Research Overview

Dr. John Arnold's laboratory efforts have directed at the development of innovative technologies in the arena of respiratory support, including high frequency oscillatory ventilation, partial liquid ventilation, non-invasive monitoring of regional lung mechanics to guide lung protective ventilation, and now ICU data analytics. Of note, Dr. Arnold was the principal investigator of the first randomized, controlled trial of high frequency oscillatory ventilation in pediatric patients with respiratory failure.

This study was recognized by the FDA in the device approval process and has led to the widespread use of HFOV in pediatric intensive care units worldwide. Dr. Arnold’s primary research focus at the moment involves a monitoring technology called Electrical Impedance Tomography (EIT) and a new technology called Trending, Tracking, and Triggering (T3) for capturing and processing digital data in the ICU. EIT promises to be a safe and reliable technology which describes regional differences in lung volume change during mechanical ventilation. His research collaboration is now focused on the use of EIT to guide lung protective ventilation in an animal model of lung injury. Boston Children’s Hospital with the help of Etiometry has developed a revolutionary software product for ICU data analysis, known as T3. The primary functions of the T3 system are to aggregate, store, and display comprehensive real-time patient data for clinicians. Additionally, the software gives researchers direct access to this rich data set in a standardized format. Thus the software improves patient care both at the bedside as well as through improved clinical practices that result from a streamlined research pipeline. This software provides a solution to one of the greatest hurdles in modern medicine: the acquisition and archiving of data arriving from various monitors, devices and systems, at different rates and formats.

As a result of the synergism between Dr. Arnold’s clinical research interests and laboratory research related to lung injury and respiratory support, he has been involved in the evolving dialogue regarding the importance of lung protective ventilation in the management of lung injury. He has developed a strong network of collaborators from the world of adult critical care medicine who share a similar focus on innovative modes of ventilation in lung injury.

Dr. Arnold has been sought out by clinical investigators in the adult critical care arena to help refine and monitor clinical trial design regarding innovative modes of ventilatory support in adults. Examples include a consultative role in the clinical trial that led to approval of a high frequency device for adult patients. In addition, he currently serves as a member of the Data Safety Monitoring Board of an ongoing clinical trial designed to further explore the impact of early use of high frequency oscillatory ventilation in adult patients.

In Dr. Arnold’s pursuit of an academic career as a translational researcher, he sought to address some of the significant challenges in pediatric critical care. He began his academic journey by focusing on one of the most complex challenges in pediatric critical care which is the optimal mode of sedation and analgesia for infants and children during prolonged stays in intensive care.

Dr. Arnold’s contributions include the first description of iatrogenic opioid tolerance and dependence in infants and children and authorship of a practical approach to the management of these problems in pediatric intensive care. He was the principal investigator of a feasibility study designed to define the risks and benefits of the use of potent inhaled anesthetics as sedating agents in ventilated pediatric patients which has led to the development of a practice guideline for the use of isoflurane in the MSICU at Children’s Hospital.

About the Researcher

Dr. Arnold currently is a member of the Society of Critical Care Medicine’s Task Force for Pediatric and Neonatal Sedation and Analgesia. His subsequent academic interests have been focused on the optimal approaches to lung protective ventilation. He has been able to combine his roles as an experienced clinician, medical director of Respiratory Care and the Extracorporeal Membrane Oxygenation Program, a mentor to many now successful clinician-scientists and an active translational researcher to become a national and international leader in the management of pediatric acute respiratory distress syndrome.

PUBLICATIONS

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  1. Madenci AL, Baer HJ, Vitali SH, Zalieckas JM, Arnold JH, Weldon CB. Time versus treatment: interpreting longitudinal data analysis of treprostinil. J Pediatr. 2019 Mar; 206:304-305. View abstract
  2. Smallwood CD, Walsh BK, Arnold JH, Gouldstone A. Equilibration Time Required for Respiratory System Compliance and Oxygenation Response Following Changes in Positive End-Expiratory Pressure in Mechanically Ventilated Children. Crit Care Med. 2018 May; 46(5):e375-e379. View abstract
