Lehtinen Laboratory | Recent Publications

Below you will see a list of our publications. If you have difficulties accessing any of our publications or data sets, please contact Maria, and we will do our best to make them available.

* indicates co-first authorship

Fame RM and Lehtinen MK. Emergence and developmental roles of the Cerebrospinal fluid system. Developmental Cell 2020 52(3):261-275. [Article PDF]

Fame, RM, Shannon, ML, Chau, KF, Head, JP, Lehtinen, MK. Concerted metabolic shift in early forebrain alters the CSF proteome and depends on cMYC downregulation for mitochondrial maturation. Development Epub Oct. 1, 2019. [Article PDF]

Lun, MP, Shannon, ML, Keles, S, Reisli, I, Luche, N, Ryan, D, Capuder, K, Notarangelo, L, and Lehtinen, MK. Spatio-temporal gradient of cortical neuron death contributes to microcephaly in knock-in mouse model of Ligase 4 syndrome. Am J Pathology Epub Sept. 18, 2019. [Article PDF]

Orefice, LL, Mosko, JR, Morency, DT, Wells, MF, Tasnim, A, Mozeika, SM, Anda, MY, Chirila, M, Emanuel, AJ, Rankin, G, Fame, RM, Lehtinen, MK, Feng, G, and Ginty, DD. Targeting peripheral somatosensory neurons to improve tactile-related phenotypes in ASD models. Cell 2019 Aug. 8;178:867-886.  [Article PDF]

Dani, N*, Herbst, RH*, Habib, N*, Head, J, Dionne, D, Cui, J, McCabe, C, Shipley, FB, Rodman, C, Zhang, F, Rozenblatt-Rosen, O, Regev, A, Lehtinen, MK. A cellular and spatial map of the choroid plexus across brain ventricles and ages. BioRxiv [Preprint] May 5, 2019. [Article PDF]

Fame RM and Lehtinen MK. Sister, sister: Ependymal cells and adult neural stem cell are separated at birth by Geminin family members. Neuron 2019, 102(2):278-279.   [Article PDF]

Smith, RS, Kenny, CJ, Ganesh, V, Jang, A, Borges-Monroy, R, Partlow, JN, Hill, RS, Shin, T, Chen, AY, Doan, RN, Anttonen, A-K, Ignatius, J, Medne, L, Bönnemann, CG, Hecht, JL, Salonen, O, Barkovich, AJ, Poduri, A, Wilke, M, de Wit, MCY, Mancini, GMS, Sztriha, L, Im, K, Amrom, D, Andermann, E, Paetau, R, Lehesjoki, A-E, Walsh, CA, and Lehtinen, MK. Sodium channel SCN3A (NaV1.3) regulation of human cerebral cortical folding and oral motor development. Neuron 2018, 99(5): 905-913. Epub Aug. 23. [Article]

Coulter, ME, Dorobantu, CM, Lodewijk, GA, Delalande, F, Cianferani, S, Ganesh, V, Smith, R, Lim, ET, Xu, CS, Pang, S, Wong, ET, Lidov, HGW, Calicchio, ML, Yang, E, Gonzalez, DM, Schlaeger, T, Mochida, G, Hess, H, Lee, W-CA, Lehtinen, MK, Kirchhausen, T, Haussler, D, Jacobs, FMJ, Gaudin, R, Walsh, CA. The ESCRT-III protein CHMP1A mediates secretion of sonic hedgehog on ART subtype of extracellular vesicles. Cell Reports 2018 24(4)973-986.

Chau, KF, Shannon, ML, Fame, RM, Fonseca, E, Mullan, H, Johnson, MB, Sendamarai, AK, Springel, MW, Laurent, B, Lehtinen, MK. Downregulation of ribosome biogenesis during early forebrain development. eLife 2018 Publish on acceptance May 10. [Article PDF]

Shannon, ML*, Fame, RM*, Chau, KF*, Dani, N, Calicchio, ML, Géléoc, GS, Lidov, HGW, Alexandrescu, S, Lehtinen, MK. Mice expressing c-MYC in neural precursors develop choroid plexus and ciliary body tumors. Am J Pathology 2018. Epub ahead of print. [Article PDF]

Lehtinen, MK. Adolescent obesity thwarts lifelong sleep. Science Translational Medicine 2018 Jan 3; 10(422): pii: eaar7510. [Article PDF]

Lehtinen, MK. Epilepsy clocks out. Science Translational Medicine 2017 Nov 9(416): eaaq1237 [Article PDF]

Lehtinen, MK. Going with your gut in multiple sclerosis. Science Translational Medicine 2017 Oct 4; 9(410): pii eaap8164 [Article PDF]

Lehtinen, MK.
Cellular eyelashes help striatal neurons hook up. Science Translational Medicine 2017 Aug 23: 9(404): pii: eaao4214 [Article PDF]


Lehtinen, MK. Shining new light on migraine. Science Translational Medicine 2017 July 12; 9(398): pii: eaan8206. [Article PDF]

