A, Bartholomew D, Hall E, Lopez C, Kaplow J, Koenen KC, Bosquet M, Allee L, Erikson I, Moulton S. Incidence of and risk factors for acute stress disorder in children with injuries. J Trauma. 2005 Oct; 59(4):946-53. View abstract
  36. Bosquet, M., & Warren, S. L. (2005, April). Society for Research in Child Development, Atlanta, Georgia. . The parent-child relationship and child emotional reactivity: Mechanisms for the development of child anxiety. 2005. View abstract
  37. Saxe, G. S., Bosquet, M., Stoddard, F., & Kassam-Adams, N. Screening for PTSD in injured children. 2004. View abstract
  38. Hall, E., Saxe, G., Kaplow, J., Koenen, K.C., Miller, A., Bartholomew, D., Lopez, C., Bosquet, M., King, L., & King, D. Acute stress symptoms in parents of children with burns or injuries. 2004. View abstract
  39. Bosquet, M., Saxe, G., & Kassam-Adams, N. A 4-Item Screener for ASD and PTSD in Children. 2004. View abstract
  40. Miller, A., Saxe, G., Stoddard, F., Bartholomew, D., Hall, E., Lopez, C., Kaplow, J., Koenen, K.C., Bosquet, M., & Reich, W. . Reliability and validity of the DICA-ASD. 2004. View abstract
  41. Saxe, G., Miller, A., Bartholomew, D., Hall, E., Lopez, C., Kaplow, J., Koenen, K., Bosquet, M., Allee, L., Erikson, I., & Moulton, S. Prevalence of and risk factors for Acute Stress Disorder in children with injuries. 2004. View abstract
  42. Bosquet, M. How research informs clinical work with traumatized young children. J. D. Osofsky (Ed.), Young Children and Trauma: What do we know and what do we need to know? N. 2004. View abstract
  43. Saxe, G. N., & Bosquet, M. The PTSD Screen. 2004. View abstract
  44. Bosquet, M. . An examination of the development of anxiety symptoms from a developmental psychopathology perspective. 2003. View abstract
  45. Egeland, B., Bosquet, M., & Levy, A. K. Continuities and discontinuities in the intergenerational transmission of child maltreatment: Implications for breaking the cycle of abuse. Browne, K., Hanks, H., Stratton, P., & Hamilton, C. (Eds.), Early prediction and prevention of child abuse: A handbook. 2002; 217-232. View abstract
  46. Egeland, B., & Bosquet, M. Emotion regulation in early childhood: The role of attachment-oriented interventions. B. S. Zuckerman, A. F. Lieberman, & N. A. Fox (Eds.), Emotional regulation and developmental health: Infancy and early childhood. 2002; 101-124. View abstract
  47. Ghosh Ippen, C., Ford, J., Racusin, R., Acker, M., Bosquet, M., Rogers, K., Ellis, C., Schiffman, J., Ribbe, D., Cone, P., Lukovitz, M., Edwards, J., The Child Trauma Research Project of the Early Trauma Treatment Network, & The National Center for PTSD Dartmouth Child Trauma Research Group. . Traumatic Events Screening Inventory-Parent Report Revised. 2002. View abstract
  48. Michelle Bosquet. An examination of the development of anxiety symptoms from a developmental psychopathology perspective. 2001. View abstract
  49. Bosquet M, Egeland B. Associations among maternal depressive symptomatology, state of mind and parent and child behaviors: implications for attachment-based interventions. Attach Hum Dev. 2001 Sep; 3(2):173-99. View abstract
  50. Bosquet, M. Associations among maternal state of mind, depression, and parent and child behaviors: Implications for attachment interventions. 2001. View abstract
  51. Egeland, B., & Bosquet M. . Review of the book Cycles of maltreatment: Facts, fallacies, and interventions. Child Abuse and Neglect: The International Journal. 2001; 25:313-314. View abstract
  52. Bosquet M, Egeland B. Predicting parenting behaviors from Antisocial Practices content scale scores of the MMPI-2 administered during pregnancy. J Pers Assess. 2000 Feb; 74(1):146-62. View abstract
  53. Nelson, C. A., & Bosquet, M. . Neurobiology of fetal and infant development: Implications for infant mental health. C.H. Zeanah, Jr. (Ed.), Handbook of infant mental health. 2000; 37-59. View abstract
  54. Egeland, B., Weinfield, N. S., Bosquet, M., & Cheng, V. K. Remembering, repeating, and working through: Lessons from attachment-based interventions. J. D. Osofsky & H. E. Fitzgerald (Eds.), WAIMH Handbook of infant mental health: Vol. 4. Infant mental health in groups at high risk. 2000; 4:35-89. View abstract
  55. Bosquet, M. Associations between maternal personality and clinical symptomatology measured pre-partum and infant attachment. 1999. View abstract
  56. Bosquet, M. Associations between maternal antisocial attitudes measured pre-partum and parenting behaviors. 1999. View abstract
  57. Reznick, J. S., Fueser, J. J., & Bosquet, M. . Self-corrected reaching in a three-location delayed-response search task. Psychological Science. 1998; 9:66-70. View abstract
  58. Bosquet, M., & Warren, S. L. Could my child be at risk for developing an anxiety disorder? Special focus on anxiety disorders in children, adolescents, and young adults (2nd ed., pp. 25-27). 1998. View abstract
  59. Bosquet, M. . Predicting parent behavior from the Antisocial Practices Content Scores administered during pregnancy. . 1997. View abstract
  60. Schuder, M., Bosquet, M., & Erickson, M. F. The effects of a home visitation intervention on paternal involvement. 1997. View abstract
  61. Bosquet, M., Chazan, R., & Carter, A. S. . Associations between maternal depression and infant affect and behavior. 1996. View abstract
  62. Carter, A., Bosquet, M., & Chazan, R. The association of maternal depressive symptoms and infant behavioral inhibition at four months of age. 1994. View abstract
  63. Reznick, J. S., & Bosquet, M. . Reaching beyond infant forgetting. 1994. View abstract