  3. Rettig JS, Arnold JH. Dexmedetomidine in the PICU: Can We Get More for Less? Pediatr Crit Care Med. 2017 09; 18(9):893-894. View abstract
  4. Walsh BK, Smallwood CD, Arnold JH. The Quality of Quality Metrics-Reply. Respir Care. 2017 02; 62(2):254-255. View abstract
  5. Walsh BK, Smallwood C, Rettig J, Kacmarek RM, Thompson J, Arnold JH. Daily Goals Formulation and Enhanced Visualization of Mechanical Ventilation Variance Improves Mechanical Ventilation Score. Respir Care. 2017 Mar; 62(3):268-278. View abstract
  6. Schlosser K, Smallwood C, Arnold J, Lee G, Priebe G, Walsh B, Santillana M. 1015: IDENTIFICATION OF PEDIATRIC VENTILATOR-ASSOCIATED CONDITIONS USING CONTINUOUS VENTILATOR DATA. Crit Care Med. 2016 Dec; 44(12 Suppl 1):330. View abstract
  7. Alexander P, Fynn-Thompson F, Buchmiller T, Porras D, Marshall A, Thiagarajan R, Arnold J. 1629: LIQUID FLUOROCARBON LAVAGE FOR AIRWAY THROMBUS AFTER SEVERE HEMOPTYSIS REQUIRING ECMO. Crit Care Med. 2016 Dec; 44(12 Suppl 1):482. View abstract
  8. Smallwood C, Walsh B, Rettig J, Thompson J, Santillana M, Arnold J. 955: A MACHINE-LEARNING ALGORITHM FOR OXYGENATION RESPONSE PREDICTION IN MECHANICALLY VENTILATED CHILDREN. Crit Care Med. 2016 Dec; 44(12 Suppl 1):315. View abstract
  9. Walsh B, Smallwood C, Rettig J, Santillana M, Arnold J. 949: DEVELOPMENT OF HEART, RESPIRATORY RATE, AND OXYGEN SATURATION PERCENTILE CURVES IN CHILDREN. Crit Care Med. 2016 Dec; 44(12 Suppl 1):313. View abstract
  10. Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Kacmarek RM, Arnold JH. Categorization in Mechanically Ventilated Pediatric Subjects: A Proposed Method to Improve Quality. Respir Care. 2016 Sep; 61(9):1168-78. View abstract
  11. Walsh BK, Betit P, Fink JB, Pereira LM, Arnold J. Characterization of Ribavirin Aerosol With Small Particle Aerosol Generator and Vibrating Mesh Micropump Aerosol Technologies. Respir Care. 2016 May; 61(5):577-85. View abstract
  12. Rettig JS, Smallwood CD, Walsh BK, Rimensberger PC, Bachman TE, Bollen CW, Duval EL, Gebistorf F, Markhorst DG, Tinnevelt M, Todd M, Zurakowski D, Arnold JH. High-Frequency Oscillatory Ventilation in Pediatric Acute Lung Injury: A Multicenter International Experience. Crit Care Med. 2015 Dec; 43(12):2660-7. View abstract
  13. Walsh BK, Davis MD, Hunt JF, Kheir JN, Smallwood CD, Arnold JH. The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res. 2015 Sep 03; 9(3):036009. View abstract
  14. Wolf GK, Gómez-Laberge C, Rettig JS, Vargas SO, Smallwood CD, Prabhu SP, Vitali SH, Zurakowski D, Arnold JH. Mechanical ventilation guided by electrical impedance tomography in experimental acute lung injury. Crit Care Med. 2013 May; 41(5):1296-304. View abstract
  15. Gómez-Laberge C, Rettig JS, Smallwood CD, Boyd TK, Arnold JH, Wolf GK. Interaction of dependent and non-dependent regions of the acutely injured lung during a stepwise recruitment manoeuvre. Physiol Meas. 2013 Feb; 34(2):163-77. View abstract
  16. Kheir JN, Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Gómez-Laberge C, Wolf GK, Arnold JH. Comparison of 2 lung recruitment strategies in children with acute lung injury. Respir Care. 2013 Aug; 58(8):1280-90. View abstract
  17. Wolf GK, Gómez-Laberge C, Kheir JN, Zurakowski D, Walsh BK, Adler A, Arnold JH. Reversal of dependent lung collapse predicts response to lung recruitment in children with early acute lung injury. Pediatr Crit Care Med. 2012 Sep; 13(5):509-15. View abstract
  18. Costello JM, O'Brien M, Wypij D, Shubert J, Salvin JW, Newburger JW, Laussen PC, Arnold JH, Fynn-Thompson F, Thiagarajan RR. Quality of life of pediatric cardiac patients who previously required extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2012 Jul; 13(4):428-34. View abstract
  19. Adler A, Amato MB, Arnold JH, Bayford R, Bodenstein M, Böhm SH, Brown BH, Frerichs I, Stenqvist O, Weiler N, Wolf GK. Whither lung EIT: where are we, where do we want to go and what do we need to get there? Physiol Meas. 2012 May; 33(5):679-94. View abstract
  20. Turner DA, Heitz D, Cooper MK, Smith PB, Arnold JH, Bateman ST. Isoflurane for life-threatening bronchospasm: a 15-year single-center experience. Respir Care. 2012 Nov; 57(11):1857-64. View abstract
  21. Rettig JS, Arnold JH. High-frequency oscillatory ventilation: learning which way to turn the dials. Pediatr Crit Care Med. 2012 Mar; 13(2):242-4. View abstract
  22. Gómez-Laberge C, Arnold JH, Wolf GK. A unified approach for EIT imaging of regional overdistension and atelectasis in acute lung injury. IEEE Trans Med Imaging. 2012 Mar; 31(3):834-42. View abstract
  23. Wolf GK, Walsh BK, Green ML, Arnold JH. Electrical activity of the diaphragm during extubation readiness testing in critically ill children. Pediatr Crit Care Med. 2011 Nov; 12(6):e220-4. View abstract
