Beggs Laboratory | Information for Healthcare Providers

Thank you for your interest in our research!

This section contains general information about our Institutional Review Board (IRB) approved studies on the genetics of the congenital myopathies.

We also provide password-protected instructions for submitting patient samples and informed consent forms that can be downloaded from this site. The information presented here is provided for the convenience of physicians and genetic counselors that would like to refer a family to our research studies. We would be happy to communicate directly if you prefer. For our contact information, go to contact us.

The congenital myopathies are a group of rare genetic disorders that are present at birth and mainly result in muscle weakness. We are interested in many types of congenital myopathies, including non-specific myopathies. Among the diseases we study are:


OMIM Entries

Gene Reviews

Congenital Fiber Type Disproportion



Multiminicore Disease


Multiminicore Disease

Centronuclear/Myotubular Myopathy

Autosomal Recessive

Autosomal Dominant

Centronuclear Myopathy

X-linked Myotubular Myopathy


X-Linked Myotubular Myopathy

Nemaline Myopathy






Nemaline Myopathy


The fundamental goals of the Beggs laboratory are to understand the molecular genetics of the congenital myopathies and use this information to develop improved diagnostic and therapeutic methods. Our research involves three complementary approaches:

  1. Enrollment of patients with congenital myopathies in our studies

  2. Identification of new muscle-specific genes and proteins through biochemical and molecular analysis

  3. Gene expression studies using the microarray technology

Visit Information for Researchers for detailed information about our research studies.


Our work consists of research studies of indefinite duration. In addition, due to the lengthy and unpredictable nature of these studies, it is unlikely that we would make any clinically-relevant findings in the near future. In addition, because this is a research laboratory, we cannot report results from this study. This is because in the United States, the Clinical Laboratory Improvement Act/Amendment (CLIA) requires that laboratories performing clinical tests meet certain quality and expertise standards. However, if we obtain information that we think might be significant to the family, we may be able to have these results confirmed by a CLIA-certified clinical laboratory.

Although there is no charge for participation in our research study, there will most likely be a charge associated with the repeat clinical testing. The charge may vary depending on the laboratory. If the patient's results were confirmed, they would be reported to the patient's referring physician/genetic counselor. Although we do not always have definitive tests that might help to make a genetic diagnosis, participation of affected families will greatly aid our research on neuromuscular disease.

We look forward to hearing from you!

How to enroll a patient into our study


1) Obtain written informed consent All participants must read and sign our IRB approved informed consent forms in order to take part in this research. If there is muscle tissue available from the affected patient (see #2 below), the patient (or parent/guardian if less than 18) must sign a consent form for DNA studies and a consent form for muscle tissue studies. Clinicians obtaining consent from their patients sign as our "collaborating physician/genetic counselor" on section IX of the consent forms.

We will be glad to answer your questions and assist you in this process. If you are a physician or a genetic counselor and would like to download our informed consent forms from this Web site, click here. To obtain your password, contact Casie Genetti, MS, CGC.

2) Locate specimens
For our studies, we will need:

  • Blood samples from the affected patient and all available and consenting first-degree relatives.

  • Unfixed, frozen muscle tissue. Often, we can use tissue remaining from a surgical biopsy or autopsy. Alternatively, if a surgical procedure is planned for the near future, this may provide an opportunity to obtain a muscle specimen without additional risk or discomfort to the patient. If you are a physician or genetic counselor and would like access to the instructions for submitting specimens, contact Casie Genetti, MS, CGC, to obtain your password.

3) Gather copies of relevant medical records
Medical records will help us correlate our findings with existing clinical data. If available, please send a pedigree, including all affected family members and first-degree relatives of each. Also, muscle pathology reports, EMG, serum muscle enzymes, and results of any other neuromuscular-related tests are important. Please also include notes from neurologists and/or geneticists describing initial presentation.

Please ask your patient to sign an authorization for release of medical information.


Enrollment forms

Please contact our study coordinator, Casie Genetti.