Lehtinen Laboratory | Recent Publications

Below you will see a list of our publications. If you have difficulties accessing any of our publications or data sets, please contact Maria, and we will do our best to make them available.

* indicates co-first authorship

Fame, RM, Shannon, ML, Chau, KF, Head, JP, Lehtinen, MK. Concerted metabolic shift in early forebrain alters the CSF proteome and depends on cMYC downregulation for mitochondrial maturation. Development Epub Oct. 1, 2019. [Article PDF]

Lun, MP, Shannon, ML, Keles, S, Reisli, I, Luche, N, Ryan, D, Capuder, K, Notarangelo, L, and Lehtinen, MK. Spatio-temporal gradient of cortical neuron death contributes to microcephaly in knock-in mouse model of Ligase 4 syndrome. Am J Pathology Epub Sept. 18, 2019. [Article PDF]

Orefice, LL, Mosko, JR, Morency, DT, Wells, MF, Tasnim, A, Mozeika, SM, Anda, MY, Chirila, M, Emanuel, AJ, Rankin, G, Fame, RM, Lehtinen, MK, Feng, G, and Ginty, DD. Targeting peripheral somatosensory neurons to improve tactile-related phenotypes in ASD models. Cell 2019 Aug. 8;178:867-886.  [Article PDF]

Dani, N*, Herbst, RH*, Habib, N*, Head, J, Dionne, D, Cui, J, McCabe, C, Shipley, FB, Rodman, C, Zhang, F, Rozenblatt-Rosen, O, Regev, A, Lehtinen, MK. A cellular and spatial map of the choroid plexus across brain ventricles and ages. BioRxiv [Preprint] May 5, 2019. [Article PDF]

Fame RM and Lehtinen MK. Sister, sister: Ependymal cells and adult neural stem cell are separated at birth by Geminin family members. Neuron 2019, 102(2):278-279.   [Article PDF]

Smith, RS, Kenny, CJ, Ganesh, V, Jang, A, Borges-Monroy, R, Partlow, JN, Hill, RS, Shin, T, Chen, AY, Doan, RN, Anttonen, A-K, Ignatius, J, Medne, L, Bönnemann, CG, Hecht, JL, Salonen, O, Barkovich, AJ, Poduri, A, Wilke, M, de Wit, MCY, Mancini, GMS, Sztriha, L, Im, K, Amrom, D, Andermann, E, Paetau, R, Lehesjoki, A-E, Walsh, CA, and Lehtinen, MK. Sodium channel SCN3A (NaV1.3) regulation of human cerebral cortical folding and oral motor development. Neuron 2018, 99(5): 905-913. Epub Aug. 23. [Article]

Coulter, ME, Dorobantu, CM, Lodewijk, GA, Delalande, F, Cianferani, S, Ganesh, V, Smith, R, Lim, ET, Xu, CS, Pang, S, Wong, ET, Lidov, HGW, Calicchio, ML, Yang, E, Gonzalez, DM, Schlaeger, T, Mochida, G, Hess, H, Lee, W-CA, Lehtinen, MK, Kirchhausen, T, Haussler, D, Jacobs, FMJ, Gaudin, R, Walsh, CA. The ESCRT-III protein CHMP1A mediates secretion of sonic hedgehog on ART subtype of extracellular vesicles. Cell Reports 2018 24(4)973-986.

Chau, KF, Shannon, ML, Fame, RM, Fonseca, E, Mullan, H, Johnson, MB, Sendamarai, AK, Springel, MW, Laurent, B, Lehtinen, MK. Downregulation of ribosome biogenesis during early forebrain development. eLife 2018 Publish on acceptance May 10. [Article PDF]

Shannon, ML*, Fame, RM*, Chau, KF*, Dani, N, Calicchio, ML, Géléoc, GS, Lidov, HGW, Alexandrescu, S, Lehtinen, MK. Mice expressing c-MYC in neural precursors develop choroid plexus and ciliary body tumors. Am J Pathology 2018. Epub ahead of print. [Article PDF]

Lehtinen, MK. Adolescent obesity thwarts lifelong sleep. Science Translational Medicine 2018 Jan 3; 10(422): pii: eaar7510. [Article PDF]

Lehtinen, MK. Epilepsy clocks out. Science Translational Medicine 2017 Nov 9(416): eaaq1237 [Article PDF]

Lehtinen, MK. Going with your gut in multiple sclerosis. Science Translational Medicine 2017 Oct 4; 9(410): pii eaap8164 [Article PDF]

Lehtinen, MK.
Cellular eyelashes help striatal neurons hook up. Science Translational Medicine 2017 Aug 23: 9(404): pii: eaao4214 [Article PDF]


Lehtinen, MK. Shining new light on migraine. Science Translational Medicine 2017 July 12; 9(398): pii: eaan8206. [Article PDF]

Lehtinen, MK. Say good night to your pain. Science Translational Medicine 2017 May 31; 9(392):pii: eaan4298. [Article PDF]

Lehtinen, MK. Filtering more than light in the developing retina. Science Translational Medicine 2017 April 19; 9(386):pii: eaan2782. [Article PDF]


Anttonen, A-K, Laari, A, Kousi, M, Yang, YJ, Jääskeläinen, T, Somer, M, Siintola, E, Jakkula, E, Muona, M, Tegelberg, S, Lönnqvist, T, Pihko, H, Valanne, H, Paetau, A, Lun, MP, Hästbacka, J, Kopra, O, Joensuu, T, Katsanis, N, Lehtinen, MK, Palvimo, JJ, Lehesjoki, A-E. ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with impaired cerebellar granule cell migration. Brain 2017, March 1, Epub ahead of print.