  24. Ferguson LP, Walsh BK, Munhall D, Arnold JH. A spontaneous breathing trial with pressure support overestimates readiness for extubation in children. Pediatr Crit Care Med. 2011 Nov; 12(6):e330-5. View abstract
  25. Ventre KM, Wolf GK, Arnold JH. Pediatric respiratory diseases: 2011 update for the Rogers' Textbook of Pediatric Intensive Care. Pediatr Crit Care Med. 2011 May; 12(3):325-38. View abstract
  26. Green ML, Walsh BK, Wolf GK, Arnold JH. Electrocardiographic guidance for the placement of gastric feeding tubes: a pediatric case series. Respir Care. 2011 Apr; 56(4):467-71. View abstract
  27. Mehta NM, Turner D, Walsh B, Zurakowski D, Betit P, Wilson J, Arnold JH. Factors associated with survival in pediatric extracorporeal membrane oxygenation--a single-center experience. J Pediatr Surg. 2010 Oct; 45(10):1995-2003. View abstract
  28. Wolf GK, Grychtol B, Frerichs I, Zurakowski D, Arnold JH. Regional lung volume changes during high-frequency oscillatory ventilation. Pediatr Crit Care Med. 2010 Sep; 11(5):610-5. View abstract
  29. Grychtol B, Wolf GK, Adler A, Arnold JH. Towards lung EIT image segmentation: automatic classification of lung tissue state from analysis of EIT monitored recruitment manoeuvres. Physiol Meas. 2010 Aug; 31(8):S31-43. View abstract
  30. Wolf GK, Grychtol B, Boyd TK, Zurakowski D, Arnold JH. Regional overdistension identified with electrical impedance tomography in the perflubron-treated lung. Physiol Meas. 2010 Aug; 31(8):S85-95. View abstract
  31. Walsh BK, Craig N, Betit P, Thompson JE, Arnold JH. Respiratory distress associated with inadequate mechanical ventilator flow response in a neonate with congenital diaphragmatic hernia. Respir Care. 2010 Mar; 55(3):342-5. View abstract
  32. Wolf GK, Arnold JH. Synchronizing ventilatory support with the neural signal to breathe. Pediatr Crit Care Med. 2010 Jan; 11(1):142-3. View abstract
  33. O'Reilly EB, Montenegro B, Arnold J, Tomita S. Infant botulism mimicking Hirschprung's disease. J Pediatr Surg. 2009 Oct; 44(10):e5-7. View abstract
  34. Turner DA, Heitz D, Zurakowski D, Arnold JH. Automated measurement of the lower inflection point in a pediatric lung model. Pediatr Crit Care Med. 2009 Jul; 10(4):511-6. View abstract
  35. Adler A, Arnold JH, Bayford R, Borsic A, Brown B, Dixon P, Faes TJ, Frerichs I, Gagnon H, Gärber Y, Grychtol B, Hahn G, Lionheart WR, Malik A, Patterson RP, Stocks J, Tizzard A, Weiler N, Wolf GK. GREIT: a unified approach to 2D linear EIT reconstruction of lung images. Physiol Meas. 2009 Jun; 30(6):S35-55. View abstract
  36. Grychtol B, Wolf GK, Arnold JH. Differences in regional pulmonary pressure-impedance curves before and after lung injury assessed with a novel algorithm. Physiol Meas. 2009 Jun; 30(6):S137-48. View abstract
  37. Wolf GK, Sheeran P, Heitz D, Thompson JE, Arnold JH. Gas exchange and lung mechanics during high frequency ventilation in the perflubron-treated lung. Pediatr Crit Care Med. 2008 Nov; 9(6):641-6. View abstract
  38. Turner DA, Arnold JH. Improving our approach to sedation in the pediatric intensive care unit: is it time to inhale? Pediatr Crit Care Med. 2008 Mar; 9(2):233-4. View abstract
  39. Wolf GK, Arnold JH. Assessing the benefits of noninvasive ventilation: the tissue is the issue. Crit Care Med. 2008 Jan; 36(1):349-50. View abstract
  40. Wolf GK, Arnold JH. A (large) step toward improved lung protection. Pediatr Crit Care Med. 2008 Jan; 9(1):127-8. View abstract
  41. Wolf GK, Grychtol B, Frerichs I, van Genderingen HR, Zurakowski D, Thompson JE, Arnold JH. Regional lung volume changes in children with acute respiratory distress syndrome during a derecruitment maneuver. Crit Care Med. 2007 Aug; 35(8):1972-8. View abstract
  42. Wolf GK, Arnold JH. Measurement of deadspace compartments: on the road to somewhere. Pediatr Crit Care Med. 2007 Jul; 8(4):408-9. View abstract
  43. Mehta NM, Halwick DR, Dodson BL, Thompson JE, Arnold JH. Potential drug sequestration during extracorporeal membrane oxygenation: results from an ex vivo experiment. Intensive Care Med. 2007 Jun; 33(6):1018-24. View abstract
  44. Turner DA, Arnold JH. Insights in pediatric ventilation: timing of intubation, ventilatory strategies, and weaning. Curr Opin Crit Care. 2007 Feb; 13(1):57-63. View abstract
  45. Wolf GK, Arnold JH. Electrical impedance tomography: Ready for prime time? Intensive Care Med. 2006 Sep; 32(9):1290-2. View abstract
  46. Curley MA, Harris SK, Fraser KA, Johnson RA, Arnold JH. State Behavioral Scale: a sedation assessment instrument for infants and young children supported on mechanical ventilation. Pediatr Crit Care Med. 2006 Mar; 7(2):107-14. View abstract
  47. Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL. Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. J Crit Care. 2006 Mar; 21(1):23-32; discussion 32-7. View abstract
  48. Randolph AG, Forbes PW, Gedeit RG, Arnold JH, Wetzel RC, Luckett PM, O'Neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH. Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. Pediatr Crit Care Med. 2005 Nov; 6(6):642-7. View abstract
