Research Overview

Recipient of NIH Mentored Clinical Scientist Development Award (K08): 2013-2018
Project Title: Immediate and Delayed Effects of Morphine on Brain Circuits: Animal - Human Correlation

Opioids are considered standard of care and used for management of acute pain, as well as for sedation of children of all ages. Our understanding of sequelae associated with prolonged opioid treatment on developing brain are limited. The is unique aspect of this project is in its translational effort to define the impact of prolonged morphine exposure in the rats of different ages using neuroimaging, behavioral, and immunohistochemical techniques (AIM 1), as well as in children of different ages using neuroimaging (AIM 2). Functional magnetic resonance imaging (fMRI) in both rats and children will allow a translational systems level investigation of prolonged morphine administration and its long-term effects.

About Dusica Bajic

Dr. Bajic received her MD from the Medical School of the University of Belgrade, Serbia and PhD from the Department of Pharmacology at the University of Illinois at Chicago, IL. Her postdoctoral training included: (1) Postdoctoral Fellow at the Department of Anatomy and Cell Biology at the University of Illinois at Chicago, (2) Anesthesia Residency training at Yale New Haven Hospital, Yale University, as well as (3) Pediatric Anesthesia Fellowship at Children's Hospital Boston, Harvard University where she now works as board certified staff anesthesiologist since 2008.

Researcher Services

Researcher Areas

  • Anesthesiology
  • Opioid Tolerance

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Goins EC, Bajic D. Astrocytic hypertrophy in the rat ventral tegmental area following chronic morphine differs with age. J Neurol Neurorehabilit Res. 2018; 3(1):14-21. View abstract
  2. Bajic D, Craig MM, Mongerson CRL, Borsook D, Becerra L. Identifying Rodent Resting-State Brain Networks with Independent Component Analysis. Front Neurosci. 2017; 11:685. View abstract
  3. Mongerson CRL, Jennings RW, Borsook D, Becerra L, Bajic D. Resting-State Functional Connectivity in the Infant Brain: Methods, Pitfalls, and Potentiality. Front Pediatr. 2017; 5:159. View abstract
  4. Bajic D, Craig MM, Borsook D, Becerra L. Probing Intrinsic Resting-State Networks in the Infant Rat Brain. Front Behav Neurosci. 2016; 10:192. View abstract
  5. Craig MM, Bajic D. Long-term behavioral effects in a rat model of prolonged postnatal morphine exposure. Behav Neurosci. 2015 Oct; 129(5):643-55. View abstract
  6. Bajic D, Soiza-Reilly M, Spalding AL, Berde CB, Commons KG. Endogenous cholinergic neurotransmission contributes to behavioral sensitization to morphine. PLoS One. 2015; 10(2):e0117601. View abstract
  7. Bajic D. In: Mattes K, Laubach A, Wang E, Anderson A. (Eds), Pediatric Anesthesiology Board Review. Plastic and Oral-Maxillary Facial Surgery. 2015. View abstract
  8. Bajic D, Proudfit HK. Projections from the rat cuneiform nucleus to the A7, A6 (locus coeruleus), and A5 pontine noradrenergic cell groups. J Chem Neuroanat. 2013 May; 50-51:11-20. View abstract
  9. Bajic D, Commons KG, Soriano SG. Morphine-enhanced apoptosis in selective brain regions of neonatal rats. Int J Dev Neurosci. 2013 Jun; 31(4):258-66. View abstract
  10. Bajic D, Berde CB, Commons KG. Periaqueductal gray neuroplasticity following chronic morphine varies with age: role of oxidative stress. Neuroscience. 2012 Dec 13; 226:165-77. View abstract
  11. Bajic D, Van Bockstaele EJ, Proudfit HK. Ultrastructural analysis of rat ventrolateral periaqueductal gray projections to the A5 cell group. Neuroscience. 2012 Nov 08; 224:145-59. View abstract
  12. Soriano SG, Liu Q, Li J, Liu JR, Han XH, Kanter JL, Bajic D, Ibla JC. Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology. 2010 May; 112(5):1155-63. View abstract
  13. Bajic D, Commons KG. Acute noxious stimulation modifies morphine effect in serotonergic but not dopaminergic midbrain areas. Neuroscience. 2010 Mar 17; 166(2):720-9. View abstract
  14. Bajic D, Commons KG. Visualizing acute pain-morphine interaction in descending monoamine nuclei with Fos. Brain Res. 2010 Jan 08; 1306:29-38. View abstract
  15. Ibla JC, Hayashi H, Bajic D, Soriano SG. Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. Curr Drug Saf. 2009 Jan; 4(1):11-6. View abstract
  16. Bajic D. Abnormal electrolytes: Prolonged emergences. Anesthesia Processes. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008. View abstract
  17. Bajic D, Burm M. Carotid chemoreceptor function. Physiology and Cardiovascular. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008. View abstract
  18. Bajic D, Nguyen H. Cholestasis: Coagulopathy Rx. Hematology and Pharmacology. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008. View abstract
  19. Bajic D. Carbon Monoxide and inhalational anesthetics. Physics Equipment. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008. View abstract
  20. Bajic D, Obergfell, R. Hypotension: compensatory mechanisms. Cardiovascular and Physiology. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008. View abstract
  21. Bajic D. Newborn respiratory distress syndrome: symptoms. Pediatrics. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008. View abstract
  22. Bajic D, Miller K. Pneumoperitoneum: vagal arrest. Pediatrics and Respiratory. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008. View abstract
  23. Bajic D, Kim J, Johanson R. Respiratory center functions. Neurologic, Respiratory, and Physiology. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008. View abstract
  24. Bajic D, Hoang QV, Nakajima S, Nakajima Y. Dissociated histaminergic neuron cultures from the tuberomammillary nucleus of rats: culture methods and ghrelin effects. J Neurosci Methods. 2004 Jan 30; 132(2):177-84. View abstract
  25. Hoang QV, Bajic D, Yanagisawa M, Nakajima S, Nakajima Y. Effects of orexin (hypocretin) on GIRK channels. J Neurophysiol. 2003 Aug; 90(2):693-702. View abstract
  26. Bajic D, Koike M, Albsoul-Younes AM, Nakajima S, Nakajima Y. Two different inward rectifier K+ channels are effectors for transmitter-induced slow excitation in brain neurons. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14494-9. View abstract
  27. Van Bockstaele EJ, Bajic D, Proudfit H, Valentino RJ. Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus. Physiol Behav. 2001 Jun; 73(3):273-83. View abstract
  28. Bajic D, Van Bockstaele EJ, Proudfit HK. Ultrastructural analysis of ventrolateral periaqueductal gray projections to the A7 catecholamine cell group. Neuroscience. 2001; 104(1):181-97. View abstract
  29. Bajic D, Proudfit HK, Van Bockstaele EJ. Periaqueductal gray neurons monosynaptically innervate extranuclear noradrenergic dendrites in the rat pericoerulear region. J Comp Neurol. 2000 Nov 27; 427(4):649-62. View abstract
  30. Bajic D. Projections of neurons in the periaqueductal gray and cuneiform nucleus to pontine noradrenergic neurons [Ph.D. Thesis]; Chicago (IL): Univ. of Illinois at Chicago. pp.224. 2000. View abstract
  31. Bajic D, Proudfit HK. Projections of neurons in the periaqueductal gray to pontine and medullary catecholamine cell groups involved in the modulation of nociception. J Comp Neurol. 1999 Mar 15; 405(3):359-79. View abstract