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David Bellinger, PhD
Professor
of Neurology
Harvard Medical
School/Children's Hospital
Department of
Neurology
MRRC Project(s)
U01 DE 11886
Health Effects of Dental Amalgams in Children
R01 HL64951-01
Neurobehavioral Sequelae of Cardiac Surgery
The overall focus
of this research program is the functional sequelae of two broad classes
of early insults to the developing nervous system, exogenous chemical
exposures, (e.g., lead, fluoride, mercury, and cocaine), and endogenous
metabolic insults related to serious medical conditions (e.g., congenital
heart lesions). The specific aims of the chemical exposure studies are
(1) to develop new strategies for exposure assessment, (2) to define the
"behavioral signature", if any, associated with different exposure
scenarios, (3) to identify factors that function as effect modifiers (i.e.,
that either enhance or mitigate the magnitude or presentation of toxicant-related
effects), and (4) to evaluate exposure abatement interventions. The specific
aims of the studies on endogenous insults related to medical conditions
are to characterize the associated behavioral risks, particularly those
that are associated with invasive interventions, such as reparative cardiac
procedures for serious congenital heart disease.
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