  49. Mehta NM, Arnold JH. Genetic polymorphisms in acute respiratory distress syndrome: new approach to an old problem. Crit Care Med. 2005 Oct; 33(10):2443-5. View abstract
  50. Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13; 294(2):229-37. View abstract
  51. Wolf GK, Arnold JH. Noninvasive assessment of lung volume: respiratory inductance plethysmography and electrical impedance tomography. Crit Care Med. 2005 Mar; 33(3 Suppl):S163-9. View abstract
  52. Ventre KM, Arnold JH. Patient in impending respiratory failure. Paediatr Respir Rev. 2004 Dec; 5(4):339, 341. View abstract
  53. Ventre KM, Arnold JH. High frequency oscillatory ventilation in acute respiratory failure. Paediatr Respir Rev. 2004 Dec; 5(4):323-32. View abstract
  54. Vitali SH, Arnold JH. Bench-to-bedside review: Ventilator strategies to reduce lung injury -- lessons from pediatric and neonatal intensive care. Crit Care. 2005 Apr; 9(2):177-83. View abstract
  55. Hardart GE, Hardart MK, Arnold JH. Intracranial hemorrhage in premature neonates treated with extracorporeal membrane oxygenation correlates with conceptional age. J Pediatr. 2004 Aug; 145(2):184-9. View abstract
  56. Arnold JH. Electrical impedance tomography: on the path to the Holy Grail. Crit Care Med. 2004 Mar; 32(3):894-5. View abstract
  57. Mehta NM, Arnold JH. Mechanical ventilation in children with acute respiratory failure. Curr Opin Crit Care. 2004 Feb; 10(1):7-12. View abstract
  58. Ventre KM, Arnold JH. Acute parenchymal disease in infants and children, in Fink MB, Shoemaker WC, et al (eds.), Textbook of Critical Care (5th edition), Elsevier, Philadelphia, in press. 2004. View abstract
  59. Cooper MK, Arnold JH. Respiratory Disorders: ECMO, in Cloherty JP, Stark AR, Eichenwald E (eds). Manual of Neonatal Care (5th edition), Williams & Wilkins, Philadelphia. 2004; 364-70. View abstract
  60. Wolf JK, Arnold JH. Assessment of alveolar recruitment: new approaches. Yearbook of Critical Care, in press. 2004. View abstract
  61. Randolph AG, Forbes P, Gedeit RG, Arnold JH, Wetzel R, Luckett PM, O’Neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH. Cumulative fluid balance does not influence weaning duration or extubation outcomes in children. Ped Crit Care Med, in press. 2004. View abstract
  62. Wolf GK, Arnold JH. Non-invasive assessment of lung volume: respiratory inductance plethysmography and electric impedance tomography. Critical Care Medicine, in press. 2004. View abstract
  63. Wolf GK, van Genderingen HR, Thompson JE, Watson K, Arnold JH. Changes in Lung Impedance Following Derecruitment During High Frequency Ventilation. Presented at the Pediatric Academic Societies Annual Meeting, San Francisco, CA. 2004. View abstract
  64. Mehta NM, Arnold JH. Sublingual capnometry in pediatric patients. Yearbook of Critical Care, in press. 2004. View abstract
  65. Vitali SH, Arnold JH. Bench-to-bedside review: Ventilator strategies to reduce lung injury- lessons from pediatric and neonatal intensive care. Critical Care Forum, in press. 2004. View abstract
  66. Vitali SH, Camerota AJ, Arnold JH. Anesthesia and analgesia, in Avery GB, Fletcher MA, MacDonald MG (eds.), Neonatology: Pathophysiology and Management of the Newborn (6th Edition), J.B. Lippincott, Philadelphia, in press. 2004. View abstract
  67. Arnold JH. Electrical impedance tomography: on the path to the Holy Grail. Crit Care Med 32: 894-895, 2004. 2004; 32:894-5. View abstract
  68. Downard CD, Betit P, Chang RW, Garza JJ, Arnold JH, Wilson JM. Impact of AMICAR on hemorrhagic complications of ECMO: a ten-year review. J Pediatr Surg. 2003 Aug; 38(8):1212-6. View abstract
  69. Doctor A, Al-Khadra E, Tan P, Watson KF, Diesen DL, Workman LJ, Thompson JE, Rose CE, Arnold JH. Extended high-frequency partial liquid ventilation in lung injury: gas exchange, injury quantification, and vapor loss. J Appl Physiol (1985). 2003 Sep; 95(3):1248-58. View abstract
  70. Randolph AG, Meert KL, O'Neil ME, Hanson JH, Luckett PM, Arnold JH, Gedeit RG, Cox PN, Roberts JS, Venkataraman ST, Forbes PW, Cheifetz IM. The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Respir Crit Care Med. 2003 May 15; 167(10):1334-40. View abstract
  71. Curley MAQ, Dodson BL, Arnold JH. Designing a Nurse-Implemented Sedation Algorithm for Use in a Pediatric Intensive Care Unit – A Preliminary Report. Ped Crit Care Med. 2003; 4:A158. View abstract
  72. Lee LK, Shannon M, Arnold JH. The use of high frequency oscillatory ventilation in hydrocarbon pneumonitis. Int J Med Toxicol. 2003; 6:6. View abstract
  73. Goins RA, Ascher D, Waecker N, Arnold J, Moorefield E. Comparison of fluconazole and nystatin oral suspensions for treatment of oral candidiasis in infants. Pediatr Infect Dis J. 2002 Dec; 21(12):1165-7. View abstract
  74. Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA. 2002 Nov 27; 288(20):2561-8. View abstract