Lehtinen, MK. Say good night to your pain. Science Translational Medicine 2017 May 31; 9(392):pii: eaan4298. [Article PDF]

Lehtinen, MK. Filtering more than light in the developing retina. Science Translational Medicine 2017 April 19; 9(386):pii: eaan2782. [Article PDF]


Anttonen, A-K, Laari, A, Kousi, M, Yang, YJ, Jääskeläinen, T, Somer, M, Siintola, E, Jakkula, E, Muona, M, Tegelberg, S, Lönnqvist, T, Pihko, H, Valanne, H, Paetau, A, Lun, MP, Hästbacka, J, Kopra, O, Joensuu, T, Katsanis, N, Lehtinen, MK, Palvimo, JJ, Lehesjoki, A-E. ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with impaired cerebellar granule cell migration. Brain 2017, March 1, Epub ahead of print.

Lehtinen, MK. The brain’s matchmakers. Science Translational Medicine 2017 March 8; 9(380): pii: eaam9863. [Article PDF]

Dani, N and Lehtinen, MK (2016). CSF makes waves in the neural stem cell niche. Cell Stem Cell 19(5)565-566.[Article PDF]

Crespel, A, Ferlazzo, E, Fraceschetti, S, Genton, P, Gouider, R, Kälviäinen, R, Korja, M, Lehtinen, MK*, Mervaala, E, Simonato, M, Vaarmann, A (2016). Unverricht-Lundborg disease. Epileptic disorders Epub ahead of print, Sept. 1, 2016. *corresponding author

Mathew RS, Mullan H, Blusztajn JK, Lehtinen MK, 2016. Comment on “Multiple repressive mechanisms in the hippocampus during memory formation.” Science 353(6298):453.[Article PDF]

Terauchi, A, Johnson-Venkatesh, E, Bullock, B, Lehtinen, MK, Umemori, H, 2016. Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain. eLife 10.7554/eLife.12151. [Link to Article PDF]

Li, L, Picotte, K, Wang, J, Lun, MP, Ohli, J, Lidov, HGW, Calicchio, ML, Zeng, E, Salisbury, J, Wechsler-Reya, R, Lehtinen, MK, Schüller, U, and Zhao, H, 2016. Notch and Sonic Hedgehog converge on primary cilium in choroid plexus tumor. Nature Cell Biology 18(4):418-30. [Article PDF]

Chau, KF, Springel, MW, Broadbelt, KG, Park, H-Y, Topal, S, Lun, MP, Mullan, H, Maynard, T, Steen, H, LaMantia, A-S, Lehtinen, MK, 2015. Progressive differentiation and instructive capacities of amniotic fluid and cerebrospinal fluid proteomes following neural tube closure. Developmental Cell 35, 789–802. Highlighted as Featured Article. [Article PDF]

Zhou, G, Hotta, J, Lehtinen, MK, Forss, N, Hari, R (2015). Enlargement of choroid plexus in complex regional pain syndrome. Scientific Reports 5:14329 [Article PDF]

Lun, MP, Monuki, ES, and Lehtinen, MK, 2015. Development and functions of the choroid plexus-cerebrospinal fluid system. Nature Reviews Neuroscience, Published online July 15, 2015.

Chang, J., Lehtinen, MK, Sive, H, 2015. Zebrafish cerebrospinal fluid mediates neuronal survival through a retinoid signaling pathway. Developmental Neurobiology, Epub ahead of print. [Article PDF]

Lun, MP, Johnson, MB, Broadbelt, KG, Watanabe, M, Kang, Y-J, Chau, KF, Springel, MW, Malesz, A, Sousa, AMM, Pletikos, M, Adelita, T, Calicchio, ML, Zhang, Y, Holtzman, MJ, Lidov, HGW, Sestan, N, Steen, H, Monuki, ES, Lehtinen, MK, 2015. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional cerebrospinal fluid production. J Neuroscience, 35(12): 4903-4916. PMCID: in process. [Article PDF]

Lehtinen MK, Dymecki, S, Bjornsson, C, Gilbertson, R, Holtzman, D, Monuki, E, 2013. The Society for Neuroscience Minisymposium Review. The choroid plexus and cerebrospinal fluid: Emerging roles in development, disease, and therapy. J Neuroscience, 33(45): 17553-17559. PMCID: PMC3818536 [Article PDF]

Zappaterra, MW, LaMantia, AS, Walsh, CA, and Lehtinen, MK, 2013. Isolation of cerebrospinal fluid from rodent embryos for use with dissected cerebral cortical explants. Journal of Visualized Experiments, March 11: 73. PMCID: PMC3635544 [Article PDF]

Lehtinen, MK, 2012. Adult neurogenesis: VCAM stems the tide. Cell Stem Cell, 11:137-38. PMCID: PMC3437932 [Article PDF]

Zappaterra MW and Lehtinen, MK, 2012. The cerebrospinal fluid: Regulator of neurogenesis, behavior, and beyond. Cellular and Molecular Life Sciences. 69(17):2863-78. PMCID: PMC3856656. [Article PDF]

