Klagsbrun Laboratory | Influential Publications

Shing Y, Folkman J, Sullivan R, Butterfield C, Murray J, Klagsbrun M. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 1984; 223:1196-1299. Available on PubMed. (Times Cited: 672) 

Klagsbrun M, Shing Y. Heparin affinity of anionic and cationic capillary endothelial cell growth factors: analysis of hypothalamus-derived growth factors and fibroblast growth factors. Proc Natl Acad Sci USA 1985; 82:805-809. Available on PubMed Central. 

Folkman J, Klagsbrun M. Angiogenic factors. Science 1987; 235:442-447. Available on PubMed. (Times Cited: 3,579)

Vlodavsky I, Folkman J, Sullivan R, Fridman R, Ishai-Michaeli R, Sasse J, Klagsbrun M. Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci USA 1987; 84:2292-2296. Available on PubMed Central. (Times Cited: 945)

Rogelj S, Weinberg RA, Fanning P, Klagsbrun M. Basic fibroblast growth factor fused to a single peptide transforms cells. Nature 1988; 331:173-175. Available on PubMed.

Klagsbrun M. The affinity of fibroblast growth factors (FGFs) for heparin; FGF-heparan sulfate interactions in cells and extracellular matrix. Curr Opin Cell Biol 1990; 2:857-863. Available on PubMed.

Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 1991; 64:841-848. Available on PubMed. (Times Cited: 1,860)

Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 1991; 251:936-939. Available on PubMed. (Times Cited: 827)

Klagsbrun M, Baird A. A dual receptor system is required for basic fibroblast growth factor activity. Cell 1991; 67:229-231. Available on PubMed. (Times Cited: 526)

Higashiyama S, Abraham JA, Klagsbrun M. Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with heparin sulfate. J Cell Biol 1993; 122:933-940. Available on PubMed Central.

Raab G, Kover K, Paria BC, Dey SK, Ezzell RM, Klagsbrun M. Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor. Development 1996; 122:637-645. Available on PubMed.

Soker S, Fidder H, Neufeld G, Klagsbrun M. Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain. J Biol Chem 1996; 271:5761-5767. Available on PubMed.

Raab G, Klagsbrun M. Heparin-binding EGF-like growth factor. Biochim Biophys Acta 1997; 1333:F179-199. Available on PubMed.

Soker S, Takashima S, Miao H-Q, Neufeld G, Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998; 92:735-745. Available on PubMed. (Times Cited: 1,077)

Klagsbrun M, Moses MA. Molecular angiogenesis. Chem Biol 1999; 6:R217-224. Available on PubMed.

Miao H-Q, Soker S, Feiner L, Alonso JL, Raper JA, Klagsbrun M. Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and VEGF165. J Cell Biol 1999; 146:233-241. Available on PubMed Central.

Gagnon ML, Bielenberg DR, Gechtman Z, Miao H-Q, Takashima S, Soker S, Klagsbrun M. Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and anti-tumor activity. Proc Natl Acad Sci USA 2000; 97:2573-2578. Available on PubMed Central.

Miao H-Q, Lee P, Lin H, Soker S, Klagsbrun M. Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J 2000; 14:2532-2539. Available on PubMed.

Nishi E, Prat A, Hospital V, Elenius K, Klagsbrun M. N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. EMBO J 2001; 20:3342-3350. Available on PubMed Central.

Takashima, S, Kitakaze S, Asakura M, Asanuma H, Sanada S, Tashiro F, Niwa H, Miyazaki J, Hirota S, Kitamura U, Kitsukawa T, Fujisawa H, Klagsbrun M, Hori M. Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc Natl Acad Sci USA 2002; 99:3657-3662. Available on PubMed Central.

Lee P, Goishi K, Davidson AJ, Mannix R, Zon L, Klagsbrun M. Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc Natl Acad Sci USA 2002; 99:10470-10475. Available on PubMed Central.

Goishi K, Lee P, Davidson, AJ, Nishi E, Zon LI, Klagsbrun M. Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects. Mech Dev 2003; 120:811-822. Available on PubMed.

Hida K, Hida Y, Amin D, Flint A, Panigrahy D, Morton CC, Klagsbrun M. Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res 2004; 64:8249-8255. Available on PubMed.

Bielenberg DR, Hida Y, Shimizu A, Kaipainen A, Kreuter M, Kim CC, Klagsbrun M. Semaphorin 3F, a chemorepulsant for endothelial cells induces a poorly vascularized, encapsulated, non-metastatic tumor phenotype. J Clin Invest 2004; 114:1260-1271. Available on PubMed Central.

Goishi K, Klagsbrun M. Vascular endothelial growth factor and its receptors in embryonic zebrafish blood vessel development, Curr Top Dev Biol 2004; 62:127-152. Available on PubMed.

Klagsbrun M, Eichmann A. A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis. Cytokine & Growth Factor Reviews 2005; 16:535-548. Available on PubMed.

Geretti E, Shimizu A, Kurschat P, Klagsbrun M. Site-directed mutagenesis in the B-neuropilin-2 domain selectively enhances its affinity to VEGF165, but not to SEMA3F. J Biol Chem 2007; 282:25698-25707. Available on PubMed.

Dudley AC, Khan ZA, Shih S-C, Kang S-Y, Zwaans BM, Klagsbrun M. Calcification of multipotent prostate tumor endothelium. Cancer Cell 2008; 14:201-211. Available on PubMed

Shimizu A, Mammoto A, Italiano Jr J, Pravda E, Dudley AC, Ingber DI, Klagsbrun M. ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human tumor cells. J Biol Chem 2008; 283:27230-27238. Available on PubMed.