  75. Arnold JH. To recruit or not derecruit: that is the question. Crit Care Med. 2002 Aug; 30(8):1925-7. View abstract
  76. Randolph AG, Venkataraman S, Gedeit R, Hanson J, Meert K, Luckett P, Arnold JH, Lilley M, Thompson J, Cheifetz I, Wetzel R, Cox P, Roberts J. Weaning critically ill children from ventilatory support: a randomized trial comparing two protocols to standard care. Am J Resp Crit Care Med. 2002; 165:A156. View abstract
  77. Brazelton TB, Watson KF, Murphy M, Al-Khadra E, Thompson JE, Arnold JH. Identification of optimal lung volume during high-frequency oscillatory ventilation using respiratory inductive plethysmography. Crit Care Med. 2001 Dec; 29(12):2349-59. View abstract
  78. Priebe GP, Arnold JH. High-frequency oscillatory ventilation in pediatric patients. Respir Care Clin N Am. 2001 Dec; 7(4):633-45. View abstract
  79. Arnold JH. Measurement of the alveolar deadspace: are we there yet? Crit Care Med. 2001 Jun; 29(6):1287-8. View abstract
  80. Doctor A, Price B, Bhargava N, DiCanzio J, Arnold JH. High-frequency oscillatory ventilation of the perfluorocarbon-filled lung: dose-response relationships in an animal model of acute lung injury. Crit Care Med. 2001 Apr; 29(4):847-54. View abstract
  81. Bateman ST, Doctor A, Price B, Murphy MA, Thompson JE, Zurakowski D, Taylor GA, Arnold JH. Optimizing intrapulmonary perfluorocarbon distribution: fluoroscopic comparison of mode of ventilation and body position. Crit Care Med. 2001 Mar; 29(3):601-8. View abstract
  82. Hardart GE, Hardart KM, Arnold JH. The effect of post-gestational age on the incidence of intracranial hemorrhage in premature infants treated with extracorporeal membrane oxygenation. Crit Care Med. 2001; 29:A140. View abstract
  83. Randolph AG, Venkataraman S, Hanson J, Luckett P, Gedeit R, Meert K, Wetzel R, Cheifetz I, Cox P, Roberts J, Lilley M, Thompson J, Arnold JH. Evaluation of a pediatric extubation readiness test. Crit Care Med. 2001; 29:A142. View abstract
  84. Arnold JH, Anas NG, Luckett P, Cheifetz IM, Reyes G, Newth CJ, Kocis KC, Heidemann SM, Hanson JH, Brogan TV, Bohn DJ. High-frequency oscillatory ventilation in pediatric respiratory failure: a multicenter experience. Crit Care Med. 2000 Dec; 28(12):3913-9. View abstract
  85. Arnold JH. High-frequency ventilation in the pediatric intensive care unit. Pediatr Crit Care Med. 2000 Oct; 1(2):93-9. View abstract
  86. Arnold JH. High-frequency oscillatory ventilation and partial liquid ventilation: liquid breathing to a different beat (frequency) Crit Care Med. 2000 Jul; 28(7):2660-2. View abstract
  87. Curley MA, Thompson JE, Arnold JH. The effects of early and repeated prone positioning in pediatric patients with acute lung injury. Chest. 2000 Jul; 118(1):156-63. View abstract
  88. Bateman ST, Arnold JH. Acute respiratory failure in children. Curr Opin Pediatr. 2000 Jun; 12(3):233-7. View abstract
  89. Arnold JH. Partial liquid breathing: are we headed in the right direction? Crit Care Med. 2000 May; 28(5):1675-6. View abstract
  90. Medalion B, Blackstone EH, Lytle BW, White J, Arnold JH, Cosgrove DM. Aortic valve replacement: is valve size important? J Thorac Cardiovasc Surg. 2000 May; 119(5):963-74. View abstract
  91. Arnold JH, Stenz RI, Grenier B, Thompson JE. Single-breath CO2 analysis as a predictor of lung volume change in a model of acute lung injury. Crit Care Med. 2000 Mar; 28(3):760-4. View abstract
  92. Arnold JH. Innovative methods of respiratory support in infants and children. Clinical Pediatric Anesthesia. 2000; 6:29-34. View abstract
  93. Bateman ST, Arnold JH. Acute respiratory failure: pediatrics. Curr Opin Pediatr. 2000; 12:233-7. View abstract
  94. Arnold JH. High frequency ventilation in the pediatric intensive care unit. Ped Crit Care Med 1:93-99, 2000. 2000; 1:93-9. View abstract
  95. Doctor A, Al-Khadra E, Tan P, Watson K, Thompson J, Arnold JH. Extended high frequency partial liquid ventilation in lung injury: gas exchange and lung injury scores. Am J Resp Crit Care Med. 2000; 161:A46. View abstract
  96. Brazelton TB, Watson KF, Thompson JE, Arnold JH. Identification of optimal lung volume during high frequency oscillatory ventilation using inductive plethysmography. Am J Resp Crit Care Med. 2000; 161:A47. View abstract
  97. Arnold JH. Volatile anesthetic use in the pediatric ICU. Clinical Pediatric Anesthesia 6: 41-42, 2000. 2000; 6:41-2. View abstract
  98. Curley MAQ, Thompson JE, Fackler JC, Arnold JH. Effect of prone positioning on clinical outcomes in pediatric patients with acute lung injury (ALI)/ARDS. Am J Resp Crit Care Med. 2000; 161:A81. View abstract
  99. Doctor A, Al-Khadra E, Watson K, Thompson J, Arnold JH.. Perfluorocarbon (PFC) vapor loss during high frequency ventilation: effect of intrapulmonary PFC distribution. Am J Resp Crit Care Med. 2000; 161:A46. View abstract
  100. Doctor A, Mazzoni MC, DelBalzo U, DiCanzio J, Arnold JH. High-frequency oscillatory ventilation of the perfluorocarbon-filled lung: preliminary results in an animal model of acute lung injury. Crit Care Med. 1999 Nov; 27(11):2500-7. View abstract