Poduri, A, Evrony, GD, Cai, X, Elhosary, PC, Beroukhim, R, Hill, A, Lehtinen, MK, Hill, RS, Barry, BJ, Bourgeois, BFD, Riviello, JJ, Barkovich, AJ, Black, PM, Ligon, K, Walsh, CA, 2012. Somatic mutations cause hemispheric developmental brain malformations. Neuron 74:41-48. PMCID: PMC3460551 [Article PDF]

Lehtinen, MK and Walsh, CA, 2011. Neurogenesis at the brain-cerebrospinal fluid interface. Annual Review of Cell and Developmental Biology 27: 653-79. PMCID: PMC3777264 [Article PDF]

Lehtinen, MK*, Zappaterra, MW*, Chen, X, Yang, Y, Hill, A, Lun, M, Maynard, T, Gonzalez, D, Kim, S, Ye, P, D’Ercole, AJ, Wong, ET, LaMantia, AS, and Walsh, CA, 2011. The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron 69(5): 893-905. Highlighted in [A] Nature as Research Highlight 471:269; [B] Anna Buckley and Chay T Kuo: Faculty of 1000, 5 April 2011; [C] Selected as Hot Topic by Society for Neuroscience, 2011. PMCID: PMC3085909 [Article PDF]

Lehtinen, MK, Lehesjoki, A-E, Kälviäinen, R, 2011. Unverricht-Lundborg disease. In: Shorvon, S, Guerrini, R, and Andermann, F, eds. The Causes of Epilepsy. Cambridge: Cambridge University Press. Pp. 135-138. [Article PDF]

Tucker, ES, Lehtinen, MK, Maynard, T, Zirlinger, M, Dulac, C, Rawson, N, Pevny, L, and LaMantia, A-S, 2010. Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium. Development 137(15):2471-81. Highlighted in In this Issue, Development. PMCID: PMC2927696 [Article PDF]

Kim, S*, Lehtinen, MK*, Sessa, A, Zappaterra, MW, Cho, S-H, Gonzalez, D, Boggan, B, Austin, CA, Wijnholds, J, Gambella, MJ, Malicki, J, LaMantia, A-S, Broccoli, V, and Walsh, CA, 2010. The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66(1) 69-84. Featured as Spotlight Article, and Featured Topic in Development on Neuron website. PMCID: PMC2872122 [Article PDF]

Lehtinen, MK, Tegelberg, S, Schipper, H, Su, H, Zukor, H, Manninen, O, Kopra, O, Joensuu, T, Hakala, P, Bonni, A, and Lehesjoki, A-E, 2009. Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1. J Neuroscience 29(18):5910-5915. PMCID: PMC2694495 [Article PDF]

Yuan, Z*, Lehtinen, MK*, Merlo, P, Villén, J, Gygi, S, and Bonni, A, 2009. Regulation of neuronal death by MST-FOXO1 signaling. J Biol Chem 284(17):11285-92. PMCID: PMC2670133 [Article PDF]

Lehtinen MK and Bonni, A, 2008. Demystifying MST family kinases in cell death. Current Molecular Medicine 8(4): 313-8. [Article PDF]

Lehtinen, MK*, Yuan, Z*, Boag, P, Yang, Y, Villén, J, Becker, EBE, DiBacco, S, de la Iglesia, N, Gygi, S, Blackwell, TK, and Bonni, A, 2006. A conserved MST-FOXO signaling pathway mediates oxidative stress responses and extends lifespan. Cell 125: 987-1001. PMID: 16751106. Highlighted in [A] Nature as Research Highlight 441:788-789; [B] Jonathan Chernoff: Faculty of 1000 Biology, 3 Jul 2006. [Article PDF]

Lehtinen MK and Bonni, A, 2006. Modeling oxidative stress in the nervous system. Current Molecular Medicine 6(8): 871-81. [Article PDF]

Benedito, A, Lehtinen, M, Massol, R, Kirchhausen, T, Rao, A, and Bonni, A, 2004. The transcription factor NFAT3 mediates neuronal survival. J Biol Chem 280(4): 2818-25. [Article PDF]

Shalizi, A, Lehtinen, M, Gaudillière, B, Donovan, N, Han, J, Konishi, Y, and Bonni, A, 2003. Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. J Neuroscience 23(19): 7326-36. PMID: 12917366 [Article PDF]

Konishi, Y, Lehtinen, M, Donovan, N, and Bonni, A, 2002. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Molecular Cell 9(5): 1005-16. Highlighted in Antony Carr: Faculty of 1000 Biology, 24 Jun 2002. PMID: 12049737 [Article PDF]

Wiemelt, AP, Lehtinen, M, and McMorris, FA, 2001. Agonists calcitonin, corticotropin-releasing hormone, and vasoactive intestinal peptide, but not prostaglandins or B-adrenergic agonists, elevate cyclic adenosine monophosphate levels in oligodendroglial cells. J Neuroscience Research 65: 165-172. [Article PDF]