Lehtinen, MK. The brain’s matchmakers. Science Translational Medicine 2017 March 8; 9(380): pii: eaam9863. [Article PDF]

Dani, N and Lehtinen, MK (2016). CSF makes waves in the neural stem cell niche. Cell Stem Cell 19(5)565-566.[Article PDF]

Crespel, A, Ferlazzo, E, Fraceschetti, S, Genton, P, Gouider, R, Kälviäinen, R, Korja, M, Lehtinen, MK*, Mervaala, E, Simonato, M, Vaarmann, A (2016). Unverricht-Lundborg disease. Epileptic disorders Epub ahead of print, Sept. 1, 2016. *corresponding author

Mathew RS, Mullan H, Blusztajn JK, Lehtinen MK, 2016. Comment on “Multiple repressive mechanisms in the hippocampus during memory formation.” Science 353(6298):453.[Article PDF]

Terauchi, A, Johnson-Venkatesh, E, Bullock, B, Lehtinen, MK, Umemori, H, 2016. Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain. eLife 10.7554/eLife.12151. [Link to Article PDF]

Li, L, Picotte, K, Wang, J, Lun, MP, Ohli, J, Lidov, HGW, Calicchio, ML, Zeng, E, Salisbury, J, Wechsler-Reya, R, Lehtinen, MK, Schüller, U, and Zhao, H, 2016. Notch and Sonic Hedgehog converge on primary cilium in choroid plexus tumor. Nature Cell Biology 18(4):418-30. [Article PDF]

Chau, KF, Springel, MW, Broadbelt, KG, Park, H-Y, Topal, S, Lun, MP, Mullan, H, Maynard, T, Steen, H, LaMantia, A-S, Lehtinen, MK, 2015. Progressive differentiation and instructive capacities of amniotic fluid and cerebrospinal fluid proteomes following neural tube closure. Developmental Cell 35, 789–802. Highlighted as Featured Article. [Article PDF]

Zhou, G, Hotta, J, Lehtinen, MK, Forss, N, Hari, R (2015). Enlargement of choroid plexus in complex regional pain syndrome. Scientific Reports 5:14329 [Article PDF]

Lun, MP, Monuki, ES, and Lehtinen, MK, 2015. Development and functions of the choroid plexus-cerebrospinal fluid system. Nature Reviews Neuroscience, Published online July 15, 2015.

Chang, J., Lehtinen, MK, Sive, H, 2015. Zebrafish cerebrospinal fluid mediates neuronal survival through a retinoid signaling pathway. Developmental Neurobiology, Epub ahead of print. [Article PDF]

Lun, MP, Johnson, MB, Broadbelt, KG, Watanabe, M, Kang, Y-J, Chau, KF, Springel, MW, Malesz, A, Sousa, AMM, Pletikos, M, Adelita, T, Calicchio, ML, Zhang, Y, Holtzman, MJ, Lidov, HGW, Sestan, N, Steen, H, Monuki, ES, Lehtinen, MK, 2015. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional cerebrospinal fluid production. J Neuroscience, 35(12): 4903-4916. PMCID: in process. [Article PDF]

Lehtinen MK, Dymecki, S, Bjornsson, C, Gilbertson, R, Holtzman, D, Monuki, E, 2013. The Society for Neuroscience Minisymposium Review. The choroid plexus and cerebrospinal fluid: Emerging roles in development, disease, and therapy. J Neuroscience, 33(45): 17553-17559. PMCID: PMC3818536 [Article PDF]

Zappaterra, MW, LaMantia, AS, Walsh, CA, and Lehtinen, MK, 2013. Isolation of cerebrospinal fluid from rodent embryos for use with dissected cerebral cortical explants. Journal of Visualized Experiments, March 11: 73. PMCID: PMC3635544 [Article PDF]

Lehtinen, MK, 2012. Adult neurogenesis: VCAM stems the tide. Cell Stem Cell, 11:137-38. PMCID: PMC3437932 [Article PDF]

Zappaterra MW and Lehtinen, MK, 2012. The cerebrospinal fluid: Regulator of neurogenesis, behavior, and beyond. Cellular and Molecular Life Sciences. 69(17):2863-78. PMCID: PMC3856656. [Article PDF]

