Researchers in the Department of Anesthesiology conduct a variety of basic and clinical investigations in laboratories, ICUs and main operating rooms, and clinical services. Basic research includes studies of: - The role of white cell/endothelial adhesion molecules in the pathophysiology of extracorporeal circulation and ischemia/reperfusion injury and the use of specific monoclonal antibodies ito attenuate such injuries
- Cell volume regulation in the brain and the role of cell volume disturbances in various brain injuries.
- Tachyphylaxis to local anesthetic agents
- Novel longer-lasting local anesthetics
Clinical research includes studies of: - Cardiovascular effects of sevoflurane
- Local anesthetics applied to the skin for venipuncture
- Factors affecting neurologic injury associated with cardiac surgery in infants
- Efficacy of ketorolac for pain relief in outpatient procedures
- Role of magnesium in dysrhythmias following cardiac surgery in infants
- Role of nitric oxide in pediatric pulmonary diseases
- Use of transcranial Doppler to better understand the effects of anesthetics on cerebral function
- Transesophageal echocardiography in intraoperative diagnosis of residual cardiac defects
- Use of new methods of ventilatory support as alternatives to ECMO
Featured researchers in the Department of Anesthesiology hold faculty appointments at Harvard Medical School.
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