Kunkel Laboratory - Overview

The primary focus of the Kunkel laboratory is the study of Duchenne Muscular Dystrophy (DMD), a progressive muscle wasting disease that affects about 1 in 5000 male births. Since our discovery of mutations in the dystrophin gene as the cause of DMD, we have dedicated over 30 years of research to investigating disease mechanisms and potential treatments. In addition to DMD, the Kunkel laboratory also researches Limb Girdle Muscular Dystrophy (LGMD) using zebrafish models. 

The Kunkel laboratory also has research efforts in interstitial cystitis and autism spectrum disorder (ASD). Interestingly, about 1 in 5 boys with DMD also presents with ASD, a much higher prevalence than in the general male population of 1 in 37. This has led us to investigate a potential role of dystrophin absence in the development of ASD.

Please see the links to the left for more information.