Poduri, A, Evrony, GD, Cai, X, Elhosary, PC, Beroukhim, R, Hill, A, Lehtinen, MK, Hill, RS, Barry, BJ, Bourgeois, BFD, Riviello, JJ, Barkovich, AJ, Black, PM, Ligon, K, Walsh, CA, 2012. Somatic mutations cause hemispheric developmental brain malformations. Neuron 74:41-48. PMCID: PMC3460551 [Article PDF]

Lehtinen, MK and Walsh, CA, 2011. Neurogenesis at the brain-cerebrospinal fluid interface. Annual Review of Cell and Developmental Biology 27: 653-79. PMCID: PMC3777264 [Article PDF]

Lehtinen, MK*, Zappaterra, MW*, Chen, X, Yang, Y, Hill, A, Lun, M, Maynard, T, Gonzalez, D, Kim, S, Ye, P, D’Ercole, AJ, Wong, ET, LaMantia, AS, and Walsh, CA, 2011. The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron 69(5): 893-905. Highlighted in [A] Nature as Research Highlight 471:269; [B] Anna Buckley and Chay T Kuo: Faculty of 1000, 5 April 2011; [C] Selected as Hot Topic by Society for Neuroscience, 2011. PMCID: PMC3085909 [Article PDF]

Lehtinen, MK, Lehesjoki, A-E, Kälviäinen, R, 2011. Unverricht-Lundborg disease. In: Shorvon, S, Guerrini, R, and Andermann, F, eds. The Causes of Epilepsy. Cambridge: Cambridge University Press. Pp. 135-138. [Article PDF]

Tucker, ES, Lehtinen, MK, Maynard, T, Zirlinger, M, Dulac, C, Rawson, N, Pevny, L, and LaMantia, A-S, 2010. Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium. Development 137(15):2471-81. Highlighted in In this Issue, Development. PMCID: PMC2927696 [Article PDF]

Kim, S*, Lehtinen, MK*, Sessa, A, Zappaterra, MW, Cho, S-H, Gonzalez, D, Boggan, B, Austin, CA, Wijnholds, J, Gambella, MJ, Malicki, J, LaMantia, A-S, Broccoli, V, and Walsh, CA, 2010. The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66(1) 69-84. Featured as Spotlight Article, and Featured Topic in Development on Neuron website. PMCID: PMC2872122 [Article PDF]

Lehtinen, MK, Tegelberg, S, Schipper, H, Su, H, Zukor, H, Manninen, O, Kopra, O, Joensuu, T, Hakala, P, Bonni, A, and Lehesjoki, A-E, 2009. Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1. J Neuroscience 29(18):5910-5915. PMCID: PMC2694495 [Article PDF]

Yuan, Z*, Lehtinen, MK*, Merlo, P, Villén, J, Gygi, S, and Bonni, A, 2009. Regulation of neuronal death by MST-FOXO1 signaling. J Biol Chem 284(17):11285-92. PMCID: PMC2670133 [Article PDF]

Lehtinen MK and Bonni, A, 2008. Demystifying MST family kinases in cell death. Current Molecular Medicine 8(4): 313-8. [Article PDF]

Lehtinen, MK*, Yuan, Z*, Boag, P, Yang, Y, Villén, J, Becker, EBE, DiBacco, S, de la Iglesia, N, Gygi, S, Blackwell, TK, and Bonni, A, 2006. A conserved MST-FOXO signaling pathway mediates oxidative stress responses and extends lifespan. Cell 125: 987-1001. PMID: 16751106. Highlighted in [A] Nature as Research Highlight 441:788-789; [B] Jonathan Chernoff: Faculty of 1000 Biology, 3 Jul 2006. [Article PDF]

Lehtinen MK and Bonni, A, 2006. Modeling oxidative stress in the nervous system. Current Molecular Medicine 6(8): 871-81. [Article PDF]

Benedito, A, Lehtinen, M, Massol, R, Kirchhausen, T, Rao, A, and Bonni, A, 2004. The transcription factor NFAT3 mediates neuronal survival. J Biol Chem 280(4): 2818-25. [Article PDF]

Shalizi, A, Lehtinen, M, Gaudillière, B, Donovan, N, Han, J, Konishi, Y, and Bonni, A, 2003. Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. J Neuroscience 23(19): 7326-36. PMID: 12917366 [Article PDF]

Konishi, Y, Lehtinen, M, Donovan, N, and Bonni, A, 2002. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Molecular Cell 9(5): 1005-16. Highlighted in Antony Carr: Faculty of 1000 Biology, 24 Jun 2002. PMID: 12049737 [Article PDF]

Wiemelt, AP, Lehtinen, M, and McMorris, FA, 2001. Agonists calcitonin, corticotropin-releasing hormone, and vasoactive intestinal peptide, but not prostaglandins or B-adrenergic agonists, elevate cyclic adenosine monophosphate levels in oligodendroglial cells. J Neuroscience Research 65: 165-172. [Article PDF]