  101. Fackler J, Arnold J. When knowing is not understanding. Crit Care Med. 1999 Nov; 27(11):2598-9. View abstract
  102. Arnold JH. Partial liquid breathing: more questions than answers. Crit Care Med. 1999 Sep; 27(9):2058-60. View abstract
  103. Arnold JH. Surfactant replacement in acute lung injury--the saga continues. Crit Care Med. 1999 Jan; 27(1):31-2. View abstract
  104. Brazelton TB, Watson KF, Thompson JE, Arnold JH. . Bench validation of respiratory inductive plethysmography in determining the end expiratory lung volume during high frequency ventilation. Ped Res. 1999; 45:37A. View abstract
  105. Doctor A, Price B, Murphy M, Bhargava N, Thompson J, Arnold JH. High frequency partial liquid ventilation in lung injury: dose-response and frequency manipulation data. Am J Resp Crit Care Med. 1999; 159:A78. View abstract
  106. Goldstein B, Arnold JH (eds). . Pediatric Respiratory Failure. New Horizons: The Science and Practice of Acute Medicine. 1999; 7:275-439. View abstract
  107. Doctor A, Arnold JH. Mechanical support of acute lung injury: options for strategic ventilation. New Horizons. 1999; 7:359-373. View abstract
  108. Brazelton TB, Watson KF, Thompson JE, Arnold JH. Respiratory inductive plethysmography is stable during high frequency ventilation. Ped Res. 1999; 45:38A. View abstract
  109. Camerota AJ, Arnold JH. Anesthesia and analgesia, in Avery GB, Fletcher MA, MacDonald MG (eds.), Neonatology: Pathophysiology and Management of the Newborn (5th Edition), J.B. Lippincott, Philadelphia. 1999; 1447-59. View abstract
  110. Bateman ST, Doctor A, Price BW, Murphy MA, Bhargava N, Taylor G, Thompson, JE, Arnold JH. Fluoroscopic comparisons of intrapulmonary perfluorocarbon distribution: supine vs. prone position using either conventional or high frequency oscillatory ventilation. Am J Resp Crit Care Med. 1999; 159:A602. View abstract
  111. Curley MAQ, Thompson JE, Arnold JH. Effects of early and repeated prone positioning in pediatric patients with acute lung injury. Crit Care Med. 1999; 27:A125. View abstract
  112. Arnold JH. Taking the low (stretch) road. Chest. 1998 Oct; 114(4):955-7. View abstract
  113. Medalion B, Lytle BW, McCarthy PM, Stewart RW, Arheart KL, Arnold JH, Loop FD, Cosgrove DM. Aortic valve replacement for octogenarians: are small valves bad? Ann Thorac Surg. 1998 Sep; 66(3):699-705; discussion 705-6. View abstract
  114. Stenz RI, Grenier B, Thompson JE, Arnold JH. Single-breath CO2 analysis as a predictor of lung volume in a healthy animal model during controlled ventilation. Crit Care Med. 1998 Aug; 26(8):1409-13. View abstract
  115. Doctor A, Ibla JC, Grenier BM, Zurakowski D, Ferretti ML, Thompson JE, Lillehei CW, Arnold JH. Pulmonary blood flow distribution during partial liquid ventilation. J Appl Physiol (1985). 1998 May; 84(5):1540-50. View abstract
  116. Arnold JH. Liquid ventilation: recent concepts, in Salvo I, Vidysagar D (eds.), Anaesthesia and Intensive Care in Neonates and Children, Springer-Verlag, Milan. 1998; 243-51. View abstract
  117. Doctor A, Price B, Murphy M, Bhargava N, Thompson J, Arnold JH. High frequency partial liquid ventilation in lung injury: dose-response data. Ped Res. 1998; 43:35A. View abstract
  118. Arnold JH. High frequency ventilation. Respiratory Care. 1998; 43:961-65. View abstract
  119. Arnold JH, Fackler JC. Anesthetic principles and operating room anesthesia regimens, in Fuhrman BP, Zimmerman JJ (eds.), Pediatric Critical Care (2nd edition), C.V. Mosby, St. Louis. 1998; 1353-62. View abstract
  120. Arnold JH. High frequency ventilation, in Salvo I, Vidysagar D (eds.), Anaesthesia and Intensive Care in Neonates and Children, Springer-Verlag, Milan. 1998; 219-25. View abstract
  121. Bateman ST, Doctor A, Price BW, Murphy MA, Bhargava N, Taylor G, Thompson, JE, Arnold JH. Optimizing intrapulmonary perfluorocarbon: dosing method and mode of ventilation. Ped Res. 1998; 43:34A. View abstract
  122. Arnold JH, Stenz RI, Grenier B, Thompson JE, Arnold LW. Noninvasive determination of cardiac output in a model of acute lung injury. Crit Care Med. 1997 May; 25(5):864-8. View abstract
  123. Green TP, Fackler JC, Steinhart C, Bohn DJ, Heulitt MJ, Newth CJK, Hirschl RB, Nichols D, Klein MD, Martin L, Arnold JH, Ware J. Improved outcome for acute hypoxemic respiratory failure in children: interim results of a prospective, multi-institutional study from the PARF Study Group. Ped Res. 1997; 41:33A. View abstract
  124. Doctor A, Mazzoni M, DelBalzo U, Arnold J. Histopathology of acute lung injury: high frequency oscillation of the perfluorocarbon-filled lung. Ped Res. 1997; 41:32A. View abstract
  125. Doctor A, Mazzoni M, DelBalzo U, Arnold J. High frequency oscillation of the perfluorocarbon-filled lung: preliminary results in an animal model of acute lung injury. Ped Res 41: 32A, 1997. 1997; 41:32A. View abstract
