Engle Laboratory

The Congenital Cranial Dysinnervation Disorders and Disorders of Axon Guidance


Neurogenetics Research



Human Disorders:
For research participants
and collaborators

Welcome to the Engle Laboratory, an HHMI molecular genetics and developmental neuroscience research lab at the Boston Children's Hospital and affiliated with Harvard Medical School. The lab has several themes:

  1. The CCDDs: Clinical and genetic studies of complex eye movement syndromes called the Congenital Cranial Dysinnervation Disorders (CCDDs).
  2. Axon Guidance: Neurodevelopmental studies of the genetic causes of the CCDDs. We have discovered that complex strabismus syndromes can be sensitive indicators of human genetic errors in axon growth and guidance. These include horizontal gaze palsy with progressive scoliosis, Duane syndrome, CFEOM1, and CFEOM3 that result from mutations in ROBO3, CHN1, KIF21A, and TUBB3 respectively.
  3. Strabismus: Genetic studies of the common forms of strabismus, including esotropia and exotropia.


In 2008, Dr. Engle became a Howard Hughes Medical Institute Investigator. For further information on this please click on: Engle/HHMI

We are always pleased to consider potential postdocs and Harvard grad students for positions in the Engle lab: Job Opportunities. Lab members have a broad range of interests, including but not limited to developmental neurobiology, cell biology of the cytoskeleton, axon transport, cell signaling, molecular genetics of Mendelian and complex traits, and the definition of new human disease phenotypes - especially those of axon guidance. Please contact Dr. Elizabeth Engle at elizabeth.engle@childrens.harvard.edu.