  126. Arnold JH, Stenz RI, Thompson JE, Arnold LW. Noninvasive determination of cardiac output using single breath CO2 analysis. Crit Care Med. 1996 Oct; 24(10):1701-5. View abstract
  127. Ibla JC, Arnold JH, Thompson JE, Breuer CK, Benjamin PK, Lillehei CW. Effects of nitric oxide on hyperinflation-induced pulmonary hypertension in the isolated-perfused lung. Crit Care Med. 1996 Aug; 24(8):1388-95. View abstract
  128. Arnold JH. High frequency oscillatory ventilation: theory and practice in paediatric patients. Paediatr Anaesth. 1996; 6(6):437-41. View abstract
  129. Arnold JH. Liquid breathing: stretching the technological envelope. Crit Care Med. 1996 Jan; 24(1):4-6. View abstract
  130. Arnold JH, Thompson JE, Arnold LW. Single breath CO2 analysis: description and validation of a method. Crit Care Med. 1996 Jan; 24(1):96-102. View abstract
  131. Doctor A, Ibla J, Grenier B, Thompson J, Lillehei C, Arnold J. Redistribution of regional pulmonary blood flow during partial liquid ventilation. Ped Res. 1996; 39:46A. View abstract
  132. Arnold JH. High frequency oscillatory ventilation: theory and practice in pediatric patients. Paediatric Anesthesia. 1996; 6:437-41. View abstract
  133. Fackler JC, Arnold JH, Nichols D, Rogers MC. Acute Respiratory Failure Syndrome. In Rogers MC, (ed.), Textbook of Pediatric Intensive Care, 3rd Edition, Williams & Wilkins, Baltimore. 1996; 197-233. View abstract
  134. Arnold JH, Berde CB. Sedation in the intensive care unit, in Todres D, Fugate J (eds.), A Practice of Pediatric Intensive Care, Little, Brown and Co., Boston. 1996; 582-94. View abstract
  135. Arnold JH, Bower LK, Thompson JE. Respiratory deadspace measurements in neonates with congenital diaphragmatic hernia. Crit Care Med. 1995 Feb; 23(2):371-5. View abstract
  136. Arnold JH, Stenz R, Grenier B, Thompson JE, Arnold LW. Single breath CO2 analysis in an animal model of acute lung injury and pulmonary hypoperfusion. Anesthesiology. 1995; 83:A465. View abstract
  137. Arnold JH. Loughlin GM, Eigen H (eds.), Respiratory Disease in Children: Diagnosis and Management. Crit Care Med. 1995; 23:1795. View abstract
  138. Stenz R, Grenier B, Thompson JE, Arnold JH. Single breath CO2 analysis as a predictor of lung volume in a healthy animal model. Anesthesiology 83:A1221, 1995. 1995; 83:A1221. View abstract
  139. Ibla JC, Arnold JH, Thompson J, Breuer C, Benjamin P, Lillehei C. The effect of nitric oxide on overdistension induced pulmonary hypertension in an isolated perfused sheep lung model. Crit Care Med. 1995; 23:A216. View abstract
  140. Arnold JH, Hanson JH, Toro-Figuero LO, Gutiérrez J, Berens RJ, Anglin DL. Prospective, randomized comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. Crit Care Med. 1994 Oct; 22(10):1530-9. View abstract
  141. Lillehei CW, Shamberger RC, Mayer JE, Burke RP, Koka BV, Arnold J, Wessel DL, Lanzberg M, Palazzo R. Size disparity in pediatric lung transplantation. J Pediatr Surg. 1994 Aug; 29(8):1152-5; discussion 1155-6. View abstract
  142. Burns J, Arnold JH. Pediatric critical care. Curr Opin Pediatr. 1994 Jun; 6(3):295-302. View abstract
  143. Adatia I, Lillehei C, Arnold JH, Thompson JE, Palazzo R, Fackler JC, Wessel DL. Inhaled nitric oxide in the treatment of postoperative graft dysfunction after lung transplantation. Ann Thorac Surg. 1994 May; 57(5):1311-8. View abstract
  144. Anand KJ, Arnold JH. Opioid tolerance and dependence in infants and children. Crit Care Med. 1994 Feb; 22(2):334-42. View abstract
  145. Arnold JH, Anand KJS. Anesthesia and analgesia. in Avery GB, Fletcher MA, MacDonald MG (eds.), Neonatology: Pathophysiology and Management of the Newborn (4th Edition), J.B. Lippincott, Philadelphia. 1994; 1334-45. View abstract
  146. Burns J, Arnold JH. Current opinion in pediatrics: pediatric critical care. Current Science. 1994; 6:295-302. View abstract
  147. Arnold JH, Hanson JH, Pediatric HFOV Study Group. . Outcome of pediatric patients managed with high frequency oscillatory ventilation. Anesthesiology. 1994; 81:A269. View abstract
  148. Arnold JH, Thompson JE, Tabor T. Single breath CO2 analysis: bench validation in a lung model. Ped Res. 1994; 35:49A. View abstract
  149. Arnold JH, Arnold LW, Thompson JE, Tabor T. Single breath CO2 analysis in a model of pulmonary hypoperfusion. Ped Res. 1994; 35:48A. View abstract
  150. Arnold JH, Thompson JE, Benjamin PK. Respiratory deadspace measurements in neonates during extracorporeal membrane oxygenation. Crit Care Med. 1993 Dec; 21(12):1895-900. View abstract
  151. Arnold JH, Truog RD, Molengraft JA. Tolerance to isoflurane during prolonged administration. Anesthesiology. 1993 May; 78(5):985-8. View abstract
  152. Arnold JH, Truog RD, Rice SA. Prolonged administration of isoflurane to pediatric patients during mechanical ventilation. Anesth Analg. 1993 Mar; 76(3):520-6. View abstract
  153. Arnold JH, Truog RD, Thompson JE, Fackler JC. High-frequency oscillatory ventilation in pediatric respiratory failure. Crit Care Med. 1993 Feb; 21(2):272-8. View abstract
  154. Arnold JH, Benjamin PK, Thompson JE. Changes in dynamic lung compliance and VD/VT ratio during ECMO. Presented at the 8th Annual Children's Hospital National Medical Center ECMO Symposium. 1993. View abstract
  155. Waisel DB, Brunner JX, Arnold JH, Kohane I, Fackler JC. PEFIOS: A PEEP-FiO2-SpO2 closed loop controller of arterial oxygen saturation. Anesthesiology. 1993; 79:A287. View abstract
  156. Arnold JH, Hanson JH, Anglin DL. Prospective randomized comparison of high frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. Anesthesiology. 1993; 79:A1221. View abstract
  157. Teaching Video. "High frequency oscillatory ventilation in pediatric respiratory failure". 1993. View abstract
  158. Arnold JH, Truog RD, Rice SA. Prolonged administration of isoflurane to pediatric patients during mechanical ventilation. Presented at the 6th Annual Pediatric Critical Care Colloquium. 1993. View abstract
  159. Josephs LG, Arnold JH, Sawyers JL. Laparoscopic highly selective vagotomy. J Laparoendosc Surg. 1992 Jun; 2(3):151-3. View abstract
  160. Coltharp WH, Arnold JH, Alford WC, Burrus GR, Glassford DM, Lea JW, Petracek MR, Starkey TD, Stoney WS, Thomas CS, et al. Videothoracoscopy: improved technique and expanded indications. Ann Thorac Surg. 1992 May; 53(5):776-8; discussion 779. View abstract
  161. Truog RD, Arnold JH. The "ethics of evidence" and randomized controlled trials. J Clin Ethics. 1992; 3(1):65-7. View abstract
  162. Arnold JH, Fackler JC. Anesthetic principles and operating room anesthesia regimens. in Fuhrman BP, Zimmerman JJ (eds.), Pediatric Critical Care, C.V. Mosby, St. Louis. 1992; 1265-73. View abstract
  163. Arnold JH, Benjamin PK, Thompson JE. Changes in VD/VT in infants with pulmonary hypertension during extracorporeal membrane oxygenation (ECMO). Anesthesiology. 1992; 77:A240. View abstract
  164. Arnold JH, Truog RD. Sedation in neonatal and pediatric intensive care. Sedation in neonatal and pediatric intensive care, Journal of Intensive Care Medicine. 1992; 7:244-60. View abstract
  165. Arnold JH, Truog RD, Thompson JE, Fackler JC. High frequency oscillatory ventilation in pediatric respiratory failure. Presented at the 5th Annual Pediatric Critical Care Colloquium. 1992. View abstract
  166. Arnold JH, Benjamin PK, Thompson JE. Online measurement ofV CO2 during mechanical ventilation in infants. Anesthesiology. 1992; 77:A467. View abstract
  167. Arnold JH, Truog RD, Scavone JM, Fenton T. Changes in the pharmacodynamic response to fentanyl in neonates during continuous infusion. J Pediatr. 1991 Oct; 119(4):639-43. View abstract
  168. Truog RD, Arnold JH, Rockoff MA. Sedation before ventilator withdrawal: medical and ethical considerations. J Clin Ethics. 1991; 2(2):127-9. View abstract
  169. Arnold JH, Truog RD, Scavone JM. Fentanyl binding to the ECMO circuit: is the process saturable? Presented at the 7th Annual Children's Hospital National Medical Center ECMO Symposium. 1991. View abstract
  170. Arnold JH, Truog RD, Scavone JM. Plasma levels of midazolam during ECMO. Presented at the 7th Annual Children's Hospital National Medical Center ECMO Symposium. 1991. View abstract
  171. Arnold JH, Truog RD, Orav EJ, Scavone JM, Hershenson MB. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology. 1990 Dec; 73(6):1136-40. View abstract
  172. Truog RD, Arnold JH, Fackler JC. ECMO: Ethical allocation of a scarce medical resource. Presented at the 6th Annual Children's Hospital National Medical Center ECMO Symposium. 1990. View abstract
  173. Kupsky WJ, Kinney HC, Arnold JH, Truog RD, Vacanti JP. Neuropathologic findings in 23 neonates treated with extracorporeal membrane oxygenation. Presented at the 6th Annual Children's Hospital National Medical Center ECMO Symposium. 1990. View abstract
  174. Truog RD, Arnold JH, Fackler JC. Scarce ICU resources and the obligation to limit therapy. Presented at the annual meeting of the American Academy of Pediatrics. 1990. View abstract
  175. Arnold JH, Truog RD. Sedation for infants undergoing extracorporeal membrane oxygenation. Presented at the 6th Annual Children's Hospital National Medical Center ECMO Symposium. 1990. View abstract
  176. Arnold JH, Truog RD. Rapid development of tolerance during fentanyl infusion. Anesthesiology. 1990; 73:A406. View abstract
  177. Arnold JH, Truog RD, Hershenson MB. Neonatal abstinence syndrome in infants sedated with fentanyl. Anesthesiology. 1989; 71:A218. View abstract
  178. Kupsky WJ, Kinney HC, Lidov HGW, Arnold JH, Truog R, Vacanti JP. Neuropathology of infants dying after extracorporeal membrane oxygenation. J Neuropathol Exp Neurol. 1989; 48:307. View abstract
  179. Arnold JH, Scott AV, Spitznagel JK. Specificity of PPD skin tests in childhood tuberculin converters: comparison with mycobacterial species from tissues and secretions. J Pediatr. 1970 Apr; 76(4):512-22. View abstract